JPH07505872A - サイクロスポリン誘導体含有医薬組成物 - Google Patents
サイクロスポリン誘導体含有医薬組成物Info
- Publication number
- JPH07505872A JPH07505872A JP5517998A JP51799893A JPH07505872A JP H07505872 A JPH07505872 A JP H07505872A JP 5517998 A JP5517998 A JP 5517998A JP 51799893 A JP51799893 A JP 51799893A JP H07505872 A JPH07505872 A JP H07505872A
- Authority
- JP
- Japan
- Prior art keywords
- weight
- pharmaceutical composition
- carrier medium
- vegetable oil
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
Claims (13)
- 1.活性成分として([3′−デスオキシ−3′−オキソ−MeBmt]1−[ Va1]2−シクロスポリン(Ciclosporin))および(1)親水層 ;(2)エステル転移したエトキシル化植物油;および(3)界面活性剤から成 る担体媒質を含む医薬組成物。
- 2.o/w(水中油)型マイクロエマルジョンを提供するマイクロエマルジョン 予備濃縮物の形である、請求項1記載の組成物。
- 3.エステル転移したエトキシル化植物油を担体媒質の10から85重量%、界 面活性剤を担体媒質の5から80重量%、親水相を担体媒質の10から50重量 %で含む、請求項1記載の医薬組成物。
- 4.エステル転移したエトキシル化植物油を担体媒質の15から70重量%、界 面活性剤を担体媒質の10から70重量%、親水相を担体媒質の15から40重 量%で含む、請求項3記載の医薬組成物。
- 5.エステル転移したエトキシル化植物油を担体媒質の約20重量%、界面活性 剤を担体媒質の約60重量%、親水相を担体媒質の20重量%で含む、請求項4 記載の医薬組成物。
- 6.親水相がトランスクトール、グリコフロールおよび1,2−プロピレングリ コールまたはその混合物を含む、請求項1記載の医薬組成物。
- 7.親水相が、更なる親水性共成分としてエタノールを含む、請求項6記載の医 薬組成物。
- 8.エタノールを親水相の0から60重量%で含む、請求項7記載の医薬組成物 。
- 9.活性成分が組成物の5から15重量%で存在する、請求項1記載の医薬組成 物。
- 10.エステル転移したエトキシル化植物油がエステル転移したエトキシル化ト ウモロコシ油である、請求項1記載の医薬組成物。
- 11.界面活性剤が天然または水素化ヒマシ油およびエチレンオキシドの反応産 物、またはポリオキシエチレンソルビタン脂肪酸エステルである、請求項1記載 の医薬組成物。
- 12.人における多剤耐性症候群を治療するために使用する、請求項1記載の医 薬組成物。
- 13.親水相、エステル転移したエトキシル化植物油および界面活性剤を相対的 な量の緊密な混合物にし、活性成分を加えることからなる、請求項1で定義の医 薬組成物の製造法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9208712.1 | 1992-04-22 | ||
GB929208712A GB9208712D0 (en) | 1992-04-22 | 1992-04-22 | Pharmaceutical compositions containing cyclosporin derivates |
PCT/EP1993/000955 WO1993020833A1 (en) | 1992-04-22 | 1993-04-20 | Pharmaceutical composition containing cyclosporin derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH07505872A true JPH07505872A (ja) | 1995-06-29 |
JP2818298B2 JP2818298B2 (ja) | 1998-10-30 |
Family
ID=10714386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5517998A Expired - Fee Related JP2818298B2 (ja) | 1992-04-22 | 1993-04-20 | サイクロスポリン誘導体含有医薬組成物 |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0637248B1 (ja) |
JP (1) | JP2818298B2 (ja) |
KR (2) | KR950701227A (ja) |
AT (1) | ATE219940T1 (ja) |
AU (1) | AU672793B2 (ja) |
CA (1) | CA2132740C (ja) |
CY (1) | CY2399B1 (ja) |
CZ (1) | CZ287359B6 (ja) |
DE (1) | DE69332078T2 (ja) |
DK (1) | DK0637248T3 (ja) |
ES (1) | ES2179052T3 (ja) |
FI (1) | FI111130B (ja) |
GB (1) | GB9208712D0 (ja) |
HU (1) | HU218279B (ja) |
NO (1) | NO315075B1 (ja) |
NZ (1) | NZ252681A (ja) |
PT (1) | PT637248E (ja) |
RU (1) | RU2126263C1 (ja) |
SG (1) | SG50692A1 (ja) |
SK (1) | SK282745B6 (ja) |
UA (1) | UA34454C2 (ja) |
WO (1) | WO1993020833A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012006931A (ja) * | 1999-02-26 | 2012-01-12 | Lipocine Inc | 疎水性治療剤の改善された送達のための組成物および方法 |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
GB2222770B (en) | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
ES2098739T3 (es) * | 1992-05-13 | 1997-05-01 | Sandoz Ltd | Composiciones oftalmicas conteniendo una cyclosporin. |
EP0589843B1 (en) | 1992-09-25 | 2001-11-28 | Novartis AG | Pharmaceutical compositions containing cyclosporins |
GB2278780B (en) * | 1993-05-27 | 1998-10-14 | Sandoz Ltd | Macrolide formulations |
CH686761A5 (de) | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
GB2315216B (en) * | 1993-10-05 | 1998-10-14 | Ciba Geigy Ag | Microemulsion preconcentrates comprising FK506 or 33-epi-chloro-33-desoxy-ascomycin |
RU2158601C2 (ru) | 1994-11-03 | 2000-11-10 | Новартис Аг | Новые лекарственные формы циклоспорина для орального применения с простым составом и высокой биодоступностью и способ их получения |
HU215966B (hu) * | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum |
US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
US5766629A (en) | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
DE19544507B4 (de) | 1995-11-29 | 2007-11-15 | Novartis Ag | Cyclosporin enthaltende Präparate |
GB9601120D0 (en) * | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
WO1999006024A1 (en) * | 1997-07-29 | 1999-02-11 | Pharmacia & Upjohn Company | Self-emulsifying formulation for lipophilic compounds |
ATE225174T1 (de) * | 1997-07-29 | 2002-10-15 | Upjohn Co | Selbstemulgierende formulierung enthaltend saure lipophile verbindungen |
US6187747B1 (en) | 1997-09-08 | 2001-02-13 | Panacea Biotech Limited | Pharmaceutical composition comprising cyclosporin |
US6008191A (en) * | 1997-09-08 | 1999-12-28 | Panacea Biotec Limited | Pharmaceutical compositions containing cyclosporin |
US6346511B1 (en) | 1997-09-08 | 2002-02-12 | Panacea Biotec Limited | Pharmaceutical composition comprising cyclosporin |
IL158765A0 (en) | 2001-06-21 | 2004-05-12 | Pfizer Prod Inc | Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors |
US6828301B2 (en) | 2002-02-07 | 2004-12-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for hepatitis C viral protease inhibitors |
EP2204167A1 (en) * | 2009-01-05 | 2010-07-07 | Azad Pharma AG | Pharmaceutical microemulsion for preventing supramolecular aggregation of amphiphilic molecules |
CA2767692C (en) | 2009-07-07 | 2017-03-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition for a hepatitis c viral protease inhibitor |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54132223A (en) * | 1978-03-07 | 1979-10-15 | Sandoz Ag | Novel pharmaceutical composition |
JPS6445396A (en) * | 1987-06-17 | 1989-02-17 | Sandoz Ag | Cyclosporins and medicinal use |
JPH02121929A (ja) * | 1988-09-16 | 1990-05-09 | Sandoz Ag | シクロスポリン含有医薬組成物 |
-
1992
- 1992-04-22 GB GB929208712A patent/GB9208712D0/en active Pending
-
1993
- 1993-04-20 AT AT93911768T patent/ATE219940T1/de not_active IP Right Cessation
- 1993-04-20 ES ES93911768T patent/ES2179052T3/es not_active Expired - Lifetime
- 1993-04-20 RU RU94046413A patent/RU2126263C1/ru active
- 1993-04-20 CA CA002132740A patent/CA2132740C/en not_active Expired - Fee Related
- 1993-04-20 DK DK93911768T patent/DK0637248T3/da active
- 1993-04-20 SG SG1996008843A patent/SG50692A1/en unknown
- 1993-04-20 SK SK1272-94A patent/SK282745B6/sk not_active IP Right Cessation
- 1993-04-20 HU HU9403055A patent/HU218279B/hu not_active IP Right Cessation
- 1993-04-20 EP EP93911768A patent/EP0637248B1/en not_active Expired - Lifetime
- 1993-04-20 DE DE69332078T patent/DE69332078T2/de not_active Expired - Fee Related
- 1993-04-20 PT PT93911768T patent/PT637248E/pt unknown
- 1993-04-20 WO PCT/EP1993/000955 patent/WO1993020833A1/en active IP Right Grant
- 1993-04-20 UA UA94105950A patent/UA34454C2/uk unknown
- 1993-04-20 NZ NZ252681A patent/NZ252681A/en not_active IP Right Cessation
- 1993-04-20 AU AU42611/93A patent/AU672793B2/en not_active Ceased
- 1993-04-20 CZ CZ19942617A patent/CZ287359B6/cs not_active IP Right Cessation
- 1993-04-20 JP JP5517998A patent/JP2818298B2/ja not_active Expired - Fee Related
-
1994
- 1994-10-20 KR KR1019940703729A patent/KR950701227A/ko not_active IP Right Cessation
- 1994-10-21 NO NO19943998A patent/NO315075B1/no not_active IP Right Cessation
- 1994-10-21 FI FI944978A patent/FI111130B/fi active
-
2000
- 2000-12-08 KR KR10-2000-7013956A patent/KR100414853B1/ko not_active IP Right Cessation
-
2003
- 2003-12-31 CY CY0300096A patent/CY2399B1/xx unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54132223A (en) * | 1978-03-07 | 1979-10-15 | Sandoz Ag | Novel pharmaceutical composition |
JPS6445396A (en) * | 1987-06-17 | 1989-02-17 | Sandoz Ag | Cyclosporins and medicinal use |
JPH02121929A (ja) * | 1988-09-16 | 1990-05-09 | Sandoz Ag | シクロスポリン含有医薬組成物 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012006931A (ja) * | 1999-02-26 | 2012-01-12 | Lipocine Inc | 疎水性治療剤の改善された送達のための組成物および方法 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPH07505872A (ja) | サイクロスポリン誘導体含有医薬組成物 | |
US8722664B2 (en) | Spontaneously dispersible N-benzoyl staurosporine compositions | |
AU765935B2 (en) | Substantially oil-free cyclosporin compositions | |
JPH09118894A (ja) | 医薬組成物 | |
WO1997036610A1 (en) | Cyclosporin-containing pharmaceutical composition | |
JP2016106152A (ja) | 生物学的利用能を向上した医薬組成物 | |
JP2003500454A5 (ja) | ||
AU2001237875B2 (en) | New self emulsifying drug delivery system | |
WO2000053212A1 (fr) | Composition pharmaceutique contenant une cyclosporine | |
WO2005032516A1 (en) | Formulation and manufacturing process of self-microemulsified aceclofenac soft capsules | |
JP2005255677A (ja) | シクロスポリン製剤 | |
MXPA01008293A (en) | Spontaneously dispersible n-benzoyl staurosporine compositions |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080821 Year of fee payment: 10 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080821 Year of fee payment: 10 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090821 Year of fee payment: 11 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090821 Year of fee payment: 11 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100821 Year of fee payment: 12 |
|
LAPS | Cancellation because of no payment of annual fees |