FI111074B - Menetelmä nitraattoalkaanikarboksyylihappojohdannaisten valmistamiseksi - Google Patents

Menetelmä nitraattoalkaanikarboksyylihappojohdannaisten valmistamiseksi Download PDF

Info

Publication number
FI111074B
FI111074B FI911703A FI911703A FI111074B FI 111074 B FI111074 B FI 111074B FI 911703 A FI911703 A FI 911703A FI 911703 A FI911703 A FI 911703A FI 111074 B FI111074 B FI 111074B
Authority
FI
Finland
Prior art keywords
nitrate
acid
pivaloyl
ethyl ester
general formula
Prior art date
Application number
FI911703A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI911703A0 (fi
FI911703A (fi
Inventor
Edgar Fritschi
Martin Feelisch
Eike Noack
Klaus Sandrock
Ralf Kanzler
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Publication of FI911703A0 publication Critical patent/FI911703A0/fi
Publication of FI911703A publication Critical patent/FI911703A/fi
Application granted granted Critical
Publication of FI111074B publication Critical patent/FI111074B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Lubricants (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI911703A 1990-04-10 1991-04-09 Menetelmä nitraattoalkaanikarboksyylihappojohdannaisten valmistamiseksi FI111074B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4011505A DE4011505C2 (de) 1990-04-10 1990-04-10 Nitratoalkancarbonsäure-Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE4011505 1990-04-10

Publications (3)

Publication Number Publication Date
FI911703A0 FI911703A0 (fi) 1991-04-09
FI911703A FI911703A (fi) 1991-10-11
FI111074B true FI111074B (fi) 2003-05-30

Family

ID=6404098

Family Applications (1)

Application Number Title Priority Date Filing Date
FI911703A FI111074B (fi) 1990-04-10 1991-04-09 Menetelmä nitraattoalkaanikarboksyylihappojohdannaisten valmistamiseksi

Country Status (18)

Country Link
EP (1) EP0451760B1 (ru)
JP (1) JP2848979B2 (ru)
AT (1) ATE127787T1 (ru)
CZ (1) CZ279744B6 (ru)
DE (2) DE4011505C2 (ru)
DK (1) DK0451760T3 (ru)
ES (1) ES2079506T3 (ru)
FI (1) FI111074B (ru)
GR (1) GR3017418T3 (ru)
HR (1) HRP920948B1 (ru)
HU (1) HU218202B (ru)
IE (1) IE68060B1 (ru)
PL (1) PL167089B1 (ru)
PT (1) PT97279B (ru)
RU (1) RU2017748C1 (ru)
SI (1) SI9110630B (ru)
SK (1) SK278385B6 (ru)
YU (1) YU48610B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4321306A1 (de) * 1993-06-26 1995-01-05 Sanol Arznei Schwarz Gmbh Disulfide
US5807847A (en) * 1996-06-04 1998-09-15 Queen's University At Kingston Nitrate esters
DE19634793A1 (de) * 1996-08-29 1998-03-05 Sanol Arznei Schwarz Gmbh S- und O-Nitratoacylverbindungen
WO2003013432A2 (en) * 2001-08-10 2003-02-20 Nitromed, Inc. Methods of use for novel sulfur containing organic nitrate compounds
EP2722326A1 (en) 2011-10-24 2014-04-23 Nicox S.A. Quinone based nitric oxide donating compounds
CA2876021C (en) * 2012-07-10 2020-09-22 Xpd Holdings, Llc Stabilized multi-functional antioxidant compounds and methods of use
WO2014169976A1 (en) 2013-04-18 2014-10-23 Nicox Science Ireland Quinone based nitric oxide donating compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3443998A1 (de) * 1984-12-01 1986-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3512627A1 (de) * 1985-04-06 1986-10-09 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu deren herstellung, verwendung derselben und diese enthaltende arzneimittel
JP2628756B2 (ja) * 1988-09-15 1997-07-09 シュバルツファルマ アクチェンゲゼルシャフト 新規有機ニトレート及びそれらの製造方法

Also Published As

Publication number Publication date
SI9110630B (sl) 2000-08-31
HRP920948A2 (en) 1997-10-31
JPH05178804A (ja) 1993-07-20
PL167089B1 (pl) 1995-07-31
JP2848979B2 (ja) 1999-01-20
CZ279744B6 (cs) 1995-06-14
RU2017748C1 (ru) 1994-08-15
PT97279A (pt) 1991-12-31
HRP920948B1 (en) 2000-04-30
IE68060B1 (en) 1996-05-15
DE4011505C2 (de) 1995-01-12
GR3017418T3 (en) 1995-12-31
DE4011505A1 (de) 1991-10-24
FI911703A0 (fi) 1991-04-09
HU218202B (hu) 2000-06-28
HUT57707A (en) 1991-12-30
EP0451760A1 (de) 1991-10-16
SI9110630A (en) 1997-06-30
DE59106452D1 (de) 1995-10-19
PT97279B (pt) 1998-08-31
ES2079506T3 (es) 1996-01-16
IE911023A1 (en) 1991-10-23
CS9100984A2 (en) 1991-11-12
HU911143D0 (en) 1991-10-28
YU63091A (sh) 1994-01-20
DK0451760T3 (da) 1996-01-02
ATE127787T1 (de) 1995-09-15
YU48610B (sh) 1999-03-04
EP0451760B1 (de) 1995-09-13
SK278385B6 (en) 1997-02-05
FI911703A (fi) 1991-10-11
SK98491A3 (en) 1995-07-11

Similar Documents

Publication Publication Date Title
US5284872A (en) Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof
US5661129A (en) Organic nitrates containing a disulfide group as cardiovascular agents
US5428061A (en) Organic nitrates and method for their preparation
US4443475A (en) Amides of acyl-carnitines, process for preparing same and pharmaceutical compositions containing such amides
EP0274453A2 (fr) Nouveaux composés à activité d'inhibiteurs de collagénase, procédé pour les préparer et compositions pharmaceutiques contenant ces composés
JPH05125029A (ja) 新規なアミド化合物又はその塩
US5359128A (en) Malic acid derivatives and compositions for the treatment of psoriasis
FI111074B (fi) Menetelmä nitraattoalkaanikarboksyylihappojohdannaisten valmistamiseksi
JP2628756B2 (ja) 新規有機ニトレート及びそれらの製造方法
US4496584A (en) Amidine derivatives with anti-complement activity
JPH05507295A (ja) Ｎ―（α―置換―ピリジニル）カルボニルジペプチド抗高血圧剤
FR2640269A1 (fr) Composes organometalliques, leurs modes de preparation et compositions pharmaceutiques les contenant
JPH05105627A (ja) 腸機能性疾患の治療に用いられる新規な医薬組成物と、その調整方法と、治療用医薬の調製方法
KR830002378B1 (ko) 1-(3-메르캅토-2-메틸프로파노일)프롤릴 아미노산 유도체의 제조방법
HU203091B (en) Process for producing new labdane derivatives and pharmaceutical compositions comprising such compounds
FR2568253A1 (fr) Nouvelle amidine
AU2008200720A1 (en) Geranyl compounds
CA2297944A1 (en) The groups with anticancer activity and the method of making their derivatives

Legal Events

Date Code Title Description
MA Patent expired