FI111441B - Menetelmä valmistaa nanokapseleita sisältävää farmaseuttista seosta - Google Patents

Menetelmä valmistaa nanokapseleita sisältävää farmaseuttista seosta Download PDF

Info

Publication number
FI111441B
FI111441B FI940115A FI940115A FI111441B FI 111441 B FI111441 B FI 111441B FI 940115 A FI940115 A FI 940115A FI 940115 A FI940115 A FI 940115A FI 111441 B FI111441 B FI 111441B
Authority
FI
Finland
Prior art keywords
nanocapsules
aqueous phase
surfactant
alkyl
suspension
Prior art date
Application number
FI940115A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI940115A0 (fi
FI940115A (fi
Inventor
Michel Deleers
Henri Vranckx
Martine Demoustier
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of FI940115A0 publication Critical patent/FI940115A0/fi
Publication of FI940115A publication Critical patent/FI940115A/fi
Application granted granted Critical
Publication of FI111441B publication Critical patent/FI111441B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B01J13/18—In situ polymerisation with all reactants being present in the same phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI940115A 1993-01-18 1994-01-11 Menetelmä valmistaa nanokapseleita sisältävää farmaseuttista seosta FI111441B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9300875 1993-01-18
GB939300875A GB9300875D0 (en) 1993-01-18 1993-01-18 Nanocapsule containing pharmaceutical compositions

Publications (3)

Publication Number Publication Date
FI940115A0 FI940115A0 (fi) 1994-01-11
FI940115A FI940115A (fi) 1994-07-19
FI111441B true FI111441B (fi) 2003-07-31

Family

ID=10728864

Family Applications (1)

Application Number Title Priority Date Filing Date
FI940115A FI111441B (fi) 1993-01-18 1994-01-11 Menetelmä valmistaa nanokapseleita sisältävää farmaseuttista seosta

Country Status (21)

Country Link
US (1) US5500224A (ko)
EP (1) EP0608207B1 (ko)
JP (1) JP3688731B2 (ko)
KR (1) KR100311056B1 (ko)
AT (1) ATE172111T1 (ko)
AU (1) AU670840B2 (ko)
CA (1) CA2113243C (ko)
CY (1) CY2132B1 (ko)
DE (1) DE69413857T2 (ko)
DK (1) DK0608207T3 (ko)
ES (1) ES2122217T3 (ko)
FI (1) FI111441B (ko)
GB (1) GB9300875D0 (ko)
HU (1) HUT67213A (ko)
NO (1) NO307445B1 (ko)
NZ (1) NZ250673A (ko)
PL (1) PL173254B1 (ko)
RU (1) RU2145498C1 (ko)
SG (1) SG43682A1 (ko)
TW (1) TW336174B (ko)
ZA (1) ZA94205B (ko)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2721510B1 (fr) * 1994-06-22 1996-07-26 Rhone Poulenc Rorer Sa Nanoparticules filtrables dans des conditions stériles.
EP0808154B1 (en) * 1995-02-06 2000-12-20 Elan Pharma International Limited Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids
JP3759986B2 (ja) * 1995-12-07 2006-03-29 フロイント産業株式会社 シームレスカプセルおよびその製造方法
FR2766368B1 (fr) * 1997-07-24 2000-03-31 Univ Claude Bernard Lyon Procede de preparation de nanocapsules de type vesiculaire, utilisables notamment comme vecteurs colloidaux de principes actifs pharmaceutiques ou autres
US6761903B2 (en) 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US6982281B1 (en) * 2000-11-17 2006-01-03 Lipocine Inc Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US6458383B2 (en) 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
CA2400172C (en) * 2000-02-28 2010-04-20 Genesegues, Inc. Nanocapsule encapsulation system and method
FR2806005B1 (fr) * 2000-03-10 2002-06-14 Univ Claude Bernard Lyon Procede de preparation de particules colloidales sous forme de nanocapsules
US7153525B1 (en) * 2000-03-22 2006-12-26 The University Of Kentucky Research Foundation Microemulsions as precursors to solid nanoparticles
CN1531436A (zh) * 2001-05-09 2004-09-22 (株)美大富历寿 用于增强粘膜吸收的两亲肝素衍生物制剂
US20030095928A1 (en) * 2001-09-19 2003-05-22 Elan Pharma International Limited Nanoparticulate insulin
WO2003047493A2 (en) * 2001-12-03 2003-06-12 Dor Biopharma Inc. Stabilized reverse micelle compositions and uses thereof
US20040038303A1 (en) * 2002-04-08 2004-02-26 Unger Gretchen M. Biologic modulations with nanoparticles
CN100577203C (zh) 2002-07-18 2010-01-06 赫利克斯生物药品公司 尿素酶用于抑制癌症细胞生长的用途
US20060189554A1 (en) * 2002-09-24 2006-08-24 Russell Mumper Nanoparticle-Based vaccine delivery system containing adjuvant
WO2004084870A1 (en) * 2003-03-28 2004-10-07 Sigmoid Biotechnologies Limited Solid oral dosage form containing seamless microcapsules
US20060003002A1 (en) * 2003-11-03 2006-01-05 Lipocine, Inc. Pharmaceutical compositions with synchronized solubilizer release
EP1814530A2 (en) * 2004-09-27 2007-08-08 Sigmoid Biotechnologies Limited Dihydropyrimidine microcapsule-formulations
FR2899797A1 (fr) * 2006-04-13 2007-10-19 Oreal Emulsion eau dans l'huile pour le traitement des fibres keratiniques comprenant un monomere cyanoacrylate et de l'ammoniaque
FR2899800B1 (fr) * 2006-04-13 2008-10-10 Oreal Emulsion eau dans l'huile pour le traitement des fibres keratiniques comprenant un monomere cyanoacrylate
WO2008122965A2 (en) 2007-04-04 2008-10-16 Sigmoid Pharma Limited Pharmaceutical cyclosporin compositions
CA2685118C (en) * 2007-04-26 2016-11-01 Sigmoid Pharma Limited Manufacture of multiple minicapsules
US20100215737A1 (en) * 2007-05-01 2010-08-26 Ivan Coulter Combination pharmaceutical compositions
EP2257220B1 (en) * 2008-03-13 2017-06-14 Liebel-Flarsheim Company LLC Multi-function, foot-activated controller for imaging system
EA201001569A1 (ru) * 2008-05-06 2011-10-31 Глаксо Груп Лимитед Инкапсуляция биологически активных агентов
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
BRPI1012196B1 (pt) 2009-05-18 2021-11-30 Sublimity Therapeutics Limited Composição compreendendo gotas de óleo
CN102573802A (zh) 2009-08-12 2012-07-11 希格默伊德药业有限公司 包含聚合物基质和油相的免疫调节组合物
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
RU2566069C2 (ru) * 2013-05-31 2015-10-20 Общество с ограниченной ответственностью "Изварино Фарма" Система доставки вещества белковой природы в виде наночастиц и способ ее получения
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
US20170189344A1 (en) * 2014-05-30 2017-07-06 AbbVie Deutschland GmbH & Co. KG Highly drug-loaded poly(alkyl 2-cyanoacrylate) nanocapsules
WO2016033556A1 (en) 2014-08-28 2016-03-03 Lipocine Inc. BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
JP6679593B2 (ja) 2014-09-03 2020-04-15 ジーンセグエス，インコーポレイテッド 療法用ナノ粒子および関連する組成物、方法、およびシステム
SI3215127T1 (sl) 2014-11-07 2021-03-31 Sublimity Therapeutics Limited DCU Alpha Innovation Campus Sestavki, obsegajoči ciklosporin
WO2016116907A1 (en) 2015-01-23 2016-07-28 Helix Biopharma Corporation Antibody-urease conjugates for therapeutic purposes
RU2590651C1 (ru) * 2015-03-30 2016-07-10 Александр Александрович Кролевец Способ получения нанокапсул рибофлавина в геллановой камеди
WO2018098501A1 (en) 2016-11-28 2018-05-31 Lipocine Inc. Oral testosterone undecanoate therapy
WO2023089240A1 (en) * 2021-11-19 2023-05-25 Nanoform Finland Oyj A composition comprising nanosized active pharmaceutical ingredient

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2515960A1 (fr) * 1981-11-06 1983-05-13 Alkhouri Fallouh Nazir Nanocapsules ou nanoparticules biodegradables contenant une substance biologiquement active, leur preparation et leur application
JPS6061521A (ja) * 1983-09-16 1985-04-09 Kyowa Hakko Kogyo Co Ltd マイクロカプセル化製剤
DE3341001A1 (de) * 1983-11-12 1985-05-23 Krause, Hans Jürgen Nanopartikel aus bioabbaubarem, synthetischem material, verfahren zu deren herstellung und ihre anwendung
FR2659554B1 (fr) * 1990-03-16 1994-09-30 Oreal Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant.

Also Published As

Publication number Publication date
PL173254B1 (pl) 1998-02-27
DE69413857T2 (de) 1999-04-15
NO307445B1 (no) 2000-04-10
AU5309794A (en) 1994-07-21
DE69413857D1 (de) 1998-11-19
RU2145498C1 (ru) 2000-02-20
US5500224A (en) 1996-03-19
TW336174B (en) 1998-07-11
PL301841A1 (en) 1994-07-25
AU670840B2 (en) 1996-08-01
HU9400107D0 (en) 1994-05-30
JP3688731B2 (ja) 2005-08-31
ATE172111T1 (de) 1998-10-15
NO940111D0 (no) 1994-01-12
SG43682A1 (en) 1997-11-14
FI940115A0 (fi) 1994-01-11
CA2113243C (en) 2008-08-05
FI940115A (fi) 1994-07-19
NZ250673A (en) 1994-11-25
EP0608207A1 (fr) 1994-07-27
RU94002474A (ru) 1996-11-10
DK0608207T3 (da) 1999-06-23
ZA94205B (en) 1994-08-22
KR940018086A (ko) 1994-08-16
CY2132B1 (en) 2002-06-21
KR100311056B1 (ko) 2002-03-21
HUT67213A (en) 1995-03-28
NO940111L (no) 1994-07-19
JPH06256172A (ja) 1994-09-13
CA2113243A1 (en) 1994-07-19
EP0608207B1 (fr) 1998-10-14
ES2122217T3 (es) 1998-12-16
GB9300875D0 (en) 1993-03-10

Similar Documents

Publication Publication Date Title
FI111441B (fi) Menetelmä valmistaa nanokapseleita sisältävää farmaseuttista seosta
FI107993B (fi) Mikropartikkelien valmistus
Li et al. A novel biodegradable system based on gelatin nanoparticles and poly (lactic-co-glycolic acid) microspheres for protein and peptide drug delivery
NL194577C (nl) Preparaat voor de lang aanhoudende en gecontroleerde afgifte van medicamenteuze stoffen.
Lowe et al. Calcitonin and insulin in isobutylcyanoacrylate nanocapsules: protection against proteases and effect on intestinal absorption in rats
KR100638041B1 (ko) 수용성 약물의 경구투여용 나노입자 조성물 및 그의제조방법
Longer et al. Bioadhesive polymers as platforms for oral controlled drug delivery III: oral delivery of chlorothiazide using a bioadhesive polymer
JP4651192B2 (ja) 少なくとも一つの重合体および一つ又は複数の有効成分と複合体を形成できる少なくとも一つの化合物から成るナノ粒子およびその製造方法
FI109576B (fi) Nanopartikkeleita, joilla on retikuloendoteelijärjestelmän toimesta pidentynyt sieppausaika
EP0580690B1 (en) Improvements in pharmaceutical compositions
Ammoury et al. Jejunal absorption, pharmacological activity, and pharmacokinetic evaluation of indomethacin-loaded poly (d, l-lactide) and poly (isobutyl-cyanoacrylate) nanocapsules in rats
EP0465238B1 (en) Process for preparing noncohesive coating layer
US6884438B1 (en) Method for preparing vesicular nanocapsules
JPS63232840A (ja) 微小カプセル形物質の分散コロイド系の製造方法
JPS6133112A (ja) 生物学的に劣化可能なマイクロカプセルとその製造方法
DE112006002617T5 (de) Verfahren zur Herstellung von Core-Shell-Kompositen bzw. Kern-Hüllen-Kompositen mit vernetzten Hüllen und daraus entstehende Core-Shell-Komposite
JPH0657005A (ja) ナノカプセルあるいはナノ粒子の分散コロイダル系の連続製造方法
Devrim et al. Formulation and evaluation of reconstitutable suspensions containing ibuprofen-loaded Eudragit microspheres
Guterres et al. Influence of benzyl benzoate as oil core on the physicochemical properties of spray-dried powders from polymeric nanocapsules containing indomethacin
CH653552A5 (de) Mikrokapseln enthaltend partikel einer pharmazeutisch aktiven verbindung und verfahren zu deren herstellung.
Zhang et al. An improvement of double emulsion technique for preparing bovine serum albumin-loaded PLGA microspheres
WO2006061827A1 (en) Microemulsion comprising carbamazepine having solubility
CA2396379A1 (en) Pharmaceutical compositions for oral administration
KR100241652B1 (ko) 이푸리플라본의 경구 투여용 제제의 제조 방법
WO2017134655A1 (en) Improved oral absorption of octreotide and salts thereof