EP1984004A4 - Die therapie verstärkendes glucan - Google Patents

Die therapie verstärkendes glucan

Info

Publication number
EP1984004A4
EP1984004A4 EP07718218A EP07718218A EP1984004A4 EP 1984004 A4 EP1984004 A4 EP 1984004A4 EP 07718218 A EP07718218 A EP 07718218A EP 07718218 A EP07718218 A EP 07718218A EP 1984004 A4 EP1984004 A4 EP 1984004A4
Authority
EP
European Patent Office
Prior art keywords
therapy
glucan
enhancing
enhancing glucan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07718218A
Other languages
English (en)
French (fr)
Other versions
EP1984004A2 (de
Inventor
Rolf Einar Engstad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arcticzymes Technologies ASA
Memorial Sloan Kettering Cancer Center
Original Assignee
Biotec Pharmacon ASA
Sloan Kettering Institute for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/334,763 external-priority patent/US7906492B2/en
Application filed by Biotec Pharmacon ASA, Sloan Kettering Institute for Cancer Research filed Critical Biotec Pharmacon ASA
Publication of EP1984004A2 publication Critical patent/EP1984004A2/de
Publication of EP1984004A4 publication Critical patent/EP1984004A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111—Immunoglobulin superfamily
    • A61K39/001113—CD22, BL-CAM, siglec-2 or sialic acid- binding Ig-related lectin 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001124—CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001129—Molecules with a "CD" designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/001171—Gangliosides, e.g. GM2, GD2 or GD3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP07718218A 2006-01-17 2007-01-17 Die therapie verstärkendes glucan Withdrawn EP1984004A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/334,763 US7906492B2 (en) 2001-01-16 2006-01-17 Therapy-enhancing glucan
PCT/US2007/001427 WO2007084661A2 (en) 2006-01-17 2007-01-17 Therapy-enhancing glucan

Publications (2)

Publication Number Publication Date
EP1984004A2 EP1984004A2 (de) 2008-10-29
EP1984004A4 true EP1984004A4 (de) 2010-03-03

Family

ID=40382391

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07718218A Withdrawn EP1984004A4 (de) 2006-01-17 2007-01-17 Die therapie verstärkendes glucan

Country Status (4)

Country Link
EP (1) EP1984004A4 (de)
JP (1) JP2009528267A (de)
AU (1) AU2008207369B2 (de)
WO (1) WO2007084661A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7507724B2 (en) 2001-01-16 2009-03-24 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
US7906492B2 (en) 2001-01-16 2011-03-15 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
JP5153188B2 (ja) * 2007-03-30 2013-02-27 小林製薬株式会社 Ｔｈ１／Ｔｈ２バランス改善剤
WO2009063221A2 (en) * 2007-11-13 2009-05-22 Biotec Pharmacon Asa Methods of treating or preventing inflammatory diseases of the intestinal tract
WO2012014978A1 (ja) * 2010-07-29 2012-02-02 国立大学法人北海道大学 免疫アジュバント
WO2012105219A1 (ja) * 2011-01-31 2012-08-09 オリンパス株式会社 抗体療法の効果増強剤
EP2844262B1 (de) 2012-04-30 2018-01-10 Biothera, Inc. Immuntherapeutische zusammensetzung mit beta-glucan
EP2832360A1 (de) 2013-07-30 2015-02-04 Fresenius Kabi Deutschland GmbH Polysaccharid zur Verwendung bei der Prävention der Bildung von Metastasen und/oder Rezidiven
JP6893594B2 (ja) * 2014-07-10 2021-06-23 ハイバーセル，インク． 腫瘍微小環境に影響する抗癌剤と組み合わせたβ−グルカン
WO2018156888A1 (en) 2017-02-24 2018-08-30 Biothera Pharmaceuticals, Inc. Beta glucan immunopharmacodynamics
WO2019178236A1 (en) * 2018-03-13 2019-09-19 Biothera Pharmaceuticals, Inc. Beta glucan and cd40 agonist combination immunotherapy
KR20210013564A (ko) * 2018-04-24 2021-02-04 메모리얼 슬로안 케터링 캔서 센터 경구용 효모 베타-글루칸을 이용한 저 면역원성 항원-특이적 백신의 면역원성 향상 방법
WO2020061203A1 (en) * 2018-09-21 2020-03-26 Nantcell, Inc. Methods and compositions for modulating myeloid-derived suppressor cells
JP7048102B2 (ja) 2019-05-23 2022-04-05 国立研究開発法人医薬基盤・健康・栄養研究所 免疫賦活活性を有する核酸多糖複合体の抗腫瘍薬としての応用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817643A (en) * 1992-08-21 1998-10-06 Alpha-Beta Technology, Inc. Underivatized, aqueous soluable β(1-3) glucan, composition and method of making same
WO2002058711A1 (en) * 2001-01-16 2002-08-01 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
WO2005018544A2 (en) * 2003-07-16 2005-03-03 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
US20060009419A1 (en) * 2002-09-04 2006-01-12 Ross Gordon D Therapy-enhancing glucan
WO2006119395A2 (en) * 2005-05-03 2006-11-09 Biopolymer Engineering, Inc. Combination of a beta-glucan and an egf receptor antagonist for the treatment of cancer and infection

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340080C (en) * 1985-03-11 1998-10-13 Dorothee Herlyn Human tumor therapy
JPH05503952A (ja) * 1989-09-08 1993-06-24 アルファ　ベータ　テクノロジー，インコーポレイティッド 可溶性グルカン類の製造方法
US5801005A (en) * 1993-03-17 1998-09-01 University Of Washington Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated
US5696079A (en) * 1993-05-19 1997-12-09 The United States Of America As Represented By The Department Of Health And Human Services Immunologic enhancement with intermittent interleukin-2 therapy
EP0640348A1 (de) * 1993-07-26 1995-03-01 Akzo Nobel N.V. Adjuvansmischung auf Ölbasis und auf Wasserbasis
NO300692B1 (no) * 1994-04-29 1997-07-07 Biotec Mackzymal As Solubilisert forgrenet ß-1,3-glukan og anvendelse derav samt anvendelse av usolubilisert forgrenet ß-1,3-glukan
US5951976A (en) * 1996-03-28 1999-09-14 Whitenead Institute For Biomedical Research Opsonin-enhanced cells, and methods of modulating an immune response to an antigen
JP2004507446A (ja) * 2000-02-04 2004-03-11 トーマス・ジェファーソン・ユニバーシティ 低用量ハプテン化腫瘍細胞および腫瘍細胞抽出物の免疫治療
GB0211118D0 (en) * 2002-05-15 2002-06-26 Polonelli Luciano Vaccines

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817643A (en) * 1992-08-21 1998-10-06 Alpha-Beta Technology, Inc. Underivatized, aqueous soluable β(1-3) glucan, composition and method of making same
WO2002058711A1 (en) * 2001-01-16 2002-08-01 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
US20060009419A1 (en) * 2002-09-04 2006-01-12 Ross Gordon D Therapy-enhancing glucan
WO2005018544A2 (en) * 2003-07-16 2005-03-03 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
WO2006119395A2 (en) * 2005-05-03 2006-11-09 Biopolymer Engineering, Inc. Combination of a beta-glucan and an egf receptor antagonist for the treatment of cancer and infection

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CHEN ET AL: "Medicinal importance of fungal beta-(1->3), (1->6)-glucans", MYCOLOGICAL RESEARCH, ELSEVIER, GB, vol. 111, no. 6, 1 June 2007 (2007-06-01), pages 635 - 652, XP022163026, ISSN: 0953-7562 *
CHEUNG N-K V ET AL: "Orally administered beta-glucans enhance anti-tumor effects of monoclonal antibodies", CANCER IMMUNOLOGY AND IMMUNOTHERAPY, SPRINGER-VERLAG, BERLIN, DE, vol. 51, no. 10, 1 November 2002 (2002-11-01), pages 557 - 564, XP002297978, ISSN: 0340-7004 *
HERLYN D ET AL: "Stimulation of monoclonal antibody-dependent macrophage-mediated cytotoxicity against human tumors by lentinan", INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, ELMSFORD,NY, US, vol. 7, no. 3, 1 January 1985 (1985-01-01), pages 332, XP023842271, ISSN: 0192-0561, [retrieved on 19850101] *
HONG F ET AL: "Mechanism by which orally administered [beta]-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models", JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 173, no. 2, 15 July 2004 (2004-07-15), pages 797 - 806, XP009125353, ISSN: 0022-1767 *
KANEKO Y ET AL: "Activity of lentinan against cancer and AIDS", INTERNATIONAL JOURNAL OF IMMUNOTHERAPY, BIOSCIENCE EDIPRINT INC., CAROUGE-GENEVA, CH, vol. 5, no. 4, 1 January 1989 (1989-01-01), pages 203 - 213, XP009125324, ISSN: 0255-9625 *
PELLEY R P ET AL: "Plants, polysaccharides and the treatment and prevention of neoplasia", CRITICAL REVIEWS IN ONCOGENESIS, BOCA RATON, FL, vol. 11, no. 3&4, 1 January 2000 (2000-01-01), pages 189 - 225, XP002963429, ISSN: 0893-9675 *
PENNA C ET AL: "PULMONARY METASTASES NEUTRALIZATION AND TUMOR REJECTION BY IN VIVO ADMINISTRATION OF BETA GLUCAN AND BISPECIFIC ANTIBODY", INTERNATIONAL JOURNAL OF CANCER, JOHN WILEY & SONS, INC, UNITED STATES, SWITZERLAND, GERMANY, vol. 65, 1 January 1996 (1996-01-01), pages 377 - 382, XP002924638, ISSN: 0020-7136 *
VETVICKA V ET AL: "SOLUBLE BETA-GLUCAN POLYSACCHARIDE BINDING TO THE LECTIN SITE OF NEUTROPHIL OR NATURAL KILLER CELL COMPLEMENT RECEPTOR TYPE 3 (CD11B/CD18) GENERATES A PRIMED STATE OF THE RECEPTOR CAPABLE OF MEDIATING CYTOTOXICITY OF IC3B-OPSONIZED TARGET CELLS", JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, US, vol. 98, no. 1, 1 July 1996 (1996-07-01), pages 50 - 61, XP001000371, ISSN: 0021-9738 *

Also Published As

Publication number Publication date
EP1984004A2 (de) 2008-10-29
WO2007084661A2 (en) 2007-07-26
AU2008207369A1 (en) 2008-09-11
WO2007084661B1 (en) 2008-01-10
JP2009528267A (ja) 2009-08-06
WO2007084661A3 (en) 2007-11-08
AU2008207369B2 (en) 2009-12-17

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