FI118414B - Hypokolesteroleemisia, antiateroskleroottisia ja hypotriglyserideemisiä merkaptoasetyyliamidijohdannaisia - Google Patents

Hypokolesteroleemisia, antiateroskleroottisia ja hypotriglyserideemisiä merkaptoasetyyliamidijohdannaisia Download PDF

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Publication number
FI118414B
FI118414B FI963785A FI963785A FI118414B FI 118414 B FI118414 B FI 118414B FI 963785 A FI963785 A FI 963785A FI 963785 A FI963785 A FI 963785A FI 118414 B FI118414 B FI 118414B
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FI
Finland
Prior art keywords
compound
hydrogen
formula
alkyl
cholesterol
Prior art date
Application number
FI963785A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI963785A (fi
FI963785A0 (fi
Inventor
Richard C Dage
Gary A Flynn
John F French
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of FI963785A publication Critical patent/FI963785A/fi
Publication of FI963785A0 publication Critical patent/FI963785A0/fi
Application granted granted Critical
Publication of FI118414B publication Critical patent/FI118414B/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
FI963785A 1994-03-24 1996-09-23 Hypokolesteroleemisia, antiateroskleroottisia ja hypotriglyserideemisiä merkaptoasetyyliamidijohdannaisia FI118414B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21778194 1994-03-24
US08/217,781 US5484783A (en) 1994-03-24 1994-03-24 Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
US9502476 1995-02-28
PCT/US1995/002476 WO1995025548A2 (en) 1994-03-24 1995-02-28 Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide derivatives

Publications (3)

Publication Number Publication Date
FI963785A FI963785A (fi) 1996-09-23
FI963785A0 FI963785A0 (fi) 1996-09-23
FI118414B true FI118414B (fi) 2007-11-15

Family

ID=22812484

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963785A FI118414B (fi) 1994-03-24 1996-09-23 Hypokolesteroleemisia, antiateroskleroottisia ja hypotriglyserideemisiä merkaptoasetyyliamidijohdannaisia

Country Status (20)

Country Link
US (1) US5484783A (es)
EP (1) EP0751775B1 (es)
JP (1) JPH09510220A (es)
KR (1) KR970701550A (es)
CN (1) CN1144483A (es)
AT (1) ATE217527T1 (es)
AU (1) AU705029B2 (es)
CA (1) CA2184693C (es)
DE (1) DE69526731T2 (es)
DK (1) DK0751775T3 (es)
ES (1) ES2173180T3 (es)
FI (1) FI118414B (es)
HU (1) HU226643B1 (es)
IL (1) IL113074A (es)
NO (1) NO313176B1 (es)
NZ (1) NZ282949A (es)
PT (1) PT751775E (es)
TW (1) TW323954B (es)
WO (1) WO1995025548A2 (es)
ZA (1) ZA952285B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US5834353A (en) * 1997-10-20 1998-11-10 Texas Instruments-Acer Incorporated Method of making deep sub-micron meter MOSFET with a high permitivity gate dielectric
US6378430B1 (en) 1999-10-15 2002-04-30 King Press Corporation Cylinder with plate gripping device
DE10229180A1 (de) * 2002-06-28 2004-01-29 Aventis Pharma Deutschland Gmbh Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen
DK1670768T3 (da) * 2003-10-08 2009-11-09 Lilly Co Eli Forbindelser og fremgangsmåder til at behandle dyslipidæmi

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US3334095A (en) * 1965-02-16 1967-08-01 Sandoz Ag Novel pyrrolo-oxazines and pyrrolo-oxazoles
US3334091A (en) * 1965-03-25 1967-08-01 Sandoz Ag Sedatives
GB1525845A (en) * 1976-07-30 1978-09-20 Ucb Sa 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
US4320057A (en) * 1980-06-23 1982-03-16 American Home Products Corporation Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
ZA833214B (en) * 1982-05-12 1983-12-28 Hoffmann La Roche Bicyclic compounds
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
HUT40660A (en) * 1985-04-30 1987-01-28 Lilly Co Eli Process for production of derivatives of 7-substituated bicyclic pirasilididone
ZA874107B (es) * 1986-06-13 1987-12-09
ZA874106B (en) * 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
US5061694A (en) * 1989-10-23 1991-10-29 E. R. Squibb & Sons, Inc. Method for stabilizing or causing regression of atherosclerosis in coronary arteries employing an ace inhibitor
GB8926512D0 (en) * 1989-11-23 1990-01-10 Pfizer Ltd Therapeutic agents
AU7168091A (en) * 1989-12-22 1991-07-24 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
CA2057786C (en) * 1990-12-21 2002-06-18 Gary A. Flynn Amino and nitro containing tricyclic compounds useful as inhibitors or ace
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
EP0533084A1 (en) * 1991-09-16 1993-03-24 Schering Corporation Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating and preventing myointimal proliferation
RU2124503C1 (ru) * 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase

Also Published As

Publication number Publication date
US5484783A (en) 1996-01-16
ES2173180T3 (es) 2002-10-16
CA2184693A1 (en) 1995-09-28
HU9602603D0 (en) 1996-11-28
NZ282949A (en) 1997-07-27
WO1995025548A2 (en) 1995-09-28
PT751775E (pt) 2002-10-31
CN1144483A (zh) 1997-03-05
EP0751775A1 (en) 1997-01-08
FI963785A (fi) 1996-09-23
FI963785A0 (fi) 1996-09-23
EP0751775B1 (en) 2002-05-15
IL113074A0 (en) 1995-06-29
HUT74886A (en) 1997-02-28
AU2091495A (en) 1995-10-09
ZA952285B (en) 1996-01-09
DE69526731D1 (en) 2002-06-20
DK0751775T3 (da) 2002-08-26
JPH09510220A (ja) 1997-10-14
NO313176B1 (no) 2002-08-26
CA2184693C (en) 2001-01-02
HU226643B1 (en) 2009-05-28
DE69526731T2 (de) 2003-02-06
AU705029B2 (en) 1999-05-13
TW323954B (en) 1998-01-01
NO963989D0 (no) 1996-09-23
IL113074A (en) 2000-07-26
WO1995025548A3 (en) 1995-11-09
NO963989L (no) 1996-11-22
KR970701550A (ko) 1997-04-12
ATE217527T1 (de) 2002-06-15

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