FI112649B - Menetelmä terapeuttisesti käyttökelpoisten diamiiniyhdisteiden valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten diamiiniyhdisteiden valmistamiseksi Download PDF

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Publication number
FI112649B
FI112649B FI930360A FI930360A FI112649B FI 112649 B FI112649 B FI 112649B FI 930360 A FI930360 A FI 930360A FI 930360 A FI930360 A FI 930360A FI 112649 B FI112649 B FI 112649B
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FI
Finland
Prior art keywords
group
formula
same
compound
homopiperazine
Prior art date
Application number
FI930360A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI930360A (fi
FI930360A0 (fi
Inventor
Yoshio Takahashi
Seiichi Sato
Tomio Ohta
Sadahiro Shimizu
Kiyoshi Kawamura
Koichiro Watanabe
Original Assignee
Kowa Co
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Application filed by Kowa Co filed Critical Kowa Co
Publication of FI930360A publication Critical patent/FI930360A/fi
Publication of FI930360A0 publication Critical patent/FI930360A0/fi
Application granted granted Critical
Publication of FI112649B publication Critical patent/FI112649B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/49—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI930360A 1989-05-30 1993-01-28 Menetelmä terapeuttisesti käyttökelpoisten diamiiniyhdisteiden valmistamiseksi FI112649B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP1136652A JP2722250B2 (ja) 1989-05-30 1989-05-30 新規なジアミン化合物及びこれを含有する脳機能障害改善剤
JP13665289 1989-05-30
JP9000970 1990-07-30
PCT/JP1990/000970 WO1992002487A1 (fr) 1989-05-30 1990-07-30 Nouveau compose de diamine et agent de protection contre les lesions cerebrales contenant un tel compose

Publications (3)

Publication Number Publication Date
FI930360A FI930360A (fi) 1993-01-28
FI930360A0 FI930360A0 (fi) 1993-01-28
FI112649B true FI112649B (fi) 2003-12-31

Family

ID=15180337

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930360A FI112649B (fi) 1989-05-30 1993-01-28 Menetelmä terapeuttisesti käyttökelpoisten diamiiniyhdisteiden valmistamiseksi

Country Status (14)

Country Link
US (1) US5389630A (es)
EP (1) EP0541798B1 (es)
JP (1) JP2722250B2 (es)
KR (1) KR0171569B1 (es)
AT (1) ATE130842T1 (es)
CA (1) CA2087604C (es)
DE (1) DE69023928T2 (es)
DK (1) DK0541798T3 (es)
ES (1) ES2081996T3 (es)
FI (1) FI112649B (es)
HU (1) HU220592B1 (es)
NO (1) NO179322C (es)
RU (1) RU2045522C1 (es)
WO (1) WO1992002487A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU672617B2 (en) * 1992-06-22 1996-10-10 Regents Of The University Of California, The Glycine receptor antagonists and the use thereof
DE4314962A1 (de) * 1993-05-06 1994-11-10 Bayer Ag Substituierte Piperazine
WO1995004050A1 (fr) * 1993-07-28 1995-02-09 Santen Pharmaceutical Co., Ltd. Nouveau derive de 1,4-di(phenylalkyl)piperazine
US6017953A (en) * 1993-12-28 2000-01-25 Allergan Sales, Inc. Thromboxane ligands
KR100327270B1 (ko) * 1994-01-14 2002-08-01 닛뽕쇼지가부시끼가이샤 디아자시클로알킨알킬술폰아미드유도체
US5602123A (en) 1994-11-02 1997-02-11 Kowa Co., Ltd. Therapeutic agent for myocardial ischemic damages or reperfusion
US5849737A (en) * 1995-04-14 1998-12-15 The Regents Of The University Of California Compositions and methods for treating pain
US5944021A (en) * 1995-06-07 1999-08-31 Rodriguez; Victorio C. Therapeutic use of a carbonic anhydrase enzyme inhibitor for the treatment of brain edema
US5755237A (en) * 1995-06-07 1998-05-26 Rodriguez; Victorio C. Therapeutic use of acetazolamide for the treatment of brain edema
JP3808921B2 (ja) * 1995-11-20 2006-08-16 興和株式会社 細胞接着阻害剤
US6462034B1 (en) 1998-04-03 2002-10-08 Theravance, Inc. Local anesthetic compounds and uses
CO5040088A1 (es) 1998-04-03 2001-05-29 Advanced Medicine Inc Nuevos compuestos y usos anestesicos locales
SG83735A1 (en) * 1999-07-03 2001-10-16 Advanced Medicine Inc Novel local anesthetic compounds and uses
AU7734700A (en) 1999-10-01 2001-05-10 Advanced Medicine, Inc. Macrocyclic quinazolinones and their use as local anesthetics
EP1931347A4 (en) * 2005-08-09 2011-02-16 Ms Science Corp PIPERAZIN DERIVATIVES
HUP0500879A2 (en) 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
WO2007034252A1 (en) * 2005-09-22 2007-03-29 Sanofi-Aventis Amino-alkyl-amide derivatives as ccr3 receptor liquids
HUP0500877A2 (en) * 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
HUP0500886A2 (en) * 2005-09-23 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use
KR20080075922A (ko) * 2005-12-16 2008-08-19 뉴로파마 에스.에이. 칼슘 채널 차단제로서의 디벤젠 유도체
EP2340835A1 (en) 2006-01-27 2011-07-06 M's Science Corporation Piperidine and piperazine derivatives
CN101394844A (zh) 2006-02-14 2009-03-25 东弗吉尼亚医学院 甲氧基聚乙二醇硫酯螯合物及其用途
WO2012176878A1 (ja) * 2011-06-23 2012-12-27 学校法人自治医科大学 プロテアソーム阻害剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5732255A (en) * 1980-08-05 1982-02-20 Kowa Co Trimethoxyphenyl derivative
CS244821B2 (en) * 1983-06-16 1986-08-14 Boehringer Ingelheim Ltd Production method of new substituted phenylalkyl(piperazinyl or homopiperazinyle)-prpylureas or thioureas
US4661481A (en) * 1983-06-16 1987-04-28 Boehringer Ingelheim Pharmaceuticals, Inc Substituted phenylalkylhomopiperazinylpropyl(ureas or thioureas) useful for treatment of immulogical, inflammatory and allergic disorders
DE3403778A1 (de) * 1984-02-03 1985-08-08 Degussa Ag, 6000 Frankfurt Cyanomethyl-(2-cyano-ethyl)-(3-hydroxy-propyl)-amin seine verwendung zur herstellung von 1-(3-hydroxy-propyl)-1,4-diazepan und 1,4-bis(3-(3,4,5-trimethoxybenzoyloxy)-propyl)-diazepan
JP2556722B2 (ja) * 1988-02-18 1996-11-20 興和株式会社 新規なスルホンアミド化合物

Also Published As

Publication number Publication date
NO930328D0 (no) 1993-01-29
JP2722250B2 (ja) 1998-03-04
RU2045522C1 (ru) 1995-10-10
NO179322B (no) 1996-06-10
EP0541798A1 (en) 1993-05-19
DK0541798T3 (da) 1995-12-27
AU6056590A (en) 1992-03-02
FI930360A (fi) 1993-01-28
HU220592B1 (hu) 2002-03-28
EP0541798A4 (es) 1994-04-13
DE69023928D1 (de) 1996-01-11
ATE130842T1 (de) 1995-12-15
HU9300228D0 (en) 1993-04-28
FI930360A0 (fi) 1993-01-28
EP0541798B1 (en) 1995-11-29
JPH032144A (ja) 1991-01-08
HUT63143A (en) 1993-07-28
NO179322C (no) 1996-09-18
US5389630A (en) 1995-02-14
ES2081996T3 (es) 1996-03-16
KR0171569B1 (ko) 1999-05-01
NO930328L (no) 1993-01-29
DE69023928T2 (de) 1996-04-18
CA2087604C (en) 2000-04-18
AU647034B2 (en) 1994-03-17
WO1992002487A1 (fr) 1992-02-20

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MA Patent expired