FI103888B - Analoginen menetelmä valmistaa terapeuttisesti aktiivista akridiinijohdannaista - Google Patents
Analoginen menetelmä valmistaa terapeuttisesti aktiivista akridiinijohdannaistaInfo
- Publication number
- FI103888B FI103888B FI933149A FI933149A FI103888B FI 103888 B FI103888 B FI 103888B FI 933149 A FI933149 A FI 933149A FI 933149 A FI933149 A FI 933149A FI 103888 B FI103888 B FI 103888B
- Authority
- FI
- Finland
- Prior art keywords
- group
- 4alkoxy
- 4alkyl
- hydrogen atom
- atom
- Prior art date
Links
- 125000000641 acridinyl group Chemical class C1(=CC=CC2=NC3=CC=CC=C3C=C12)* 0.000 title 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- -1 C1-4alkylthio Chemical group 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
- C07C205/26—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups and being further substituted by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Dry Shavers And Clippers (AREA)
- Soft Magnetic Materials (AREA)
- Paper (AREA)
- Laminated Bodies (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919100637A GB9100637D0 (en) | 1991-01-11 | 1991-01-11 | Chemical compounds |
| GB919100628A GB9100628D0 (en) | 1991-01-11 | 1991-01-11 | Chemical compounds |
| GB919115956A GB9115956D0 (en) | 1991-07-24 | 1991-07-24 | Chemical compounds |
| GB919115981A GB9115981D0 (en) | 1991-07-24 | 1991-07-24 | Chemical compounds |
| PCT/EP1992/000020 WO1992012132A1 (en) | 1991-01-11 | 1992-01-07 | Acridine derivatives |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI933149L FI933149L (fi) | 1993-07-09 |
| FI933149A0 FI933149A0 (fi) | 1993-07-09 |
| FI103888B1 FI103888B1 (fi) | 1999-10-15 |
| FI103888B true FI103888B (fi) | 1999-10-15 |
Family
ID=27450605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI933149A FI103888B (fi) | 1991-01-11 | 1993-07-09 | Analoginen menetelmä valmistaa terapeuttisesti aktiivista akridiinijohdannaista |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5604237A (cs) |
| EP (2) | EP0494623A1 (cs) |
| JP (1) | JP2783680B2 (cs) |
| KR (1) | KR100220538B1 (cs) |
| AT (1) | ATE153660T1 (cs) |
| AU (1) | AU652996B2 (cs) |
| CA (1) | CA2100258C (cs) |
| CZ (1) | CZ283038B6 (cs) |
| DE (1) | DE69220037T2 (cs) |
| DK (1) | DK0569380T3 (cs) |
| ES (1) | ES2104887T3 (cs) |
| FI (1) | FI103888B (cs) |
| GE (1) | GEP20002210B (cs) |
| GR (1) | GR3024525T3 (cs) |
| HU (2) | HUT68856A (cs) |
| IE (1) | IE920083A1 (cs) |
| IL (1) | IL100631A (cs) |
| MX (1) | MX9200109A (cs) |
| NO (1) | NO300267B1 (cs) |
| NZ (1) | NZ241278A (cs) |
| PL (1) | PL168202B1 (cs) |
| RU (1) | RU2119482C1 (cs) |
| SG (1) | SG45403A1 (cs) |
| SK (1) | SK280864B6 (cs) |
| WO (1) | WO1992012132A1 (cs) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE153660T1 (de) * | 1991-01-11 | 1997-06-15 | Glaxo Lab Sa | Acridinderivate |
| TR28930A (tr) * | 1992-05-07 | 1997-07-21 | Zeneca Ltd | Alkil sübstitüentli nitrotoluen türevleri |
| GB9209872D0 (en) * | 1992-05-07 | 1992-06-24 | Ici Plc | Alkyl substituted nitrotoluene derivatives |
| DE69310367T2 (de) * | 1992-07-10 | 1997-08-14 | Glaxo Lab Sa | Anilide-derivate |
| RU2036198C1 (ru) * | 1993-04-01 | 1995-05-27 | Товарищество с ограниченной ответственностью "Полисан" | N-МЕТИЛ-N-( α,D -ГЛЮКОПИРАНОЗИЛ) АММОНИЯ-2-(АКРИДОН-9-ОН-10-ИЛ)АЦЕТАТ(ЦИКЛОФЕРОН), ОБЛАДАЮЩИЙ ИНТЕРФЕРОНОГЕННОЙ, ПРОТИВОВИРУСНОЙ, В ТОМ ЧИСЛЕ АНТИВИЧ, АНТИПАРАЗИТАРНОЙ, АНТИПРОМОТОРНОЙ И РАДИОПРОТЕКТИВНОЙ АКТИВНОСТЬЮ |
| US5387685A (en) * | 1993-07-16 | 1995-02-07 | American Cyanamid Co | MDR reversal agents |
| DE4422517A1 (de) * | 1994-06-28 | 1996-01-04 | Dresden Arzneimittel | Neue (2-(3,4-Dimethoxy-phenyl)-ethyl)-(2-phenoxy-ethyl)-amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE69531691T2 (de) * | 1994-08-04 | 2004-07-08 | C & C Research Labs | Neues amin-derivat, verfahren zur herstellung und dessen verwendung als anti-arrhythmisches mittel |
| CA2201628A1 (en) * | 1994-10-05 | 1996-04-18 | Wei-Qin Tong | Parenteral pharmaceutical compositions containing gf120918a |
| FR2726267B1 (fr) * | 1994-10-26 | 1998-01-02 | Smithkline Beecham Lab | Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer |
| US6395770B1 (en) | 1995-10-26 | 2002-05-28 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for administering taxanes orally to human patients |
| US6245805B1 (en) | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
| AU1597197A (en) * | 1996-02-01 | 1997-08-22 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thienoquinolines |
| US6713517B1 (en) | 1996-03-08 | 2004-03-30 | Oxigene, Inc. | Use of aryl N-substituted carboxamides directly and as radio-and chemosensitizers for killing tumor and cancer cells and novel compounds for such use |
| RU2118532C1 (ru) * | 1996-04-10 | 1998-09-10 | Олег Викторович Травкин | Противоинфекционное, противовоспалительное и противоопухолевое лекарственное средство |
| MY118642A (en) * | 1996-10-18 | 2004-12-31 | Xenova Ltd | Anthranilic acid derivatives as multi drug resistance modulators |
| CZ135199A3 (cs) * | 1996-10-18 | 1999-09-15 | Xenova Limited | Způsob přípravy N-/2-(dimethylamino)ethyl/akridin-4-karboxyamidu |
| GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| GB9710612D0 (en) * | 1997-05-23 | 1997-07-16 | Glaxo Group Ltd | Synthesis of acridine derivatives |
| SK157599A3 (en) * | 1997-05-27 | 2002-10-08 | Baker Norton Pharma | Method and compositions for administering taxanes orally to human patients |
| GB9718903D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
| GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| GB9812189D0 (en) * | 1998-06-05 | 1998-08-05 | Glaxo Group Ltd | Methods and compositions for increasing penetration of HIV protease inhibitors |
| AU4698299A (en) * | 1998-06-30 | 2000-01-17 | Du Pont Pharmaceuticals Company | 5-HT7 receptor antagonists |
| RU2135474C1 (ru) * | 1998-08-19 | 1999-08-27 | Травкин Олег Викторович | Соли 1-дезокси-1-n-метиламиногексаспиртов с n-акридонуксусной кислотой, обладающие иммуномодулирующей активностью, и лекарственное средство на их основе |
| EP1119563B1 (en) | 1998-10-08 | 2006-02-01 | SmithKline Beecham plc | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) |
| GB9824579D0 (en) * | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| AU4955200A (en) | 1999-05-17 | 2000-12-05 | Cancer Research Ventures Limited | A method of improving bioavailability of orally administered drugs, a method of screening for enhancers of such bioavailability and novel pharmaceutical compositions for oral delivery of drugs |
| EP2289549A3 (en) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunoconjugates for treating cancer |
| US6521635B1 (en) | 2000-01-20 | 2003-02-18 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of MXR transport by acridine derivatives |
| PT1261325E (pt) | 2000-02-18 | 2010-12-10 | New York Medical College | Composições inibidoras de tumores que incluem nitroacridinas |
| US6703392B2 (en) * | 2000-03-14 | 2004-03-09 | Actelion Pharmaceuticals Ltd. | 1,2,3,4-tetrahydroisoquinoline derivatives |
| EP1288202A4 (en) | 2000-05-11 | 2003-07-02 | Banyu Pharma Co Ltd | N-acyltetrahydroisoquinoline derivatives |
| CN1469735A (zh) * | 2000-10-16 | 2004-01-21 | ����˹��ҩ�﹫˾ | 米托蒽醌的脂质体制剂 |
| EP1506188B1 (en) * | 2002-05-14 | 2009-02-25 | Xenova Limited | Process for the preparation of a hydrate of an anthranilic acid derivative |
| RU2279873C2 (ru) * | 2002-05-31 | 2006-07-20 | Ар.Пи.ШЕРЕР ТЕКНОЛОДЖИЗ, ИНК. | Пероральная фармацевтическая композиция для мягких капсул, содержащая винорелбин, и способ лечения |
| WO2004039795A2 (en) * | 2002-10-29 | 2004-05-13 | Fujisawa Pharmaceutical Co., Ltd. | Amide compounds for the treatment of hyperlipidemia |
| BRPI0508263B8 (pt) | 2004-03-01 | 2021-05-25 | Idorsia Pharmaceuticals Ltd | derivados de 1, 2, 3, 4-tetra-hidro-isoquinolina, composição farmacêutica, e, uso de derivado de 1, 2, 3, 4-tetra-hidro-isoquinolina |
| RU2326115C2 (ru) * | 2005-11-21 | 2008-06-10 | Ефаг АО | Соли 1-алкиламино-1-дезоксиполиолов с 9-оксоакридин-10-уксусной кислотой, лекарственные препараты на их основе, применение, способы профилактики и лечения |
| BRPI0709049A2 (pt) * | 2006-03-22 | 2011-06-21 | Janssen Pharmaceutica Nv | composto inibidor da interação entre mdm2 e p53, composição farmacêutica, processo para preparar a referida composição farmacêutica, uso do composto, combinação, e processo para preparar o referido composto |
| RU2346691C2 (ru) * | 2007-03-29 | 2009-02-20 | Ефаг АО | Применение 9-оксоакридин-10-уксусной кислоты и/или ее соли в комбинации с антиэстрогеном и/или прогестином для лечения эстрогензависимых опухолей, способ лечения и наборы |
| RU2346692C2 (ru) * | 2007-03-29 | 2009-02-20 | Ефаг АО | Применение 9-оксоакридин-10-уксусной кислоты, ее солей и сложных эфиров в комбинированной терапии рака яичников, способ лечения и наборы |
| SE531698C2 (sv) * | 2007-07-12 | 2009-07-07 | Respiratorius Ab | Nya bronkdilaterande a,b-omättade amider |
| WO2015142670A1 (en) * | 2014-03-15 | 2015-09-24 | Medisyn Technologies, Inc. | Anti-diabetic compounds, pharmaceutical compositions containing them, and method to treat diabetes |
| CN104434808A (zh) | 2014-07-03 | 2015-03-25 | 石药集团中奇制药技术（石家庄）有限公司 | 一种治疗性纳米粒子及其制备方法 |
| KR20200134257A (ko) * | 2018-03-21 | 2020-12-01 | 이즈미 테크놀로지 엘엘씨 | 엘라크리다의 중수소화 유사체 |
| CN115385847B (zh) * | 2021-06-15 | 2023-09-29 | 山东第一医科大学(山东省医学科学院) | 多取代二芳基类化合物及其制备方法和应用 |
| CN117414367A (zh) * | 2022-08-09 | 2024-01-19 | 北京清华长庚医院 | 一种逆转仑伐替尼耐药的药物组合物及其用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4250182A (en) * | 1972-02-24 | 1981-02-10 | Burroughs Wellcome Co. | Pharmaceutical composition containing acridone compounds and method of using same |
| US4021551A (en) * | 1972-06-07 | 1977-05-03 | Boehringer Ingelheim Gmbh | 3,6-Bis-(heterocyclic aminoacyl-amino)-acridines and salts thereof |
| US4127573A (en) * | 1972-09-06 | 1978-11-28 | Burroughs Wellcome Co. | Ditetrazole substituted acridone compounds |
| ATE12779T1 (de) * | 1980-09-30 | 1985-05-15 | Bayer Ag | Verfahren zur herstellung eines antithrombinheparin-komplexes sowie diesen komplex enthaltende pharmazeutische mischungen. |
| NZ198115A (en) * | 1981-08-21 | 1985-05-31 | New Zealand Dev Finance | 9-anilinoacridines;pharmaceutical compositions |
| NZ201084A (en) * | 1982-06-25 | 1985-10-11 | New Zealand Dev Finance | 4-carboxamidoacridine derivatives and pharmaceutical compositions containing such |
| IN164921B (cs) * | 1986-07-22 | 1989-07-08 | Hoechst India | |
| US5104858A (en) * | 1988-09-29 | 1992-04-14 | Yale University | Sensitizing multidrug resistant cells to antitumor agents |
| CA1340821C (en) * | 1988-10-06 | 1999-11-16 | Nobuyuki Fukazawa | Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components |
| IE902182A1 (en) * | 1989-06-19 | 1991-01-02 | Wellcome Found | Medicaments |
| ATE153660T1 (de) * | 1991-01-11 | 1997-06-15 | Glaxo Lab Sa | Acridinderivate |
| US5296602A (en) * | 1991-03-18 | 1994-03-22 | Sloan-Kettering Institute For Cancer Research | Multisubstituted 1-hydroxy-9-acridones with anticancer activity |
| US5240936A (en) * | 1992-05-14 | 1993-08-31 | Texas A&M University System | Treating or preventing ocular inflammation or systemic imflammatory disease |
-
1992
- 1992-01-07 AT AT92901861T patent/ATE153660T1/de not_active IP Right Cessation
- 1992-01-07 GE GEAP19922653A patent/GEP20002210B/en unknown
- 1992-01-07 EP EP92100123A patent/EP0494623A1/en active Pending
- 1992-01-07 AU AU11543/92A patent/AU652996B2/en not_active Expired
- 1992-01-07 CA CA002100258A patent/CA2100258C/en not_active Expired - Lifetime
- 1992-01-07 HU HU9301989A patent/HUT68856A/hu unknown
- 1992-01-07 ES ES92901861T patent/ES2104887T3/es not_active Expired - Lifetime
- 1992-01-07 SG SG1996006197A patent/SG45403A1/en unknown
- 1992-01-07 DK DK92901861.2T patent/DK0569380T3/da active
- 1992-01-07 PL PL92299989A patent/PL168202B1/pl unknown
- 1992-01-07 DE DE69220037T patent/DE69220037T2/de not_active Expired - Lifetime
- 1992-01-07 WO PCT/EP1992/000020 patent/WO1992012132A1/en not_active Ceased
- 1992-01-07 RU RU93051543A patent/RU2119482C1/ru active
- 1992-01-07 CZ CS931378A patent/CZ283038B6/cs not_active IP Right Cessation
- 1992-01-07 JP JP4501671A patent/JP2783680B2/ja not_active Expired - Lifetime
- 1992-01-07 SK SK730-93A patent/SK280864B6/sk not_active IP Right Cessation
- 1992-01-07 KR KR1019930702079A patent/KR100220538B1/ko not_active Expired - Lifetime
- 1992-01-07 EP EP92901861A patent/EP0569380B1/en not_active Expired - Lifetime
- 1992-01-10 NZ NZ241278A patent/NZ241278A/en not_active IP Right Cessation
- 1992-01-10 MX MX9200109A patent/MX9200109A/es unknown
- 1992-01-10 IL IL10063192A patent/IL100631A/en not_active IP Right Cessation
- 1992-01-10 IE IE008392A patent/IE920083A1/en not_active IP Right Cessation
-
1993
- 1993-07-09 FI FI933149A patent/FI103888B/fi active
- 1993-07-09 NO NO932512A patent/NO300267B1/no not_active IP Right Cessation
-
1995
- 1995-06-06 US US08/468,620 patent/US5604237A/en not_active Expired - Lifetime
- 1995-06-29 HU HU95P/P00524P patent/HU211623A9/hu unknown
-
1997
- 1997-08-22 GR GR970402168T patent/GR3024525T3/el unknown
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