FI114396B - Menetelmä (E)-2'-deoksi-2'-(fluorimetyleeni)sytidiininmonohydraatin valmistamiseksi - Google Patents

Menetelmä (E)-2'-deoksi-2'-(fluorimetyleeni)sytidiininmonohydraatin valmistamiseksi Download PDF

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Publication number
FI114396B
FI114396B FI962769A FI962769A FI114396B FI 114396 B FI114396 B FI 114396B FI 962769 A FI962769 A FI 962769A FI 962769 A FI962769 A FI 962769A FI 114396 B FI114396 B FI 114396B
Authority
FI
Finland
Prior art keywords
cytidine
exocyclic
added
give
deoxy
Prior art date
Application number
FI962769A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI962769A0 (fi
FI962769A (fi
Inventor
Richard Eugene Donaldson
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of FI962769A0 publication Critical patent/FI962769A0/fi
Publication of FI962769A publication Critical patent/FI962769A/fi
Application granted granted Critical
Publication of FI114396B publication Critical patent/FI114396B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI962769A 1994-01-07 1996-07-05 Menetelmä (E)-2'-deoksi-2'-(fluorimetyleeni)sytidiininmonohydraatin valmistamiseksi FI114396B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17895294A 1994-01-07 1994-01-07
US17895294 1994-01-07
US9414648 1994-12-13
PCT/US1994/014648 WO1995018815A1 (fr) 1994-01-07 1994-12-13 Monohydrate de (e)-2'-desoxy-2'-(fluoromethylene)cytidine

Publications (3)

Publication Number Publication Date
FI962769A0 FI962769A0 (fi) 1996-07-05
FI962769A FI962769A (fi) 1996-07-05
FI114396B true FI114396B (fi) 2004-10-15

Family

ID=22654587

Family Applications (1)

Application Number Title Priority Date Filing Date
FI962769A FI114396B (fi) 1994-01-07 1996-07-05 Menetelmä (E)-2'-deoksi-2'-(fluorimetyleeni)sytidiininmonohydraatin valmistamiseksi

Country Status (20)

Country Link
EP (1) EP0738273B1 (fr)
JP (1) JPH09511227A (fr)
KR (1) KR100330328B1 (fr)
CN (1) CN1043231C (fr)
AT (1) ATE186732T1 (fr)
AU (1) AU684604B2 (fr)
CA (1) CA2179987C (fr)
DE (1) DE69421721T2 (fr)
DK (1) DK0738273T3 (fr)
ES (1) ES2141330T3 (fr)
FI (1) FI114396B (fr)
GR (1) GR3032614T3 (fr)
HU (1) HU217849B (fr)
IL (1) IL112242A (fr)
MX (1) MX9500363A (fr)
NO (1) NO306409B1 (fr)
NZ (1) NZ279030A (fr)
TW (1) TW397838B (fr)
WO (1) WO1995018815A1 (fr)
ZA (1) ZA9512B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2309350C (fr) 1997-11-12 2007-04-03 Mitsubishi Chemical Corporation Derives de purine et medicament les renfermant en tant qu'ingredient actif
DE60006663T2 (de) 1999-05-11 2004-10-07 Mitsubishi Chem Corp Dihydrat eines purinderivates, medikamente die dieses als aktiven wirkstoff enthalten und zwischenprodukte zu dessen herstellung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2002648C (fr) * 1988-11-15 2000-02-29 James R. Mccarthy Derives 2'-halogenomethylidene, 2'-ethenylidene et 2'-ethynyle de cytidine, uridine et guanosine
FI95269C (fi) * 1989-05-15 1996-01-10 Squibb Bristol Myers Co 2',3'-dideoksi-inosiinimonohydraatin, 2',3'-dideoksi-2',3'-didehydrot ymidiinimonohydraatin ja 2',3'-dideoksi-2'-fluori-inosiinihemihydraatin antiviraalisia, hyvin vesiliukoisia, stabiileja, kiteisiä suoloja
JPH0615557B2 (ja) * 1990-02-19 1994-03-02 ヤマサ醤油株式会社 ２’―デオキシ―２’―メチリデンシチジンの２水和物結晶
EP0640092B1 (fr) * 1992-05-12 1996-12-11 Merrell Pharmaceuticals Inc. Procede de preparation d'inhibiteurs de ribonucleotide-reductase

Also Published As

Publication number Publication date
EP0738273A1 (fr) 1996-10-23
NZ279030A (en) 1997-05-26
ES2141330T3 (es) 2000-03-16
IL112242A0 (en) 1995-03-30
NO962848D0 (no) 1996-07-05
CA2179987A1 (fr) 1995-07-13
EP0738273B1 (fr) 1999-11-17
GR3032614T3 (en) 2000-05-31
AU684604B2 (en) 1997-12-18
CA2179987C (fr) 1999-01-19
AU1553295A (en) 1995-08-01
NO306409B1 (no) 1999-11-01
CN1141045A (zh) 1997-01-22
WO1995018815A1 (fr) 1995-07-13
ATE186732T1 (de) 1999-12-15
TW397838B (en) 2000-07-11
JPH09511227A (ja) 1997-11-11
HU217849B (hu) 2000-04-28
MX9500363A (es) 1998-04-30
CN1043231C (zh) 1999-05-05
FI962769A0 (fi) 1996-07-05
FI962769A (fi) 1996-07-05
DE69421721T2 (de) 2000-04-27
HU9601848D0 (en) 1996-09-30
HUT75055A (en) 1997-03-28
NO962848L (no) 1996-09-06
KR100330328B1 (ko) 2002-12-05
DK0738273T3 (da) 2000-04-17
DE69421721D1 (de) 1999-12-23
IL112242A (en) 2000-08-31
ZA9512B (en) 1995-09-11

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