FI101302B1 - Menetelmä terapeuttisesti käyttökelpoisten 7-(2-karboksialkyyli-2-okso)metyyliamino-5-okso-pyrrolo- ja -6-okso-pyrido- ja -pyratsino[2,1-a]bentsatsepiini- ja -[1,4]oksatsino- ja -tiatsino[3,4-a][2]bentsatsepiini-4-karboksyylihappojohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten 7-(2-karboksialkyyli-2-okso)metyyliamino-5-okso-pyrrolo- ja -6-okso-pyrido- ja -pyratsino[2,1-a]bentsatsepiini- ja -[1,4]oksatsino- ja -tiatsino[3,4-a][2]bentsatsepiini-4-karboksyylihappojohdannaisten valmistamiseksi

Info

Publication number
FI101302B1
FI101302B1 FI924310A FI924310A FI101302B1 FI 101302 B1 FI101302 B1 FI 101302B1 FI 924310 A FI924310 A FI 924310A FI 924310 A FI924310 A FI 924310A FI 101302 B1 FI101302 B1 FI 101302B1
Authority
FI
Finland
Prior art keywords
oxo
benzazepine
carboxyalkyl
thiazino
oxazino
Prior art date
Application number
FI924310A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI101302B (fi
FI924310A (fi
FI924310A0 (fi
Inventor
Alan M Warshawsky
Gary A Flynn
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI924310A0 publication Critical patent/FI924310A0/fi
Publication of FI924310A publication Critical patent/FI924310A/fi
Application granted granted Critical
Publication of FI101302B publication Critical patent/FI101302B/fi
Publication of FI101302B1 publication Critical patent/FI101302B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FI924310A 1991-09-27 1992-09-25 Menetelmä terapeuttisesti käyttökelpoisten 7-(2-karboksialkyyli-2-okso)metyyliamino-5-okso-pyrrolo- ja -6-okso-pyrido- ja -pyratsino[2,1-a]bentsatsepiini- ja -[1,4]oksatsino- ja -tiatsino[3,4-a][2]bentsatsepiini-4-karboksyylihappojohdannaisten valmistamiseksi FI101302B1 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US76728991A 1991-09-27 1991-09-27
US76728991 1991-09-27
US92948292A 1992-08-20 1992-08-20
US92948292 1992-08-20

Publications (4)

Publication Number Publication Date
FI924310A0 FI924310A0 (fi) 1992-09-25
FI924310A FI924310A (fi) 1993-03-28
FI101302B FI101302B (fi) 1998-05-29
FI101302B1 true FI101302B1 (fi) 1998-05-29

Family

ID=27117892

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924310A FI101302B1 (fi) 1991-09-27 1992-09-25 Menetelmä terapeuttisesti käyttökelpoisten 7-(2-karboksialkyyli-2-okso)metyyliamino-5-okso-pyrrolo- ja -6-okso-pyrido- ja -pyratsino[2,1-a]bentsatsepiini- ja -[1,4]oksatsino- ja -tiatsino[3,4-a][2]bentsatsepiini-4-karboksyylihappojohdannaisten valmistamiseksi

Country Status (15)

Country Link
EP (1) EP0534396B1 (es)
JP (1) JP3173674B2 (es)
KR (1) KR100271242B1 (es)
AT (1) ATE143972T1 (es)
AU (1) AU657793B2 (es)
CA (1) CA2079143C (es)
DE (1) DE69214397T2 (es)
DK (1) DK0534396T3 (es)
ES (1) ES2095380T3 (es)
FI (1) FI101302B1 (es)
GR (1) GR3021420T3 (es)
HU (1) HU214821B (es)
IL (1) IL103283A (es)
NO (1) NO300846B1 (es)
NZ (1) NZ244462A (es)

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US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
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US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
US5594106A (en) * 1993-08-23 1997-01-14 Immunex Corporation Inhibitors of TNF-α secretion
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
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EP0746566A1 (en) * 1994-02-14 1996-12-11 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
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US5616775A (en) * 1994-05-05 1997-04-01 Bristol-Myers Squibb Co. Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
US5641880A (en) * 1994-12-21 1997-06-24 Hoechst Marion Roussel, Inc. Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
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DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
WO1999065500A1 (en) 1998-06-17 1999-12-23 Bristol-Myers Squibb Company Preventing cerebral infarction through administration of adp-receptor antiplatelet and antihypertensive drugs in combination
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WO2001015674A2 (en) 1999-08-30 2001-03-08 Aventis Pharma Deutschland Gmbh Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
EP1443919A4 (en) 2001-11-16 2006-03-22 Bristol Myers Squibb Co DOUBLE INHIBITORS OF THE FATTY ACID BINDING PROTEIN OF THE ADIPOCYTES AND THE FATTY ACID BINDING PROTEIN OF KERATINOCYTES
US7459474B2 (en) 2003-06-11 2008-12-02 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US7371759B2 (en) 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7420059B2 (en) 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7273881B2 (en) 2004-01-16 2007-09-25 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7888381B2 (en) 2005-06-14 2011-02-15 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
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Also Published As

Publication number Publication date
NO300846B1 (no) 1997-08-04
JPH05230060A (ja) 1993-09-07
CA2079143C (en) 2004-03-16
EP0534396B1 (en) 1996-10-09
AU657793B2 (en) 1995-03-23
HU9203075D0 (en) 1992-12-28
HU214821B (hu) 1998-06-29
DE69214397T2 (de) 1997-03-06
FI101302B (fi) 1998-05-29
KR100271242B1 (ko) 2001-02-01
EP0534396A2 (en) 1993-03-31
KR930006028A (ko) 1993-04-20
AU2524692A (en) 1993-04-01
DK0534396T3 (da) 1996-11-18
NO923745D0 (no) 1992-09-25
NZ244462A (en) 1994-08-26
NO923745L (no) 1993-03-29
HUT65278A (en) 1994-05-02
CA2079143A1 (en) 1993-03-28
JP3173674B2 (ja) 2001-06-04
IL103283A0 (en) 1993-02-21
EP0534396A3 (en) 1993-06-09
ATE143972T1 (de) 1996-10-15
DE69214397D1 (de) 1996-11-14
GR3021420T3 (en) 1997-01-31
IL103283A (en) 1999-04-11
FI924310A (fi) 1993-03-28
FI924310A0 (fi) 1992-09-25
ES2095380T3 (es) 1997-02-16

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