FI115915B - 8,9-dehydroestronin alkalimetallisuola - Google Patents

8,9-dehydroestronin alkalimetallisuola Download PDF

Info

Publication number
FI115915B
FI115915B FI943903A FI943903A FI115915B FI 115915 B FI115915 B FI 115915B FI 943903 A FI943903 A FI 943903A FI 943903 A FI943903 A FI 943903A FI 115915 B FI115915 B FI 115915B
Authority
FI
Finland
Prior art keywords
dehydroestrone
alkali metal
metal salt
sulfate
tris
Prior art date
Application number
FI943903A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI943903A0 (fi
FI943903A (fi
Inventor
Panolil Chirukan Raveendranath
John Anthony Wichtowski
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of FI943903A0 publication Critical patent/FI943903A0/fi
Publication of FI943903A publication Critical patent/FI943903A/fi
Application granted granted Critical
Publication of FI115915B publication Critical patent/FI115915B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Catalysts (AREA)
FI943903A 1992-02-26 1994-08-25 8,9-dehydroestronin alkalimetallisuola FI115915B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/841,694 US5210081A (en) 1992-02-26 1992-02-26 Alkali metal 8,9-dehydroestrone sulfate esters
US84169492 1992-02-26
US9301500 1993-02-19
PCT/US1993/001500 WO1993017036A1 (en) 1992-02-26 1993-02-19 Alkali metal 8,9-dehydroestrone sulfate esters

Publications (3)

Publication Number Publication Date
FI943903A0 FI943903A0 (fi) 1994-08-25
FI943903A FI943903A (fi) 1994-08-25
FI115915B true FI115915B (fi) 2005-08-15

Family

ID=25285489

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943903A FI115915B (fi) 1992-02-26 1994-08-25 8,9-dehydroestronin alkalimetallisuola

Country Status (22)

Country Link
US (3) US5210081A (xx)
EP (2) EP0628052B1 (xx)
JP (1) JP3715645B2 (xx)
KR (1) KR100256861B1 (xx)
AR (2) AR042262A2 (xx)
AT (2) ATE174342T1 (xx)
AU (2) AU677181B2 (xx)
CA (1) CA2089707A1 (xx)
DE (2) DE69322497T2 (xx)
DK (2) DK0628052T3 (xx)
ES (2) ES2125975T3 (xx)
FI (1) FI115915B (xx)
GR (1) GR3029620T3 (xx)
HK (2) HK1020282A1 (xx)
HU (2) HUT67553A (xx)
LV (1) LV12240B (xx)
MX (1) MX9300969A (xx)
PT (1) PT864583E (xx)
SG (1) SG49715A1 (xx)
TW (1) TW257677B (xx)
WO (1) WO1993017036A1 (xx)
ZA (1) ZA93746B (xx)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210081A (en) * 1992-02-26 1993-05-11 American Home Products Corporation Alkali metal 8,9-dehydroestrone sulfate esters
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
DE4334823C2 (de) * 1993-10-09 1998-09-17 Schering Ag Verfahren zur Herstellung von Schwefelsäurehalbestern von Estrogenen
US5395831A (en) * 1994-04-08 1995-03-07 American Home Products Corporation Treating cardiac disorders with Δ9(11)-dehydro-8-isoestrone
US5861431A (en) * 1995-06-07 1999-01-19 Iotek, Inc. Incontinence treatment
US5998639A (en) * 1995-11-06 1999-12-07 Akzo Nobel, N.V. Sulfatation of estrogen mixtures
AU703814B2 (en) * 1995-12-04 1999-04-01 Wyeth Antioxidant
DE19631542C1 (de) * 1996-07-25 1997-08-28 Schering Ag Verfahren zur Herstellung von 3-Sulfatoxy-estra-1,3,5(10)-trien-Derivaten II
DE19631543C1 (de) * 1996-07-25 1997-11-20 Schering Ag Verfahren zur Herstellung von 3-Sulfatoxy-estra-1,3,5(10)-trien-Derivaten I
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
ID18256A (id) * 1996-09-16 1998-03-19 American Home Prod Penggunaan dari 8,9-dehidro estron sebagai estrogen dengan hasil netral pada tingkat prolaktin
AR014096A1 (es) * 1996-10-11 2001-02-07 Wyeth Corp 17 alfa,8,9-deshidroestradiol y 17 beta delta 8,9 deshidroestradiol, el uso de los mismos para la manufactura de un medicamento, una composicionfarmaceutica que los comprende y un procedimiento para su preparacion.
ZA979204B (en) * 1996-10-16 1999-04-14 American Home Prod Use of 8,9-dehydroestrone in treating vasomotor symptoms
IL124213A (en) * 1997-05-02 2004-12-15 Akzo Nobel Nv Sulfation of estrogen mixtures
US6432643B1 (en) 1999-10-22 2002-08-13 Duke University Method of determining Alzheimer's disease risk using apolipoprotein E4 genotype analysis in combination with decreased estrogen levels
US7989436B2 (en) 2003-07-23 2011-08-02 Duramed Pharmaceuticals, Inc. Estrogenic compounds and pharmaceutical formulations comprising the same
US6660726B2 (en) 2000-03-10 2003-12-09 Endeavor Pharmaceuticals Estrogenic compounds, pharmaceutical compositions thereof, and methods of using same
US7459445B2 (en) * 2000-03-10 2008-12-02 Duramed Pharmaceuticals, Inc. Estrogenic compounds and topical pharmaceutical formulations of the same
US6855703B1 (en) * 2000-03-10 2005-02-15 Endeavor Pharmaceuticals Pharmaceutical compositions of conjugated estrogens and methods of analyzing mixtures containing estrogenic compounds
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
US20030158432A1 (en) * 2002-01-08 2003-08-21 Leonard Thomas W. Synthesis of a mixture of sulfated estrogens using a sulfur trioxide complex
US8349819B2 (en) * 2002-10-09 2013-01-08 Dr. Reddy's Laboratories New York, Inc. Steroid extraction process from urine sources
US6992075B2 (en) * 2003-04-04 2006-01-31 Barr Laboratories, Inc. C(14) estrogenic compounds
JP2006522833A (ja) * 2003-04-11 2006-10-05 バー・ラボラトリーズ，インコーポレイテッド エストロゲンおよびプロゲスチンの投与法
AR049142A1 (es) * 2004-06-07 2006-06-28 Wyeth Corp Composiciones para recubrimientos de azucar,composiciones recubiertas y metodos para la fabricacion de los mismos
US20060040904A1 (en) * 2004-08-17 2006-02-23 Ahmed Salah U Vaginal cream compositions, kits thereof and methods of using thereof
EP1853272A1 (en) * 2005-02-03 2007-11-14 Duramed Pharmaceuticals, Inc. Compositions of unconjugated estrogens and methods for their use
AU2006263638A1 (en) * 2005-06-29 2007-01-04 Wyeth Formulations of conjugated estrogens and bazedoxifene
US8217024B2 (en) * 2005-12-27 2012-07-10 Teva Women's Health, Inc. Conjugated estrogen compositions, applicators, kits, and methods of making and use thereof
JP2010509350A (ja) * 2006-11-07 2010-03-25 ワイス エルエルシー 糖コーティングおよびその方法
KR20090104862A (ko) * 2007-01-12 2009-10-06 와이어쓰 정제내 정제 조성물
WO2008100769A2 (en) * 2007-02-09 2008-08-21 Wyeth Process for selective sulfation of aromatic hydroxyl groups
US7902147B2 (en) * 2007-11-05 2011-03-08 Duke University Chronic lymphocytic leukemia prognosis and treatment
TW201127386A (en) 2009-10-27 2011-08-16 Wyeth Llc Bazedoxifene formulations with antioxidants

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2834712A (en) * 1953-05-27 1958-05-13 American Home Prod Urinary estrogen compositions and methods for preparing them
US3079410A (en) * 1960-04-02 1963-02-26 Hoechst Ag Process for stabilizing anionic and cationic ester salts of 21-hydroxy-20-ketosteroids in an aqueous solution
US3959322A (en) * 1960-09-22 1976-05-25 Herchel Smith Synthesis of 13-alkyl-gon-4-ones
DE1200476B (de) * 1961-04-10 1965-09-09 Frosst & Co Charles E Stabilisierung von trockenen Zubereitungen synthetischer Alkalisalze von OEstronsulfat
US3551459A (en) * 1962-10-04 1970-12-29 Herchel Smith 13-methyl-8-isogonanes
US3394153A (en) * 1965-08-18 1968-07-23 Merck & Co Inc Process for the preparation of d, 1-8-dehydroestrone, and intermediates obtained therefrom
NL6805153A (xx) * 1968-04-10 1969-10-14
US3644618A (en) * 1968-10-29 1972-02-22 Frosst & Co Charles E Stable composition of synthetic sodium estrone sulfate
US3608077A (en) * 1969-11-13 1971-09-21 Syntex Corp Stabilization of metal steroid alcohol sulfates
US3649621A (en) * 1969-12-19 1972-03-14 American Home Prod Novel 3-cyclopentyl ethers of 13-alkylgon-poly-enes
GB1451109A (en) * 1973-08-17 1976-09-29 Rech Et Dapplications Scient S Derivatives of oestrone and their use in therapy
GB1528321A (en) * 1975-07-07 1978-10-11 Leo Ab Acylation process for the preparation of phenolic n,n-di-substituted carbamate esters
SE439586B (sv) * 1975-09-05 1985-06-24 Kanebo Ltd Sett att framstella ett stabilt farmaceutiskt torrpreparat av ett alkalimetallsalt av dehydroepiandrosteronsulfat
US4154820A (en) * 1976-02-23 1979-05-15 Akzona Incorporated Compositions containing alkali metal sulfate salts of conjugated estrogens and antioxidants as stabilizers
US5210081A (en) * 1992-02-26 1993-05-11 American Home Products Corporation Alkali metal 8,9-dehydroestrone sulfate esters

Also Published As

Publication number Publication date
ATE174342T1 (de) 1998-12-15
FI943903A0 (fi) 1994-08-25
DE69322497T2 (de) 1999-05-06
PT864583E (pt) 2007-01-31
AR042262A2 (es) 2005-06-15
AR042345A2 (es) 2005-06-15
HK1011369A1 (en) 1999-07-09
DK0628052T3 (da) 1999-07-12
EP0864583A3 (en) 2004-07-21
JPH07504197A (ja) 1995-05-11
GR3029620T3 (en) 1999-06-30
CA2089707A1 (en) 1993-08-27
US6169082B1 (en) 2001-01-02
DE69334073D1 (de) 2006-11-23
FI943903A (fi) 1994-08-25
TW257677B (xx) 1995-09-21
SG49715A1 (en) 1998-06-15
AU711571B2 (en) 1999-10-14
WO1993017036A1 (en) 1993-09-02
HK1020282A1 (en) 2000-04-07
LV12240A (lv) 1999-03-20
HU211971A9 (en) 1996-01-29
ES2274555T3 (es) 2007-05-16
KR100256861B1 (ko) 2000-08-01
EP0864583B1 (en) 2006-10-11
DK0864583T3 (da) 2006-12-04
ZA93746B (en) 1994-08-03
EP0864583A2 (en) 1998-09-16
US5288717A (en) 1994-02-22
KR950700318A (ko) 1995-01-16
AU3726093A (en) 1993-09-13
MX9300969A (es) 1993-09-01
EP0628052A1 (en) 1994-12-14
US5210081A (en) 1993-05-11
HUT67553A (en) 1995-04-28
AU677181B2 (en) 1997-04-17
HU9402457D0 (en) 1994-10-28
JP3715645B2 (ja) 2005-11-09
LV12240B (en) 1999-06-20
EP0628052B1 (en) 1998-12-09
ES2125975T3 (es) 1999-03-16
DE69322497D1 (de) 1999-01-21
ATE342272T1 (de) 2006-11-15
DE69334073T2 (de) 2007-02-01
AU2007697A (en) 1997-07-03

Similar Documents

Publication Publication Date Title
FI115915B (fi) 8,9-dehydroestronin alkalimetallisuola
US6458778B1 (en) Estradienes
WO2003104254A2 (en) Novel derivatives of androstane and androstene with ascorbic a cid and use thereof in treating or preventing various conditions, diseases, and disorders
US5124321A (en) 17-halomethylene estratrienes
US6713465B1 (en) Pregnanes
EP0973790B1 (en) Estra-5(10),7-dienes with estrogenic activity
JPH06329697A (ja) 骨疾患治療剤
EP0444424B1 (en) Bile acid unsaturated derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
AU746326B2 (en) Pharmaceutically acceptable salts of 5alpha-pregnan-3beta, 16alp ha-diol-20-one 3-sulfate useful as progestins and CNS disorders
EP0980382B1 (en) Estrogenic 19-norandrost-17-one derivatives with an aromatic b-ring
EP0980381B1 (en) Pharmaceutically acceptable salts of 5.alpha.-pregn-16-en-3.beta.-ol-20-one 3-sulphate ester with progestin activity and useful in the treatment of cns disorders
CZ20011343A3 (cs) Pregnanglukuronidy
JP2001523268A (ja) プレグナン−３，２０−ジオールのモノおよびジ硫酸エステル
KR20030090207A (ko) 결장표적성 프로드럭으로서의 코티코스테로이드21-설페이트 소듐 유도체

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 115915

Country of ref document: FI