FI101538B1 - Menetelmä uusien, terapeuttisesti käyttökelpoisten 2-metyyli-4-(4-metyyli-1-piperatsinyyli)-10H-tieno[2,3-b][1,5]bentsodiatsepiinijohdannaisten valmistamiseksi - Google Patents

Menetelmä uusien, terapeuttisesti käyttökelpoisten 2-metyyli-4-(4-metyyli-1-piperatsinyyli)-10H-tieno[2,3-b][1,5]bentsodiatsepiinijohdannaisten valmistamiseksi

Info

Publication number
FI101538B1
FI101538B1 FI932445A FI932445A FI101538B1 FI 101538 B1 FI101538 B1 FI 101538B1 FI 932445 A FI932445 A FI 932445A FI 932445 A FI932445 A FI 932445A FI 101538 B1 FI101538 B1 FI 101538B1
Authority
FI
Finland
Prior art keywords
methyl
thieno
piperazinyl
preparation
therapeutically useful
Prior art date
Application number
FI932445A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI932445L (fi
FI101538B (fi
FI932445A0 (fi
Inventor
John Fairhurst
Terrence Michael Hotten
David Edward Tupper
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929211379A external-priority patent/GB9211379D0/en
Priority claimed from GB939309025A external-priority patent/GB9309025D0/en
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of FI932445A0 publication Critical patent/FI932445A0/fi
Publication of FI932445L publication Critical patent/FI932445L/fi
Application granted granted Critical
Publication of FI101538B publication Critical patent/FI101538B/fi
Publication of FI101538B1 publication Critical patent/FI101538B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI932445A 1992-05-29 1993-05-28 Menetelmä uusien, terapeuttisesti käyttökelpoisten 2-metyyli-4-(4-metyyli-1-piperatsinyyli)-10H-tieno[2,3-b][1,5]bentsodiatsepiinijohdannaisten valmistamiseksi FI101538B1 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929211379A GB9211379D0 (en) 1992-05-29 1992-05-29 Pharmaceutical compounds
GB939309025A GB9309025D0 (en) 1993-04-30 1993-04-30 Pharmaceutical compounds

Publications (4)

Publication Number Publication Date
FI932445A0 FI932445A0 (fi) 1993-05-28
FI932445L FI932445L (fi) 1993-11-30
FI101538B FI101538B (fi) 1998-07-15
FI101538B1 true FI101538B1 (fi) 1998-07-15

Family

ID=26300951

Family Applications (1)

Application Number Title Priority Date Filing Date
FI932445A FI101538B1 (fi) 1992-05-29 1993-05-28 Menetelmä uusien, terapeuttisesti käyttökelpoisten 2-metyyli-4-(4-metyyli-1-piperatsinyyli)-10H-tieno[2,3-b][1,5]bentsodiatsepiinijohdannaisten valmistamiseksi

Country Status (21)

Country Link
EP (1) EP0582368B1 (cs)
JP (1) JP3219541B2 (cs)
CN (1) CN1043994C (cs)
AT (1) ATE198891T1 (cs)
AU (1) AU668159B2 (cs)
CA (1) CA2097016A1 (cs)
CZ (1) CZ282783B6 (cs)
DE (1) DE69329887T2 (cs)
DK (1) DK0582368T3 (cs)
ES (1) ES2153373T3 (cs)
FI (1) FI101538B1 (cs)
GR (1) GR3035587T3 (cs)
HU (1) HU218278B (cs)
IL (1) IL105827A (cs)
MX (1) MX9303124A (cs)
MY (1) MY109943A (cs)
NO (1) NO305125B1 (cs)
NZ (1) NZ247703A (cs)
PT (1) PT582368E (cs)
RU (1) RU2125574C1 (cs)
TW (1) TW268005B (cs)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457101A (en) * 1994-06-03 1995-10-10 Eli Lilly And Company Thieno[1,5]benzoidiazepine use
US5574028A (en) * 1994-10-31 1996-11-12 Eli Lilly And Company Method for treating anxiety
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
CR5278A (es) * 1995-03-24 1996-07-04 Lilly Co Eli Formulacion oral de 2-metil-tieno-benzodiacepina
EG24221A (en) * 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
US5891461A (en) * 1995-09-14 1999-04-06 Cygnus, Inc. Transdermal administration of olanzapine
AU721290B2 (en) * 1996-03-25 2000-06-29 Eli Lilly And Company Method for treating migraine pain
IL126203A (en) * 1996-03-25 2002-12-01 Lilly Co Eli A synergistic painkiller that contains olenzapine and another painkiller
JP2001517202A (ja) * 1996-03-25 2001-10-02 イーライ・リリー・アンド・カンパニー 痛み処置方法
RS49597B (sr) 1996-09-23 2007-06-04 Eli Lilly And Company, Olanzapin dihidrat d
ZA978515B (en) * 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine
WO1998013027A1 (en) * 1996-09-24 1998-04-02 Eli Lilly And Company Coated particle formulation
RU2185383C1 (ru) * 2001-05-22 2002-07-20 Институт молекулярной генетики РАН ВЫСОКОМЕЧЕННЫЙ ТРИТИЕМ 2-МЕТИЛ-4-(4-МЕТИЛ-1-ПИПЕРАЗИНИЛ)-10Н-ТИЕНО[2,3-b][1,5]БЕНЗОДИАЗЕПИН
PL2888590T3 (pl) 2012-08-21 2020-11-30 Janssen Pharmaceutica Nv Przeciwciała dla olanzapiny i ich zastosowanie
PL3415516T3 (pl) 2012-08-21 2022-03-28 Janssen Pharmaceutica Nv Hapteny rysperydonu i paliperydonu
ES2666000T3 (es) 2012-08-21 2018-04-30 Janssen Pharmaceutica, N.V. Anticuerpos para aripiprazol y uso de los mismos
EP2888287A4 (en) 2012-08-21 2016-04-20 Ortho Clinical Diagnostics Inc ANTIBODIES AGAINST PALIPERIDONE HAPTENES AND THEIR USE
ES2926662T3 (es) 2012-08-21 2022-10-27 Janssen Pharmaceutica Nv Anticuerpos contra haptenos de risperidona y uso de los mismos
AU2013305935B2 (en) 2012-08-21 2017-08-24 Saladax Biomedical Inc. Haptens of quetiapine for use in immunoassays
CN110054693A (zh) 2012-08-21 2019-07-26 詹森药业有限公司 喹硫平半抗原的抗体及其用途
WO2014031587A1 (en) * 2012-08-21 2014-02-27 Janssen Pharmaceutica Nv Haptens of olanzipine
EP3581195B1 (en) 2012-08-21 2025-10-01 Janssen Pharmaceutica NV Antibodies to olanzapine haptens and use thereof
US9504682B2 (en) 2012-08-21 2016-11-29 Janssen Pharmaceutica Nv Haptens of aripiprazole
US9465041B2 (en) 2012-08-21 2016-10-11 Janssen Pharmaceutica Nv Antibodies to paliperidone and use thereof
WO2014031635A1 (en) 2012-08-21 2014-02-27 Ortho-Clinical Diagnostics, Inc Antibodies to aripiprazole haptens and use thereof
TR201911272T4 (tr) 2012-08-21 2019-08-21 Janssen Pharmaceutica Nv Paliperidon haptenleri.
PT2888593T (pt) 2012-08-21 2018-12-12 Janssen Pharmaceutica Nv Anticorpos contra risperidona e utilizações dos mesmos
PT3333195T (pt) 2012-08-21 2020-10-12 Janssen Pharmaceutica Nv Anticorpos contra a quetiapina e sua utilização
AU2016370853A1 (en) 2015-12-17 2018-06-07 Saladax Biomedical Inc. Antibodies to quetiapine and use thereof
JP6949025B2 (ja) 2015-12-17 2021-10-13 ヤンセン ファーマシューティカ エヌ．ベー． リスペリドンに対する抗体及びその使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH569730A5 (cs) * 1972-04-04 1975-11-28 Wander Ag Dr A
US3962248A (en) * 1972-04-04 1976-06-08 Sandoz, Inc. Process for making 11-piperazino-diazepines, oxazepines, thiazepines and azepines
SU629879A3 (ru) * 1974-11-26 1978-10-25 Лилли Индастриз Лимитед, (Фирма) Способ получени тиено(1,5) бензодиазепинов или их солей
US4061752A (en) * 1975-08-06 1977-12-06 Sandoz Ltd. 6-Piperazino-11-methylene-dibenzazepines[b,e]
DK416476A (da) * 1975-09-24 1977-03-25 Sandoz Ag Fremgangsmade til fremstilling af diazepinderivater
CH624682A5 (cs) * 1976-11-10 1981-08-14 Sandoz Ag
US4761411A (en) * 1983-05-18 1988-08-02 Hoechst-Roussel Pharmaceuticals Inc. Dihydrobenzopyrrolobenzodiazepines useful for treating pyschoses
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
FI932445L (fi) 1993-11-30
IL105827A0 (en) 1993-09-22
NO931917L (no) 1993-11-30
FI101538B (fi) 1998-07-15
NO931917D0 (no) 1993-05-26
AU3980793A (en) 1993-12-02
NO305125B1 (no) 1999-04-06
CA2097016A1 (en) 1993-11-30
IL105827A (en) 1997-02-18
EP0582368A1 (en) 1994-02-09
DE69329887D1 (de) 2001-03-01
ATE198891T1 (de) 2001-02-15
NZ247703A (en) 1995-07-26
EP0582368B1 (en) 2001-01-24
HU9301579D0 (en) 1993-09-28
RU2125574C1 (ru) 1999-01-27
AU668159B2 (en) 1996-04-26
FI932445A0 (fi) 1993-05-28
CN1043994C (zh) 1999-07-07
MY109943A (en) 1997-10-31
ES2153373T3 (es) 2001-03-01
HUT66180A (en) 1994-09-28
PT582368E (pt) 2001-05-31
DK0582368T3 (da) 2001-02-05
HU218278B (en) 2000-07-28
JP3219541B2 (ja) 2001-10-15
CZ282783B6 (cs) 1997-10-15
CZ102493A3 (en) 1993-12-15
MX9303124A (es) 1993-11-01
JPH0687862A (ja) 1994-03-29
DE69329887T2 (de) 2001-05-23
TW268005B (cs) 1996-01-11
CN1085903A (zh) 1994-04-27
GR3035587T3 (en) 2001-06-29

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