ES8801282A1 - Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas - Google Patents
Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinasInfo
- Publication number
- ES8801282A1 ES8801282A1 ES555530A ES555530A ES8801282A1 ES 8801282 A1 ES8801282 A1 ES 8801282A1 ES 555530 A ES555530 A ES 555530A ES 555530 A ES555530 A ES 555530A ES 8801282 A1 ES8801282 A1 ES 8801282A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- hydroxy
- mono
- amino
- acylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE BENZO-(PIRANO Y TIOPIRANO)-PIRIDINAS, DE FORNMULA GENERAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN CICLIZAR MEDIANTE N-ALQUILACION REDUCTIVA EN UN DISOLVENTE INERTE UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE LA LINEA DE PUNTOS INDICA LA POSICION DEL ENLACE DOBLE EN CASO DADO EXISTENTE; X SIGNIFICA EL ANILLO; Y UNO DE LOS RESTOS Z1 Y Z2 SIGNIFICA OXO O HIDROXI. LA CICLIZACION SE LLEVA A EFECTO BAJO PROTECCION INTERMEDIA DE LOS GRUPOS FUNCIONALES CAPACES DE REACCION CUYA REACTIVIDAD PUDIERA REPERCUTIR EN FORMA PERTURBADORA. DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES PSICOTROPICAS EN MAMIFEROS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60903784A | 1984-05-10 | 1984-05-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8801282A1 true ES8801282A1 (es) | 1988-01-01 |
ES555530A0 ES555530A0 (es) | 1988-01-01 |
Family
ID=24439108
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542929A Expired ES8706687A1 (es) | 1984-05-10 | 1985-05-08 | Procedimiento para la obtencion de benzo-(pirano y tiopira- no)-piridinas |
ES555529A Expired ES8801281A1 (es) | 1984-05-10 | 1986-05-30 | Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas |
ES555530A Expired ES8801282A1 (es) | 1984-05-10 | 1986-05-30 | Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas |
ES555527A Expired ES8801279A1 (es) | 1984-05-10 | 1986-05-30 | Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas |
ES555528A Expired ES8801280A1 (es) | 1984-05-10 | 1986-05-30 | Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542929A Expired ES8706687A1 (es) | 1984-05-10 | 1985-05-08 | Procedimiento para la obtencion de benzo-(pirano y tiopira- no)-piridinas |
ES555529A Expired ES8801281A1 (es) | 1984-05-10 | 1986-05-30 | Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES555527A Expired ES8801279A1 (es) | 1984-05-10 | 1986-05-30 | Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas |
ES555528A Expired ES8801280A1 (es) | 1984-05-10 | 1986-05-30 | Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas |
Country Status (20)
Country | Link |
---|---|
US (1) | US4604397A (es) |
EP (1) | EP0161218B1 (es) |
JP (1) | JPS60243090A (es) |
AR (1) | AR243526A1 (es) |
AT (1) | ATE64735T1 (es) |
AU (1) | AU592308B2 (es) |
CA (1) | CA1298582C (es) |
DD (1) | DD235872A5 (es) |
DE (1) | DE3583307D1 (es) |
DK (1) | DK168571B1 (es) |
ES (5) | ES8706687A1 (es) |
FI (1) | FI83652C (es) |
GR (1) | GR851116B (es) |
HU (1) | HU199476B (es) |
IE (1) | IE57978B1 (es) |
IL (1) | IL75135A (es) |
NO (1) | NO162860C (es) |
NZ (1) | NZ212031A (es) |
PT (1) | PT80415B (es) |
ZA (1) | ZA853507B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8426584D0 (en) * | 1984-10-19 | 1984-11-28 | Beecham Group Plc | Compounds |
US4666916A (en) * | 1985-11-08 | 1987-05-19 | Ciba-Geigy Corporation | Hexahydro-(1)-benzo-(pyrano and thiopyrano) (4,3-C)pyridines, useful as serotin-2 blocking agents |
US4792548A (en) * | 1986-05-21 | 1988-12-20 | Warner-Lambert Company | Trans-benzopyran-(4,3-b)-1,4-oxazine derivatives, intermediates and pharmaceutical use |
US4801605A (en) * | 1986-08-29 | 1989-01-31 | Ciba-Geigy Corporation | 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans |
FR2619112B1 (fr) * | 1987-08-07 | 1989-11-17 | Synthelabo | Derives de (piperidinyl-4)methyl-2 benzo(b)furo(2,3-c) pyridines, leur preparation et leur application en therapeutique |
US4992465A (en) * | 1988-09-27 | 1991-02-12 | Ciba-Geigy Corporation | 3-amino-dihydro-(1)-benzopyrans |
US5962463A (en) * | 1992-10-09 | 1999-10-05 | Massachusetts Institute Of Technology | Methods of stimulating non-amyloidogenic processing of the amyloid precursor protein |
FR2721027B1 (fr) | 1994-06-08 | 1996-07-19 | Adir | Nouveaux dérivés tétracycliques de la 1,4-oxazine, leur procédé de préparation et les compositions pharmaceutiques les contenant. |
FR2741074B1 (fr) | 1995-11-09 | 1997-12-19 | Adir | Nouveaux composes tetracycliques de la 1,4-oxazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US6342533B1 (en) | 1998-12-01 | 2002-01-29 | Sepracor, Inc. | Derivatives of (−)-venlafaxine and methods of preparing and using the same |
EP1905757A1 (en) * | 1999-04-06 | 2008-04-02 | Sepracor Inc. | Derivatives of Venlafaxine and methods of preparing and using the same |
WO2005032485A2 (en) * | 2003-10-03 | 2005-04-14 | Psychogenics, Inc. | Compounds and methods for the treatment of attention-deficit hyperactivity disorder |
MX2008000249A (es) * | 2005-07-06 | 2008-03-18 | Sepracor Inc | Combinaciones de eszopiclona y o-desmetilvenlafaxina y metodos de tratamiento de menopausia y trastornos del estado de animo, ansiedad y cognitivos. |
BRPI1003506B1 (pt) | 2010-09-24 | 2019-12-03 | Ache Int Bvi Ltd | composto alquil-piperazino-fenil-4(3h)quinazolinonas e uso do composto alquil-piperazino-fenil-4(3h)quinazolinonas associado aos receptores serotoninérgicos 5-ht1a e 5-ht2a |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1143819A (es) * | 1965-09-27 | |||
US3514464A (en) * | 1967-05-29 | 1970-05-26 | Little Inc A | 5-oxo-1,2,3,4-tetrahydro-5h-(1)benzopyrano(3,4-c)pyridines |
US3689497A (en) * | 1971-03-09 | 1972-09-05 | Warner Lambert Co | Substituted benzopyrano (3,4-b) pyridines and process for their preparation |
US3915996A (en) * | 1972-10-16 | 1975-10-28 | Abbott Lab | Process for making benzopyrans |
US4025630A (en) * | 1973-09-19 | 1977-05-24 | Abbott Laboratories | Anesthesia methods using benzopyrans and esters thereof as pre-anesthesia medication |
US4292316A (en) * | 1978-10-02 | 1981-09-29 | Abbott Laboratories | Antiglaucoma agents |
US4210758A (en) * | 1979-03-21 | 1980-07-01 | Warner-Lambert Company | 1,5-Dihydro-1,5-dioxo-N-1H-tetrazol-5-yl-4H-[1]benzopyrano[3,4-b]pyridine-2-carboxamides |
US4198511A (en) * | 1979-03-21 | 1980-04-15 | Warner-Lambert Company | 1,5-Dihydro-1,5-dioxo-N-1H-tetrazol-5-yl-4H-[1]benzopyrano[3,4-b]pyridine-3-carboxamides and process thereof |
JPS5746903A (en) * | 1980-09-05 | 1982-03-17 | Mitsubishi Chem Ind Ltd | Agricultural and gardening fungicide |
NL8005754A (nl) * | 1980-10-18 | 1982-05-17 | Akzo Nv | Benzo 4,5 pyrano 2,3-c pyrrool derivaten. |
US4420480A (en) * | 1981-11-20 | 1983-12-13 | Merck & Co., Inc. | Hexahydronaphth[1,2-b]-1,4-oxazines |
US4540691A (en) * | 1984-04-13 | 1985-09-10 | Nelson Research & Development Co. | Dopamine agonists and use thereof |
US4666916A (en) * | 1985-11-08 | 1987-05-19 | Ciba-Geigy Corporation | Hexahydro-(1)-benzo-(pyrano and thiopyrano) (4,3-C)pyridines, useful as serotin-2 blocking agents |
-
1985
- 1985-05-06 DE DE8585810208T patent/DE3583307D1/de not_active Expired - Lifetime
- 1985-05-06 EP EP85810208A patent/EP0161218B1/de not_active Expired - Lifetime
- 1985-05-06 AT AT85810208T patent/ATE64735T1/de not_active IP Right Cessation
- 1985-05-07 DD DD85276081A patent/DD235872A5/de not_active IP Right Cessation
- 1985-05-08 FI FI851802A patent/FI83652C/fi not_active IP Right Cessation
- 1985-05-08 PT PT80415A patent/PT80415B/pt not_active IP Right Cessation
- 1985-05-08 IL IL75135A patent/IL75135A/xx unknown
- 1985-05-08 CA CA000481003A patent/CA1298582C/en not_active Expired - Lifetime
- 1985-05-08 GR GR851116A patent/GR851116B/el unknown
- 1985-05-08 ES ES542929A patent/ES8706687A1/es not_active Expired
- 1985-05-09 NO NO851846A patent/NO162860C/no unknown
- 1985-05-09 ZA ZA853507A patent/ZA853507B/xx unknown
- 1985-05-09 IE IE1155/85A patent/IE57978B1/en not_active IP Right Cessation
- 1985-05-09 JP JP60096820A patent/JPS60243090A/ja active Granted
- 1985-05-09 DK DK205285A patent/DK168571B1/da not_active IP Right Cessation
- 1985-05-09 AU AU42248/85A patent/AU592308B2/en not_active Ceased
- 1985-05-09 HU HU851751A patent/HU199476B/hu not_active IP Right Cessation
- 1985-05-09 NZ NZ212031A patent/NZ212031A/xx unknown
- 1985-05-10 AR AR85300343A patent/AR243526A1/es active
- 1985-09-03 US US06/771,934 patent/US4604397A/en not_active Expired - Lifetime
-
1986
- 1986-05-30 ES ES555529A patent/ES8801281A1/es not_active Expired
- 1986-05-30 ES ES555530A patent/ES8801282A1/es not_active Expired
- 1986-05-30 ES ES555527A patent/ES8801279A1/es not_active Expired
- 1986-05-30 ES ES555528A patent/ES8801280A1/es not_active Expired
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970519 |