ES8801281A1 - Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas - Google Patents
Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinasInfo
- Publication number
- ES8801281A1 ES8801281A1 ES555529A ES555529A ES8801281A1 ES 8801281 A1 ES8801281 A1 ES 8801281A1 ES 555529 A ES555529 A ES 555529A ES 555529 A ES555529 A ES 555529A ES 8801281 A1 ES8801281 A1 ES 8801281A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- hydroxy
- mono
- amino
- acylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE BENZO-(PIRANO Y TIOPIRANO)-PIRIDINAS, DE FORMULA GENERAL (I), Y DE SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN REDUCIR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE X SIGNIFICA UN ANILLO; R1 SIGNIFICA HIDROGENO O ALQUILO; Y R6 SIGNIFICA C2-7-ALQUILO O ARIL C2-7-ALQUILO, MEDIANTE UN PROCEDIMIENTO DE HIDROGENACION CATALITICA EN UN DISOLVENTE POLAR O POR REDUCCION CON UN AGENTE REDUCTOR DE HIDROGENACION SENCILLO O COMPLEJO. DICHA REDUCCION SE LLEVA A EFECTO BAJO PROTECCION INTERMEDIA DE LOS GRUPOS FUNCIONALES CAPACES DE REACCION, CUYA REACTIVIDAD PUDIERA REPERCUTIR DE MANERA PERTURBADORA. DE APLICACION EN TERAPEUTICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60903784A | 1984-05-10 | 1984-05-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES555529A0 ES555529A0 (es) | 1988-01-01 |
ES8801281A1 true ES8801281A1 (es) | 1988-01-01 |
Family
ID=24439108
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542929A Expired ES8706687A1 (es) | 1984-05-10 | 1985-05-08 | Procedimiento para la obtencion de benzo-(pirano y tiopira- no)-piridinas |
ES555527A Expired ES8801279A1 (es) | 1984-05-10 | 1986-05-30 | Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas |
ES555528A Expired ES8801280A1 (es) | 1984-05-10 | 1986-05-30 | Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas |
ES555530A Expired ES8801282A1 (es) | 1984-05-10 | 1986-05-30 | Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas |
ES555529A Expired ES8801281A1 (es) | 1984-05-10 | 1986-05-30 | Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542929A Expired ES8706687A1 (es) | 1984-05-10 | 1985-05-08 | Procedimiento para la obtencion de benzo-(pirano y tiopira- no)-piridinas |
ES555527A Expired ES8801279A1 (es) | 1984-05-10 | 1986-05-30 | Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas |
ES555528A Expired ES8801280A1 (es) | 1984-05-10 | 1986-05-30 | Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas |
ES555530A Expired ES8801282A1 (es) | 1984-05-10 | 1986-05-30 | Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas |
Country Status (20)
Country | Link |
---|---|
US (1) | US4604397A (es) |
EP (1) | EP0161218B1 (es) |
JP (1) | JPS60243090A (es) |
AR (1) | AR243526A1 (es) |
AT (1) | ATE64735T1 (es) |
AU (1) | AU592308B2 (es) |
CA (1) | CA1298582C (es) |
DD (1) | DD235872A5 (es) |
DE (1) | DE3583307D1 (es) |
DK (1) | DK168571B1 (es) |
ES (5) | ES8706687A1 (es) |
FI (1) | FI83652C (es) |
GR (1) | GR851116B (es) |
HU (1) | HU199476B (es) |
IE (1) | IE57978B1 (es) |
IL (1) | IL75135A (es) |
NO (1) | NO162860C (es) |
NZ (1) | NZ212031A (es) |
PT (1) | PT80415B (es) |
ZA (1) | ZA853507B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8426584D0 (en) * | 1984-10-19 | 1984-11-28 | Beecham Group Plc | Compounds |
US4666916A (en) * | 1985-11-08 | 1987-05-19 | Ciba-Geigy Corporation | Hexahydro-(1)-benzo-(pyrano and thiopyrano) (4,3-C)pyridines, useful as serotin-2 blocking agents |
US4792548A (en) * | 1986-05-21 | 1988-12-20 | Warner-Lambert Company | Trans-benzopyran-(4,3-b)-1,4-oxazine derivatives, intermediates and pharmaceutical use |
US4801605A (en) * | 1986-08-29 | 1989-01-31 | Ciba-Geigy Corporation | 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans |
FR2619112B1 (fr) * | 1987-08-07 | 1989-11-17 | Synthelabo | Derives de (piperidinyl-4)methyl-2 benzo(b)furo(2,3-c) pyridines, leur preparation et leur application en therapeutique |
US4992465A (en) * | 1988-09-27 | 1991-02-12 | Ciba-Geigy Corporation | 3-amino-dihydro-(1)-benzopyrans |
US5962463A (en) * | 1992-10-09 | 1999-10-05 | Massachusetts Institute Of Technology | Methods of stimulating non-amyloidogenic processing of the amyloid precursor protein |
FR2721027B1 (fr) * | 1994-06-08 | 1996-07-19 | Adir | Nouveaux dérivés tétracycliques de la 1,4-oxazine, leur procédé de préparation et les compositions pharmaceutiques les contenant. |
FR2741074B1 (fr) | 1995-11-09 | 1997-12-19 | Adir | Nouveaux composes tetracycliques de la 1,4-oxazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US6342533B1 (en) * | 1998-12-01 | 2002-01-29 | Sepracor, Inc. | Derivatives of (−)-venlafaxine and methods of preparing and using the same |
DE60039132D1 (de) * | 1999-04-06 | 2008-07-17 | Sepracor Inc | O-Desmethylvenlafaxin-Succinat |
WO2005032485A2 (en) * | 2003-10-03 | 2005-04-14 | Psychogenics, Inc. | Compounds and methods for the treatment of attention-deficit hyperactivity disorder |
MX2008000249A (es) * | 2005-07-06 | 2008-03-18 | Sepracor Inc | Combinaciones de eszopiclona y o-desmetilvenlafaxina y metodos de tratamiento de menopausia y trastornos del estado de animo, ansiedad y cognitivos. |
BRPI1003506B1 (pt) | 2010-09-24 | 2019-12-03 | Ache Int Bvi Ltd | composto alquil-piperazino-fenil-4(3h)quinazolinonas e uso do composto alquil-piperazino-fenil-4(3h)quinazolinonas associado aos receptores serotoninérgicos 5-ht1a e 5-ht2a |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1143819A (es) * | 1965-09-27 | |||
US3514464A (en) * | 1967-05-29 | 1970-05-26 | Little Inc A | 5-oxo-1,2,3,4-tetrahydro-5h-(1)benzopyrano(3,4-c)pyridines |
US3689497A (en) * | 1971-03-09 | 1972-09-05 | Warner Lambert Co | Substituted benzopyrano (3,4-b) pyridines and process for their preparation |
US3915996A (en) * | 1972-10-16 | 1975-10-28 | Abbott Lab | Process for making benzopyrans |
US4025630A (en) * | 1973-09-19 | 1977-05-24 | Abbott Laboratories | Anesthesia methods using benzopyrans and esters thereof as pre-anesthesia medication |
US4292316A (en) * | 1978-10-02 | 1981-09-29 | Abbott Laboratories | Antiglaucoma agents |
US4210758A (en) * | 1979-03-21 | 1980-07-01 | Warner-Lambert Company | 1,5-Dihydro-1,5-dioxo-N-1H-tetrazol-5-yl-4H-[1]benzopyrano[3,4-b]pyridine-2-carboxamides |
US4198511A (en) * | 1979-03-21 | 1980-04-15 | Warner-Lambert Company | 1,5-Dihydro-1,5-dioxo-N-1H-tetrazol-5-yl-4H-[1]benzopyrano[3,4-b]pyridine-3-carboxamides and process thereof |
JPS5746903A (en) * | 1980-09-05 | 1982-03-17 | Mitsubishi Chem Ind Ltd | Agricultural and gardening fungicide |
NL8005754A (nl) * | 1980-10-18 | 1982-05-17 | Akzo Nv | Benzo 4,5 pyrano 2,3-c pyrrool derivaten. |
US4420480A (en) * | 1981-11-20 | 1983-12-13 | Merck & Co., Inc. | Hexahydronaphth[1,2-b]-1,4-oxazines |
US4540691A (en) * | 1984-04-13 | 1985-09-10 | Nelson Research & Development Co. | Dopamine agonists and use thereof |
US4666916A (en) * | 1985-11-08 | 1987-05-19 | Ciba-Geigy Corporation | Hexahydro-(1)-benzo-(pyrano and thiopyrano) (4,3-C)pyridines, useful as serotin-2 blocking agents |
-
1985
- 1985-05-06 EP EP85810208A patent/EP0161218B1/de not_active Expired - Lifetime
- 1985-05-06 DE DE8585810208T patent/DE3583307D1/de not_active Expired - Lifetime
- 1985-05-06 AT AT85810208T patent/ATE64735T1/de not_active IP Right Cessation
- 1985-05-07 DD DD85276081A patent/DD235872A5/de not_active IP Right Cessation
- 1985-05-08 CA CA000481003A patent/CA1298582C/en not_active Expired - Lifetime
- 1985-05-08 PT PT80415A patent/PT80415B/pt not_active IP Right Cessation
- 1985-05-08 FI FI851802A patent/FI83652C/fi not_active IP Right Cessation
- 1985-05-08 IL IL75135A patent/IL75135A/xx unknown
- 1985-05-08 GR GR851116A patent/GR851116B/el unknown
- 1985-05-08 ES ES542929A patent/ES8706687A1/es not_active Expired
- 1985-05-09 NZ NZ212031A patent/NZ212031A/xx unknown
- 1985-05-09 JP JP60096820A patent/JPS60243090A/ja active Granted
- 1985-05-09 IE IE1155/85A patent/IE57978B1/en not_active IP Right Cessation
- 1985-05-09 AU AU42248/85A patent/AU592308B2/en not_active Ceased
- 1985-05-09 DK DK205285A patent/DK168571B1/da not_active IP Right Cessation
- 1985-05-09 ZA ZA853507A patent/ZA853507B/xx unknown
- 1985-05-09 HU HU851751A patent/HU199476B/hu not_active IP Right Cessation
- 1985-05-09 NO NO851846A patent/NO162860C/no unknown
- 1985-05-10 AR AR85300343A patent/AR243526A1/es active
- 1985-09-03 US US06/771,934 patent/US4604397A/en not_active Expired - Lifetime
-
1986
- 1986-05-30 ES ES555527A patent/ES8801279A1/es not_active Expired
- 1986-05-30 ES ES555528A patent/ES8801280A1/es not_active Expired
- 1986-05-30 ES ES555530A patent/ES8801282A1/es not_active Expired
- 1986-05-30 ES ES555529A patent/ES8801281A1/es not_active Expired
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970519 |