FI106225B - Menetelmä ja magneettilaite kiinteällä faasilla tapahtuvaa immunologista analyysiä varten - Google Patents
Menetelmä ja magneettilaite kiinteällä faasilla tapahtuvaa immunologista analyysiä varten Download PDFInfo
- Publication number
- FI106225B FI106225B FI923327A FI923327A FI106225B FI 106225 B FI106225 B FI 106225B FI 923327 A FI923327 A FI 923327A FI 923327 A FI923327 A FI 923327A FI 106225 B FI106225 B FI 106225B
- Authority
- FI
- Finland
- Prior art keywords
- particles
- substance
- walls
- affinity
- magnetic
- Prior art date
Links
- 230000005291 magnetic effect Effects 0.000 title claims abstract description 63
- 238000000034 method Methods 0.000 title claims abstract description 53
- 230000001900 immune effect Effects 0.000 title claims abstract description 22
- 238000004458 analytical method Methods 0.000 title claims description 5
- 239000007790 solid phase Substances 0.000 title description 2
- 239000002245 particle Substances 0.000 claims abstract description 77
- 239000000126 substance Substances 0.000 claims abstract description 54
- 239000006249 magnetic particle Substances 0.000 claims abstract description 36
- 230000008021 deposition Effects 0.000 claims abstract description 3
- 230000003068 static effect Effects 0.000 claims description 17
- 230000033001 locomotion Effects 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 6
- 238000005497 microtitration Methods 0.000 claims description 6
- 238000005406 washing Methods 0.000 claims description 6
- 238000011534 incubation Methods 0.000 claims description 5
- 230000008105 immune reaction Effects 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 230000028993 immune response Effects 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 229910052719 titanium Inorganic materials 0.000 claims 1
- 239000010936 titanium Substances 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 31
- 239000000427 antigen Substances 0.000 description 16
- 102000036639 antigens Human genes 0.000 description 16
- 108091007433 antigens Proteins 0.000 description 16
- 238000010790 dilution Methods 0.000 description 14
- 239000012895 dilution Substances 0.000 description 14
- 210000003743 erythrocyte Anatomy 0.000 description 14
- 239000000725 suspension Substances 0.000 description 13
- 238000011282 treatment Methods 0.000 description 12
- 238000009826 distribution Methods 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
- 230000001788 irregular Effects 0.000 description 9
- 210000002966 serum Anatomy 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 210000002381 plasma Anatomy 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 6
- 238000003556 assay Methods 0.000 description 6
- 238000004062 sedimentation Methods 0.000 description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 5
- 239000004793 Polystyrene Substances 0.000 description 5
- 239000003124 biologic agent Substances 0.000 description 5
- 229940098773 bovine serum albumin Drugs 0.000 description 5
- 238000005119 centrifugation Methods 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 239000012071 phase Substances 0.000 description 5
- 229920002223 polystyrene Polymers 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 239000011550 stock solution Substances 0.000 description 5
- 239000000872 buffer Substances 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 102000006395 Globulins Human genes 0.000 description 3
- 108010044091 Globulins Proteins 0.000 description 3
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000003018 immunoassay Methods 0.000 description 3
- 102000018358 immunoglobulin Human genes 0.000 description 3
- 229910052742 iron Inorganic materials 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 238000004448 titration Methods 0.000 description 3
- 229910000859 α-Fe Inorganic materials 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 239000012267 brine Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 230000005674 electromagnetic induction Effects 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 101150110188 30 gene Proteins 0.000 description 1
- 101150116295 CAT2 gene Proteins 0.000 description 1
- 101100326920 Caenorhabditis elegans ctl-1 gene Proteins 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- GCKMFJBGXUYNAG-HLXURNFRSA-N Methyltestosterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)CC2 GCKMFJBGXUYNAG-HLXURNFRSA-N 0.000 description 1
- 101100126846 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) katG gene Proteins 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000026058 directional locomotion Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 230000005672 electromagnetic field Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000004180 red 2G Substances 0.000 description 1
- -1 red blood cells Proteins 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000001119 stannous chloride Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 229940085503 testred Drugs 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical applications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/806—Electrical property or magnetic property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/824—Immunological separation techniques
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9109242 | 1991-07-22 | ||
| FR9109242A FR2679660B1 (fr) | 1991-07-22 | 1991-07-22 | Procede et dispositif magnetique d'analyse immunologique sur phase solide. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI923327A0 FI923327A0 (fi) | 1992-07-21 |
| FI923327A FI923327A (fi) | 1993-01-23 |
| FI106225B true FI106225B (fi) | 2000-12-15 |
Family
ID=9415389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI923327A FI106225B (fi) | 1991-07-22 | 1992-07-21 | Menetelmä ja magneettilaite kiinteällä faasilla tapahtuvaa immunologista analyysiä varten |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5318914A (ja) |
| EP (1) | EP0528708B1 (ja) |
| JP (1) | JP2510932B2 (ja) |
| AT (1) | ATE137024T1 (ja) |
| AU (1) | AU648680B2 (ja) |
| CA (1) | CA2074278C (ja) |
| DE (1) | DE69209935T2 (ja) |
| DK (1) | DK0528708T3 (ja) |
| ES (1) | ES2086688T3 (ja) |
| FI (1) | FI106225B (ja) |
| FR (1) | FR2679660B1 (ja) |
| GR (1) | GR3019891T3 (ja) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5403745A (en) * | 1990-04-27 | 1995-04-04 | Genzyme Corporation | Determination of analytes in biological fluids in the presence of substances interfering with assays therefor |
| IE76732B1 (en) * | 1990-08-07 | 1997-11-05 | Becton Dickinson Co | One step test for absolute counts |
| JP3142873B2 (ja) * | 1993-02-01 | 2001-03-07 | ラブシステムズ オユ | 磁性粒子の特異的結合による検定の方法および装置 |
| FI930440A0 (fi) | 1993-02-01 | 1993-02-01 | Labsystems Oy | Bestaemningsfoerfarande |
| JP3607320B2 (ja) * | 1994-09-02 | 2005-01-05 | 株式会社日立製作所 | 微粒子を用いた分析における固相の回収方法及び装置 |
| FI944937A0 (fi) | 1994-10-20 | 1994-10-20 | Labsystems Oy | Separeringsanordning |
| FI944939A0 (fi) * | 1994-10-20 | 1994-10-20 | Labsystems Oy | Foerfarande foer separering av partiklar |
| FI944940A0 (fi) * | 1994-10-20 | 1994-10-20 | Labsystems Oy | Tvaofasigt separeringsfoerfarande |
| FI944938A0 (fi) * | 1994-10-20 | 1994-10-20 | Labsystems Oy | Foerflyttningsanordning |
| US5571481A (en) * | 1995-02-17 | 1996-11-05 | Vicam, L.P. | Magnetic capture rack with slidable magnetic member |
| DE19512368A1 (de) * | 1995-04-01 | 1996-10-02 | Boehringer Mannheim Gmbh | System zur Freisetzung und Isolierung von Nukleinsäuren |
| US6919175B1 (en) | 1995-04-01 | 2005-07-19 | Roche Diagnostics Gmbh | System for releasing and isolating nucleic acids |
| US5835329A (en) * | 1995-06-05 | 1998-11-10 | Solid Phase Sciences Corporation | Apparatus for agitation separation of magnetic particles |
| US5639669A (en) * | 1995-06-07 | 1997-06-17 | Ledley; Robert | Separation of fetal cells from maternal blood |
| US5660990A (en) * | 1995-08-18 | 1997-08-26 | Immunivest Corporation | Surface immobilization of magnetically collected materials |
| US5776784A (en) * | 1996-01-11 | 1998-07-07 | Dade International Inc. | Apparatus and method for reagent separation in a chemical analyzer |
| US5856194A (en) | 1996-09-19 | 1999-01-05 | Abbott Laboratories | Method for determination of item of interest in a sample |
| US5795784A (en) | 1996-09-19 | 1998-08-18 | Abbott Laboratories | Method of performing a process for determining an item of interest in a sample |
| CH688987A5 (de) * | 1996-11-13 | 1998-07-15 | Doebelin Werner | Reaktionskammer fuer die chemische Synthese oder verwandte Anwendungen. |
| FR2758884B1 (fr) * | 1997-01-30 | 1999-04-02 | Bio Merieux | Procede pour isoler, notamment detecter ou quantifier un analyte dans un milieu |
| WO1998034114A1 (de) * | 1997-01-30 | 1998-08-06 | Merck Patent Gmbh | Verfahren zur immunologischen bestimmung eines analyten |
| JPH10246725A (ja) * | 1997-03-03 | 1998-09-14 | Mikio Nakayama | 抗体又は抗原の検出方法 |
| EP0970365B1 (en) * | 1997-03-25 | 2003-10-01 | Immunivest Corporation | Apparatus and methods for capture and analysis of particulate entities |
| GB9719774D0 (en) * | 1997-09-18 | 1997-11-19 | Glaxo Group Ltd | Device |
| US6046585A (en) * | 1997-11-21 | 2000-04-04 | Quantum Design, Inc. | Method and apparatus for making quantitative measurements of localized accumulations of target particles having magnetic particles bound thereto |
| US6180418B1 (en) | 1998-01-20 | 2001-01-30 | The United States Of America As Represented By The Secretary Of The Navy | Force discrimination assay |
| US6036857A (en) * | 1998-02-20 | 2000-03-14 | Florida State University Research Foundation, Inc. | Apparatus for continuous magnetic separation of components from a mixture |
| DK1623764T3 (da) | 1998-05-01 | 2009-05-25 | Gen Probe Inc | Automatiseret fremgangsmåde til isolation og amplifikation af en målnucleinsyresekvens |
| US8337753B2 (en) | 1998-05-01 | 2012-12-25 | Gen-Probe Incorporated | Temperature-controlled incubator having a receptacle mixing mechanism |
| US6776174B2 (en) * | 1998-08-21 | 2004-08-17 | Paul E. Nisson | Apparatus for washing magnetic particles |
| US6176609B1 (en) * | 1998-10-13 | 2001-01-23 | V & P Scientific, Inc. | Magnetic tumble stirring method, devices and machines for mixing in vessels |
| WO2000052446A1 (en) * | 1999-03-02 | 2000-09-08 | Qualigen, Inc. | Methods and apparatus for separation of biological fluids |
| US6193892B1 (en) | 1999-03-03 | 2001-02-27 | Promega Corporation | Magnetic separation assembly and method |
| JP4856831B2 (ja) * | 1999-07-19 | 2012-01-18 | オルガノン・テクニカ・ベー・ヴエー | 磁性粒子を流体と混合するための装置および方法 |
| JP4171139B2 (ja) * | 1999-07-21 | 2008-10-22 | 住友電気工業株式会社 | 磁性体標識による免疫検査方法とその装置 |
| JP2002001092A (ja) * | 2000-06-22 | 2002-01-08 | Shimadzu Corp | 排液装置 |
| US6645431B2 (en) * | 2001-01-22 | 2003-11-11 | Thomas W. Astle | Apparatus for automated magnetic separation of materials in laboratory trays |
| US6613284B2 (en) * | 2001-02-01 | 2003-09-02 | V&P Scientific, Inc. | Microarrayer |
| US6518747B2 (en) | 2001-02-16 | 2003-02-11 | Quantum Design, Inc. | Method and apparatus for quantitative determination of accumulations of magnetic particles |
| US20030040129A1 (en) * | 2001-08-20 | 2003-02-27 | Shah Haresh P. | Binding assays using magnetically immobilized arrays |
| CN100354429C (zh) * | 2001-09-06 | 2007-12-12 | 基因描绘系统有限公司 | 一种检测样品中靶分子的方法 |
| GB0124341D0 (en) * | 2001-10-10 | 2001-11-28 | Randox Lab Ltd | Assay |
| US6461034B1 (en) * | 2001-11-14 | 2002-10-08 | V & P Scientific, Inc. | Use of a bubble paddle tumble stirrer to mix the contents of a vessel while the contents are being removed |
| AU2003239963A1 (en) * | 2002-05-31 | 2003-12-19 | The Regents Of The University Of California | Method and apparatus for detecting substances of interest |
| US20040065593A1 (en) * | 2002-09-26 | 2004-04-08 | Cell Works Inc. (A Delaware Corporation) | Automated magnetic sorter |
| US7601491B2 (en) * | 2003-02-06 | 2009-10-13 | Becton, Dickinson And Company | Pretreatment method for extraction of nucleic acid from biological samples and kits therefor |
| US20040157219A1 (en) * | 2003-02-06 | 2004-08-12 | Jianrong Lou | Chemical treatment of biological samples for nucleic acid extraction and kits therefor |
| CN100439515C (zh) * | 2003-03-03 | 2008-12-03 | 清华大学 | 一种核酸分析芯片实验室系统与应用 |
| CN1280428C (zh) * | 2003-05-19 | 2006-10-18 | 清华大学 | 一种基于微小颗粒的生物芯片系统及其应用 |
| FI20031635A0 (fi) * | 2003-11-11 | 2003-11-11 | Thermo Electron Oy | Partikkelien erotusväline |
| US20050239091A1 (en) * | 2004-04-23 | 2005-10-27 | Collis Matthew P | Extraction of nucleic acids using small diameter magnetically-responsive particles |
| FR2869996B1 (fr) * | 2004-05-05 | 2006-12-15 | Diagast Soc Par Actions Simpli | Utilisation de ferrofluides pour le phenotypage sanguin et applications derivees |
| DE102004033811A1 (de) * | 2004-07-12 | 2006-02-02 | Salama, Abdulgabar, Prof. Dr. | Verfahren zum einfachen und schnellen Nachweis von Zellen und Biomolekülen mit Hilfe paramagnetischer Partikel |
| EP1773865A1 (en) * | 2004-08-03 | 2007-04-18 | Becton, Dickinson and Company | Use of magnetic material to fractionate samples |
| EP1861721B1 (en) | 2005-03-10 | 2017-05-03 | Gen-Probe Incorporated | Systems and methods to perform assays for detecting or quantifying analytes within samples |
| JP5144493B2 (ja) * | 2005-03-28 | 2013-02-13 | ベクトン・ディキンソン・アンド・カンパニー | 液体培地中の懸濁物質を撹拌するための改善されたシステムおよび方法 |
| JP4587903B2 (ja) * | 2005-07-29 | 2010-11-24 | シチズンホールディングス株式会社 | 測定器具及びこれを用いた測定用キット、測定方法並びに測定装置 |
| US20100158657A1 (en) * | 2005-08-12 | 2010-06-24 | Toru Maekawa | Method for Manipulation Using Rotational Magnetic Field |
| CN1325518C (zh) * | 2005-09-09 | 2007-07-11 | 李勇 | 人细胞膜抗原的保存方法及磁性粒子包被人细胞膜抗原 |
| EP1937829A4 (en) * | 2005-09-26 | 2011-08-03 | Rapid Micro Biosystems Inc | CASSETTE CONTAINING A GROWTH MEDIUM |
| FR2892820B1 (fr) * | 2005-11-03 | 2008-02-01 | Diagast Soc Par Actions Simpli | Procede magnetique d'immunodiagnostic pour la mise en evidence de complexe anticorps/antigene, en particulier de groupe sanguin |
| DE102006030056B3 (de) * | 2006-06-29 | 2007-06-21 | Ika - Werke Gmbh & Co. Kg | Mikrotiterplatte mit Rührelementen |
| EP2030689B1 (de) * | 2007-08-31 | 2013-02-13 | Tecan Trading AG | Mikroplatten-Träger mit Magneten |
| WO2009072457A1 (ja) * | 2007-12-03 | 2009-06-11 | Tokyo Institute Of Technology | 被覆磁性微粒子を用いたバイオセンシング方法及び該方法に用いるバイオセンシング装置 |
| CN101990639B (zh) * | 2008-04-09 | 2014-08-13 | 株式会社百奥尼 | 自动提纯设备、多井板试样盒以及用于从生物试样提取核酸的方法 |
| US11865534B2 (en) | 2008-09-24 | 2024-01-09 | First Light Diagnostics, Inc. | Imaging analyzer for testing analytes |
| DE102009048918A1 (de) * | 2009-10-10 | 2011-04-14 | Siemens Healthcare Diagnostics Products Gmbh | Vorrichtung zum Mischen einer Flüssigkeitsprobe |
| US8512558B2 (en) * | 2010-02-19 | 2013-08-20 | Roche Molecular Systems, Inc. | Magnetic separation system comprising flexible magnetic pins |
| SE535918C2 (sv) * | 2010-06-10 | 2013-02-19 | Hemocue Ab | Detektion av magnetiskt inmärkta biologiska komponenter |
| FR2963107B1 (fr) | 2010-07-21 | 2019-06-28 | Diagast | Complexe immuno-magnetique et son utilisation pour le groupage/phenotypage erythrocytaire |
| FR2963108B1 (fr) | 2010-07-21 | 2017-06-23 | Diagast | Procede magnetique d'immunodiagnostic et kit pour la mise en evidence de complexe anticorps/antigene de groupe/phenotype sanguin |
| US9046507B2 (en) | 2010-07-29 | 2015-06-02 | Gen-Probe Incorporated | Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure |
| US8718948B2 (en) | 2011-02-24 | 2014-05-06 | Gen-Probe Incorporated | Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector |
| US8920751B2 (en) | 2011-07-08 | 2014-12-30 | Life Technologies Corporation | Automated enrichment for nucleic acid sequencing |
| EP3327110B1 (en) | 2011-11-07 | 2020-01-29 | Rapid Micro Biosystems, Inc. | Cassette for sterility testing |
| CA3171698A1 (en) | 2012-04-16 | 2013-10-24 | Rapid Micro Biosystems, Inc. | Cell culturing device |
| CN109358202B (zh) | 2013-03-15 | 2023-04-07 | 雅培制药有限公司 | 具有竖直布置的圆盘传送带的自动化诊断分析仪及相关方法 |
| CN114137240A (zh) | 2013-03-15 | 2022-03-04 | 雅培制药有限公司 | 具有后面可进入轨道系统的自动化诊断分析仪及相关方法 |
| CN105190317B (zh) | 2013-03-15 | 2018-05-04 | 雅培制药有限公司 | 具有预处理转盘的诊断分析机及相关方法 |
| CN103323586A (zh) * | 2013-06-14 | 2013-09-25 | 中国科学院苏州生物医学工程技术研究所 | 一种血小板磁化免疫标记分析方法 |
| US10739236B1 (en) | 2015-07-08 | 2020-08-11 | BioSpec Products, Inc. | Apparatus and method for vortex mixing and cell disruption of a laboratory sample |
| CN105543089A (zh) * | 2016-03-08 | 2016-05-04 | 湖南圣湘生物科技有限公司 | 一种磁珠法核酸提取装置及方法 |
| RU2643385C1 (ru) * | 2016-11-11 | 2018-02-01 | Общество с ограниченной ответственностью "ДРД" | Устройство для разделения магнитных частиц из реакционных жидкостей |
| KR102256776B1 (ko) | 2018-07-26 | 2021-05-27 | (주)바이오니아 | 자석봉 블록의 교체가 가능한 표적물질 추출장치 |
| CN110372071B (zh) * | 2019-08-02 | 2021-09-17 | 江苏天鑫中冶环保设备有限公司 | 一种煤矿井下用矿井水磁分离水体净化工艺及设备 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3693941A (en) * | 1971-08-23 | 1972-09-26 | Jan S Suchy | Electromagnetically propelled stirrer and shaker |
| US4085037A (en) * | 1975-12-29 | 1978-04-18 | Union Carbide Corporation | Process for separation of non-magnetic particles with ferromagnetic media |
| SE397637B (sv) * | 1976-03-09 | 1977-11-14 | Wik G | Magnetomrorare |
| US4272510A (en) * | 1976-04-26 | 1981-06-09 | Smith Kendall O | Magnetic attraction transfer process for use in solid phase radioimmunoassays and in other assay methods |
| EP0052324B1 (de) * | 1980-11-17 | 1986-03-05 | Helmut Dipl.-Ing. Herz | Magnet-Rühreinrichtung |
| SE8601143L (sv) * | 1986-03-12 | 1987-09-13 | Carbematrix Ab | Sett och anordning for samling och spridning av ferromagnetiska partiklar i ett fluidformigt medium |
| JPH0737989B2 (ja) * | 1986-07-04 | 1995-04-26 | 東ソー株式会社 | 免疫反応の測定方法および装置 |
| US4988618A (en) * | 1987-11-16 | 1991-01-29 | Gene-Trak Systems | Magnetic separation device and methods for use in heterogeneous assays |
| DE68919565T2 (de) * | 1988-07-20 | 1995-06-29 | Olympus Optical Co | Immuntestverfahren unter Verwendung magnetischer Markerteilchen. |
| JP2647931B2 (ja) * | 1988-10-31 | 1997-08-27 | オリンパス光学工業株式会社 | 免疫学的測定方法 |
| JPH02210262A (ja) * | 1989-02-10 | 1990-08-21 | Shinotesuto Kenkyusho:Kk | 間接凝集反応測定法 |
| US4911555A (en) * | 1989-05-04 | 1990-03-27 | The Jackson Laboratory | Magnetic stirrer for multiple samples |
-
1991
- 1991-07-22 FR FR9109242A patent/FR2679660B1/fr not_active Expired - Fee Related
-
1992
- 1992-07-21 US US07/916,494 patent/US5318914A/en not_active Expired - Lifetime
- 1992-07-21 EP EP92402101A patent/EP0528708B1/fr not_active Expired - Lifetime
- 1992-07-21 ES ES92402101T patent/ES2086688T3/es not_active Expired - Lifetime
- 1992-07-21 DE DE69209935T patent/DE69209935T2/de not_active Expired - Lifetime
- 1992-07-21 DK DK92402101.7T patent/DK0528708T3/da active
- 1992-07-21 FI FI923327A patent/FI106225B/fi not_active IP Right Cessation
- 1992-07-21 AT AT92402101T patent/ATE137024T1/de active
- 1992-07-21 AU AU20456/92A patent/AU648680B2/en not_active Expired
- 1992-07-21 CA CA002074278A patent/CA2074278C/en not_active Expired - Lifetime
- 1992-07-22 JP JP4216480A patent/JP2510932B2/ja not_active Expired - Lifetime
-
1994
- 1994-03-14 US US08/209,274 patent/US5558839A/en not_active Expired - Fee Related
-
1996
- 1996-05-13 GR GR960401271T patent/GR3019891T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3019891T3 (en) | 1996-08-31 |
| DE69209935D1 (de) | 1996-05-23 |
| EP0528708A1 (fr) | 1993-02-24 |
| EP0528708B1 (fr) | 1996-04-17 |
| ATE137024T1 (de) | 1996-05-15 |
| AU2045692A (en) | 1993-01-28 |
| US5318914A (en) | 1994-06-07 |
| CA2074278C (en) | 2004-06-08 |
| DE69209935T2 (de) | 1996-10-02 |
| FR2679660A1 (fr) | 1993-01-29 |
| DK0528708T3 (da) | 1996-08-12 |
| ES2086688T3 (es) | 1996-07-01 |
| FR2679660B1 (fr) | 1993-11-12 |
| US5558839A (en) | 1996-09-24 |
| FI923327A0 (fi) | 1992-07-21 |
| AU648680B2 (en) | 1994-04-28 |
| JPH05203651A (ja) | 1993-08-10 |
| FI923327A (fi) | 1993-01-23 |
| JP2510932B2 (ja) | 1996-06-26 |
| CA2074278A1 (en) | 1993-01-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI106225B (fi) | Menetelmä ja magneettilaite kiinteällä faasilla tapahtuvaa immunologista analyysiä varten | |
| EP0351857B1 (en) | Immunoassay method using magnetic marker particles | |
| US5338689A (en) | Method and card for detecting antigens and/or antibodies | |
| US5460940A (en) | Method for detecting antigens and/or antibodies | |
| US5340749A (en) | Method for collecting and preparing specimens for immune reactions | |
| ES2779043T3 (es) | Métodos de inmunodiagnóstico magnético y kits para la determinación de complejos de anticuerpo/antígeno en la agrupación y el fenotipado sanguíneo de eritrocitos | |
| JP5223676B2 (ja) | 特に血液型の抗体／抗原複合体の存在の証明のための磁気的免疫診断方法 | |
| WO1992004961A1 (en) | Apparatus and methods for magnetic separation | |
| CN110308288B (zh) | 一种新型血小板交叉配型试剂盒 | |
| JP2532670B2 (ja) | 磁性マ―カ―粒子を用いた免疫学的測定方法 | |
| WO1989011102A1 (en) | Capillary flow device and double capture assay method | |
| JP2614997B2 (ja) | 凝集反応のための反応促進装置 | |
| JPH08201391A (ja) | マ−カ−粒子を用いた免疫学的測定方法 | |
| JP3290730B2 (ja) | 反応形態の展開装置および方法 | |
| JPH07117541B2 (ja) | 磁性粒子を用いた免疫学的測定方法 | |
| JP2647931B2 (ja) | 免疫学的測定方法 | |
| JPH03191864A (ja) | 間接凝集免疫測定方法及び装置 | |
| JP2716227B2 (ja) | 磁性マーカー粒子を用いた免疫学的測定方法 | |
| JPH06148188A (ja) | 免疫学的再検査方法 | |
| Plapp et al. | The evolution of pretransfusion testing: from agglutination to solid-phase red cell adherence tests | |
| US20050130223A1 (en) | Method, system and kit for detecting an analyte in a sample |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TC | Name/ company changed in patent |
Owner name: BIO-RAD INNOVATIONS Free format text: BIO-RAD INNOVATIONS |
|
| MA | Patent expired |