ES8800047A1 - Un procedimiento para preparar una composicion terapeutica a base de vitamina b12 - Google Patents
Un procedimiento para preparar una composicion terapeutica a base de vitamina b12Info
- Publication number
- ES8800047A1 ES8800047A1 ES553999A ES553999A ES8800047A1 ES 8800047 A1 ES8800047 A1 ES 8800047A1 ES 553999 A ES553999 A ES 553999A ES 553999 A ES553999 A ES 553999A ES 8800047 A1 ES8800047 A1 ES 8800047A1
- Authority
- ES
- Spain
- Prior art keywords
- compositions containing
- containing vitamin
- nasal compositions
- vitamin
- nasal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title 1
- 229940045999 vitamin b 12 Drugs 0.000 title 1
- 229930003779 Vitamin B12 Natural products 0.000 abstract 2
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 abstract 2
- 239000002562 thickening agent Substances 0.000 abstract 2
- 235000019163 vitamin B12 Nutrition 0.000 abstract 2
- 239000011715 vitamin B12 Substances 0.000 abstract 2
- 235000000639 cyanocobalamin Nutrition 0.000 abstract 1
- 239000011666 cyanocobalamin Substances 0.000 abstract 1
- 229960002104 cyanocobalamin Drugs 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 229920000609 methyl cellulose Polymers 0.000 abstract 1
- 239000001923 methylcellulose Substances 0.000 abstract 1
- 235000010981 methylcellulose Nutrition 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR UNA COMPOSICION A BASE DE VITAMINA B12. CONSISTE EN MEZCLAR UNA CANTIDAD TERAPEUTICAMENTE EFECTIVA DE UNA VITAMINA B12, TAL COMO CIANOCOBALAMINA, CON UNA DISOLUCION TAMPON ACUOSA, ISOTONICA, DE UN PH COMPRENDIDO ENTRE 4 Y 6 QUE CONTIENE SUFICIENTE AGENTE ESPESANE, TAL COMO METIL-CELULOSA, PARA QUE LA VISCOSIDAD SEA DE 2.500 A 6.500 CPS; MEZCLANDOSE ADICIONALMENTE DE 1 A 10 POR CIEN EN PESO, SOBRE EL PESO TOTAL, DE UN HUECTANTE Y DE 0,2 A 2 POR CIEN EN PESO, SOBRE EL PESO TOTAL, DE UN TENSOACTIVO; OBTENIENDOSE UNA COMPOSICION QUE SE PRESENTA EN FORMA DE DOSIS UNITARIA Y QUE COMPRENDE DE 50 A 1.000 MG DE LA VITAMINA B12. TIENE APLICACIONES TERAPEUTICAS. O
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/848,690 US4724231A (en) | 1985-04-16 | 1986-04-08 | Nasel compositions containing vitamin B12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES553999A0 ES553999A0 (es) | 1987-11-01 |
| ES8800047A1 true ES8800047A1 (es) | 1987-11-01 |
Family
ID=25304012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES553999A Expired ES8800047A1 (es) | 1986-04-08 | 1986-04-15 | Un procedimiento para preparar una composicion terapeutica a base de vitamina b12 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4724231A (es) |
| EP (1) | EP0216917B1 (es) |
| JP (1) | JPH0669952B2 (es) |
| AT (1) | ATE54254T1 (es) |
| AU (1) | AU584703B2 (es) |
| ES (1) | ES8800047A1 (es) |
| HU (1) | HU196124B (es) |
| IE (1) | IE58533B1 (es) |
| OA (1) | OA08486A (es) |
| WO (1) | WO1986005988A1 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2074396A1 (es) * | 1993-03-24 | 1995-09-01 | Farmalider Sa | Sistema de administracion nasal de cianocobalamina (vitamina b12). |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05213759A (ja) * | 1992-02-05 | 1993-08-24 | All Yakuhin Kogyo Kk | 安定なビタミンｂ１２含有内用液剤 |
| CA2151148A1 (en) * | 1992-12-10 | 1994-06-23 | Richard D. Levere | Method for stimulating production of heme oxygenase using vitamin b12 |
| BE1007839A6 (nl) * | 1993-12-20 | 1995-10-31 | Merkus Franciscus W H M Prof | Farmaceutische compositie voor de nasale toediening van hydroxocobalamine. |
| US5925625A (en) * | 1994-05-13 | 1999-07-20 | Merkus; Franciscus W. H. M. | Pharmaceutical composition for the intranasal administration of hydroxocobalamin |
| US6080783A (en) * | 1998-09-01 | 2000-06-27 | Gum Tech International, Inc. | Method and composition for delivering zinc to the nasal membrane |
| FR2787029A1 (fr) * | 1998-12-09 | 2000-06-16 | Biovector Therapeutics | Utilisation dans une composition pharmaceutique pour l'administration par voie nasale de vitamine b12 pour la delivrance d'agents actifs au systeme nerveux central |
| MXPA01006297A (es) * | 1998-12-28 | 2002-06-04 | Biogentec Inc | Tratamiento con cianocobalamina (vitamina b12) para enfermedades alergicas. |
| DE19961307A1 (de) * | 1999-12-18 | 2001-07-12 | Krewel Meuselbach Gmbh | Medizinprodukt zur Befeuchtung und Reinigung der Nasenschleimhaut |
| EP1450739A4 (en) * | 2001-10-12 | 2008-12-17 | Cns Inc | NASAL MOISTURIZING GEL AND APPLICATOR |
| US7714011B2 (en) * | 2002-09-13 | 2010-05-11 | Zicam, Llc | Compositions to reduce congestion and methods for application thereof to the nasal membrane |
| US7229636B1 (en) * | 2003-03-04 | 2007-06-12 | Nastech Pharmaceutical Company Inc. | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery |
| US7404489B1 (en) | 2003-03-04 | 2008-07-29 | Qol Medical, Llc | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery |
| CA2575706A1 (en) * | 2004-08-02 | 2006-02-23 | Bebaas, Inc. | Vitamin b12 compositions |
| US20070111964A1 (en) * | 2005-08-17 | 2007-05-17 | Fleming And Company, Pharmaceuticals | Vitamin B12 nasal spray and method of use |
| US20130131007A1 (en) | 2005-09-07 | 2013-05-23 | Bebaas, Inc. | Vitamin b12 compositions |
| US20070178141A1 (en) * | 2005-09-07 | 2007-08-02 | Bebaas, Inc. | Vitamin B12 compositions |
| EP2918276A1 (en) * | 2006-05-30 | 2015-09-16 | Orahealth Corporation | Cobalamin compositions and methods for treating or preventing mucositis |
| CN101600729A (zh) * | 2006-06-23 | 2009-12-09 | 帕尔医疗公司 | 用于鼻内递送的氰钴胺低粘度水性制剂 |
| CN101011409B (zh) * | 2007-02-06 | 2010-08-11 | 浙江爱生药业有限公司 | 一种维生素b12滴鼻液组合物 |
| DE202010012255U1 (de) | 2010-09-07 | 2010-11-18 | Krewel Meuselbach Gmbh | Nasenspray |
| ES2686299T3 (es) * | 2010-10-29 | 2018-10-17 | Troikaa Pharmaceuticals Ltd | Composiciones nasales de vitamina B12 |
| JP5797227B2 (ja) * | 2013-05-21 | 2015-10-21 | パル ファーマシューティカル， インコーポレーテッド | 鼻内送達用シアノコバラミン低粘度水性製剤 |
| GB202013645D0 (en) | 2020-08-31 | 2020-10-14 | Innotesto Bvba | Pharmacetical compositions for the nasal administration of a colbalamin compound |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3282781A (en) * | 1960-11-25 | 1966-11-01 | Merck & Co Inc | Inhalant compositions |
| US3584115A (en) * | 1968-05-31 | 1971-06-08 | Arthur Ira Gebhart | Method of applying visible aerosol compositions |
| US3957966A (en) * | 1972-05-19 | 1976-05-18 | Gaf Corporation | Stabilized vitamin food coatings |
| NL7708731A (nl) * | 1976-08-13 | 1978-02-15 | Montedison Spa | Werkwijze voor de bereiding van nieuwe drijf- middelsamenstellingen voor aerosolen. |
| IT1164227B (it) * | 1983-05-13 | 1987-04-08 | Angeli Inst Spa | Composizione farmaceutica atta alla somministrazione nasale di sali quaternari d'ammonio ed attivita' anticolinergica |
| DE3323389A1 (de) * | 1983-06-29 | 1985-01-10 | B. Braun Melsungen Ag, 3508 Melsungen | Auf schleimhaeute des mundes, der nase und/oder des rachens wirkende arzneimittel auf der basis von heparin und tensiden |
| US4525341A (en) * | 1984-04-09 | 1985-06-25 | Mayor Pharmaceutical Laboratories, Inc. | Method of administering vitamins |
-
1986
- 1986-04-08 US US06/848,690 patent/US4724231A/en not_active Expired - Lifetime
- 1986-04-15 WO PCT/US1986/000793 patent/WO1986005988A1/en active IP Right Grant
- 1986-04-15 EP EP86902732A patent/EP0216917B1/en not_active Expired - Lifetime
- 1986-04-15 JP JP61502336A patent/JPH0669952B2/ja not_active Expired - Fee Related
- 1986-04-15 AT AT86902732T patent/ATE54254T1/de not_active IP Right Cessation
- 1986-04-15 ES ES553999A patent/ES8800047A1/es not_active Expired
- 1986-04-15 AU AU57757/86A patent/AU584703B2/en not_active Ceased
- 1986-04-15 IE IE97486A patent/IE58533B1/en not_active IP Right Cessation
- 1986-04-15 HU HU862345A patent/HU196124B/hu not_active IP Right Cessation
-
1987
- 1987-02-26 OA OA59077A patent/OA08486A/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2074396A1 (es) * | 1993-03-24 | 1995-09-01 | Farmalider Sa | Sistema de administracion nasal de cianocobalamina (vitamina b12). |
Also Published As
| Publication number | Publication date |
|---|---|
| HUT43493A (en) | 1987-11-30 |
| JPH0669952B2 (ja) | 1994-09-07 |
| HU196124B (en) | 1988-10-28 |
| OA08486A (fr) | 1988-07-29 |
| EP0216917A1 (en) | 1987-04-08 |
| ES553999A0 (es) | 1987-11-01 |
| EP0216917B1 (en) | 1990-07-04 |
| IE860974L (en) | 1986-10-16 |
| AU5775786A (en) | 1986-11-05 |
| IE58533B1 (en) | 1993-10-06 |
| WO1986005988A1 (en) | 1986-10-23 |
| JPS62500789A (ja) | 1987-04-02 |
| EP0216917A4 (en) | 1987-10-05 |
| ATE54254T1 (de) | 1990-07-15 |
| AU584703B2 (en) | 1989-06-01 |
| US4724231A (en) | 1988-02-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20041102 |