FI112666B - Itiöimätön Bacillus subtilis, sen valmistus ja käyttö - Google Patents

Itiöimätön Bacillus subtilis, sen valmistus ja käyttö Download PDF

Info

Publication number
FI112666B
FI112666B FI20012143A FI20012143A FI112666B FI 112666 B FI112666 B FI 112666B FI 20012143 A FI20012143 A FI 20012143A FI 20012143 A FI20012143 A FI 20012143A FI 112666 B FI112666 B FI 112666B
Authority
FI
Finland
Prior art keywords
gene
strain
region
sigg
deleted
Prior art date
Application number
FI20012143A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI20012143L (fi
FI20012143A0 (fi
Inventor
Pertti Koski
Susanna Kaeaeriaeinen
Original Assignee
Ipsat Therapies Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsat Therapies Oy filed Critical Ipsat Therapies Oy
Publication of FI20012143A0 publication Critical patent/FI20012143A0/fi
Priority to FI20012143A priority Critical patent/FI112666B/fi
Priority to AU2002340536A priority patent/AU2002340536C1/en
Priority to PL370064A priority patent/PL205348B1/pl
Priority to US10/494,411 priority patent/US7319030B2/en
Priority to CA2465828A priority patent/CA2465828C/en
Priority to PCT/FI2002/000861 priority patent/WO2003040352A1/en
Priority to NZ532865A priority patent/NZ532865A/en
Priority to HU0402070A priority patent/HUP0402070A3/hu
Priority to ES02774801.1T priority patent/ES2452292T3/es
Priority to EP02774801.1A priority patent/EP1451292B1/en
Priority to JP2003542599A priority patent/JP5486142B2/ja
Publication of FI20012143L publication Critical patent/FI20012143L/fi
Application granted granted Critical
Publication of FI112666B publication Critical patent/FI112666B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102Mutagenizing nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07Bacillus
    • C12R2001/125Bacillus subtilis ; Hay bacillus; Grass bacillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
FI20012143A 2001-11-06 2001-11-06 Itiöimätön Bacillus subtilis, sen valmistus ja käyttö FI112666B (fi)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FI20012143A FI112666B (fi) 2001-11-06 2001-11-06 Itiöimätön Bacillus subtilis, sen valmistus ja käyttö
NZ532865A NZ532865A (en) 2001-11-06 2002-11-05 Non-sporulating bacillus subtilis having parts of the gene encoding sigma G deleted
PL370064A PL205348B1 (pl) 2001-11-06 2002-11-05 Nieprzetrwalnikujący szczep Bacillus subtilis, sposób wytwarzania nieprzetrwalnikującego szczepu Bacillus subtilis, zastosowanie nieprzetrwalnikującego szczepu Bacillus subtilis i sposób wytwarzania biologicznie przygotowanego preparatu
US10/494,411 US7319030B2 (en) 2001-11-06 2002-11-05 Non-sporulating Bacillus subtilis having parts of the gene encoding sigma G deleted
CA2465828A CA2465828C (en) 2001-11-06 2002-11-05 Non-sporulating bacillus subtilis having parts of the gene encoding sigma g deleted
PCT/FI2002/000861 WO2003040352A1 (en) 2001-11-06 2002-11-05 Non-sporulating bacillus subtilis having parts of the gene encoding sigma g deleted
AU2002340536A AU2002340536C1 (en) 2001-11-06 2002-11-05 Non-sporulating bacillus subtilis having parts of the gene encoding sigma G deleted
HU0402070A HUP0402070A3 (en) 2001-11-06 2002-11-05 Non-sporulating bacillus subtilis having parts of the gene encoding sigma g deleted
ES02774801.1T ES2452292T3 (es) 2001-11-06 2002-11-05 Bacillus subtilis no esporulante que tiene partes del gen que codifica Sigma G eliminadas
EP02774801.1A EP1451292B1 (en) 2001-11-06 2002-11-05 Non-sporulating bacillus subtilis having parts of the gene encoding sigma g deleted
JP2003542599A JP5486142B2 (ja) 2001-11-06 2002-11-05 シグマgをコードする遺伝子の部分が欠失している非胞子形成枯草菌

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20012143 2001-11-06
FI20012143A FI112666B (fi) 2001-11-06 2001-11-06 Itiöimätön Bacillus subtilis, sen valmistus ja käyttö

Publications (3)

Publication Number Publication Date
FI20012143A0 FI20012143A0 (fi) 2001-11-06
FI20012143L FI20012143L (fi) 2003-05-07
FI112666B true FI112666B (fi) 2003-12-31

Family

ID=8562192

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20012143A FI112666B (fi) 2001-11-06 2001-11-06 Itiöimätön Bacillus subtilis, sen valmistus ja käyttö

Country Status (11)

Country Link
US (1) US7319030B2 (pl)
EP (1) EP1451292B1 (pl)
JP (1) JP5486142B2 (pl)
AU (1) AU2002340536C1 (pl)
CA (1) CA2465828C (pl)
ES (1) ES2452292T3 (pl)
FI (1) FI112666B (pl)
HU (1) HUP0402070A3 (pl)
NZ (1) NZ532865A (pl)
PL (1) PL205348B1 (pl)
WO (1) WO2003040352A1 (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4713469B2 (ja) * 2003-06-18 2011-06-29 ディーエスエム アイピー アセッツ ビー.ブイ. 胞子形成できない微生物を用いたパントテネート(Pantothenate)の製造
DE10344200A1 (de) * 2003-09-22 2005-05-04 Basf Ag Verfahren zur Herstellung eines D-Pantothensäure und/oder deren Salze enthaltendes Tierfuttersupplement
FI119190B (fi) * 2006-06-21 2008-08-29 Ipsat Therapies Oy Modifioitu beta-laktamaasi ja menetelmä sen valmistamiseksi
FI20105572A0 (fi) 2010-05-24 2010-05-24 Prevab R Lcc Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt
JP6685925B2 (ja) 2014-04-17 2020-04-22 シンセティック バイオロジクス,インコーポレイテッド 治療用として改善された特性を有するβ−ラクタマーゼ
CA2958755C (en) 2014-08-28 2023-02-28 Synthetic Biologics, Inc. E. coli-based production of beta-lactamase
CA2962959C (en) 2014-10-08 2023-04-04 Synthetic Biologics, Inc. Beta-lactamase formulations and uses thereof
WO2016105498A1 (en) 2014-12-23 2016-06-30 Synthetic Biologics, Inc. Methods and compositions for inhibiting or preventing adverse effects of oral antibiotics
JP6810697B2 (ja) 2015-02-23 2021-01-13 シンセティック・バイオロジクス・インコーポレイテッド 腸内マイクロバイオームの保護のために抗生物質と共に使用するカルバペネマーゼ
KR20170122776A (ko) 2015-03-06 2017-11-06 신세틱 바이오로직스, 인코퍼레이티드 마이크로바이옴 보호를 위한 안전하고 유효한 베타-락타마제 투약
CN105200076A (zh) * 2015-09-23 2015-12-30 江南大学 一株重组表达γ-内酰胺酶的枯草芽孢杆菌、固定化及应用
EP3789495A1 (en) * 2019-09-03 2021-03-10 Jennewein Biotechnologie GmbH Production of sialylated oligosaccharides in bacillus cells

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2003078A1 (en) * 1988-11-18 1990-05-18 Alan Sloma Protease deletion
AU6353896A (en) * 1995-07-07 1997-02-10 Novo Nordisk A/S Production of proteins using bacillus incapable of sporulation
WO2002097064A1 (en) * 2001-05-29 2002-12-05 Kao Corporation Host microorganisms

Also Published As

Publication number Publication date
PL205348B1 (pl) 2010-04-30
CA2465828C (en) 2014-05-13
WO2003040352A9 (en) 2003-08-14
JP2005508184A (ja) 2005-03-31
NZ532865A (en) 2005-09-30
CA2465828A1 (en) 2003-05-15
PL370064A1 (pl) 2005-05-16
US20050158843A1 (en) 2005-07-21
HUP0402070A3 (en) 2010-01-28
FI20012143L (fi) 2003-05-07
US7319030B2 (en) 2008-01-15
EP1451292A1 (en) 2004-09-01
AU2002340536B2 (en) 2007-05-24
EP1451292B1 (en) 2014-01-29
JP5486142B2 (ja) 2014-05-07
ES2452292T3 (es) 2014-03-31
AU2002340536C1 (en) 2008-05-08
WO2003040352A1 (en) 2003-05-15
HUP0402070A2 (hu) 2005-01-28
FI20012143A0 (fi) 2001-11-06

Similar Documents

Publication Publication Date Title
Boland et al. Complete spore-cortex hydrolysis during germination of Bacillus subtilis 168 requires SleB and YpeB
JP2637532B2 (ja) 原核微生物の染色体dnaにおける安定した遺伝子増幅
Szurmant et al. YycH and YycI interact to regulate the essential YycFG two-component system in Bacillus subtilis
Wu et al. Engineering a Bacillus subtilis expression-secretion system with a strain deficient in six extracellular proteases
FI105483B (fi) Menetelmä kiinnostavan endogeenisen entsyymin tuotannon tehostamiseksi alkalofiilisessa Bacillus-isäntäsolussa
Gilmore et al. Production of muramic δ-lactam in Bacillus subtilis spore peptidoglycan
US4469791A (en) Genetically engineered microorganisms for massive production of amylolytic enzymes and process for preparing same
FI112666B (fi) Itiöimätön Bacillus subtilis, sen valmistus ja käyttö
JP2001514529A (ja) プロテアーゼ活性を有するポリペプチドをコードする核酸
JPH11509096A (ja) 胞子形成できないバチルスを用いるタンパク質の生産
US8293516B2 (en) Recombinant microorganism
Horsburgh et al. Characterization of LytH, a differentiation-associated peptidoglycan hydrolase of Bacillus subtilis involved in endospore cortex maturation
AU2002340536A1 (en) Non-sporulating bacillus subtilis having parts of the gene encoding sigma G deleted
US5834233A (en) Method of limiting the survival of genetically engineered microorganisms in their enivronment
Szurmant et al. The essential YycFG two‐component system of Bacillus subtilis
Ho et al. Co-expression of a prophage system and a plasmid system in Bacillus subtilis
Waldeck et al. Targeted deletion of the uvrBA operon and biological containment in the industrially important Bacillus licheniformis
EP0900271B1 (en) Bacterial donor cell useful in conjugation
AU2007211926A1 (en) Non-sporulating bacillus subtilis having parts of the gene encoding sigma G deleted
US5763187A (en) Bacterial donor cell useful in conjugation
WO1997026361A9 (en) Bacterial donor cell useful in conjugation
FI75367B (fi) Foerfarande foer framstaellning av en genetiskt manipulerad mikroorganism innehaollande en foer amylas kodande rekombinant-dna, och ett foerfarande foer framstaellning av amylas.
FR2635788A1 (fr) Sequence d'adn comprenant la partie fonctionnelle du locus sacuh de b. subtilis, vecteurs contenant la sequence correspondante, et leur utilisation dans des procedes de production de proteines
JPH02227083A (ja) 新規プラスミド
FR2632320A2 (fr) Sequence d'adn comprenant la partie fonctionnelle du locus sacu de b. subtilis, vecteurs contenant la sequence correspondante, et leur utilisation dans des procedes de production de proteines