FI113177B - Uusia 1,3-dioksolo[4,5-h]-, 1,4-dioksano[2,3-h]- ja 1,5-dioksepino[2,3-h] [2,3]bentsodiatsepiinijohdannaisia, niiden valmistus ja käyttö lääkkeenä - Google Patents
Uusia 1,3-dioksolo[4,5-h]-, 1,4-dioksano[2,3-h]- ja 1,5-dioksepino[2,3-h] [2,3]bentsodiatsepiinijohdannaisia, niiden valmistus ja käyttö lääkkeenä Download PDFInfo
- Publication number
- FI113177B FI113177B FI970434A FI970434A FI113177B FI 113177 B FI113177 B FI 113177B FI 970434 A FI970434 A FI 970434A FI 970434 A FI970434 A FI 970434A FI 113177 B FI113177 B FI 113177B
- Authority
- FI
- Finland
- Prior art keywords
- alkyl
- benzodiazepine
- eller
- dioxolo
- methyl
- Prior art date
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- -1 1,5-dioxepino [2,3-h] [2,3] benzodiazepine derivatives Chemical class 0.000 title claims description 28
- 239000003814 drug Substances 0.000 title claims description 12
- 238000002360 preparation method Methods 0.000 title claims description 8
- 238000000034 method Methods 0.000 title claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 44
- 125000000217 alkyl group Chemical group 0.000 claims description 21
- RPBDCDQMCRHNLM-UHFFFAOYSA-N C1=NNC=C2C=CC=CC2=C1 Chemical compound C1=NNC=C2C=CC=CC2=C1 RPBDCDQMCRHNLM-UHFFFAOYSA-N 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 13
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 239000001257 hydrogen Substances 0.000 claims description 10
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- 150000002367 halogens Chemical class 0.000 claims description 8
- UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 claims description 7
- 150000002431 hydrogen Chemical class 0.000 claims description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 6
- 150000001412 amines Chemical class 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 230000002829 reductive effect Effects 0.000 claims description 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 4
- 229940049706 benzodiazepine Drugs 0.000 claims description 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 4
- 125000004185 ester group Chemical group 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims description 3
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- 150000001298 alcohols Chemical class 0.000 claims description 3
- 239000003054 catalyst Substances 0.000 claims description 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 2
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- 210000004705 lumbosacral region Anatomy 0.000 claims 1
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- 238000004519 manufacturing process Methods 0.000 abstract description 2
- RQKDTQACQPHOQL-UHFFFAOYSA-N 3h-2,3-benzodiazepine Chemical class C1=NNC=CC2=CC=CC=C21 RQKDTQACQPHOQL-UHFFFAOYSA-N 0.000 abstract 1
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
- YONPGGFAJWQGJC-UHFFFAOYSA-K titanium(iii) chloride Chemical compound Cl[Ti](Cl)Cl YONPGGFAJWQGJC-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4428835A DE4428835A1 (de) | 1994-08-01 | 1994-08-01 | Neue 3-substituierte 3H-2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel |
| DE4428835 | 1994-08-01 | ||
| PCT/DE1995/001029 WO1996004283A1 (de) | 1994-08-01 | 1995-07-28 | Neue 3-substituierte 3h-2,3-benzodiazepinderivate, deren herstellung und verwendung als arzneimittel |
| DE9501029 | 1995-07-28 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI970434A0 FI970434A0 (fi) | 1997-01-31 |
| FI970434L FI970434L (fi) | 1997-01-31 |
| FI113177B true FI113177B (fi) | 2004-03-15 |
Family
ID=6525693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI970434A FI113177B (fi) | 1994-08-01 | 1997-01-31 | Uusia 1,3-dioksolo[4,5-h]-, 1,4-dioksano[2,3-h]- ja 1,5-dioksepino[2,3-h] [2,3]bentsodiatsepiinijohdannaisia, niiden valmistus ja käyttö lääkkeenä |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5756495A (cs) |
| EP (1) | EP0775143B1 (cs) |
| JP (1) | JPH10504543A (cs) |
| KR (1) | KR100386709B1 (cs) |
| CN (1) | CN1048728C (cs) |
| AT (1) | ATE223415T1 (cs) |
| AU (1) | AU693241B2 (cs) |
| CA (1) | CA2195747C (cs) |
| CZ (1) | CZ291276B6 (cs) |
| DE (2) | DE4428835A1 (cs) |
| DK (1) | DK0775143T3 (cs) |
| ES (1) | ES2181787T3 (cs) |
| FI (1) | FI113177B (cs) |
| HU (1) | HU225500B1 (cs) |
| MX (1) | MX9700813A (cs) |
| NO (1) | NO319151B1 (cs) |
| NZ (1) | NZ290777A (cs) |
| PT (1) | PT775143E (cs) |
| RU (1) | RU2146678C1 (cs) |
| SK (1) | SK284103B6 (cs) |
| WO (1) | WO1996004283A1 (cs) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP9701325A1 (hu) | 1997-07-31 | 2000-08-28 | Gyógyszerkutató Intézet Kft. | Új 2,3-benzodiazepin-származékok |
| UA67749C2 (uk) | 1997-08-12 | 2004-07-15 | Егіш Дьйодьсердьяр Рт. | Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування |
| PL338681A1 (en) * | 1997-08-12 | 2000-11-20 | Egyt Gyogyszervegyeszeti Gyar | Derivatives of 1,3-dioxolo/4,5-h/2,3-benzodiazepins as inhibitors of ampa/cainate receptors |
| HU227128B1 (en) * | 1999-07-07 | 2010-07-28 | Egyt Gyogyszervegyeszeti Gyar | New 2,3-benzodiazepine derivatives |
| NO320473B1 (no) * | 2002-09-09 | 2005-12-12 | Norsk Hydro As | Anordning ved separator for separasjon av flerfasefluid. |
| US6858605B2 (en) | 2003-02-04 | 2005-02-22 | Ivax Drug Research Institute, Ltd. | Substituted 2,3-benzodiazepine derivatives |
| GB0405034D0 (en) * | 2004-03-05 | 2004-04-07 | Novartis Ag | Organic compounds |
| WO2006107860A2 (en) * | 2005-04-04 | 2006-10-12 | Eisai Co., Ltd. | Dihydropyridine compounds and compositions for headaches |
| NZ566137A (en) * | 2005-09-09 | 2011-05-27 | Novartis Ag | The use of diphenyl thioether derivatives to treat autoimmune diseases |
| WO2015121268A1 (de) * | 2014-02-14 | 2015-08-20 | Bayer Pharma Aktiengesellschaft | 1-phenyl-3h-2,3-benzodiazepine und ihre verwendung als bromodomänen-inhibitoren |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU219778B (hu) * | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
| SI9111433B (sl) * | 1991-08-22 | 1999-02-28 | Pliva | Novi N-sulfonil-tetrahidro-/1,3/-dioksepino/5,6-b/azirini, postopek priprave, intermediati za njihovo pripravo in uporaba |
-
1994
- 1994-08-01 DE DE4428835A patent/DE4428835A1/de not_active Withdrawn
-
1995
- 1995-07-28 JP JP8506095A patent/JPH10504543A/ja not_active Ceased
- 1995-07-28 HU HU9700320A patent/HU225500B1/hu unknown
- 1995-07-28 AT AT95927636T patent/ATE223415T1/de not_active IP Right Cessation
- 1995-07-28 CA CA002195747A patent/CA2195747C/en not_active Expired - Fee Related
- 1995-07-28 NZ NZ290777A patent/NZ290777A/en unknown
- 1995-07-28 DE DE59510364T patent/DE59510364D1/de not_active Expired - Fee Related
- 1995-07-28 CZ CZ1997159A patent/CZ291276B6/cs not_active IP Right Cessation
- 1995-07-28 ES ES95927636T patent/ES2181787T3/es not_active Expired - Lifetime
- 1995-07-28 AU AU31609/95A patent/AU693241B2/en not_active Ceased
- 1995-07-28 DK DK95927636T patent/DK0775143T3/da active
- 1995-07-28 US US08/776,536 patent/US5756495A/en not_active Expired - Fee Related
- 1995-07-28 RU RU97103140A patent/RU2146678C1/ru not_active IP Right Cessation
- 1995-07-28 PT PT95927636T patent/PT775143E/pt unknown
- 1995-07-28 SK SK135-97A patent/SK284103B6/sk unknown
- 1995-07-28 KR KR1019970700650A patent/KR100386709B1/ko not_active Expired - Fee Related
- 1995-07-28 WO PCT/DE1995/001029 patent/WO1996004283A1/de active IP Right Grant
- 1995-07-28 MX MX9700813A patent/MX9700813A/es unknown
- 1995-07-28 EP EP95927636A patent/EP0775143B1/de not_active Expired - Lifetime
- 1995-07-28 CN CN95194402A patent/CN1048728C/zh not_active Expired - Fee Related
-
1997
- 1997-01-31 NO NO19970435A patent/NO319151B1/no unknown
- 1997-01-31 FI FI970434A patent/FI113177B/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10504543A (ja) | 1998-05-06 |
| CN1155285A (zh) | 1997-07-23 |
| AU693241B2 (en) | 1998-06-25 |
| PT775143E (pt) | 2003-01-31 |
| KR100386709B1 (ko) | 2003-08-19 |
| SK284103B6 (sk) | 2004-09-08 |
| CA2195747C (en) | 2006-01-24 |
| EP0775143B1 (de) | 2002-09-04 |
| ES2181787T3 (es) | 2003-03-01 |
| DK0775143T3 (da) | 2002-12-02 |
| ATE223415T1 (de) | 2002-09-15 |
| NZ290777A (en) | 1998-07-28 |
| EP0775143A1 (de) | 1997-05-28 |
| SK13597A3 (en) | 1997-07-09 |
| NO319151B1 (no) | 2005-06-27 |
| AU3160995A (en) | 1996-03-04 |
| RU2146678C1 (ru) | 2000-03-20 |
| DE59510364D1 (de) | 2002-10-10 |
| HU225500B1 (en) | 2007-01-29 |
| DE4428835A1 (de) | 1996-02-08 |
| HUT76801A (en) | 1997-11-28 |
| CZ291276B6 (cs) | 2003-01-15 |
| MX9700813A (es) | 1997-05-31 |
| US5756495A (en) | 1998-05-26 |
| NO970435L (no) | 1997-01-31 |
| FI970434A0 (fi) | 1997-01-31 |
| WO1996004283A1 (de) | 1996-02-15 |
| CZ15997A3 (en) | 1997-06-11 |
| FI970434L (fi) | 1997-01-31 |
| NO970435D0 (no) | 1997-01-31 |
| CA2195747A1 (en) | 1996-02-15 |
| CN1048728C (zh) | 2000-01-26 |
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