FI110407B - Förfarande för framställning av en tryckbelagd aerosolkomposition - Google Patents
Förfarande för framställning av en tryckbelagd aerosolkomposition Download PDFInfo
- Publication number
- FI110407B FI110407B FI941388A FI941388A FI110407B FI 110407 B FI110407 B FI 110407B FI 941388 A FI941388 A FI 941388A FI 941388 A FI941388 A FI 941388A FI 110407 B FI110407 B FI 110407B
- Authority
- FI
- Finland
- Prior art keywords
- polymer
- pvp
- process according
- propellant
- units
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Otolaryngology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Colloid Chemistry (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (8)
1. Förfarande för framställning av en tryckbelagd aerosolkomposition, vilken komposition omfattar kondenserad fluorvätealkan, pulveriserat läkemedel 5 dispergerat däri och polymer löslig i den kondenserade fluorvätealkanen, kännetecknat därav, att polymeren, vars koncentration är 0,00001 - 10 % vilt/vikt, är vald bland polymerer, som innehäller äterkommande amid inne-hällande strukturella grupper, polyvinylacetat och kopolymerer av akrylsy-ra/metakrylsyra-ester, i vilket förfarande läkemedelspulvret och polymeren 10 dispergeras i den kondenserade fluorvätealkanen.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att polymeren innehäller äterkommande strukturella enheter, som innehäller en amidgrupp. 15
3. Förfarande enligt patentkravet 1 eller 2, kännetecknat därav, att poly meren innehäller äterkommande l-etylen-pyrrolidin-2-onenheter.
4. Förfarande enligt nägot av patentkraven 1 - 3, kännetecknat därav, att polymeren är polyvinylpyrrolidon. 20 i i , v
5. Förfarande enligt nägot av patentkraven 1 - 3, kännetecknat därav, att polymeren är en kopolymer, som innehäller äterkommande 1-etylen-pyrroli-‘ ' din-2-onenheter. tili » ! ♦ : ; 25
6. Förfarande enligt nägot av patentkraven 1 - 3 eller 5, kännetecknat där av, att polymeren är polyvinylpyrrolidon/vinylacetat-kopolymer.
7. Förfarande enligt patentkravet 1, kännetecknat därav, att polymeren är polyvinylacetat eller en kopolymer av akrylsyra/metakrylsyraestrar. 30
8. Förfarande enligt nägot av föregäende patentkrav, kännetecknat därav, * att läkemedlet är terbutalinsulfat, beklometasondipropionat, salbutamolsulfat, flutikasonpropionat, reproterolhydroklorid, fenoterolhydrobromid, natrium-kromoglykat, nedokromilnatrium, tipredan, pentamidin-isoetionat, klemastin, 35 acetyl-6-metylkolinbromid och/eller budesonid.
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9120396 | 1991-09-25 | ||
| GB919120396A GB9120396D0 (en) | 1991-09-25 | 1991-09-25 | Formulations |
| GB9120675 | 1991-09-28 | ||
| GB919120675A GB9120675D0 (en) | 1991-09-28 | 1991-09-28 | Formulation |
| GB9124661 | 1991-11-19 | ||
| GB919124661A GB9124661D0 (en) | 1991-11-19 | 1991-11-19 | Formulations |
| GB929203212A GB9203212D0 (en) | 1992-02-14 | 1992-02-14 | Pharmaceutical formulations |
| GB9203212 | 1992-02-14 | ||
| PCT/GB1992/001749 WO1993005765A1 (en) | 1991-09-25 | 1992-09-23 | Pressurised aerosol compositions |
| GB9201749 | 1992-09-23 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI941388A0 FI941388A0 (sv) | 1994-03-25 |
| FI941388A FI941388A (sv) | 1994-03-25 |
| FI110407B true FI110407B (sv) | 2003-01-31 |
Family
ID=27450754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI941388A FI110407B (sv) | 1991-09-25 | 1994-03-25 | Förfarande för framställning av en tryckbelagd aerosolkomposition |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6641800B1 (sv) |
| EP (2) | EP0534731A1 (sv) |
| JP (1) | JP3142136B2 (sv) |
| KR (1) | KR100275426B1 (sv) |
| CN (1) | CN1050285C (sv) |
| AT (1) | ATE132739T1 (sv) |
| AU (1) | AU654397B2 (sv) |
| BG (1) | BG61752B1 (sv) |
| BR (1) | BR9206549A (sv) |
| CA (1) | CA2119932C (sv) |
| CZ (1) | CZ282506B6 (sv) |
| DE (1) | DE69207606T3 (sv) |
| DK (1) | DK0605578T4 (sv) |
| ES (1) | ES2082507T5 (sv) |
| FI (1) | FI110407B (sv) |
| GR (2) | GR3019098T3 (sv) |
| HK (1) | HK1005564A1 (sv) |
| HU (2) | HUT67480A (sv) |
| IL (1) | IL103238A (sv) |
| MX (1) | MX9205483A (sv) |
| MY (1) | MY108309A (sv) |
| NO (1) | NO307124B1 (sv) |
| NZ (1) | NZ244439A (sv) |
| RO (1) | RO114735B1 (sv) |
| RU (1) | RU2122852C1 (sv) |
| SK (1) | SK279456B6 (sv) |
| TW (1) | TW216442B (sv) |
| UA (1) | UA41873C2 (sv) |
| WO (1) | WO1993005765A1 (sv) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7101534B1 (en) | 1991-12-18 | 2006-09-05 | 3M Innovative Properties Company | Suspension aerosol formulations |
| GB9214819D0 (en) * | 1992-07-13 | 1992-08-26 | Minnesota Mining & Mfg | Valve assemblies |
| AU679511B2 (en) * | 1993-03-17 | 1997-07-03 | Minnesota Mining And Manufacturing Company | Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid |
| JPH08507792A (ja) * | 1993-03-17 | 1996-08-20 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | ジオール−二酸から誘導される分散助剤を含むエーロゾル配合物 |
| ES2183001T3 (es) | 1995-06-27 | 2003-03-16 | Boehringer Ingelheim Pharma | Nuevo preparado medicamentoso estable para la produccion de aerosoles exentos de gas propulsor. |
| GB9616237D0 (en) | 1996-08-01 | 1996-09-11 | Norton Healthcare Ltd | Aerosol formulations |
| US6039932A (en) * | 1996-09-27 | 2000-03-21 | 3M Innovative Properties Company | Medicinal inhalation aerosol formulations containing budesonide |
| US6126919A (en) * | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
| US20010031244A1 (en) | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
| US6433040B1 (en) | 1997-09-29 | 2002-08-13 | Inhale Therapeutic Systems, Inc. | Stabilized bioactive preparations and methods of use |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US6086376A (en) * | 1998-01-30 | 2000-07-11 | Rtp Pharma Inc. | Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant |
| US6136294C1 (en) * | 1998-09-22 | 2002-09-24 | Aeropharm Technology Inc | Amino acid stabilized medical aerosol formulation |
| DZ2947A1 (fr) | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
| IT1313553B1 (it) | 1999-07-23 | 2002-09-09 | Chiesi Farma Spa | Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione. |
| US6540982B1 (en) * | 2000-01-25 | 2003-04-01 | Aeropharm Technology Incorporated | Medical aerosol formulation |
| IT1317846B1 (it) | 2000-02-22 | 2003-07-15 | Chiesi Farma Spa | Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva. |
| WO2001078735A1 (en) * | 2000-04-13 | 2001-10-25 | Innovata Biomed Limited | Medicaments for treating respiratory disorders comprising formoterol and fluticasone |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| WO2001085136A2 (en) | 2000-05-10 | 2001-11-15 | Alliance Pharmaceutical Corporation | Phospholipid-based powders for drug delivery |
| CZ303833B6 (cs) | 2000-05-22 | 2013-05-22 | Chiesi Farmaceutici S.P.A. | Aerosolový prostredek |
| DE60103527T2 (de) | 2001-07-02 | 2005-06-16 | Chiesi Farmaceutici S.P.A. | Optimierte Tobramycin-Formulierung zur Aerosolbildung |
| GB0208742D0 (en) | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
| MXPA04005865A (es) | 2001-12-19 | 2004-09-13 | Nektar Therapeutics | Suministro de aminoglucosidos a los pulmones. |
| US7544177B2 (en) * | 2002-01-24 | 2009-06-09 | The Regents Of The University Of California | Aerosol device to deliver bioactive agent |
| SE0200312D0 (sv) * | 2002-02-01 | 2002-02-01 | Astrazeneca Ab | Novel composition |
| US7244742B2 (en) * | 2002-08-17 | 2007-07-17 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic |
| GB0328630D0 (en) * | 2003-12-10 | 2004-01-14 | Medpharm Ltd | Metered dose inhalation preparations |
| EP1595531A1 (en) | 2004-05-13 | 2005-11-16 | CHIESI FARMACEUTICI S.p.A. | Stable pharmaceutical solution formulations for pressurized metered dose inhalers |
| WO2005089738A2 (en) * | 2004-03-17 | 2005-09-29 | Mpex Pharmaceuticals, Inc. | Use and administration of bacterial efflux pump inhibitors |
| US7994225B2 (en) * | 2004-03-17 | 2011-08-09 | Rempex Pharmaceuticals, Inc. | Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections |
| US20070031343A1 (en) * | 2005-08-04 | 2007-02-08 | Bonfour Charles A Iii | Flavored medicinal inhalant |
| FR2895260B1 (fr) * | 2005-12-23 | 2009-02-20 | Servier Lab | Nouvelle composition pharmaceutique a base d'huile essentielle pour pulverisation nasale et/ou buccale |
| DE102006017320A1 (de) * | 2006-04-11 | 2007-10-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolsuspensionsformulierungen mit TG 227 ea oder TG 134 a als Treibmittel |
| ES2691033T3 (es) | 2007-02-11 | 2018-11-23 | Map Pharmaceuticals Inc. | Método de administración terapéutica de DHE para activar el alivio rápido de la migraña a la vez que se reduce al mínimo el perfil de los efectos secundarios |
| WO2008152398A2 (en) * | 2007-06-14 | 2008-12-18 | Cipla Limited | Formulations for inhalation |
| GB0712454D0 (en) | 2007-06-27 | 2007-08-08 | Generics Uk Ltd | Pharmaceutical compositions |
| EP2274039A2 (en) | 2008-05-06 | 2011-01-19 | Wilson-Cook Medical Inc. | Apparatus and methods for delivering therapeutic agents |
| CN102238939B (zh) * | 2008-11-04 | 2015-05-20 | 希普拉有限公司 | 药物气溶胶组合物 |
| CA2747390C (en) | 2008-12-23 | 2016-10-04 | Wilson-Cook Medical Inc. | Apparatus and methods for containing and delivering therapeutic agents |
| US8118777B2 (en) | 2009-05-29 | 2012-02-21 | Cook Medical Technologies Llc | Systems and methods for delivering therapeutic agents |
| US9101744B2 (en) | 2009-05-29 | 2015-08-11 | Cook Medical Technologies Llc | Systems and methods for delivering therapeutic agents |
| CN102416179B (zh) | 2010-09-28 | 2014-05-07 | 益得生物科技股份有限公司 | 用于哮喘的吸入性复方组合物 |
| US9867931B2 (en) | 2013-10-02 | 2018-01-16 | Cook Medical Technologies Llc | Therapeutic agents for delivery using a catheter and pressure source |
| US11931227B2 (en) | 2013-03-15 | 2024-03-19 | Cook Medical Technologies Llc | Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding |
| GB201402513D0 (en) * | 2014-02-13 | 2014-04-02 | Cardiff Scintigraphics Ltd | Pressurised metered dose inhalers and method of manufacture |
| WO2016018892A1 (en) | 2014-07-29 | 2016-02-04 | 3M Innovative Properties Company | Method of preparing a pharmaceutical composition |
| JP7063806B2 (ja) * | 2015-10-23 | 2022-05-09 | ビーエーエスエフ ソシエタス・ヨーロピア | 皮膚適用のための香料制御放出性配合物 |
| US10702495B2 (en) | 2017-02-20 | 2020-07-07 | Nexien Biopharma, Inc. | Method and compositions for treating dystrophies and myotonia |
| EP3750528A1 (en) | 2019-06-11 | 2020-12-16 | Nexien Biopharma, Inc. | Compositions for treating dystrophies and myotonia |
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| US417295A (en) * | 1889-12-17 | Fabriken | ||
| AT274245B (de) | 1967-05-17 | 1969-09-10 | Verfahren zur Herstellung eines Spezialklebers für Verbandmaterialien | |
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| US5874064A (en) * | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
-
1992
- 1992-09-22 IL IL10323892A patent/IL103238A/en not_active IP Right Cessation
- 1992-09-22 NZ NZ244439A patent/NZ244439A/en not_active IP Right Cessation
- 1992-09-23 JP JP05505930A patent/JP3142136B2/ja not_active Expired - Fee Related
- 1992-09-23 RU RU94022269/14A patent/RU2122852C1/ru active
- 1992-09-23 AU AU26471/92A patent/AU654397B2/en not_active Expired
- 1992-09-23 EP EP92308657A patent/EP0534731A1/en active Pending
- 1992-09-23 MY MYPI92001697A patent/MY108309A/en unknown
- 1992-09-23 CA CA002119932A patent/CA2119932C/en not_active Expired - Lifetime
- 1992-09-23 DK DK92920611T patent/DK0605578T4/da active
- 1992-09-23 RO RO94-00492A patent/RO114735B1/ro unknown
- 1992-09-23 CZ CZ94695A patent/CZ282506B6/cs not_active IP Right Cessation
- 1992-09-23 ES ES92920611T patent/ES2082507T5/es not_active Expired - Lifetime
- 1992-09-23 WO PCT/GB1992/001749 patent/WO1993005765A1/en active IP Right Grant
- 1992-09-23 BR BR9206549A patent/BR9206549A/pt not_active Application Discontinuation
- 1992-09-23 DE DE69207606T patent/DE69207606T3/de not_active Expired - Lifetime
- 1992-09-23 KR KR1019940700969A patent/KR100275426B1/ko not_active IP Right Cessation
- 1992-09-23 HU HU9400853A patent/HUT67480A/hu unknown
- 1992-09-23 EP EP92920611A patent/EP0605578B2/en not_active Expired - Lifetime
- 1992-09-23 AT AT92920611T patent/ATE132739T1/de active
- 1992-09-23 UA UA94005331A patent/UA41873C2/uk unknown
- 1992-09-23 SK SK340-94A patent/SK279456B6/sk not_active IP Right Cessation
- 1992-09-25 CN CN92112491A patent/CN1050285C/zh not_active Expired - Lifetime
- 1992-09-25 MX MX9205483A patent/MX9205483A/es unknown
- 1992-09-29 TW TW081107686A patent/TW216442B/zh not_active IP Right Cessation
-
1994
- 1994-03-24 BG BG98681A patent/BG61752B1/bg unknown
- 1994-03-24 NO NO941077A patent/NO307124B1/no not_active IP Right Cessation
- 1994-03-25 FI FI941388A patent/FI110407B/sv not_active IP Right Cessation
-
1995
- 1995-03-20 HU HU95P/P00090P patent/HU210818A9/hu unknown
-
1996
- 1996-02-23 GR GR960400518T patent/GR3019098T3/el unknown
-
1998
- 1998-05-29 HK HK98104659A patent/HK1005564A1/xx not_active IP Right Cessation
-
1999
- 1999-12-10 GR GR990403193T patent/GR3032103T3/el unknown
-
2000
- 2000-07-13 US US09/616,069 patent/US6641800B1/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |