FI111516B - Anordning avsedd för styrd leverans av ett nyttigt medel - Google Patents

Anordning avsedd för styrd leverans av ett nyttigt medel Download PDF

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Publication number
FI111516B
FI111516B FI931371A FI931371A FI111516B FI 111516 B FI111516 B FI 111516B FI 931371 A FI931371 A FI 931371A FI 931371 A FI931371 A FI 931371A FI 111516 B FI111516 B FI 111516B
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Finland
Prior art keywords
beneficial agent
medium
wall
aqueous
hydrogel
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FI931371A
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English (en)
Finnish (fi)
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FI931371A0 (fi
FI931371A (fi
Inventor
Avinash Govind Thombre
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Pfizer
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Publication of FI931371A0 publication Critical patent/FI931371A0/fi
Publication of FI931371A publication Critical patent/FI931371A/fi
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Publication of FI111516B publication Critical patent/FI111516B/sv

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Materials For Medical Uses (AREA)

Claims (20)

1. Anordning avsedd för styrd leverans av ett nyt-tigt medel till en vattenhaltig omgivning, känneteck-5 nad av att anordningen omfattar en formad vägg, vilken omger och avgränsar en inre reservoar, varvid väggen ätmin-stone till en del utformats av ett material som är genomträngligt för ett hydrofobiskt medium som är avsett att innehälla ett nyttigt medel, da väggen är närvarande i den 10 vattenhaltiga omgivningen, och reservoaren innehäller en blandning av en hydrofilisk, svällbar komposition och det hydrofobiska mediet som är avsett att innehälla det nyttiga medlet, varvid det nyttiga mediet är olösligt eller parti -elit olösligt i den vattenhaltiga omgivningen.
2. Anordning enligt patentkrav 1, känneteck- n a d av att väggen till ätminstone en del bildats av ett material, vilket är genomträngligt för den vattenhaltiga omgivningen.
3. Anordning enligt patentkrav 1, känneteck- 20 nad av att materialet, vilket är genomträngligt för det hydrofobiska mediet som är avsett att innehälla det nyttiga mediet, är ett mikroporöst membran.
4. Anordning enligt patentkrav 3, känneteck- nad av att det mikroporösa membranet är en sintrad poly- *· 2 5 mer.
5. Anordning enligt patentkrav 3, känneteck- nad av att väggen som är genomtränglig för det hydrofobiska mediet som är avsett att innehälla det nyttiga mediet, är en osintrad, filmbildande polymer, vilken är porös 30. den vattenhaltiga omgivningen.
·· 6. Anordning enligt patentkrav 4, känneteck- nad av att den sintrade polymeren impregnerats med ett hydrofobiskt medium med lägt ängtryck.
7. Anordning enligt patentkrav 4, känneteck- 35 nad av att den sintrade polymeren impregnerats med en 111516 hydrogel och fuktats med ett hydrofobiskt medium med lägt angtryck.
8. Anordning enligt patentkrav 4, känneteck-nad av att den sintrade polymeren impregnerats med en 5 hydrofilisk hydrogel som fuktats med ett hydrofiliskt medium, och att den fuktade hydrogelen försetts med genomgaende hal.
9. Anordning enligt patentkrav 2, känneteck-nad av att materialet, vilket är genomträngligt för den 10 vattenhaltiga omgivningen, är ett mikroporöst membran.
10. Anordning enligt patentkrav 9, känneteck-nad av att materialet som är genomträngligt för den vattenhaltiga omgivningen, är en sintrad polymer.
11. Anordning enligt patentkrav 10, känneteck- 15. a d av att den sintrade polymeren impregnerats med ett hydrofiliskt medium med lägt angtryck.
12. Anordning enligt patentkrav 10, känneteck-n a d av att den sintrade polymeren impregnerats med en hydrogel och fuktats med ett hydrofiliskt medium med lägt 20 angtryck.
13. Anordning enligt patentkrav 1, känneteck-nad av att en del av väggen är ogenomtränglig för ett vattenhaltigt medium och för ett hydrofobiskt medium som innehäller ett nyttigt medel. 2 5
14. Anordning enligt patentkrav 1, känneteck- nad av att väggen är ogenomtränglig för den svällbara kompositionen.
15. Anordning enligt patentkrav 1, känneteck-nad av att det nyttiga medlet har en vattenlöslighet 30 mindre än en del solut per 30 delar vattenlösningsmedel.
16. Anordning enligt patentkrav 15, känneteck-nad av att det nyttiga medlet har en löslighet som över-stiger ca en del.solut per 1 000 delar vattenlösningsmedel.
17. Anordning enligt patentkrav 14, känneteck- 35. a d av att hydrogelen omfattar pelletter med en storlek av ca 3,2 mm tili 12,7 mm. 111516
18. Anordning enligt patentkrav 16, känneteck-nad av att det nyttiga medlet är lösligt i det hydrofo-biska mediet.
19. Anordning enligt patentkrav 18, känneteck-5 n ad av att reservoaren innehäller tillräckligt med hydrogel sä att den svullna hydrogelen fyller ätminstone ca 50 % av reservoaren.
20. Anordning enligt patentkrav 19, känneteck-nad av att reservoaren innehäller tillräckligt med luft 10 för uppnäende av en i förväg bestämd försening av utlös-ningen. 1 · I
FI931371A 1990-09-28 1993-03-26 Anordning avsedd för styrd leverans av ett nyttigt medel FI111516B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US59020390A 1990-09-28 1990-09-28
US59020390 1990-09-28
PCT/US1991/005018 WO1992005775A1 (en) 1990-09-28 1991-07-22 Dispensing device containing a hydrophobic medium
US9105018 1991-07-22

Publications (3)

Publication Number Publication Date
FI931371A0 FI931371A0 (fi) 1993-03-26
FI931371A FI931371A (fi) 1993-03-26
FI111516B true FI111516B (sv) 2003-08-15

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Family Applications (1)

Application Number Title Priority Date Filing Date
FI931371A FI111516B (sv) 1990-09-28 1993-03-26 Anordning avsedd för styrd leverans av ett nyttigt medel

Country Status (12)

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US (1) US5431921A (sv)
EP (1) EP0550641B1 (sv)
JP (1) JP2701977B2 (sv)
AT (1) ATE106015T1 (sv)
CA (1) CA2089738C (sv)
DE (1) DE69102140T2 (sv)
DK (1) DK0550641T3 (sv)
ES (1) ES2053339T3 (sv)
FI (1) FI111516B (sv)
IE (1) IE64047B1 (sv)
PT (1) PT99066B (sv)
WO (1) WO1992005775A1 (sv)

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CA2089738C (en) 1997-01-21
WO1992005775A1 (en) 1992-04-16
FI931371A0 (fi) 1993-03-26
CA2089738A1 (en) 1992-03-29
DE69102140D1 (de) 1994-06-30
EP0550641A1 (en) 1993-07-14
ES2053339T3 (es) 1994-07-16
IE913395A1 (en) 1992-04-08
JPH05506038A (ja) 1993-09-02
EP0550641B1 (en) 1994-05-25
US5431921A (en) 1995-07-11
IE64047B1 (en) 1995-07-26
DK0550641T3 (da) 1994-08-22
FI931371A (fi) 1993-03-26
PT99066A (pt) 1993-11-30
ATE106015T1 (de) 1994-06-15
JP2701977B2 (ja) 1998-01-21
PT99066B (pt) 1999-01-29

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