FI104176B1 - Menetelmä nukleosidien uusien antiviraalisten forfolipidijohdannaisten valmistamiseksi - Google Patents

Menetelmä nukleosidien uusien antiviraalisten forfolipidijohdannaisten valmistamiseksi

Info

Publication number
FI104176B1
FI104176B1 FI930753A FI930753A FI104176B1 FI 104176 B1 FI104176 B1 FI 104176B1 FI 930753 A FI930753 A FI 930753A FI 930753 A FI930753 A FI 930753A FI 104176 B1 FI104176 B1 FI 104176B1
Authority
FI
Finland
Prior art keywords
preparation
forfolipid
nucleosides
derivatives
novel antiviral
Prior art date
Application number
FI930753A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI104176B (fi
FI930753A (fi
FI930753A0 (fi
Inventor
Harald Zilch
Herbert Leinert
Alfred Mertens
Dieter Herrmann
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25896049&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI104176(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of FI930753A publication Critical patent/FI930753A/fi
Publication of FI930753A0 publication Critical patent/FI930753A0/fi
Application granted granted Critical
Publication of FI104176B publication Critical patent/FI104176B/fi
Publication of FI104176B1 publication Critical patent/FI104176B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FI930753A 1990-08-20 1993-02-19 Menetelmä nukleosidien uusien antiviraalisten forfolipidijohdannaisten valmistamiseksi FI104176B1 (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE4026265 1990-08-20
DE4026265A DE4026265A1 (de) 1990-08-20 1990-08-20 Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
PCT/EP1991/001541 WO1992003462A1 (de) 1990-08-20 1991-08-14 Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
EP9101541 1991-08-14
US08/661,038 US5756711A (en) 1990-08-20 1996-06-10 Phospholipid derivatives of nucleosides and their use as anti-viral medicaments
US66103896 1996-06-10

Publications (4)

Publication Number Publication Date
FI930753A FI930753A (fi) 1993-02-19
FI930753A0 FI930753A0 (fi) 1993-02-19
FI104176B FI104176B (fi) 1999-11-30
FI104176B1 true FI104176B1 (fi) 1999-11-30

Family

ID=25896049

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930753A FI104176B1 (fi) 1990-08-20 1993-02-19 Menetelmä nukleosidien uusien antiviraalisten forfolipidijohdannaisten valmistamiseksi

Country Status (15)

Country Link
US (1) US5756711A (zh)
EP (1) EP0545966B1 (zh)
CN (1) CN1032258C (zh)
AT (1) ATE114316T1 (zh)
CA (1) CA2090024C (zh)
DE (2) DE4026265A1 (zh)
DK (1) DK0545966T3 (zh)
ES (1) ES2066461T3 (zh)
FI (1) FI104176B1 (zh)
HK (1) HK35597A (zh)
IE (1) IE64374B1 (zh)
NO (1) NO179710C (zh)
PT (1) PT98720B (zh)
SK (1) SK281826B6 (zh)
WO (1) WO1992003462A1 (zh)

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US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
CA2001401A1 (en) * 1988-10-25 1990-04-25 Claude Piantadosi Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions
DE4204032A1 (de) * 1992-02-12 1993-08-19 Boehringer Mannheim Gmbh Neue liponucleotide, deren herstellunmg sowie deren verwendung als antivirale arzneimittel
DE4204031A1 (de) * 1992-02-12 1993-08-19 Boehringer Mannheim Gmbh Neue lipidphosphonsaeure-nucleosid-konjugate sowie deren verwendung als antivirale arzneimittel
US6080734A (en) * 1992-08-08 2000-06-27 Roche Diagnostic Gmbh Liponucleotides of seco-nucleosides, their production as well as their use as antiviral pharmaceutical agents
DE4226279A1 (de) * 1992-08-08 1994-02-10 Boehringer Mannheim Gmbh Liponucleotide von Seco-Nucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
EP0702556B1 (en) * 1993-06-10 2002-10-23 Wake Forest University (phospho)lipids for combatting hepatitis b virus infection
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DE4418690A1 (de) * 1994-05-28 1996-01-11 Boehringer Mannheim Gmbh Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
US7135584B2 (en) 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
AU3216695A (en) 1994-08-29 1996-03-22 University Of North Carolina At Chapel Hill, The Lipid analogs for treating viral infections
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DE19505168A1 (de) * 1995-02-16 1996-08-22 Boehringer Mannheim Gmbh Spezifische Lipidkonjugate von Nucleosid-Diphosphonaten und deren Verwendung als Arzneimittel
TW343975B (en) * 1995-12-15 1998-11-01 Boehringer Mannheim Gmbh New phospholipid derivatives of phosphonocarboxylic acids, the production thereof as well as their use as antiviral pharmaceutical agents
DE19547022A1 (de) * 1995-12-15 1997-06-19 Boehringer Mannheim Gmbh Kovalente Lipid-Phosphonocarbonsäure-Konjugate, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
DE19602757A1 (de) 1996-01-26 1997-07-31 Boehringer Mannheim Gmbh Feste Instant-Release-Darreichungsformen und Verfahren zu ihrer Herstellung
US7026469B2 (en) * 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
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US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
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US8476282B2 (en) * 2008-11-03 2013-07-02 Intellikine Llc Benzoxazole kinase inhibitors and methods of use
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Also Published As

Publication number Publication date
NO179710C (no) 1996-12-04
DK0545966T3 (da) 1995-05-08
CN1059149A (zh) 1992-03-04
NO930587D0 (no) 1993-02-19
AU654670B2 (en) 1994-11-17
FI104176B (fi) 1999-11-30
CA2090024C (en) 2000-05-02
PT98720A (pt) 1992-07-31
IE64374B1 (en) 1995-07-26
SK9293A3 (en) 1993-07-07
NO179710B (no) 1996-08-26
FI930753A (fi) 1993-02-19
SK281826B6 (sk) 2001-08-06
CN1032258C (zh) 1996-07-10
EP0545966A1 (de) 1993-06-16
WO1992003462A1 (de) 1992-03-05
AU8325191A (en) 1992-03-17
DE4026265A1 (de) 1992-02-27
PT98720B (pt) 1999-02-26
FI930753A0 (fi) 1993-02-19
DE59103595D1 (de) 1995-01-05
US5756711A (en) 1998-05-26
ATE114316T1 (de) 1994-12-15
CA2090024A1 (en) 1992-02-21
HK35597A (en) 1997-03-27
ES2066461T3 (es) 1995-03-01
EP0545966B1 (de) 1994-11-23
NO930587L (no) 1993-02-19
IE912930A1 (en) 1992-02-26

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