FI101965B1 - Klavulaanihapon 2-amino-2,4,4-trimetyylipentaanisuolan käyttö klavulaanihapon alkali- tai maa-alkalimetallisuolojen valmistuksessa - Google Patents

Klavulaanihapon 2-amino-2,4,4-trimetyylipentaanisuolan käyttö klavulaanihapon alkali- tai maa-alkalimetallisuolojen valmistuksessa

Info

Publication number
FI101965B1
FI101965B1 FI931032A FI931032A FI101965B1 FI 101965 B1 FI101965 B1 FI 101965B1 FI 931032 A FI931032 A FI 931032A FI 931032 A FI931032 A FI 931032A FI 101965 B1 FI101965 B1 FI 101965B1
Authority
FI
Finland
Prior art keywords
clavulanic acid
salt
alkali
amino
preparation
Prior art date
Application number
FI931032A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI101965B (fi
FI931032A (fi
FI931032A0 (fi
Inventor
Franz Krenmueller
Harald Summer
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Publication of FI931032A0 publication Critical patent/FI931032A0/fi
Publication of FI931032A publication Critical patent/FI931032A/fi
Application granted granted Critical
Publication of FI101965B publication Critical patent/FI101965B/fi
Publication of FI101965B1 publication Critical patent/FI101965B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
FI931032A 1992-03-10 1993-03-09 Klavulaanihapon 2-amino-2,4,4-trimetyylipentaanisuolan käyttö klavulaanihapon alkali- tai maa-alkalimetallisuolojen valmistuksessa FI101965B1 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT47292 1992-03-10
AT0047292A AT400033B (de) 1992-03-10 1992-03-10 Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben

Publications (4)

Publication Number Publication Date
FI931032A0 FI931032A0 (fi) 1993-03-09
FI931032A FI931032A (fi) 1993-09-11
FI101965B FI101965B (fi) 1998-09-30
FI101965B1 true FI101965B1 (fi) 1998-09-30

Family

ID=3491521

Family Applications (1)

Application Number Title Priority Date Filing Date
FI931032A FI101965B1 (fi) 1992-03-10 1993-03-09 Klavulaanihapon 2-amino-2,4,4-trimetyylipentaanisuolan käyttö klavulaanihapon alkali- tai maa-alkalimetallisuolojen valmistuksessa

Country Status (21)

Country Link
US (4) US20010036940A1 (zh)
JP (2) JP2817563B2 (zh)
CN (3) CN1045604C (zh)
AT (1) AT400033B (zh)
AU (1) AU659282B2 (zh)
CH (1) CH685054A5 (zh)
CY (1) CY1995A (zh)
DE (1) DE4307422B4 (zh)
DK (1) DK26093A (zh)
ES (1) ES2058029B1 (zh)
FI (1) FI101965B1 (zh)
FR (1) FR2688506B1 (zh)
GB (1) GB2264944B (zh)
GR (1) GR1002329B (zh)
HK (1) HK42696A (zh)
IE (1) IE70926B1 (zh)
IT (1) IT1261213B (zh)
NL (1) NL9300430A (zh)
NO (1) NO301372B1 (zh)
SE (1) SE508043C2 (zh)
TW (1) TW364907B (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
ES2155839T3 (es) 1993-11-17 2001-06-01 Biochemie Gmbh Separacion de isomeros de cefalosporina.
GB9426261D0 (en) * 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
IL117217A0 (en) * 1995-02-25 1996-06-18 Spurcourt Ltd Clavulanic acid salts
KR100200242B1 (ko) * 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
WO2000004028A1 (en) * 1998-07-16 2000-01-27 Dsm N.V. Improved process for the preparation of salts and esters of clavulanic acid
CN1209099C (zh) * 1999-04-01 2005-07-06 Dsm公司 结晶化附聚物
DE60105016T3 (de) * 2000-05-13 2009-06-25 Smithkline Beecham P.L.C., Brentford Verfahren zur reinigung eines salzes der clavulansäure
KR101772375B1 (ko) * 2005-09-07 2017-08-29 신라젠(주) Ｇｍ-ｃｓｆ를 발현하는 폭스바이러스를 사용한 전이성 및/또는 전신 파종성 암의 전신 치료법
JP7028064B2 (ja) 2018-05-30 2022-03-02 横河電機株式会社 機器保全装置、機器保全方法、機器保全プログラム及び記録媒体
JP2023533544A (ja) 2020-07-10 2023-08-03 カーボン クリーン ソリューションズ リミテッド 低位熱を使用して溶媒から二酸化炭素を除去するための方法およびシステム

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US3288800A (en) 1962-05-29 1966-11-29 Squibb & Sons Inc Schiff's bases of 6-amino-penicillanic acid and purification of 6-aminopenicillanic acid by the use thereof
GB1508977A (en) 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
US4110165A (en) 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
IE41109B1 (en) 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
US4144242A (en) 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
GB1543563A (en) 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
GB1561395A (en) 1976-02-26 1980-02-20 Beecham Group Ltd -lactam antibiotic
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
GB2003863B (en) 1977-09-01 1982-03-31 Beecham Group Ltd Chemical process
DE2861607D1 (en) 1977-11-26 1982-03-11 Beecham Group Plc Derivatives of clavulanic acid and pharmaceutical compositions containing them
BE862211A (fr) * 1977-12-22 1978-06-22 Beecham Group Ltd Agents antibacteriens
US4454069A (en) 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
DE3063683D1 (en) 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
NZ213963A (en) 1984-10-27 1989-01-06 Antibioticos Sa Production of clavulanic acid
GB8618888D0 (en) 1986-08-01 1986-09-10 Davy Mckee Ltd Process
GR1000035B (el) 1987-01-29 1990-03-12 Beecham Group Plc Κλαβουλανικο καλιο.
US5679789A (en) 1987-01-29 1997-10-21 Beecham Group, P.L.C. Pharmaceutical compositions comprising potassium clavulanate and methods of using them
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
US5210296A (en) 1990-11-19 1993-05-11 E. I. Du Pont De Nemours And Company Recovery of lactate esters and lactic acid from fermentation broth
AT399155B (de) 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
SI9200139A (en) 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
KR100200239B1 (ko) 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9401969D0 (en) 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB2298201B (en) 1995-02-25 1997-05-28 Spurcourt Ltd Clavulanic acid salts
IL117217A0 (en) 1995-02-25 1996-06-18 Spurcourt Ltd Clavulanic acid salts
SI9500074A (en) 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko) 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
GB9515809D0 (en) 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
SI9500265A1 (en) 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
US6414142B1 (en) 1996-06-13 2002-07-02 Smithkline Beecham Corporation Process for preparing potassium clavulanate
WO1998021212A1 (en) 1996-11-11 1998-05-22 Gist-Brocades B.V. Process for the preparation of salts and esters of clavulanic acid

Also Published As

Publication number Publication date
US20030022882A1 (en) 2003-01-30
FI101965B (fi) 1998-09-30
DK26093D0 (da) 1993-03-09
IE930172A1 (en) 1993-09-22
NO930829L (no) 1993-09-13
FI931032A (fi) 1993-09-11
US20020072513A1 (en) 2002-06-13
DE4307422A1 (de) 1993-09-30
ATA47292A (de) 1995-01-15
SE508043C2 (sv) 1998-08-17
CN1145906A (zh) 1997-03-26
JPH0641143A (ja) 1994-02-15
AT400033B (de) 1995-09-25
SE9300758L (sv) 1993-09-11
AU3407093A (en) 1993-09-16
IE70926B1 (en) 1997-01-15
DK26093A (da) 1993-09-11
NO301372B1 (no) 1997-10-20
GR930100090A (el) 1993-11-30
FR2688506B1 (fr) 1995-06-23
AU659282B2 (en) 1995-05-11
US20030203886A1 (en) 2003-10-30
ES2058029A1 (es) 1994-10-16
CN1079743A (zh) 1993-12-22
GR1002329B (el) 1996-05-15
ES2058029B1 (es) 1995-05-01
CY1995A (en) 1997-09-05
HK42696A (en) 1996-03-22
GB2264944B (en) 1995-09-06
US20010036940A1 (en) 2001-11-01
CH685054A5 (de) 1995-03-15
JPH1067785A (ja) 1998-03-10
USH2158H1 (en) 2006-06-06
FR2688506A1 (fr) 1993-09-17
IT1261213B (it) 1996-05-09
ITRM930147A1 (it) 1994-09-10
NO930829D0 (no) 1993-03-08
DE4307422B4 (de) 2004-11-25
ITRM930147A0 (it) 1993-03-10
GB2264944A (en) 1993-09-15
TW364907B (en) 1999-07-21
NL9300430A (nl) 1993-10-01
JP2817563B2 (ja) 1998-10-30
CN1045604C (zh) 1999-10-13
CN1150153A (zh) 1997-05-21
SE9300758D0 (sv) 1993-03-08
FI931032A0 (fi) 1993-03-09
GB9304704D0 (en) 1993-04-28

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Owner name: SANDOZ AG