FI102166B - Förfarande för framställning av N,N-dimetylaminometylarylföreningar - Google Patents

Förfarande för framställning av N,N-dimetylaminometylarylföreningar Download PDF

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Publication number
FI102166B
FI102166B FI903457A FI903457A FI102166B FI 102166 B FI102166 B FI 102166B FI 903457 A FI903457 A FI 903457A FI 903457 A FI903457 A FI 903457A FI 102166 B FI102166 B FI 102166B
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FI
Finland
Prior art keywords
formula
mmol
compound
group
preparation
Prior art date
Application number
FI903457A
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English (en)
Finnish (fi)
Other versions
FI102166B1 (sv
FI903457A0 (fi
Inventor
Hans Petersen
Ole Buchardt
Boerge Alhede
Finn Priess Clausen
Klaus K Mccluskey
Original Assignee
Gea Farmaceutisk Fabrik As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gea Farmaceutisk Fabrik As filed Critical Gea Farmaceutisk Fabrik As
Publication of FI903457A0 publication Critical patent/FI903457A0/fi
Application granted granted Critical
Publication of FI102166B publication Critical patent/FI102166B/sv
Publication of FI102166B1 publication Critical patent/FI102166B1/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/14—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups
    • C07C209/16—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (8)

1. Förfarande för framställning av Ν,Ν-dimetylaminometylarylföreningar med den allmänna formeln I R 10 i 1 ArCHN(CH3)2 i vilken formel R betecknar en väteatom eller en metylgrupp och Ar betecknar en eventuellt substituerad fenylgrupp med formeln väri R betecknar en väteatom, kloratom eller bromatom eller en C^g-alkylgrupp, eller Ar betecknar en eventuellt substituerad furylgrupp med formeln - 20 -fy väri R2 betecknar en väteatom, C-j 6-alkylgrupp eller en grupp med formeln : ' 25 HCNOo il -CH2N(CH3)2 eller - CH2SCH2CH2NHCNHCH3, • · 30 eller Ar är en eventuellt substituerad pyridylgrupp med formeln v Q. Cl m Q :···: fT n r3^N 35 3 väri R betecknar en väteatom eller en C-^g-alkylgrupp, eller för framställning av deras salter, kännetecknat därav, att man i dimetylformamid säsom lösningsme-del omsätter en hydroximetylarylförening med den allmänna formeln II 102166 15
5 R I II AfCHOH väri R och Ar har ovan angivna betydelser, med dimetylamin och ett tetrametylfor-mamidiniumsalt med formeln III 10 \ f ^N(CH3)2 \ HC^ III 15 väri X betecknar klor, brom eller tosyl, varefter den bildade föreningen eventuellt omvandlas till sitt salt därav.
2. Förfarande enligt patentkrav 1, kännetecknat därav, att reaktionstemperaturen 20 hälles vid 80 - 130°C, och företrädesvis vid 90 - 100°C.
3. Förfarande enligt patentkrav 1 eller 2, kännetecknat därav, att dimetylamin används i en mängd av 2 mol eller mer varje mol hydroximetylarylförening II och att tetrametylformamidiniumsaltet III användes i en mängd av 1 mol eller mer varje ' 25 mol hydroximetylarylförening II. • 1 · • · • 1 ·»1 • · · • «I • · · • · · · · * · ·
FI903457A 1989-07-10 1990-07-09 Förfarande för framställning av N,N-dimetylaminometylarylföreningar FI102166B1 (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK340089 1989-07-10
DK340089A DK161513C (da) 1989-07-10 1989-07-10 Fremgangsmaade til fremstilling af n,n-dimethylaminomethylarylforbindelser

Publications (3)

Publication Number Publication Date
FI903457A0 FI903457A0 (fi) 1990-07-09
FI102166B true FI102166B (sv) 1998-10-30
FI102166B1 FI102166B1 (sv) 1998-10-30

Family

ID=8122450

Family Applications (1)

Application Number Title Priority Date Filing Date
FI903457A FI102166B1 (sv) 1989-07-10 1990-07-09 Förfarande för framställning av N,N-dimetylaminometylarylföreningar

Country Status (8)

Country Link
AT (1) AT398565B (sv)
DD (1) DD296481A5 (sv)
DE (1) DE4020964A1 (sv)
DK (1) DK161513C (sv)
FI (1) FI102166B1 (sv)
HU (1) HU206076B (sv)
NO (1) NO170578C (sv)
SE (1) SE501162C2 (sv)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5757480B2 (ja) * 2011-05-13 2015-07-29 国立大学法人広島大学 イオン液体、イオン液体の製造方法、および同イオン液体を含む蓄電装置

Also Published As

Publication number Publication date
DK340089D0 (da) 1989-07-10
NO903062L (no) 1991-01-11
DK340089A (da) 1991-01-11
FI102166B1 (sv) 1998-10-30
AT398565B (de) 1994-12-27
HU904143D0 (en) 1990-12-28
ATA131390A (de) 1994-05-15
DK161513B (da) 1991-07-15
NO170578B (no) 1992-07-27
HU206076B (en) 1992-08-28
SE9002363L (sv) 1991-01-11
NO170578C (no) 1992-11-04
SE501162C2 (sv) 1994-11-28
FI903457A0 (fi) 1990-07-09
DK161513C (da) 1991-12-23
DD296481A5 (de) 1991-12-05
SE9002363D0 (sv) 1990-07-05
DE4020964A1 (de) 1991-01-17
NO903062D0 (no) 1990-07-09
HUT54615A (en) 1991-03-28

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Owner name: A/S GEA FARMACEUTISK FABRIK