ES8702924A1 - Procedimiento para preparar aislar y purificar un polipeptido activo como antibiotico. - Google Patents

Procedimiento para preparar aislar y purificar un polipeptido activo como antibiotico.

Info

Publication number
ES8702924A1
ES8702924A1 ES548544A ES548544A ES8702924A1 ES 8702924 A1 ES8702924 A1 ES 8702924A1 ES 548544 A ES548544 A ES 548544A ES 548544 A ES548544 A ES 548544A ES 8702924 A1 ES8702924 A1 ES 8702924A1
Authority
ES
Spain
Prior art keywords
preparation
antibiotic
polypeptide
antibiotic polypeptide
epidermin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548544A
Other languages
English (en)
Other versions
ES548544A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19843440423 external-priority patent/DE3440423A1/de
Priority claimed from DE19853523478 external-priority patent/DE3523478A1/de
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES548544A0 publication Critical patent/ES548544A0/es
Publication of ES8702924A1 publication Critical patent/ES8702924A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/44—Staphylococcus
    • C12R2001/45—Staphylococcus epidermidis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

METODO PARA LA OBTENCION, SEPARACION Y PURIFICACION DEL POLIPEPTIDO EPIDERMINA. CONSISTE EN EL CULTIVO DE STAPHYLOCOCCUS EPIDERMIDIS DSM 3095 EN UN MEDIO DE CULTIVO, EN CONDICIONES AEROBIAS, A UNA TEMPERATURA COMPRENDIDA ENTRE 34JC Y 37JC; ELIMINACION DE LAS CELULAS Y SALES INORGANICAS, EXTRACCION DEL CALDO DE CULTIVO CON N-BUTANOL A PH 8, EVAPORACION DEL DISOLVENTE, DISOLUCION DEL RESIDUO EN METANOL Y PRECIPITACION DE LAS SUSTANCIAS LIPIDICAS CON ETER DIETILICO; DISOLUCION EN METANOL/ACIDO ACETICO (95:5), CENTRIFUGACION Y CROMATOGRAFIADO DE LA DISOLUCION A TRAVES DE GEL; CONCENTRACION DE LOS ELUATOS POSITIVOS Y EXTRACCION POR CONTRACORRIENTE DISCONTINUA; AISLAMIENTO DE LA EPIDERMINA A PARTIR DE LOS EXTRACTOS Y LIOFILIZACION. LA EPIDERMINA TIENE APLICACIONES FARMACOLOGICAS COMO ANTIBIOTICOS PARA EL TRATAMIENTO DE ENFERMEDADES INFECCIOSAS.
ES548544A 1984-11-06 1985-11-05 Procedimiento para preparar aislar y purificar un polipeptido activo como antibiotico. Expired ES8702924A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843440423 DE3440423A1 (de) 1984-11-06 1984-11-06 Antibiotisches polypeptid, verfahren zu seiner herstellung, dieses polypeptid erzeugender stamm von staphylococcus epidermidis, dieses polypeptid enthaltende zubereitungsformen und seine verwendung zur bekaempfung infektioeser erkrankungen
DE19853523478 DE3523478A1 (de) 1985-07-01 1985-07-01 Antibiotisches polypeptid, verfahren zu seiner herstellung, dieses polypeptid erzeugender stamm vom staphylococcus epidermidis, dieses polypeptid enthaltende zubereitungsformen und seine verwendung zur bekaempfung infektioeser erkrankungen

Publications (2)

Publication Number Publication Date
ES548544A0 ES548544A0 (es) 1987-01-16
ES8702924A1 true ES8702924A1 (es) 1987-01-16

Family

ID=25826263

Family Applications (1)

Application Number Title Priority Date Filing Date
ES548544A Expired ES8702924A1 (es) 1984-11-06 1985-11-05 Procedimiento para preparar aislar y purificar un polipeptido activo como antibiotico.

Country Status (13)

Country Link
EP (1) EP0181578B1 (es)
JP (2) JPH0670078B2 (es)
KR (1) KR930002736B1 (es)
CA (1) CA1277617C (es)
DE (1) DE3583987D1 (es)
DK (1) DK172818B1 (es)
ES (1) ES8702924A1 (es)
FI (1) FI82073C (es)
HK (1) HK63795A (es)
IL (1) IL76956A (es)
NO (1) NO164039C (es)
NZ (1) NZ214067A (es)
PT (1) PT81436B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0637384B2 (ja) * 1985-09-21 1994-05-18 株式会社資生堂 皮膚化粧料
EP0350810B1 (de) * 1988-07-15 1993-09-29 Dr. Karl Thomae GmbH Verfahren zur Gewinnung, Isolierung und Reinigung von Epidermin
DE3938140A1 (de) * 1989-11-16 1991-08-08 Beiersdorf Ag Desodorierende kosmetische mittel
AU5158093A (en) * 1992-09-10 1994-03-29 Sara Lee/De N.V. Mouth-care products with anti-bacterial activity
AU689494B2 (en) * 1993-08-20 1998-04-02 Boehringer Ingelheim Vetmedica Gmbh Method for the prevention and treatment of bovine mastitis
CA2186621A1 (en) * 1994-05-07 1995-11-16 Bruno Suri Lanthionine-containing antimicrobial compound
WO1996031192A1 (de) * 1995-04-07 1996-10-10 Kuyus-Stiftung Kosmetische zusammensetzung zur behandlung von cellulite
SE9602496D0 (sv) 1996-06-20 1996-06-20 Bengt Guss Method and means for producing a fibrinogen binding protein and its use in biotechnology
JP2006176406A (ja) * 2003-03-11 2006-07-06 Asahi Kasei Pharma Kk ペプチド系抗生物質
KR20230078378A (ko) * 2021-11-26 2023-06-02 코스맥스 주식회사 에피더미디박테리움 케라티니 추출물이 함침된 다공성 실리카 및 그의 피부상태 개선 용도

Also Published As

Publication number Publication date
IL76956A (en) 1991-07-18
DK509985A (da) 1986-05-07
CA1277617C (en) 1990-12-11
ES548544A0 (es) 1987-01-16
HK63795A (en) 1995-05-05
FI82073B (fi) 1990-09-28
FI854316A (fi) 1986-05-07
NO164039C (no) 1990-08-22
NO164039B (no) 1990-05-14
DE3583987D1 (de) 1991-10-10
DK509985D0 (da) 1985-11-05
FI854316A0 (fi) 1985-11-04
NO854405L (no) 1986-05-07
EP0181578B1 (de) 1991-09-04
DK172818B1 (da) 1999-08-02
JPH0732704B2 (ja) 1995-04-12
FI82073C (fi) 1991-01-10
JPH06113826A (ja) 1994-04-26
PT81436B (pt) 1988-01-22
KR930002736B1 (ko) 1993-04-09
KR860004147A (ko) 1986-06-18
NZ214067A (en) 1991-05-28
PT81436A (de) 1985-12-01
JPH0670078B2 (ja) 1994-09-07
IL76956A0 (en) 1986-04-29
JPS61158997A (ja) 1986-07-18
EP0181578A3 (en) 1988-08-17
EP0181578A2 (de) 1986-05-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20061114