FI111130B - Menetelmä syklosporiinijohdannaista sisältävän farmaseuttisen koostumuksen valmistamiseksi - Google Patents
Menetelmä syklosporiinijohdannaista sisältävän farmaseuttisen koostumuksen valmistamiseksi Download PDFInfo
- Publication number
- FI111130B FI111130B FI944978A FI944978A FI111130B FI 111130 B FI111130 B FI 111130B FI 944978 A FI944978 A FI 944978A FI 944978 A FI944978 A FI 944978A FI 111130 B FI111130 B FI 111130B
- Authority
- FI
- Finland
- Prior art keywords
- weight
- pharmaceutical composition
- carrier medium
- hydrophilic phase
- composition
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 20
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- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929208712A GB9208712D0 (en) | 1992-04-22 | 1992-04-22 | Pharmaceutical compositions containing cyclosporin derivates |
| GB9208712 | 1992-04-22 | ||
| EP9300955 | 1993-04-20 | ||
| PCT/EP1993/000955 WO1993020833A1 (en) | 1992-04-22 | 1993-04-20 | Pharmaceutical composition containing cyclosporin derivative |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI944978L FI944978L (fi) | 1994-10-21 |
| FI944978A0 FI944978A0 (fi) | 1994-10-21 |
| FI111130B true FI111130B (fi) | 2003-06-13 |
Family
ID=10714386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI944978A FI111130B (fi) | 1992-04-22 | 1994-10-21 | Menetelmä syklosporiinijohdannaista sisältävän farmaseuttisen koostumuksen valmistamiseksi |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0637248B1 (de) |
| JP (1) | JP2818298B2 (de) |
| KR (2) | KR950701227A (de) |
| AT (1) | ATE219940T1 (de) |
| AU (1) | AU672793B2 (de) |
| CA (1) | CA2132740C (de) |
| CY (1) | CY2399B1 (de) |
| CZ (1) | CZ287359B6 (de) |
| DE (1) | DE69332078T2 (de) |
| DK (1) | DK0637248T3 (de) |
| ES (1) | ES2179052T3 (de) |
| FI (1) | FI111130B (de) |
| GB (1) | GB9208712D0 (de) |
| HU (1) | HU218279B (de) |
| NO (1) | NO315075B1 (de) |
| NZ (1) | NZ252681A (de) |
| PT (1) | PT637248E (de) |
| RU (1) | RU2126263C1 (de) |
| SG (1) | SG50692A1 (de) |
| SK (1) | SK282745B6 (de) |
| UA (1) | UA34454C2 (de) |
| WO (1) | WO1993020833A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
| KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
| SG45449A1 (en) * | 1992-05-13 | 1998-01-16 | Sandoz Ltd | Ophthalmic compositions |
| DK0589843T3 (da) * | 1992-09-25 | 2002-04-02 | Novartis Ag | Cyclosporinholdige farmaceutiske præparater |
| CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
| GB2278780B (en) * | 1993-05-27 | 1998-10-14 | Sandoz Ltd | Macrolide formulations |
| GB2315216B (en) * | 1993-10-05 | 1998-10-14 | Ciba Geigy Ag | Microemulsion preconcentrates comprising FK506 or 33-epi-chloro-33-desoxy-ascomycin |
| ES2177652T3 (es) | 1994-11-03 | 2002-12-16 | Novartis Ag | Nuevas formas de preparacion de ciclosporina para la aplicacion oral con composicion simple y alta biodisponibilidad, y procedimiento para su obtencion. |
| HU215966B (hu) * | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum |
| US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| US5766629A (en) | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| DE19544507B4 (de) | 1995-11-29 | 2007-11-15 | Novartis Ag | Cyclosporin enthaltende Präparate |
| GB9601120D0 (en) * | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
| HU223054B1 (hu) * | 1997-03-25 | 2004-03-01 | BIOGAL Gyógyszergyár Rt. | Tisztítási eljárás nagytisztaságú ciklosporin A előállítására |
| CN1208047C (zh) * | 1997-07-29 | 2005-06-29 | 法玛西雅厄普约翰美国公司 | 亲脂性化合物的自体乳化剂 |
| NZ502566A (en) * | 1997-07-29 | 2002-03-28 | Upjohn Co | Pharmaceutical composition for acidic lipophilic compounds in a form of a self-emulsifying formulation containing a pyranone and a basic amine |
| US6008191A (en) * | 1997-09-08 | 1999-12-28 | Panacea Biotec Limited | Pharmaceutical compositions containing cyclosporin |
| US6187747B1 (en) | 1997-09-08 | 2001-02-13 | Panacea Biotech Limited | Pharmaceutical composition comprising cyclosporin |
| US6346511B1 (en) | 1997-09-08 | 2002-02-12 | Panacea Biotec Limited | Pharmaceutical composition comprising cyclosporin |
| KR20010041623A (ko) * | 1998-03-05 | 2001-05-25 | 니뽄 신야쿠 가부시키가이샤 | 흡입 투여용 지방 유제 |
| US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| TNSN03139A1 (fr) | 2001-06-21 | 2005-12-23 | Pfizer Prod Inc | Formulations auto-emulsionnables d'inhibiteurs de la proteine de transfert d'ester de cholesteryle |
| EP2116228A1 (de) * | 2001-10-19 | 2009-11-11 | Isotechnika Inc. | Neuartige Cyclosporinanalog-Mikroemulsionspräkonzentrate |
| US6828301B2 (en) | 2002-02-07 | 2004-12-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for hepatitis C viral protease inhibitors |
| RU2294959C2 (ru) * | 2005-05-18 | 2007-03-10 | Общество с ограниченной ответственностью "Карат" (ООО "Карат") | Способ получения акарицидно-моющего средства для борьбы с клещами |
| RU2293763C2 (ru) * | 2005-05-18 | 2007-02-20 | Государственное учреждение Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова Российской академии медицинских наук (ГУ НИИВС им. И.И. Мечникова РАМН) | Способ получения акарицидно-моющего средства для борьбы с клещами |
| RU2320365C2 (ru) * | 2005-09-15 | 2008-03-27 | Григорьев Лев Викторович | Фармацевтическая композиция |
| EP2204167A1 (de) * | 2009-01-05 | 2010-07-07 | Azad Pharma AG | Pharmazeutische Mikroemulsion zur Prävention von supramolekularer Aggregation von ampiphilen Molekülen |
| WO2011005646A2 (en) | 2009-07-07 | 2011-01-13 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition for a hepatitis c viral protease inhibitor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE445174B (sv) * | 1978-03-07 | 1986-06-09 | Sandoz Ag | Farmaceutisk komposition innehallande en cyklosporin och en berarsubstans |
| ES2059558T3 (es) * | 1987-06-17 | 1994-11-16 | Sandoz Ag | Ciclosporins y su uso como productos farmaceuticos. |
| CZ279654B6 (cs) * | 1987-12-21 | 1995-05-17 | Sandoz Ag | Způsob výroby cyklosporinu A |
| KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
-
1992
- 1992-04-22 GB GB929208712A patent/GB9208712D0/en active Pending
-
1993
- 1993-04-20 PT PT93911768T patent/PT637248E/pt unknown
- 1993-04-20 WO PCT/EP1993/000955 patent/WO1993020833A1/en not_active Ceased
- 1993-04-20 SG SG1996008843A patent/SG50692A1/en unknown
- 1993-04-20 UA UA94105950A patent/UA34454C2/uk unknown
- 1993-04-20 DK DK93911768T patent/DK0637248T3/da active
- 1993-04-20 EP EP93911768A patent/EP0637248B1/de not_active Expired - Lifetime
- 1993-04-20 CZ CZ19942617A patent/CZ287359B6/cs not_active IP Right Cessation
- 1993-04-20 NZ NZ252681A patent/NZ252681A/en not_active IP Right Cessation
- 1993-04-20 AU AU42611/93A patent/AU672793B2/en not_active Ceased
- 1993-04-20 SK SK1272-94A patent/SK282745B6/sk not_active IP Right Cessation
- 1993-04-20 AT AT93911768T patent/ATE219940T1/de not_active IP Right Cessation
- 1993-04-20 CA CA002132740A patent/CA2132740C/en not_active Expired - Fee Related
- 1993-04-20 JP JP5517998A patent/JP2818298B2/ja not_active Expired - Fee Related
- 1993-04-20 HU HU9403055A patent/HU218279B/hu not_active IP Right Cessation
- 1993-04-20 ES ES93911768T patent/ES2179052T3/es not_active Expired - Lifetime
- 1993-04-20 DE DE69332078T patent/DE69332078T2/de not_active Expired - Fee Related
- 1993-04-20 RU RU94046413A patent/RU2126263C1/ru active
-
1994
- 1994-10-20 KR KR1019940703729A patent/KR950701227A/ko not_active Withdrawn
- 1994-10-21 NO NO19943998A patent/NO315075B1/no not_active IP Right Cessation
- 1994-10-21 FI FI944978A patent/FI111130B/fi active
-
2000
- 2000-12-08 KR KR10-2000-7013956A patent/KR100414853B1/ko not_active Expired - Fee Related
-
2003
- 2003-12-31 CY CY0300096A patent/CY2399B1/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: NOVARTIS AG |