FI107696B - Lipidipartikkelinmuodostusmatriisi ja menetelmä sen valmistamiseksi - Google Patents
Lipidipartikkelinmuodostusmatriisi ja menetelmä sen valmistamiseksi Download PDFInfo
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- FI107696B FI107696B FI922452A FI922452A FI107696B FI 107696 B FI107696 B FI 107696B FI 922452 A FI922452 A FI 922452A FI 922452 A FI922452 A FI 922452A FI 107696 B FI107696 B FI 107696B
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- lipid
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- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 229940088623 biologically active substance Drugs 0.000 description 1
- 230000001851 biosynthetic effect Effects 0.000 description 1
- 230000036983 biotransformation Effects 0.000 description 1
- 229960001768 buspirone hydrochloride Drugs 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 229960002682 cefoxitin Drugs 0.000 description 1
- 150000001840 cholesterol esters Chemical class 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001265 ciclosporin Drugs 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000012612 commercial material Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 229940089666 egg yolk phosphatides Drugs 0.000 description 1
- 239000008344 egg yolk phospholipid Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 125000001531 monoacylglycerol group Chemical group 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000012053 oil suspension Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 238000011197 physicochemical method Methods 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000002884 skin cream Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000012421 spiking Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 125000003203 triacylglycerol group Chemical group 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Birds (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Colloid Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Saccharide Compounds (AREA)
- Fertilizers (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9003100A SE9003100D0 (sv) | 1990-09-28 | 1990-09-28 | Lipid formulation system |
| SE9003100 | 1990-09-28 | ||
| PCT/SE1991/000639 WO1992005771A1 (en) | 1990-09-28 | 1991-09-24 | Lipid formulation system |
| SE9100639 | 1991-09-24 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI922452L FI922452L (fi) | 1992-05-27 |
| FI922452A0 FI922452A0 (fi) | 1992-05-27 |
| FI107696B true FI107696B (fi) | 2001-09-28 |
Family
ID=20380490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI922452A FI107696B (fi) | 1990-09-28 | 1992-05-27 | Lipidipartikkelinmuodostusmatriisi ja menetelmä sen valmistamiseksi |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0514506B1 (de) |
| JP (1) | JP2855594B2 (de) |
| AT (1) | ATE137667T1 (de) |
| AU (1) | AU645143B2 (de) |
| CA (1) | CA2069760C (de) |
| DE (1) | DE69119400T2 (de) |
| DK (1) | DK0514506T3 (de) |
| ES (1) | ES2088024T3 (de) |
| FI (1) | FI107696B (de) |
| GR (1) | GR3020674T3 (de) |
| IE (1) | IE62194B1 (de) |
| NO (1) | NO304729B1 (de) |
| PT (1) | PT99113B (de) |
| SE (1) | SE9003100D0 (de) |
| WO (1) | WO1992005771A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260065A (en) * | 1991-09-17 | 1993-11-09 | Micro Vesicular Systems, Inc. | Blended lipid vesicles |
| SE9200952D0 (sv) * | 1992-03-27 | 1992-03-27 | Kabi Pharmacia Ab | Pharmaceutical carrier system containing defined lipids |
| SE9200951D0 (sv) * | 1992-03-27 | 1992-03-27 | Kabi Pharmacia Ab | Pharmaceutical composition containing a defined lipid system |
| HU221432B (en) * | 1994-02-04 | 2002-10-28 | Lipocore Holding Ab | Lipophilic carrier preparations |
| DE4447287C1 (de) * | 1994-12-30 | 1996-11-07 | Cevc Gregor | Präparat zum Wirkstofftransport durch Barrieren |
| SE9703691D0 (sv) | 1997-10-10 | 1997-10-10 | Astra Ab | Pharmaceutical compositions |
| GB2344520A (en) * | 1998-12-08 | 2000-06-14 | Phares Pharm Res Nv | Pharmaceutical carriers comprising lipids and polymers |
| HK1040629B (en) | 1998-12-23 | 2005-01-28 | Idea Ag | Improved formulations for local non-diffusive administration in vivo |
| AU5409699A (en) | 1999-07-05 | 2001-01-22 | Idea Ag | A method for the improvement of transport across adaptable semi-permeable barriers |
| SE0000730D0 (sv) * | 2000-03-06 | 2000-03-06 | Scotia Holdings Plc | Lipid carrier |
| SE0200475D0 (sv) * | 2002-02-15 | 2002-02-15 | Ltp Lipid Technologies Provide | Oral farmaceutisk beredning |
| SE0201922D0 (sv) * | 2002-06-20 | 2002-06-20 | Ltp Lipid Technologies Provide | Koagulationshindrande komposition (Anticoagulant Composition) |
| US7473432B2 (en) | 2002-10-11 | 2009-01-06 | Idea Ag | NSAID formulations, based on highly adaptable aggregates, for improved transport through barriers and topical drug delivery |
| FR2868704B1 (fr) * | 2004-04-07 | 2007-09-14 | Ethypharm Sa | Utilisation de lipides pour ameliorer la biodisponibilite de principes actifs proteiques en formulations injectables sous cutanees ou intra-musculaires |
| AU2005329255B2 (en) | 2004-04-15 | 2010-09-30 | Chiasma, Inc. | Compositions capable of facilitating penetration across a biological barrier |
| CN101189029A (zh) * | 2005-04-28 | 2008-05-28 | 盖伦尼卡技术股份公司 | 含脂相的药物剂型 |
| WO2007043057A2 (en) * | 2005-10-11 | 2007-04-19 | Yissum, Research Development Company Of The Hebrew University Of Jerusalem | Compositions for nasal delivery |
| RU2319506C2 (ru) * | 2005-10-12 | 2008-03-20 | Федеральное Агентство По Образованию Государственное Образовательное Учреждение Высшего Профессионального Образования "Дальневосточный Государственный Университет" | Способ получения носителя антигенов на основе липидов из морских макрофитов и тритерпенового гликозида кукумариозида |
| RU2322259C1 (ru) * | 2006-06-29 | 2008-04-20 | Федеральное Агентство По Образованию Государственное Образовательное Учреждение Высшего Профессионального Образования "Дальневосточный Государственный Университет" | Носитель антигенов |
| CN106974888B (zh) | 2008-09-17 | 2019-08-02 | 克艾思马有限公司 | 药物组合物和相关的给药方法 |
| CN101926757B (zh) | 2010-09-01 | 2013-01-02 | 北京大学 | 一种难溶性药物的液体组合物及其制备方法 |
| CA2975599A1 (en) | 2015-02-03 | 2016-08-11 | Chiasma Inc. | Method of treating diseases |
| US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
| IL308124A (en) * | 2021-05-03 | 2023-12-01 | Mcal Therapeutics Inc | micro lipids |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT8219012A0 (it) * | 1982-01-06 | 1982-01-06 | Ausonia Farma Srl | Metodo per la somministrazione orale di sostanze sotto forma di liposomi, e relative formulazioni farmaceutiche. |
| GB8613811D0 (en) * | 1986-06-06 | 1986-07-09 | Phares Pharm Res Nv | Composition & method |
| JPH0753661B2 (ja) * | 1984-03-08 | 1995-06-07 | フアレス フアーマスーチカル リサーチ エヌブイ | プロ―リポソーム組成物及びリポソームの水性分散物を作る方法 |
| US4610868A (en) * | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
| SE8603812D0 (sv) * | 1986-09-12 | 1986-09-12 | Draco Ab | Administration of liposomes to mammals |
| ATE115403T1 (de) * | 1987-01-27 | 1994-12-15 | Vestar Inc | Aus phospholipiden bestehende darreichungsform für wasserunlösliche wirksubstanzen. |
-
1990
- 1990-09-28 SE SE9003100A patent/SE9003100D0/xx unknown
-
1991
- 1991-09-13 IE IE324691A patent/IE62194B1/en not_active IP Right Cessation
- 1991-09-24 JP JP3516564A patent/JP2855594B2/ja not_active Expired - Fee Related
- 1991-09-24 CA CA002069760A patent/CA2069760C/en not_active Expired - Fee Related
- 1991-09-24 WO PCT/SE1991/000639 patent/WO1992005771A1/en not_active Ceased
- 1991-09-24 AT AT91919389T patent/ATE137667T1/de not_active IP Right Cessation
- 1991-09-24 DK DK91919389.6T patent/DK0514506T3/da active
- 1991-09-24 ES ES91919389T patent/ES2088024T3/es not_active Expired - Lifetime
- 1991-09-24 DE DE69119400T patent/DE69119400T2/de not_active Expired - Fee Related
- 1991-09-24 AU AU87105/91A patent/AU645143B2/en not_active Ceased
- 1991-09-24 EP EP91919389A patent/EP0514506B1/de not_active Expired - Lifetime
- 1991-09-27 PT PT99113A patent/PT99113B/pt not_active IP Right Cessation
-
1992
- 1992-05-26 NO NO921231A patent/NO304729B1/no unknown
- 1992-05-27 FI FI922452A patent/FI107696B/fi active
-
1996
- 1996-07-31 GR GR960402032T patent/GR3020674T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3020674T3 (en) | 1996-10-31 |
| SE9003100D0 (sv) | 1990-09-28 |
| AU645143B2 (en) | 1994-01-06 |
| WO1992005771A1 (en) | 1992-04-16 |
| IE913246A1 (en) | 1992-04-08 |
| ES2088024T3 (es) | 1996-08-01 |
| DE69119400D1 (de) | 1996-06-13 |
| NO922084L (no) | 1992-05-26 |
| ATE137667T1 (de) | 1996-05-15 |
| EP0514506B1 (de) | 1996-05-08 |
| DK0514506T3 (da) | 1996-08-12 |
| PT99113A (pt) | 1992-08-31 |
| JPH05503711A (ja) | 1993-06-17 |
| AU8710591A (en) | 1992-04-28 |
| IE62194B1 (en) | 1994-12-28 |
| JP2855594B2 (ja) | 1999-02-10 |
| NO922084D0 (no) | 1992-05-26 |
| DE69119400T2 (de) | 1996-12-05 |
| NO304729B1 (no) | 1999-02-08 |
| EP0514506A1 (de) | 1992-11-25 |
| FI922452L (fi) | 1992-05-27 |
| PT99113B (pt) | 1999-02-26 |
| CA2069760C (en) | 1998-02-10 |
| CA2069760A1 (en) | 1992-03-29 |
| FI922452A0 (fi) | 1992-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: PHARMACIA AB |