FI112948B - Menetelmä lääkeaineena käyttökelpoisten 11beta-bentsaldoksiimi-17beta-metoksi-17alpha-metoksimetyyli-estra-4,9-dieeni-johdannaisten valmistamiseksi - Google Patents

Menetelmä lääkeaineena käyttökelpoisten 11beta-bentsaldoksiimi-17beta-metoksi-17alpha-metoksimetyyli-estra-4,9-dieeni-johdannaisten valmistamiseksi Download PDF

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Publication number
FI112948B
FI112948B FI943688A FI943688A FI112948B FI 112948 B FI112948 B FI 112948B FI 943688 A FI943688 A FI 943688A FI 943688 A FI943688 A FI 943688A FI 112948 B FI112948 B FI 112948B
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FI
Finland
Prior art keywords
estra
methoxy
methoxymethyl
phenyl
progesterone
Prior art date
Application number
FI943688A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI943688A (fi
FI943688A0 (fi
Inventor
Walter Elger
Gerd Schubert
Guenther Kaufmann
Lothar Sobeck
Michael Oettel
Anatoli Kurischko
Original Assignee
Schering Ag
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Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of FI943688A0 publication Critical patent/FI943688A0/fi
Publication of FI943688A publication Critical patent/FI943688A/fi
Application granted granted Critical
Publication of FI112948B publication Critical patent/FI112948B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
FI943688A 1993-09-20 1994-08-09 Menetelmä lääkeaineena käyttökelpoisten 11beta-bentsaldoksiimi-17beta-metoksi-17alpha-metoksimetyyli-estra-4,9-dieeni-johdannaisten valmistamiseksi FI112948B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4332284A DE4332284C2 (de) 1993-09-20 1993-09-20 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4332284 1993-09-20

Publications (3)

Publication Number Publication Date
FI943688A0 FI943688A0 (fi) 1994-08-09
FI943688A FI943688A (fi) 1995-03-21
FI112948B true FI112948B (fi) 2004-02-13

Family

ID=6498354

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943688A FI112948B (fi) 1993-09-20 1994-08-09 Menetelmä lääkeaineena käyttökelpoisten 11beta-bentsaldoksiimi-17beta-metoksi-17alpha-metoksimetyyli-estra-4,9-dieeni-johdannaisten valmistamiseksi

Country Status (19)

Country Link
EP (1) EP0648779B1 (ko)
JP (1) JP2696672B2 (ko)
KR (1) KR100190775B1 (ko)
AT (1) ATE149513T1 (ko)
AU (1) AU682373B2 (ko)
CA (1) CA2130515C (ko)
CZ (1) CZ289801B6 (ko)
DE (2) DE4332284C2 (ko)
DK (1) DK0648779T3 (ko)
ES (1) ES2102144T3 (ko)
FI (1) FI112948B (ko)
GR (1) GR3023644T3 (ko)
HU (1) HU219399B (ko)
NO (1) NO304988B1 (ko)
NZ (1) NZ264228A (ko)
PL (1) PL179460B1 (ko)
RU (1) RU2130944C1 (ko)
SK (1) SK280315B6 (ko)
UA (1) UA39101C2 (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332283A1 (de) * 1993-09-20 1995-04-13 Jenapharm Gmbh Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5576310A (en) * 1994-09-20 1996-11-19 Jenapharm Gmbh 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
DE19745085A1 (de) * 1997-10-11 1999-04-15 Jenapharm Gmbh 11ß-Benzaldoxim-9alpha,10alpha-epoxy-estr-4-en-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
DE19809845A1 (de) * 1998-03-03 1999-09-09 Jenapharm Gmbh S-substituierte 11beta-Benzaldoxim-estra-4,9-dien-kohlensäurethiolester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
DE19906152B4 (de) 1999-02-10 2005-02-10 Jenapharm Gmbh & Co. Kg Wirkstoffhaltige Laminate für Transdermalsysteme
US7629334B1 (en) * 1999-08-31 2009-12-08 Bayer Schering Pharma Aktiengesellschaft Mesoprogrestins (progesterone receptor modulations) as a component of compositions for hormone replacement therapy (HRT)
CO5200773A1 (es) * 1999-08-31 2002-09-27 Jenapharm Gmbh And Co Kg Mesoprogestinas (moduladores de receptores para progestero- na) como componente de composiciones utilizadas para la terapia de sustitucion hormonal (trh)
HUP0202429A3 (en) 1999-08-31 2004-04-28 Schering Ag Use of mesoprogestins (progesterone receptor modulators) for the preparation of pharmaceutical compositions for the treatment and prevention of benign hormone dependent gynecological disorders
AU781835B2 (en) * 1999-08-31 2005-06-16 Schering Aktiengesellschaft Mesoprogestins (progesterone receptor modulators) as a component of female contraceptives
DE19961219A1 (de) * 1999-12-15 2001-07-19 Jenapharm Gmbh 11beta-Phenylestratrien-Derivate mit Fluoralkylgruppen in der aromatischen Seitenkette, deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE10056676A1 (de) * 2000-11-10 2002-05-16 Jenapharm Gmbh Verfahren zur Herstellung von 4-/17alpha-substituierten-3-oxoestra-4,9-dien-11beta-yl)benzaldehyd-(1E oder 1Z)-oximen
DE10056677A1 (de) * 2000-11-10 2002-05-16 Jenapharm Gmbh Verfahren zur Herstellung von 4-(17a-Alkoxymethyl-17ß-substituierten-3-oxoestra-4,9-dien-11ß-yl)benzaldehyd-(1E)-oxim-Derivaten
EP1285927A3 (de) * 2001-08-16 2005-06-29 Schering Aktiengesellschaft Verwendung von Glucocorticoid-Rezeptorantagonisten zur Vorbeugung und Behandlung von Erkrankungen des männlichen Reproduktionssystems
DE10221034A1 (de) 2002-05-03 2003-11-20 Schering Ag 17alpha-Fluoralkyl-11ß-benzaldoxim-Steroide, Verfahren zu deren Herstellung, diese Steroide enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
AU2003255355A1 (en) * 2002-08-02 2004-02-25 Schering Aktiengesellschaft Progesterone receptor modulators having an increased antigonadotropic activity for use in female fertility testing and hormone replacement therapy
DE10236405A1 (de) 2002-08-02 2004-02-19 Schering Ag Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie
DE102005059222B4 (de) * 2005-12-08 2007-10-11 Bayer Schering Pharma Ag 11ß-Benzaldoximderivate von D-Homoestra-4,9-dien-3-onen
EP3693376A1 (en) 2006-10-24 2020-08-12 Allergan Pharmaceuticals International Limited Compositions for suppressing endometrial proliferation
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
EP2550288A1 (en) 2010-03-22 2013-01-30 Repros Therapeutics Inc. Compositions and methods for non-toxic delivery of antiprogestins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU580843B2 (en) * 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
DE3504421A1 (de) * 1985-02-07 1986-08-07 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate
ATE172469T1 (de) * 1989-08-04 1998-11-15 Schering Ag 11 beta-aryl-gona-4,9-dien-3-one
DE4332283A1 (de) * 1993-09-20 1995-04-13 Jenapharm Gmbh Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
KR100190775B1 (ko) 1999-06-01
HU219399B (hu) 2001-04-28
KR950008531A (ko) 1995-04-19
AU682373B2 (en) 1997-10-02
CZ196994A3 (en) 1995-04-12
JP2696672B2 (ja) 1998-01-14
NZ264228A (en) 1995-04-27
EP0648779A2 (de) 1995-04-19
GR3023644T3 (en) 1997-08-29
DE59401919D1 (de) 1997-04-10
NO304988B1 (no) 1999-03-15
RU94029667A (ru) 1996-06-27
PL179460B1 (pl) 2000-09-29
PL305091A1 (en) 1995-04-03
CA2130515C (en) 2001-07-17
JPH07149790A (ja) 1995-06-13
DE4332284A1 (de) 1995-03-23
HUT68315A (en) 1995-06-28
EP0648779A3 (de) 1995-08-09
SK95894A3 (en) 1995-04-12
EP0648779B1 (de) 1997-03-05
SK280315B6 (sk) 1999-11-08
DK0648779T3 (da) 1997-09-15
FI943688A (fi) 1995-03-21
HU9402695D0 (en) 1994-11-28
FI943688A0 (fi) 1994-08-09
CZ289801B6 (cs) 2002-04-17
DE4332284C2 (de) 1997-05-28
ATE149513T1 (de) 1997-03-15
AU7035194A (en) 1995-03-30
NO942952L (no) 1995-03-21
UA39101C2 (uk) 2001-06-15
ES2102144T3 (es) 1997-07-16
RU2130944C1 (ru) 1999-05-27
CA2130515A1 (en) 1995-03-21
NO942952D0 (no) 1994-08-09

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