FI114807B - Glukaanien entsyymikäsittely - Google Patents
Glukaanien entsyymikäsittely Download PDFInfo
- Publication number
- FI114807B FI114807B FI964339A FI964339A FI114807B FI 114807 B FI114807 B FI 114807B FI 964339 A FI964339 A FI 964339A FI 964339 A FI964339 A FI 964339A FI 114807 B FI114807 B FI 114807B
- Authority
- FI
- Finland
- Prior art keywords
- glucan
- yeast
- insoluble
- linked
- residue
- Prior art date
Links
- 229920001503 Glucan Polymers 0.000 title claims abstract description 110
- 102000004190 Enzymes Human genes 0.000 title description 11
- 108090000790 Enzymes Proteins 0.000 title description 11
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 51
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims abstract description 48
- 210000005253 yeast cell Anatomy 0.000 claims abstract description 12
- 241000235070 Saccharomyces Species 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 108010045275 endo-1,6-beta-glucanase Proteins 0.000 claims description 19
- 230000000694 effects Effects 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 11
- 210000002421 cell wall Anatomy 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 9
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 7
- 239000008103 glucose Substances 0.000 claims description 7
- 235000019253 formic acid Nutrition 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 238000005406 washing Methods 0.000 claims description 6
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 2
- 150000002632 lipids Chemical class 0.000 claims description 2
- 239000003513 alkali Substances 0.000 claims 6
- 238000009835 boiling Methods 0.000 claims 4
- 238000005903 acid hydrolysis reaction Methods 0.000 claims 3
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 241001465754 Metazoa Species 0.000 abstract description 8
- 210000000987 immune system Anatomy 0.000 abstract description 7
- 238000005063 solubilization Methods 0.000 abstract description 4
- 230000007928 solubilization Effects 0.000 abstract description 4
- 239000002671 adjuvant Substances 0.000 abstract description 2
- 230000000638 stimulation Effects 0.000 abstract description 2
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000002245 particle Substances 0.000 description 36
- 239000000725 suspension Substances 0.000 description 27
- 229960005486 vaccine Drugs 0.000 description 18
- 238000002347 injection Methods 0.000 description 17
- 239000007924 injection Substances 0.000 description 17
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 235000019688 fish Nutrition 0.000 description 14
- 210000002966 serum Anatomy 0.000 description 13
- 241000251468 Actinopterygii Species 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 229940088598 enzyme Drugs 0.000 description 10
- 108010014251 Muramidase Proteins 0.000 description 9
- 102000016943 Muramidase Human genes 0.000 description 9
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 9
- 239000004325 lysozyme Substances 0.000 description 9
- 229960000274 lysozyme Drugs 0.000 description 9
- 235000010335 lysozyme Nutrition 0.000 description 9
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 230000005875 antibody response Effects 0.000 description 6
- 238000005119 centrifugation Methods 0.000 description 6
- 239000006228 supernatant Substances 0.000 description 6
- 241000972773 Aulopiformes Species 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 5
- 241000223260 Trichoderma harzianum Species 0.000 description 5
- 238000002835 absorbance Methods 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 5
- 229940081969 saccharomyces cerevisiae Drugs 0.000 description 5
- 235000019515 salmon Nutrition 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 239000008366 buffered solution Substances 0.000 description 3
- 238000003776 cleavage reaction Methods 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 235000011007 phosphoric acid Nutrition 0.000 description 3
- 230000007017 scission Effects 0.000 description 3
- 239000001632 sodium acetate Substances 0.000 description 3
- 235000017281 sodium acetate Nutrition 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 2
- 239000005695 Ammonium acetate Substances 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000012670 alkaline solution Substances 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 235000019257 ammonium acetate Nutrition 0.000 description 2
- 229940043376 ammonium acetate Drugs 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000009928 pasteurization Methods 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 230000003381 solubilizing effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000589291 Acinetobacter Species 0.000 description 1
- 101000689231 Aeromonas salmonicida S-layer protein Proteins 0.000 description 1
- 229920002498 Beta-glucan Polymers 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 241000192041 Micrococcus Species 0.000 description 1
- 229920000715 Mucilage Polymers 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 241000235528 Rhizopus microsporus var. chinensis Species 0.000 description 1
- 241000277263 Salmo Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 241000223259 Trichoderma Species 0.000 description 1
- 241000499912 Trichoderma reesei Species 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000000240 adjuvant effect Effects 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 235000019728 animal nutrition Nutrition 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012143 dye reagent concentrate Substances 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 208000010824 fish disease Diseases 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- ASHGTUMKRVIOLH-UHFFFAOYSA-L potassium;sodium;hydrogen phosphate Chemical compound [Na+].[K+].OP([O-])([O-])=O ASHGTUMKRVIOLH-UHFFFAOYSA-L 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/42—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0208—Specific bacteria not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Polymers & Plastics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO941581A NO300692B1 (no) | 1994-04-29 | 1994-04-29 | Solubilisert forgrenet ß-1,3-glukan og anvendelse derav samt anvendelse av usolubilisert forgrenet ß-1,3-glukan |
| NO941581 | 1994-04-29 | ||
| PCT/IB1995/000265 WO1995030022A1 (en) | 1994-04-29 | 1995-04-18 | Enzyme treatment of glucans |
| IB9500265 | 1995-04-18 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI964339A FI964339A (fi) | 1996-10-28 |
| FI964339A0 FI964339A0 (fi) | 1996-10-28 |
| FI114807B true FI114807B (fi) | 2004-12-31 |
Family
ID=19897060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI964339A FI114807B (fi) | 1994-04-29 | 1996-10-28 | Glukaanien entsyymikäsittely |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7883875B2 (de) |
| EP (1) | EP0759089B1 (de) |
| JP (3) | JP3992730B2 (de) |
| AT (1) | ATE222958T1 (de) |
| AU (1) | AU703251B2 (de) |
| CA (1) | CA2189010C (de) |
| DE (1) | DE69527955T2 (de) |
| DK (1) | DK0759089T3 (de) |
| ES (1) | ES2182898T3 (de) |
| FI (1) | FI114807B (de) |
| NO (1) | NO300692B1 (de) |
| WO (1) | WO1995030022A1 (de) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO300692B1 (no) | 1994-04-29 | 1997-07-07 | Biotec Mackzymal As | Solubilisert forgrenet ß-1,3-glukan og anvendelse derav samt anvendelse av usolubilisert forgrenet ß-1,3-glukan |
| US5786343A (en) * | 1997-03-05 | 1998-07-28 | Immudyne, Inc. | Phagocytosis activator compositions and their use |
| AU3657100A (en) | 1999-03-12 | 2000-10-04 | Biotec Asa | Use of water-soluble beta-(1,3) glucans as agents for producing therapeutic skintreatment agents |
| DE19911055A1 (de) * | 1999-03-12 | 2000-09-21 | Cognis Deutschland Gmbh | Verwendung von oberflächenaktiven Gemischen |
| DE19911053B4 (de) * | 1999-03-12 | 2004-10-28 | Biotec Asa | Kosmetische und/oder pharmazeutische Zubereitungen |
| US8912165B2 (en) | 1999-03-12 | 2014-12-16 | Biotec Pharmacon Asa | Methods of skin treatment and use of water-soluble β-(1,3) glucans as active agents for producing therapeutic skin treatment agents |
| DE19911052A1 (de) * | 1999-03-12 | 2000-09-21 | Cognis Deutschland Gmbh | Sonnenschutzmittel |
| DE19911056B9 (de) * | 1999-03-12 | 2005-09-08 | Biotec Asa | Kosmetische Zubereitungen und deren Verwendung |
| DE19911057C2 (de) * | 1999-03-12 | 2001-01-25 | Cognis Deutschland Gmbh | Haarkosmetische Zubereitungen |
| DE19911058B4 (de) * | 1999-03-12 | 2004-09-30 | Biotec Asa | Verwendung von nanoskaligen wasserlöslichen β-(1,3)-Glucanen |
| US8501710B2 (en) * | 1999-03-12 | 2013-08-06 | Biotec Pharmacon Asa | Methods of skin treatment and use of water-soluble β-(1,3) glucans as active agents for producing therapeutic skin treatment agents |
| DE19917744A1 (de) * | 1999-04-20 | 2000-10-26 | Cognis Deutschland Gmbh | Dekorative kosmetische Zubereitungen |
| DE19917743C2 (de) * | 1999-04-20 | 2003-08-14 | Biotec Asa | Desodorierende Zubereitungen |
| DE19920557B4 (de) * | 1999-05-05 | 2004-09-09 | Biotec Asa | Verfahren zur Herstellung von Kollagenfreien kosmetischen Zubereitungen |
| US20020009463A1 (en) * | 2000-02-23 | 2002-01-24 | Jan Raa | Novel, non-antigenic, mucosal adjuvant formulation which enhances the effects of substances, including vaccine antigens, in contact with mucosal body surfaces |
| US7507724B2 (en) | 2001-01-16 | 2009-03-24 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| US7906492B2 (en) | 2001-01-16 | 2011-03-15 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| BE1014638A6 (fr) * | 2002-02-12 | 2004-02-03 | Univ Liege | Methode de preparation de derives de la paroi cellulaire a partir de biomasse. |
| GB0211118D0 (en) | 2002-05-15 | 2002-06-26 | Polonelli Luciano | Vaccines |
| US7018986B2 (en) * | 2002-09-20 | 2006-03-28 | Immudyne | Use of beta glucans for the treatment of osteoporosis and other diseases of bone resorption |
| US20050180964A1 (en) | 2003-03-17 | 2005-08-18 | Puntenney Steven B. | Methods and compositions for the inhibition of growth of infectious Aspergillus fumigatus and other mycotic organisms in the gut of mammalian and avian species |
| JP2004210895A (ja) * | 2002-12-27 | 2004-07-29 | Immudyne Japan:Kk | 免疫機能を有する可能性β−グルカンの製造方法及び用途 |
| DE602004020117D1 (de) | 2004-02-13 | 2009-04-30 | Alpron Co Ltd | Verfahren zur herstellung von aus hefe stammendem glucan |
| US20050220846A1 (en) | 2004-04-05 | 2005-10-06 | Puntenney Steven B | Use of beta-1,3 (4)-endoglucanohydrolase, beta-1,3 (4) glucan, diatomaceous earth, mineral clay and glucomannan to augment immune function |
| AU2004218698B2 (en) * | 2004-10-08 | 2011-06-09 | Biotec BetaGlucans AS | Method |
| JP4570949B2 (ja) * | 2004-12-13 | 2010-10-27 | 株式会社アルプロン | 酵母由来グルカンの製造方法 |
| BRPI0520481B1 (pt) * | 2005-08-10 | 2020-11-10 | Steven Bruce Puntenney | composição de b-1, 3 (4) - endoglucanohidrolase, b-1, 3 (4) glucanas, terra diatomácea, argila mineral e glucomananas e método de uso para aumentar a função imunológica |
| US8323644B2 (en) | 2006-01-17 | 2012-12-04 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| EP1984004A4 (de) * | 2006-01-17 | 2010-03-03 | Sloan Kettering Inst Cancer | Die therapie verstärkendes glucan |
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| BRPI0900639C1 (pt) * | 2009-02-13 | 2011-12-20 | Hebron Farmaceutica Pesquisa Desenvolvimento E Inovacao Tecnologica Ltda | composição farmacêutica e uso desta para tratamento e/ou prevenção de doenças do trato respiratório |
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| WO2012014978A1 (ja) * | 2010-07-29 | 2012-02-02 | 国立大学法人北海道大学 | 免疫アジュバント |
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| JPS6019619B2 (ja) | 1980-09-19 | 1985-05-17 | 株式会社日立製作所 | Ｘ線管用回転陽極 |
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| US5028703A (en) * | 1988-03-11 | 1991-07-02 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
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-
1994
- 1994-04-29 NO NO941581A patent/NO300692B1/no not_active IP Right Cessation
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1995
- 1995-04-18 EP EP95914485A patent/EP0759089B1/de not_active Expired - Lifetime
- 1995-04-18 CA CA2189010A patent/CA2189010C/en not_active Expired - Lifetime
- 1995-04-18 DE DE69527955T patent/DE69527955T2/de not_active Expired - Lifetime
- 1995-04-18 WO PCT/IB1995/000265 patent/WO1995030022A1/en active IP Right Grant
- 1995-04-18 JP JP52809395A patent/JP3992730B2/ja not_active Expired - Lifetime
- 1995-04-18 ES ES95914485T patent/ES2182898T3/es not_active Expired - Lifetime
- 1995-04-18 AT AT95914485T patent/ATE222958T1/de active
- 1995-04-18 DK DK95914485T patent/DK0759089T3/da active
- 1995-04-18 AU AU21464/95A patent/AU703251B2/en not_active Ceased
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- 1996-10-28 FI FI964339A patent/FI114807B/fi not_active IP Right Cessation
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- 2005-03-30 US US11/093,427 patent/US7883875B2/en not_active Expired - Fee Related
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- 2007-05-16 JP JP2007130872A patent/JP2007228974A/ja active Pending
- 2007-12-06 US US11/951,811 patent/US8142785B2/en not_active Expired - Fee Related
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- 2008-11-13 JP JP2008290653A patent/JP2009051863A/ja active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| AU703251B2 (en) | 1999-03-25 |
| NO300692B1 (no) | 1997-07-07 |
| US20110104208A1 (en) | 2011-05-05 |
| JPH09512708A (ja) | 1997-12-22 |
| NO941581D0 (de) | 1994-04-29 |
| ATE222958T1 (de) | 2002-09-15 |
| US7883875B2 (en) | 2011-02-08 |
| CA2189010C (en) | 2010-07-13 |
| US20050255565A1 (en) | 2005-11-17 |
| JP3992730B2 (ja) | 2007-10-17 |
| FI964339A (fi) | 1996-10-28 |
| NO941581L (no) | 1995-10-30 |
| AU2146495A (en) | 1995-11-29 |
| CA2189010A1 (en) | 1995-11-09 |
| US8252295B2 (en) | 2012-08-28 |
| DE69527955T2 (de) | 2003-04-10 |
| JP2009051863A (ja) | 2009-03-12 |
| WO1995030022A1 (en) | 1995-11-09 |
| ES2182898T3 (es) | 2003-03-16 |
| DE69527955D1 (de) | 2002-10-02 |
| DK0759089T3 (da) | 2003-01-06 |
| FI964339A0 (fi) | 1996-10-28 |
| JP2007228974A (ja) | 2007-09-13 |
| US8142785B2 (en) | 2012-03-27 |
| EP0759089A1 (de) | 1997-02-26 |
| US20080124349A1 (en) | 2008-05-29 |
| EP0759089B1 (de) | 2002-08-28 |
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