ES2088024T3 - Sistema de formulacion de lipidos. - Google Patents

Sistema de formulacion de lipidos.

Info

Publication number
ES2088024T3
ES2088024T3 ES91919389T ES91919389T ES2088024T3 ES 2088024 T3 ES2088024 T3 ES 2088024T3 ES 91919389 T ES91919389 T ES 91919389T ES 91919389 T ES91919389 T ES 91919389T ES 2088024 T3 ES2088024 T3 ES 2088024T3
Authority
ES
Spain
Prior art keywords
lipid
matrix
particle forming
lipid particle
forming matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91919389T
Other languages
English (en)
Inventor
Bengt Herslof
Martin Nicklasson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia AB filed Critical Pharmacia AB
Application granted granted Critical
Publication of ES2088024T3 publication Critical patent/ES2088024T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/553—Phospholipids, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Birds (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Saccharide Compounds (AREA)
  • Fertilizers (AREA)

Abstract

LA INVENCION ESTA RELACIONADA CON UNA MATRIZ DE FORMACION DE PARTICULAS DE LIPIDOS, CARACTERIZADA EN TANTO QUE A PARTIR DE UN SISTEMA DEFINIDO DE, AL MENOS, DOS COMPONENTES LIPIDICOS SELECCIONADOS DE CLASES DE DISTINTA POLARIDAD, EN EL QUE, AL MENOS, UNO DE LOS COMPONENTES LIPIDICOS FORMA CAPAS DOBLES, SE FORMAN PARTICULAS DISCONTINUAS DE LIPIDOS DE FORMA ESPONTANEA CUANDO INTERACTUAN CON SISTEMAS ACUOSOS. PREFERIBLEMENTE, AL MENOS UNO DE LOS COMPONENTES LIPIDICOS ES ANFIFATICO Y POLAR Y UNO ES NO POLAR. ESTAS PARTICULAS DISCONTINUAS SE FORMAN ESPONTANEAMENTE A PARTIR DE LA MATRIZ SIN NINGUN TRATAMIENTO NI INICIACION QUIMICO/A NI FISICO/A. LA MATRIZ FORMADORA DE PARTICULAS LIPIDICAS PUEDE CONTENER MATERIALES BIOACTIVOS, SELECCIONADOS DEL GRUPO DE MEDICAMENTOS, HERBICIDAS, PESTICIDAS, FERTILIZANTES, INGREDIENTES O ADITIVOS ALIMENTARIOS O COSMETICOS. LA INVENCION TAMBIEN ESTA RELACIONADA CON UN PROCESO PARA LA PRODUCCION DE LA MATRIZ, EL USO DE LA MATRIZ FORMADORA DE PARTICULAS LIPIDICAS COMOSISTEMA PORTADOR PARA MATERIALES BIOACTIVOS Y COMPOSICIONES FARMACEUTICAS TALES COMO VEHICULOS ORALES, RECTALES, NASALES, VAGINALES, OCULARES O PARENTERALES, CREMAS, UNGUENTOS, CAPSULAS Y COMPRIMIDOS QUE CONTIENEN DICHA MATRIZ FORMADORA DE PARTICULAS LIPIDICAS Y UN MEDICAMENTO.
ES91919389T 1990-09-28 1991-09-24 Sistema de formulacion de lipidos. Expired - Lifetime ES2088024T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9003100A SE9003100D0 (sv) 1990-09-28 1990-09-28 Lipid formulation system

Publications (1)

Publication Number Publication Date
ES2088024T3 true ES2088024T3 (es) 1996-08-01

Family

ID=20380490

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91919389T Expired - Lifetime ES2088024T3 (es) 1990-09-28 1991-09-24 Sistema de formulacion de lipidos.

Country Status (15)

Country Link
EP (1) EP0514506B1 (es)
JP (1) JP2855594B2 (es)
AT (1) ATE137667T1 (es)
AU (1) AU645143B2 (es)
CA (1) CA2069760C (es)
DE (1) DE69119400T2 (es)
DK (1) DK0514506T3 (es)
ES (1) ES2088024T3 (es)
FI (1) FI107696B (es)
GR (1) GR3020674T3 (es)
IE (1) IE62194B1 (es)
NO (1) NO304729B1 (es)
PT (1) PT99113B (es)
SE (1) SE9003100D0 (es)
WO (1) WO1992005771A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260065A (en) * 1991-09-17 1993-11-09 Micro Vesicular Systems, Inc. Blended lipid vesicles
SE9200952D0 (sv) * 1992-03-27 1992-03-27 Kabi Pharmacia Ab Pharmaceutical carrier system containing defined lipids
SE9200951D0 (sv) * 1992-03-27 1992-03-27 Kabi Pharmacia Ab Pharmaceutical composition containing a defined lipid system
CN1091591C (zh) * 1994-02-04 2002-10-02 利珀克尔集团公司 亲脂载体制剂
DE4447287C1 (de) * 1994-12-30 1996-11-07 Cevc Gregor Präparat zum Wirkstofftransport durch Barrieren
SE9703691D0 (sv) 1997-10-10 1997-10-10 Astra Ab Pharmaceutical compositions
GB2344520A (en) * 1998-12-08 2000-06-14 Phares Pharm Res Nv Pharmaceutical carriers comprising lipids and polymers
PL193824B1 (pl) 1998-12-23 2007-03-30 Idea Ag Preparat zawierający środki penetrujące, sposób wytwarzania preparatu zawierającego środki penetrujące oraz zastosowanie preparatu do wytwarzania leku
SE0000730D0 (sv) * 2000-03-06 2000-03-06 Scotia Holdings Plc Lipid carrier
SE0200475D0 (sv) * 2002-02-15 2002-02-15 Ltp Lipid Technologies Provide Oral farmaceutisk beredning
SE0201922D0 (sv) * 2002-06-20 2002-06-20 Ltp Lipid Technologies Provide Koagulationshindrande komposition (Anticoagulant Composition)
FR2868704B1 (fr) * 2004-04-07 2007-09-14 Ethypharm Sa Utilisation de lipides pour ameliorer la biodisponibilite de principes actifs proteiques en formulations injectables sous cutanees ou intra-musculaires
US20050232981A1 (en) 2004-04-15 2005-10-20 Ben-Sasson Shmuel A Compositions capable of facilitating penetration across a biological barrier
WO2006115463A1 (en) * 2005-04-28 2006-11-02 Galenica Technology Ab Pharmaceutical dosage forms comprising a lipid phase
WO2007043057A2 (en) * 2005-10-11 2007-04-19 Yissum, Research Development Company Of The Hebrew University Of Jerusalem Compositions for nasal delivery
EP2343982B1 (en) 2008-09-17 2017-03-22 Chiasma Inc. Pharmaceutical compositions and related methods of delivery
CN101926757B (zh) 2010-09-01 2013-01-02 北京大学 一种难溶性药物的液体组合物及其制备方法
CA2975599A1 (en) 2015-02-03 2016-08-11 Chiasma Inc. Method of treating diseases
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods
AU2021444376A1 (en) * 2021-05-03 2023-11-16 Mcal Therapeutics Inc. Micronized lipids

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT8219012A0 (it) * 1982-01-06 1982-01-06 Ausonia Farma Srl Metodo per la somministrazione orale di sostanze sotto forma di liposomi, e relative formulazioni farmaceutiche.
GB8613811D0 (en) * 1986-06-06 1986-07-09 Phares Pharm Res Nv Composition & method
JPH0753661B2 (ja) * 1984-03-08 1995-06-07 フアレス フアーマスーチカル リサーチ エヌブイ プロ―リポソーム組成物及びリポソームの水性分散物を作る方法
US4610868A (en) * 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
SE8603812D0 (sv) * 1986-09-12 1986-09-12 Draco Ab Administration of liposomes to mammals
AU604288B2 (en) * 1987-01-26 1990-12-13 Vestar, Inc. Phospholipid delivery vehicle for aqueous-insoluble active ingredients

Also Published As

Publication number Publication date
NO922084D0 (no) 1992-05-26
EP0514506A1 (en) 1992-11-25
IE62194B1 (en) 1994-12-28
PT99113A (pt) 1992-08-31
JPH05503711A (ja) 1993-06-17
IE913246A1 (en) 1992-04-08
GR3020674T3 (en) 1996-10-31
FI922452A0 (fi) 1992-05-27
JP2855594B2 (ja) 1999-02-10
SE9003100D0 (sv) 1990-09-28
WO1992005771A1 (en) 1992-04-16
PT99113B (pt) 1999-02-26
ATE137667T1 (de) 1996-05-15
NO304729B1 (no) 1999-02-08
NO922084L (no) 1992-05-26
DK0514506T3 (da) 1996-08-12
DE69119400T2 (de) 1996-12-05
AU645143B2 (en) 1994-01-06
AU8710591A (en) 1992-04-28
EP0514506B1 (en) 1996-05-08
FI107696B (fi) 2001-09-28
CA2069760C (en) 1998-02-10
CA2069760A1 (en) 1992-03-29
DE69119400D1 (de) 1996-06-13
FI922452A (fi) 1992-05-27

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