FI109766B - Förfarande för framställning av proteolytisk blandning innehållande escharas - Google Patents
Förfarande för framställning av proteolytisk blandning innehållande escharas Download PDFInfo
- Publication number
- FI109766B FI109766B FI942603A FI942603A FI109766B FI 109766 B FI109766 B FI 109766B FI 942603 A FI942603 A FI 942603A FI 942603 A FI942603 A FI 942603A FI 109766 B FI109766 B FI 109766B
- Authority
- FI
- Finland
- Prior art keywords
- antioxidant
- mixture
- menetelmä
- escarase
- proteolytic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (5)
1. Förfarande för framställning av en proteolytisk blandning som innehäller , escharas, kännetecknat av att man I I I ( · '* / (a) extraherar ett bromelainpreparat med en utspädd vattenhaltig antioxidant- ! » · -1 20 lösning vid ett pH-värde av 3-4, och I f (b) utfäller den önskade proteolytiska blandningen ur det i steg (a) bildad sura ex-, : traktet genom att däri tillsätta ett proteinutfällningsmedel. i »
1. Menetelmä eskaraasia sisältävän proteolyyttisen seoksen valmistamiseksi, tunnettu siitä, että (a) bromelaiinipreparaatti uutetaan laimealla vesipitoisella antioksidanttiliuoksella 5 pH-arvossa 3-4, ja (b) vaiheessa (a) muodostuneesta happamasta uutteesta saostetaan haluttu proteo-lyyttinen seos lisäämällä uutteeseen proteiinien saostinta.
2. Förfarande enligt patentkrav 1, kännetecknat av att antioxidanten är askorbin-syra. 25 3. Förfarande enligt patentkrav 1, kännetecknat av att proteinutfällningsmedlet . * är ammoniumsulfat. ♦
2. Patenttivaatimuksen 1 mukainen menetelmä, tunnettu siitä, että antioksidantti on askorbiinihappo.
3. Patenttivaatimuksen 1 mukainen menetelmä, tunnettu siitä, että proteiinien saostin on ammoniumsulfaatti.
4. Förfarande enligt patentkrav 1, kännetecknat av att antioxidanten är askorbin-syra och proteinutfällningsmedlet är ammoniumsulfat. 109766
4. Patenttivaatimuksen 1 mukainen menetelmä, tunnettu siitä, että antioksidantti on askorbiinihappo ja proteiinien saostin on ammoniumsulfaatti.
5. Jonkin edellisen patenttivaatimuksen mukainen menetelmä, tunnettu siitä, et-15 tä proteolyyttinen seos sisältää 1-1,5 % eskaraasia. , , Patentkrav I · • »
5. Förfarande enligt nägot av föregaende patentkrav, kännetecknat av att den proteolytiska blandningen innehaller 1-1,5 % escharas. f s 1 ! *
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80196891A | 1991-12-03 | 1991-12-03 | |
US80196891 | 1991-12-03 | ||
US9210395 | 1992-12-02 | ||
PCT/US1992/010395 WO1993010811A1 (en) | 1991-12-03 | 1992-12-02 | Proteolytic mixture containing escharase and method of isolating same |
Publications (3)
Publication Number | Publication Date |
---|---|
FI942603A0 FI942603A0 (sv) | 1994-06-02 |
FI942603A FI942603A (sv) | 1994-08-02 |
FI109766B true FI109766B (sv) | 2002-10-15 |
Family
ID=25182476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI942603A FI109766B (sv) | 1991-12-03 | 1994-06-02 | Förfarande för framställning av proteolytisk blandning innehållande escharas |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0618811B1 (sv) |
JP (1) | JP3255643B2 (sv) |
AU (1) | AU676464B2 (sv) |
CA (1) | CA2125158C (sv) |
DE (1) | DE69230887T2 (sv) |
ES (1) | ES2146607T3 (sv) |
FI (1) | FI109766B (sv) |
HU (1) | HU214641B (sv) |
WO (1) | WO1993010811A1 (sv) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL165334A0 (en) * | 2004-11-22 | 2006-01-15 | Mediwound Ltd | Debriding composition from bromelain and methods of producing same |
CA3012299C (en) | 2016-01-31 | 2022-05-31 | Mediwound Ltd. | Debriding composition for treating wounds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3817834A (en) * | 1970-09-02 | 1974-06-18 | C Wilson | Recovery of salted-out proteins |
FR2423476A1 (fr) * | 1978-04-06 | 1979-11-16 | Oreal | Nouvelles dihydroxy-2,4 diphenylamines et compositions tinctoriales pour cheveux les contenant |
US4329430A (en) * | 1979-06-04 | 1982-05-11 | Klein Gerold K V | Enzyme mixture |
LU83177A1 (fr) * | 1981-02-27 | 1982-09-10 | Oreal | Utilisation d'hydroxyanthraquinones pour la coloration des fibres keratiniques humaines,procede et composition les mettant en oeuvre |
-
1992
- 1992-12-02 WO PCT/US1992/010395 patent/WO1993010811A1/en active IP Right Grant
- 1992-12-02 AU AU32342/93A patent/AU676464B2/en not_active Expired
- 1992-12-02 JP JP51032893A patent/JP3255643B2/ja not_active Expired - Fee Related
- 1992-12-02 HU HU9401684A patent/HU214641B/hu unknown
- 1992-12-02 ES ES93900778T patent/ES2146607T3/es not_active Expired - Lifetime
- 1992-12-02 CA CA002125158A patent/CA2125158C/en not_active Expired - Lifetime
- 1992-12-02 DE DE69230887T patent/DE69230887T2/de not_active Expired - Lifetime
- 1992-12-02 EP EP93900778A patent/EP0618811B1/en not_active Expired - Lifetime
-
1994
- 1994-06-02 FI FI942603A patent/FI109766B/sv not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0618811A1 (en) | 1994-10-12 |
HU214641B (hu) | 1998-04-28 |
AU3234293A (en) | 1993-06-28 |
HUT71383A (en) | 1995-11-28 |
HU9401684D0 (en) | 1994-09-28 |
DE69230887D1 (de) | 2000-05-11 |
CA2125158A1 (en) | 1993-06-10 |
FI942603A (sv) | 1994-08-02 |
ES2146607T3 (es) | 2000-08-16 |
EP0618811A4 (en) | 1996-05-29 |
JP3255643B2 (ja) | 2002-02-12 |
WO1993010811A1 (en) | 1993-06-10 |
EP0618811B1 (en) | 2000-04-05 |
DE69230887T2 (de) | 2000-10-12 |
JPH08508635A (ja) | 1996-09-17 |
AU676464B2 (en) | 1997-03-13 |
CA2125158C (en) | 2007-09-18 |
FI942603A0 (sv) | 1994-06-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB | Transfer or assigment of application |
Owner name: KLEIN, MARGARET L. |
|
MA | Patent expired |