FI106716B - Menetelmä uusien terapeuttisesti käyttökelpoisten imidatso[2,3-b]pyridiini- ja bentsimidatsolijohdannaisten valmistamiseksi - Google Patents
Menetelmä uusien terapeuttisesti käyttökelpoisten imidatso[2,3-b]pyridiini- ja bentsimidatsolijohdannaisten valmistamiseksi Download PDFInfo
- Publication number
- FI106716B FI106716B FI940659A FI940659A FI106716B FI 106716 B FI106716 B FI 106716B FI 940659 A FI940659 A FI 940659A FI 940659 A FI940659 A FI 940659A FI 106716 B FI106716 B FI 106716B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- carbon atoms
- straight
- mmol
- general formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4304455A DE4304455A1 (de) | 1993-02-15 | 1993-02-15 | Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate |
DE4304455 | 1993-02-15 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI940659A0 FI940659A0 (fi) | 1994-02-11 |
FI940659A FI940659A (fi) | 1994-08-16 |
FI106716B true FI106716B (fi) | 2001-03-30 |
Family
ID=6480447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI940659A FI106716B (fi) | 1993-02-15 | 1994-02-11 | Menetelmä uusien terapeuttisesti käyttökelpoisten imidatso[2,3-b]pyridiini- ja bentsimidatsolijohdannaisten valmistamiseksi |
Country Status (25)
Country | Link |
---|---|
US (1) | US5395840A (xx) |
EP (1) | EP0611767B1 (xx) |
JP (1) | JPH06293741A (xx) |
KR (1) | KR940019708A (xx) |
CN (1) | CN1057085C (xx) |
AT (1) | ATE196141T1 (xx) |
AU (1) | AU672262B2 (xx) |
CA (1) | CA2115536C (xx) |
CZ (1) | CZ289096B6 (xx) |
DE (2) | DE4304455A1 (xx) |
DK (1) | DK0611767T3 (xx) |
ES (1) | ES2151908T3 (xx) |
FI (1) | FI106716B (xx) |
GR (1) | GR3034957T3 (xx) |
IL (1) | IL108625A (xx) |
MY (1) | MY131595A (xx) |
NO (1) | NO300810B1 (xx) |
NZ (1) | NZ250864A (xx) |
PH (1) | PH30172A (xx) |
PL (1) | PL177834B1 (xx) |
PT (1) | PT611767E (xx) |
RU (1) | RU2119480C1 (xx) |
SK (1) | SK15294A3 (xx) |
UA (1) | UA35574C2 (xx) |
ZA (1) | ZA94984B (xx) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW300219B (xx) * | 1991-09-14 | 1997-03-11 | Hoechst Ag | |
DE19503160A1 (de) * | 1995-02-01 | 1996-08-08 | Bayer Ag | Verwendung von Phenylcyclohexylcarbonsäureamiden |
HRP960015B1 (en) * | 1995-02-01 | 2000-12-31 | Bayer Ag | Substituted indole derivatives |
DE19525028A1 (de) * | 1995-07-10 | 1997-01-16 | Bayer Ag | Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen |
JP2002507996A (ja) * | 1997-07-03 | 2002-03-12 | デュポン ファーマシューティカルズ カンパニー | 神経学的障害を治療するためのイミダゾピリミジン類およびイミダゾピリジン類 |
US6124463A (en) * | 1998-07-02 | 2000-09-26 | Dupont Pharmaceuticals | Benzimidazoles as corticotropin release factor antagonists |
US6365589B1 (en) | 1998-07-02 | 2002-04-02 | Bristol-Myers Squibb Pharma Company | Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists |
RU2001116581A (ru) * | 1998-11-17 | 2004-02-20 | БАСФ Акциенгезельшафт (DE) | Замещенные 2-фенилбензимидазолы и 2-фенилиндолы, их получение и применение |
DE19924818A1 (de) * | 1999-05-29 | 2000-11-30 | Bayer Ag | Substituierte Phenylcyclohexancarbonsäureamide |
DE19924819A1 (de) * | 1999-05-29 | 2000-11-30 | Bayer Ag | Substituierte Phenylcyclohexancarbonsäurebenzylamid (Adenosinaufnahmeinhibitoren) |
DE10044792A1 (de) | 2000-09-11 | 2002-04-04 | Bayer Ag | Substituierte Phenylcyclohexancarbonsäureamide und ihre Verwendung |
CN101437784B (zh) | 2006-05-09 | 2013-08-28 | 三菱瓦斯化学株式会社 | 4-(4-烷基环己基)苯甲醛 |
RS57869B1 (sr) | 2009-06-17 | 2018-12-31 | Vertex Pharma | Inhibitori replikacije virusa gripa |
RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
WO2012177896A1 (en) | 2011-06-24 | 2012-12-27 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
PE20140868A1 (es) | 2011-06-24 | 2014-07-18 | Amgen Inc | Antagonistas trpm8 y su uso en tratamientos |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
MX2014015769A (es) | 2012-06-29 | 2015-04-10 | Pfizer | 7h-pirrolo[2,3-d]pirimidinas 4-(amino-substituidas)novedosas como inhibidores de lrrk2. |
US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
ES2741444T3 (es) | 2013-11-13 | 2020-02-11 | Vertex Pharma | Inhibidores de la replicación de virus de la gripe |
RS57541B1 (sr) | 2013-11-13 | 2018-10-31 | Vertex Pharma | Postupci za pripremu inhibitora replikacije virusa gripa |
WO2015092592A1 (en) | 2013-12-17 | 2015-06-25 | Pfizer Inc. | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
JP6704416B2 (ja) | 2015-05-13 | 2020-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤を調製する方法 |
WO2017046675A1 (en) | 2015-09-14 | 2017-03-23 | Pfizer Inc. | Novel imidazo [4,5-c] quinoline and imidazo [4,5-c][1,5] naphthyridine derivatives as lrrk2 inhibitors |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
IE64514B1 (en) * | 1989-05-23 | 1995-08-09 | Zeneca Ltd | Azaindenes |
GB8911854D0 (en) * | 1989-05-23 | 1989-07-12 | Ici Plc | Heterocyclic compounds |
US5164407A (en) * | 1989-07-03 | 1992-11-17 | Merck & Co., Inc. | Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists |
ES2121773T3 (es) * | 1990-06-08 | 1998-12-16 | Hoechst Marion Roussel Inc | Derivados de bencimidazol, su procedimiento de preparacion, productos intermedios, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen. |
RU1836357C (ru) * | 1990-07-23 | 1993-08-23 | Др.Карл Томэ ГмбХ | Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами |
EP0470543A1 (de) * | 1990-08-10 | 1992-02-12 | Dr. Karl Thomae GmbH | Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung |
DE4031635A1 (de) * | 1990-10-05 | 1992-04-09 | Thomae Gmbh Dr K | Substituierte 1-benzyl-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DE4224133A1 (de) * | 1992-07-22 | 1994-01-27 | Thomae Gmbh Dr K | Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
DE4200954A1 (de) * | 1991-04-26 | 1992-10-29 | Bayer Ag | Heterocyclisch substituierte phenylessigsaeurederivate |
-
1993
- 1993-02-15 DE DE4304455A patent/DE4304455A1/de not_active Withdrawn
-
1994
- 1994-01-31 AU AU54807/94A patent/AU672262B2/en not_active Ceased
- 1994-02-02 EP EP94101543A patent/EP0611767B1/de not_active Expired - Lifetime
- 1994-02-02 PT PT94101543T patent/PT611767E/pt unknown
- 1994-02-02 DK DK94101543T patent/DK0611767T3/da active
- 1994-02-02 AT AT94101543T patent/ATE196141T1/de not_active IP Right Cessation
- 1994-02-02 ES ES94101543T patent/ES2151908T3/es not_active Expired - Lifetime
- 1994-02-02 DE DE59409509T patent/DE59409509D1/de not_active Expired - Fee Related
- 1994-02-08 US US08/193,835 patent/US5395840A/en not_active Expired - Fee Related
- 1994-02-09 SK SK152-94A patent/SK15294A3/sk unknown
- 1994-02-11 IL IL108625A patent/IL108625A/xx not_active IP Right Cessation
- 1994-02-11 CA CA002115536A patent/CA2115536C/en not_active Expired - Fee Related
- 1994-02-11 FI FI940659A patent/FI106716B/fi active
- 1994-02-11 UA UA94005092A patent/UA35574C2/uk unknown
- 1994-02-11 PL PL94302213A patent/PL177834B1/pl unknown
- 1994-02-11 NZ NZ250864A patent/NZ250864A/en unknown
- 1994-02-14 MY MYPI94000321A patent/MY131595A/en unknown
- 1994-02-14 JP JP6037543A patent/JPH06293741A/ja active Pending
- 1994-02-14 PH PH47762A patent/PH30172A/en unknown
- 1994-02-14 RU RU94004975A patent/RU2119480C1/ru active
- 1994-02-14 KR KR1019940002533A patent/KR940019708A/ko active IP Right Grant
- 1994-02-14 NO NO940506A patent/NO300810B1/no not_active IP Right Cessation
- 1994-02-14 ZA ZA94984A patent/ZA94984B/xx unknown
- 1994-02-15 CN CN94101553A patent/CN1057085C/zh not_active Expired - Fee Related
- 1994-02-15 CZ CZ1994329A patent/CZ289096B6/cs not_active IP Right Cessation
-
2000
- 2000-11-30 GR GR20000402660T patent/GR3034957T3/el not_active IP Right Cessation
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