DE69526731D1 - Hypocholesterolämische,antiatherosklerotische und hypotriglyceridämische mercaptoacetylamid-derivate - Google Patents
Hypocholesterolämische,antiatherosklerotische und hypotriglyceridämische mercaptoacetylamid-derivateInfo
- Publication number
- DE69526731D1 DE69526731D1 DE69526731T DE69526731T DE69526731D1 DE 69526731 D1 DE69526731 D1 DE 69526731D1 DE 69526731 T DE69526731 T DE 69526731T DE 69526731 T DE69526731 T DE 69526731T DE 69526731 D1 DE69526731 D1 DE 69526731D1
- Authority
- DE
- Germany
- Prior art keywords
- mercaptoacetylamid
- hypotriglyceridämische
- hypocholesterolämische
- antiatherosklerotische
- derivate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Artificial Filaments (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
The present invention relates to the use of certain mercaptoacetylamide and benzazapine derivatives in treating patients suffering from hypertriglyceridemia, atherosclerosis and hypercholesterolemia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/217,781 US5484783A (en) | 1994-03-24 | 1994-03-24 | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
PCT/US1995/002476 WO1995025548A2 (en) | 1994-03-24 | 1995-02-28 | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69526731D1 true DE69526731D1 (en) | 2002-06-20 |
DE69526731T2 DE69526731T2 (en) | 2003-02-06 |
Family
ID=22812484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69526731T Expired - Lifetime DE69526731T2 (en) | 1994-03-24 | 1995-02-28 | HYPOCHOLESTEROLEMIC, ANTIATHEROSCLEROTIC AND HYPOTRIGLYCERIDEMIC MERCAPTOACETYLAMIDE DERIVATIVES |
Country Status (20)
Country | Link |
---|---|
US (1) | US5484783A (en) |
EP (1) | EP0751775B1 (en) |
JP (1) | JPH09510220A (en) |
KR (1) | KR970701550A (en) |
CN (1) | CN1144483A (en) |
AT (1) | ATE217527T1 (en) |
AU (1) | AU705029B2 (en) |
CA (1) | CA2184693C (en) |
DE (1) | DE69526731T2 (en) |
DK (1) | DK0751775T3 (en) |
ES (1) | ES2173180T3 (en) |
FI (1) | FI118414B (en) |
HU (1) | HU226643B1 (en) |
IL (1) | IL113074A (en) |
NO (1) | NO313176B1 (en) |
NZ (1) | NZ282949A (en) |
PT (1) | PT751775E (en) |
TW (1) | TW323954B (en) |
WO (1) | WO1995025548A2 (en) |
ZA (1) | ZA952285B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US5834353A (en) * | 1997-10-20 | 1998-11-10 | Texas Instruments-Acer Incorporated | Method of making deep sub-micron meter MOSFET with a high permitivity gate dielectric |
US6378430B1 (en) | 1999-10-15 | 2002-04-30 | King Press Corporation | Cylinder with plate gripping device |
DE10229180A1 (en) * | 2002-06-28 | 2004-01-29 | Aventis Pharma Deutschland Gmbh | Use of vasopeptidase inhibitors in the treatment of metabolic disorders, nephropathy and AGE-associated disorders |
KR20060085675A (en) * | 2003-10-08 | 2006-07-27 | 일라이 릴리 앤드 캄파니 | Compounds and methods for treating dyslipidemia |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3334095A (en) * | 1965-02-16 | 1967-08-01 | Sandoz Ag | Novel pyrrolo-oxazines and pyrrolo-oxazoles |
US3334091A (en) * | 1965-03-25 | 1967-08-01 | Sandoz Ag | Sedatives |
GB1525845A (en) * | 1976-07-30 | 1978-09-20 | Ucb Sa | 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones |
IE50839B1 (en) * | 1980-02-26 | 1986-07-23 | Wyeth John & Brother Ltd | Novel processes for preparing proline derivatives and analogous compounds |
EP0042100A1 (en) * | 1980-06-13 | 1981-12-23 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Pyrazolopyridazine derivatives, intermediates and processes for their preparation, and medicaments containing them |
US4320057A (en) * | 1980-06-23 | 1982-03-16 | American Home Products Corporation | Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones |
US4415496A (en) * | 1981-03-23 | 1983-11-15 | Merck & Co., Inc. | Bicyclic lactams |
GB2128984B (en) * | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
ZA833214B (en) * | 1982-05-12 | 1983-12-28 | Hoffmann La Roche | Bicyclic compounds |
US4552889A (en) * | 1983-06-09 | 1985-11-12 | Eli Lilly And Company | 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension |
US4692438A (en) * | 1984-08-24 | 1987-09-08 | Hoffmann-La Roche Inc. | Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity |
US4584294A (en) * | 1984-11-07 | 1986-04-22 | Merck & Co., Inc. | Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents |
CA1274832A (en) * | 1985-04-30 | 1990-10-02 | Richard Elmer Holmes | 7-substituted bicyclic pyrazolidinones |
ZA874106B (en) * | 1986-06-13 | 1987-12-08 | Merrell Dow Pharmaceuticals Inc. | Novel antihypertensive agent |
US4973585A (en) * | 1986-06-13 | 1990-11-27 | Merrell Dow Pharmaceuticals | Tricyclic lactams active as antihypertensive agents |
CA1337654C (en) * | 1986-06-13 | 1995-11-28 | Gary A. Flynn | Fused tricyclic lactams as antihypertensive agents |
GB8629875D0 (en) * | 1986-12-15 | 1987-01-28 | Hoffmann La Roche | Pyridazodiazepine derivatives |
US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
US5061694A (en) * | 1989-10-23 | 1991-10-29 | E. R. Squibb & Sons, Inc. | Method for stabilizing or causing regression of atherosclerosis in coronary arteries employing an ace inhibitor |
GB8926512D0 (en) * | 1989-11-23 | 1990-01-10 | Pfizer Ltd | Therapeutic agents |
WO1991009840A1 (en) * | 1989-12-22 | 1991-07-11 | Schering Corporation | Mercaptocycloacyl aminoacid endopeptidase inhibitors |
CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
US5208230A (en) * | 1990-12-21 | 1993-05-04 | Merrell Dow Pharmaceuticals | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
NZ241023A (en) * | 1990-12-21 | 1994-10-26 | Merrell Dow Pharma | Condensed benzazepine derivatives and pharmaceutical compositions |
FR2679564A1 (en) * | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | NOVEL ACYLMERCAPTOALCANOLDIPEPTIDES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM. |
AU2650692A (en) * | 1991-09-16 | 1993-04-27 | Schering Corporation | Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating or preventing myointimal proliferation |
RU2124503C1 (en) * | 1992-05-18 | 1999-01-10 | И.Р.Сквибб энд Санз, Инк. | Heterocyclic nitrogen-containing derivatives of carboxylic acid, method of their synthesis, pharmaceutical composition |
US5238932A (en) * | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
-
1994
- 1994-03-24 US US08/217,781 patent/US5484783A/en not_active Expired - Lifetime
-
1995
- 1995-02-28 NZ NZ282949A patent/NZ282949A/en not_active IP Right Cessation
- 1995-02-28 HU HU9602603A patent/HU226643B1/en not_active IP Right Cessation
- 1995-02-28 KR KR1019960705294A patent/KR970701550A/en not_active Application Discontinuation
- 1995-02-28 DK DK95913501T patent/DK0751775T3/en active
- 1995-02-28 PT PT95913501T patent/PT751775E/en unknown
- 1995-02-28 CA CA002184693A patent/CA2184693C/en not_active Expired - Fee Related
- 1995-02-28 DE DE69526731T patent/DE69526731T2/en not_active Expired - Lifetime
- 1995-02-28 EP EP95913501A patent/EP0751775B1/en not_active Expired - Lifetime
- 1995-02-28 AT AT95913501T patent/ATE217527T1/en active
- 1995-02-28 JP JP7523719A patent/JPH09510220A/en active Pending
- 1995-02-28 WO PCT/US1995/002476 patent/WO1995025548A2/en active IP Right Grant
- 1995-02-28 AU AU20914/95A patent/AU705029B2/en not_active Ceased
- 1995-02-28 CN CN95192242A patent/CN1144483A/en active Pending
- 1995-02-28 ES ES95913501T patent/ES2173180T3/en not_active Expired - Lifetime
- 1995-03-20 ZA ZA952285A patent/ZA952285B/en unknown
- 1995-03-21 TW TW084102716A patent/TW323954B/en not_active IP Right Cessation
- 1995-03-22 IL IL11307495A patent/IL113074A/en not_active IP Right Cessation
-
1996
- 1996-09-23 FI FI963785A patent/FI118414B/en not_active IP Right Cessation
- 1996-09-23 NO NO19963989A patent/NO313176B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI118414B (en) | 2007-11-15 |
CA2184693C (en) | 2001-01-02 |
NO313176B1 (en) | 2002-08-26 |
KR970701550A (en) | 1997-04-12 |
FI963785A (en) | 1996-09-23 |
EP0751775B1 (en) | 2002-05-15 |
WO1995025548A2 (en) | 1995-09-28 |
TW323954B (en) | 1998-01-01 |
NO963989L (en) | 1996-11-22 |
HU9602603D0 (en) | 1996-11-28 |
AU705029B2 (en) | 1999-05-13 |
HU226643B1 (en) | 2009-05-28 |
US5484783A (en) | 1996-01-16 |
ZA952285B (en) | 1996-01-09 |
ES2173180T3 (en) | 2002-10-16 |
NO963989D0 (en) | 1996-09-23 |
EP0751775A1 (en) | 1997-01-08 |
PT751775E (en) | 2002-10-31 |
DK0751775T3 (en) | 2002-08-26 |
IL113074A (en) | 2000-07-26 |
WO1995025548A3 (en) | 1995-11-09 |
ATE217527T1 (en) | 2002-06-15 |
CA2184693A1 (en) | 1995-09-28 |
DE69526731T2 (en) | 2003-02-06 |
AU2091495A (en) | 1995-10-09 |
JPH09510220A (en) | 1997-10-14 |
CN1144483A (en) | 1997-03-05 |
HUT74886A (en) | 1997-02-28 |
IL113074A0 (en) | 1995-06-29 |
FI963785A0 (en) | 1996-09-23 |
NZ282949A (en) | 1997-07-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL323825A1 (en) | Peptidyloheterocycli compounds useful in treating diorders associated with thrombosin | |
IE893922L (en) | Hypocholesterolemic and antiatherosclerotic uses of¹bis(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane | |
MX9703944A (en) | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis. | |
DE69526731D1 (en) | Hypocholesterolämische,antiatherosklerotische und hypotriglyceridämische mercaptoacetylamid-derivate | |
HK1002658A1 (en) | Imidazopyridine-azolidinones their preparation and pharmaceutical use | |
GR3033117T3 (en) | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives | |
NZ282565A (en) | Condensed mercaptoacetylamidedisulphidebenzazepines used in treating elevated cholesterol levels, atherosclerosis, and hypotriglyceridemia | |
GB9625123D0 (en) | Treatment of cotton | |
UA32580C2 (en) | Drug for treatment of paralytic intestinal obstructioni | |
MX9706424A (en) | Use of moxonidine for the treatment of atherosclerosis. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |