FI106716B - Menetelmä uusien terapeuttisesti käyttökelpoisten imidatso[2,3-b]pyridiini- ja bentsimidatsolijohdannaisten valmistamiseksi - Google Patents

Menetelmä uusien terapeuttisesti käyttökelpoisten imidatso[2,3-b]pyridiini- ja bentsimidatsolijohdannaisten valmistamiseksi Download PDF

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Publication number
FI106716B
FI106716B FI940659A FI940659A FI106716B FI 106716 B FI106716 B FI 106716B FI 940659 A FI940659 A FI 940659A FI 940659 A FI940659 A FI 940659A FI 106716 B FI106716 B FI 106716B
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FI
Finland
Prior art keywords
formula
carbon atoms
straight
mmol
general formula
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FI940659A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI940659A0 (fi
FI940659A (fi
Inventor
Johannes-Peter Stasch
Peter Fey
Walter Huebsch
Stanislav Kazda
Andreas Knorr
Ulrich E Mueller
Juergen Dressel
Rudolf H Hanko
Thomas Kraemer
Matthias Mueller-Gliemann
Martin Beuck
Stefan Wohlfeil
Siegfried Zaiss
Original Assignee
Bayer Ag
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Publication of FI940659A0 publication Critical patent/FI940659A0/fi
Publication of FI940659A publication Critical patent/FI940659A/fi
Application granted granted Critical
Publication of FI106716B publication Critical patent/FI106716B/fi

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
FI940659A 1993-02-15 1994-02-11 Menetelmä uusien terapeuttisesti käyttökelpoisten imidatso[2,3-b]pyridiini- ja bentsimidatsolijohdannaisten valmistamiseksi FI106716B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4304455A DE4304455A1 (de) 1993-02-15 1993-02-15 Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate
DE4304455 1993-02-15

Publications (3)

Publication Number Publication Date
FI940659A0 FI940659A0 (fi) 1994-02-11
FI940659A FI940659A (fi) 1994-08-16
FI106716B true FI106716B (fi) 2001-03-30

Family

ID=6480447

Family Applications (1)

Application Number Title Priority Date Filing Date
FI940659A FI106716B (fi) 1993-02-15 1994-02-11 Menetelmä uusien terapeuttisesti käyttökelpoisten imidatso[2,3-b]pyridiini- ja bentsimidatsolijohdannaisten valmistamiseksi

Country Status (25)

Country Link
US (1) US5395840A (xx)
EP (1) EP0611767B1 (xx)
JP (1) JPH06293741A (xx)
KR (1) KR940019708A (xx)
CN (1) CN1057085C (xx)
AT (1) ATE196141T1 (xx)
AU (1) AU672262B2 (xx)
CA (1) CA2115536C (xx)
CZ (1) CZ289096B6 (xx)
DE (2) DE4304455A1 (xx)
DK (1) DK0611767T3 (xx)
ES (1) ES2151908T3 (xx)
FI (1) FI106716B (xx)
GR (1) GR3034957T3 (xx)
IL (1) IL108625A (xx)
MY (1) MY131595A (xx)
NO (1) NO300810B1 (xx)
NZ (1) NZ250864A (xx)
PH (1) PH30172A (xx)
PL (1) PL177834B1 (xx)
PT (1) PT611767E (xx)
RU (1) RU2119480C1 (xx)
SK (1) SK15294A3 (xx)
UA (1) UA35574C2 (xx)
ZA (1) ZA94984B (xx)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW300219B (xx) * 1991-09-14 1997-03-11 Hoechst Ag
DE19503160A1 (de) * 1995-02-01 1996-08-08 Bayer Ag Verwendung von Phenylcyclohexylcarbonsäureamiden
HRP960015B1 (en) * 1995-02-01 2000-12-31 Bayer Ag Substituted indole derivatives
DE19525028A1 (de) * 1995-07-10 1997-01-16 Bayer Ag Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen
JP2002507996A (ja) * 1997-07-03 2002-03-12 デュポン ファーマシューティカルズ カンパニー 神経学的障害を治療するためのイミダゾピリミジン類およびイミダゾピリジン類
US6124463A (en) * 1998-07-02 2000-09-26 Dupont Pharmaceuticals Benzimidazoles as corticotropin release factor antagonists
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
RU2001116581A (ru) * 1998-11-17 2004-02-20 БАСФ Акциенгезельшафт (DE) Замещенные 2-фенилбензимидазолы и 2-фенилиндолы, их получение и применение
DE19924818A1 (de) * 1999-05-29 2000-11-30 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide
DE19924819A1 (de) * 1999-05-29 2000-11-30 Bayer Ag Substituierte Phenylcyclohexancarbonsäurebenzylamid (Adenosinaufnahmeinhibitoren)
DE10044792A1 (de) 2000-09-11 2002-04-04 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide und ihre Verwendung
CN101437784B (zh) 2006-05-09 2013-08-28 三菱瓦斯化学株式会社 4-(4-烷基环己基)苯甲醛
RS57869B1 (sr) 2009-06-17 2018-12-31 Vertex Pharma Inhibitori replikacije virusa gripa
RU2013132681A (ru) 2010-12-16 2015-01-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
WO2012177896A1 (en) 2011-06-24 2012-12-27 Amgen Inc. Trpm8 antagonists and their use in treatments
PE20140868A1 (es) 2011-06-24 2014-07-18 Amgen Inc Antagonistas trpm8 y su uso en tratamientos
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
MX2014015769A (es) 2012-06-29 2015-04-10 Pfizer 7h-pirrolo[2,3-d]pirimidinas 4-(amino-substituidas)novedosas como inhibidores de lrrk2.
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
ES2741444T3 (es) 2013-11-13 2020-02-11 Vertex Pharma Inhibidores de la replicación de virus de la gripe
RS57541B1 (sr) 2013-11-13 2018-10-31 Vertex Pharma Postupci za pripremu inhibitora replikacije virusa gripa
WO2015092592A1 (en) 2013-12-17 2015-06-25 Pfizer Inc. Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
EP3294735B8 (en) 2015-05-13 2022-01-05 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated インフルエンザウイルスの複製の阻害剤を調製する方法
WO2017046675A1 (en) 2015-09-14 2017-03-23 Pfizer Inc. Novel imidazo [4,5-c] quinoline and imidazo [4,5-c][1,5] naphthyridine derivatives as lrrk2 inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
US5164407A (en) * 1989-07-03 1992-11-17 Merck & Co., Inc. Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
ES2121773T3 (es) * 1990-06-08 1998-12-16 Hoechst Marion Roussel Inc Derivados de bencimidazol, su procedimiento de preparacion, productos intermedios, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
RU1836357C (ru) * 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
EP0470543A1 (de) * 1990-08-10 1992-02-12 Dr. Karl Thomae GmbH Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung
DE4031635A1 (de) * 1990-10-05 1992-04-09 Thomae Gmbh Dr K Substituierte 1-benzyl-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4224133A1 (de) * 1992-07-22 1994-01-27 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4200954A1 (de) * 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate

Also Published As

Publication number Publication date
DE59409509D1 (de) 2000-10-12
NZ250864A (en) 1995-03-28
IL108625A (en) 1997-09-30
AU672262B2 (en) 1996-09-26
NO940506L (xx) 1994-08-16
PL177834B1 (pl) 2000-01-31
UA35574C2 (uk) 2001-04-16
EP0611767A1 (de) 1994-08-24
ATE196141T1 (de) 2000-09-15
AU5480794A (en) 1994-08-18
ZA94984B (en) 1994-08-24
EP0611767B1 (de) 2000-09-06
FI940659A0 (fi) 1994-02-11
DE4304455A1 (de) 1994-08-18
KR940019708A (ko) 1994-09-14
JPH06293741A (ja) 1994-10-21
ES2151908T3 (es) 2001-01-16
CZ32994A3 (en) 1994-08-17
CN1057085C (zh) 2000-10-04
IL108625A0 (en) 1994-05-30
PT611767E (pt) 2001-02-28
CA2115536C (en) 2004-11-02
NO300810B1 (no) 1997-07-28
SK15294A3 (en) 1994-12-07
RU2119480C1 (ru) 1998-09-27
DK0611767T3 (da) 2001-01-02
CN1108257A (zh) 1995-09-13
PH30172A (en) 1997-01-21
NO940506D0 (no) 1994-02-14
MY131595A (en) 2007-08-30
GR3034957T3 (en) 2001-02-28
US5395840A (en) 1995-03-07
CA2115536A1 (en) 1994-08-16
FI940659A (fi) 1994-08-16
PL302213A1 (en) 1994-08-22
CZ289096B6 (cs) 2001-11-14

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