FI108459B - Analogiamenetelmõ uusien, terapeuttisesti kõytt÷kelpoisten, kapeasti poly- tai monodisperssien vesiliukoisten anionisten oligomeerien valmistamiseksi, menetelmõ kyseistõ oligomeeriõ sisõltõvõn farmaseuttisen valmisteen valmistamiseksi sekõ kyseisen oligomeerin kõytt÷ - Google Patents

Analogiamenetelmõ uusien, terapeuttisesti kõytt÷kelpoisten, kapeasti poly- tai monodisperssien vesiliukoisten anionisten oligomeerien valmistamiseksi, menetelmõ kyseistõ oligomeeriõ sisõltõvõn farmaseuttisen valmisteen valmistamiseksi sekõ kyseisen oligomeerin kõytt÷ Download PDF

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Publication number
FI108459B
FI108459B FI943268A FI943268A FI108459B FI 108459 B FI108459 B FI 108459B FI 943268 A FI943268 A FI 943268A FI 943268 A FI943268 A FI 943268A FI 108459 B FI108459 B FI 108459B
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FI
Finland
Prior art keywords
oligomer
formula
methylphenyl
poly
produced
Prior art date
Application number
FI943268A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI943268L (fi
FI943268A0 (fi
Inventor
Alan D Cardin
William A Fordyce
Michael J Fazio
Michael J Mullins
Thomas A Chamberlin
Original Assignee
Dow Chemical Co
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co, Merrell Dow Pharma filed Critical Dow Chemical Co
Publication of FI943268L publication Critical patent/FI943268L/fi
Publication of FI943268A0 publication Critical patent/FI943268A0/fi
Application granted granted Critical
Publication of FI108459B publication Critical patent/FI108459B/fi

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/51—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
    • C08G63/6854—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/6856—Dicarboxylic acids and dihydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/688—Polyesters containing atoms other than carbon, hydrogen and oxygen containing sulfur
    • C08G63/6884—Polyesters containing atoms other than carbon, hydrogen and oxygen containing sulfur derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/6886—Dicarboxylic acids and dihydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/692—Polyesters containing atoms other than carbon, hydrogen and oxygen containing phosphorus
    • C08G63/6924—Polyesters containing atoms other than carbon, hydrogen and oxygen containing phosphorus derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/6926—Dicarboxylic acids and dihydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/04—Aromatic polycarbonates
    • C08G64/06—Aromatic polycarbonates not containing aliphatic unsaturation
    • C08G64/08—Aromatic polycarbonates not containing aliphatic unsaturation containing atoms other than carbon, hydrogen or oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/26—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from polyamines and polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G71/00—Macromolecular compounds obtained by reactions forming a ureide or urethane link, otherwise, than from isocyanate radicals in the main chain of the macromolecule
    • C08G71/02—Polyureas

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Polyamides (AREA)
  • Polyesters Or Polycarbonates (AREA)
FI943268A 1992-01-09 1994-07-08 Analogiamenetelmõ uusien, terapeuttisesti kõytt÷kelpoisten, kapeasti poly- tai monodisperssien vesiliukoisten anionisten oligomeerien valmistamiseksi, menetelmõ kyseistõ oligomeeriõ sisõltõvõn farmaseuttisen valmisteen valmistamiseksi sekõ kyseisen oligomeerin kõytt÷ FI108459B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81875392 1992-01-09
US07/818,753 US5424063A (en) 1992-01-09 1992-01-09 Narrow poly- and mono-dispersed anionic oligomers, and their uses, formulations and process
US9300094 1993-01-07
PCT/US1993/000094 WO1993014146A1 (en) 1992-01-09 1993-01-07 Narrow poly- and mono-dispersed anionic oligomers, and their uses, formulations and process

Publications (3)

Publication Number Publication Date
FI943268L FI943268L (fi) 1994-07-08
FI943268A0 FI943268A0 (fi) 1994-07-08
FI108459B true FI108459B (fi) 2002-01-31

Family

ID=25226322

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943268A FI108459B (fi) 1992-01-09 1994-07-08 Analogiamenetelmõ uusien, terapeuttisesti kõytt÷kelpoisten, kapeasti poly- tai monodisperssien vesiliukoisten anionisten oligomeerien valmistamiseksi, menetelmõ kyseistõ oligomeeriõ sisõltõvõn farmaseuttisen valmisteen valmistamiseksi sekõ kyseisen oligomeerin kõytt÷

Country Status (24)

Country Link
US (4) US5424063A (cs)
EP (1) EP0620833B1 (cs)
JP (1) JPH07509446A (cs)
KR (1) KR100255282B1 (cs)
CN (1) CN1049670C (cs)
AP (1) AP381A (cs)
AT (1) ATE159961T1 (cs)
AU (1) AU665056B2 (cs)
CA (1) CA2127356A1 (cs)
CZ (1) CZ282312B6 (cs)
DE (1) DE69315058T2 (cs)
DK (1) DK0620833T3 (cs)
ES (1) ES2110594T3 (cs)
FI (1) FI108459B (cs)
GR (1) GR3026019T3 (cs)
HU (1) HUT70831A (cs)
IL (1) IL104354A (cs)
MX (1) MX9300081A (cs)
NO (1) NO307610B1 (cs)
NZ (1) NZ246791A (cs)
OA (1) OA09962A (cs)
RU (1) RU2160746C2 (cs)
WO (1) WO1993014146A1 (cs)
ZA (1) ZA93136B (cs)

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US5276182A (en) * 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers
EP0498095B1 (en) * 1991-02-05 1995-01-04 Merrell Dow Pharmaceuticals Inc. Sulfonic stilbene derivatives in the treatment of viral diseases
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HUT72993A (en) * 1992-08-19 1996-06-28 Merrell Dow Pharma Process to prepare phatmaceutical compns. contg antiangiogenic oligomers
US5614559A (en) * 1993-11-23 1997-03-25 Procept Inc. Compound for inhibiting HIV infectivity
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EP1372551B1 (en) 2001-03-08 2008-09-17 The Trustees Of The University Of Pennsylvania Facially amphiphilic polymers as anti-infective agents
CN1100564C (zh) * 2001-08-29 2003-02-05 周根发 用于治疗hiv感染的药物、其组合物及其用途
EP2471527A3 (en) * 2003-03-17 2012-12-12 The Trustees Of The University Of Pennsylvania Facially amphiphillc polymers and oligomers and uses thereof
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US5424063A (en) * 1992-01-09 1995-06-13 The Dow Chemical Company Narrow poly- and mono-dispersed anionic oligomers, and their uses, formulations and process
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Also Published As

Publication number Publication date
RU94038426A (ru) 1996-07-20
CN1049670C (zh) 2000-02-23
CZ165594A3 (en) 1995-03-15
NO942574L (no) 1994-09-09
US6013251A (en) 2000-01-11
JPH07509446A (ja) 1995-10-19
AP381A (en) 1995-04-19
AU665056B2 (en) 1995-12-14
MX9300081A (es) 1993-12-01
HU9402058D0 (en) 1994-09-28
ES2110594T3 (es) 1998-02-16
US5512177A (en) 1996-04-30
AP9300482A0 (en) 1993-01-31
ATE159961T1 (de) 1997-11-15
CN1074437A (zh) 1993-07-21
FI943268L (fi) 1994-07-08
NO307610B1 (no) 2000-05-02
IL104354A (en) 1995-11-27
CA2127356A1 (en) 1993-07-22
KR100255282B1 (ko) 2000-05-01
US5424063A (en) 1995-06-13
HUT70831A (en) 1995-11-28
US5986044A (en) 1999-11-16
IL104354A0 (en) 1993-05-13
NZ246791A (en) 1996-08-27
FI943268A0 (fi) 1994-07-08
WO1993014146A1 (en) 1993-07-22
DK0620833T3 (da) 1997-12-22
EP0620833A1 (en) 1994-10-26
AU3436093A (en) 1993-08-03
EP0620833B1 (en) 1997-11-05
GR3026019T3 (en) 1998-04-30
DE69315058T2 (de) 1998-06-10
CZ282312B6 (cs) 1997-06-11
DE69315058D1 (de) 1997-12-11
RU2160746C2 (ru) 2000-12-20
NO942574D0 (no) 1994-07-08
ZA93136B (en) 1994-07-08
OA09962A (en) 1995-12-11

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