ES8609325A1 - Un procedimiento para preparar derivados de guanina - Google Patents
Un procedimiento para preparar derivados de guaninaInfo
- Publication number
- ES8609325A1 ES8609325A1 ES538721A ES538721A ES8609325A1 ES 8609325 A1 ES8609325 A1 ES 8609325A1 ES 538721 A ES538721 A ES 538721A ES 538721 A ES538721 A ES 538721A ES 8609325 A1 ES8609325 A1 ES 8609325A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- compounds
- hydrogen
- guanine
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/17—Unsaturated ethers containing halogen
- C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
- C07C43/1745—Unsaturated ethers containing halogen containing six-membered aromatic rings having more than one ether bound
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1787—Unsaturated ethers containing hydroxy or O-metal groups containing six-membered aromatic rings and having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NUEVOS DERIVADOS DE GUANINA Y METODOS PARA SU PREPARACION. EL PROCEDIMIENTO PARA PREPARAR DERIVADOS DE GUANINA DE FORMULA (I) SUS SALES FISIOLOGICAMENTE ACEPTABLES O LOS ISOMEROS OPTICOS DE LOS MISMOS, CONSISTE EN CONDENSAR UN COMPUESTO DETERMINADO QUE SE INDICA ASI COMO TODOS SUS SUSTITUYENTES EN LA POSICION N-9 DE UN DERIVADO DE GUANINA, LLEVANDOSE A CABO LA REACCION DE CONDENSACION A PH BASICO, TEMPERATURA DE 0-100JC, DURANTE 1 HORA A 3 DIAS Y POSTERIOR SEPARACION DE LOS GRUPOS PROTECTORES OPCIONALES. TANTO LOS DERIVADOS DE GUANINA COMO LAS COMPOSICIONES FARMACEUTICAS SE APLICAN SEGUN UN METODO PARA COMBATIR SELECTIVAMENTE LOS VIRUS, TALES COMO VIRUS DE HERPES Y OTRAS ENFERMEDADES, TANTO INFECCIOSAS COMUNES, COMO NEOPLASICAS ES DECIR EL CANCER.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8307052A SE8307052D0 (sv) | 1983-12-20 | 1983-12-20 | Novel derivatives of guanine novel derivatives of guanine |
SE8307051A SE8307051D0 (sv) | 1983-12-20 | 1983-12-20 | Novel derivatives of alkyl guanine novel derivatives of alkyl guanine |
Publications (2)
Publication Number | Publication Date |
---|---|
ES538721A0 ES538721A0 (es) | 1986-09-01 |
ES8609325A1 true ES8609325A1 (es) | 1986-09-01 |
Family
ID=26658599
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES538721A Expired ES8609325A1 (es) | 1983-12-20 | 1984-12-18 | Un procedimiento para preparar derivados de guanina |
ES546916A Expired ES8704170A1 (es) | 1983-12-20 | 1985-09-12 | Un procedimiento para preparar derivados de guanina |
ES554546A Expired ES8800946A1 (es) | 1983-12-20 | 1986-04-30 | Un procedimiento para preparar derivados de guanina |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES546916A Expired ES8704170A1 (es) | 1983-12-20 | 1985-09-12 | Un procedimiento para preparar derivados de guanina |
ES554546A Expired ES8800946A1 (es) | 1983-12-20 | 1986-04-30 | Un procedimiento para preparar derivados de guanina |
Country Status (20)
Country | Link |
---|---|
US (1) | US4798833A (es) |
EP (2) | EP0146516A3 (es) |
JP (1) | JPH0667939B2 (es) |
KR (1) | KR910010048B1 (es) |
AU (1) | AU586415B2 (es) |
CA (1) | CA1285560C (es) |
DE (1) | DE3477568D1 (es) |
DK (1) | DK159683C (es) |
ES (3) | ES8609325A1 (es) |
FI (1) | FI80885C (es) |
GB (1) | GB2151622B (es) |
GR (1) | GR82499B (es) |
HU (1) | HU193595B (es) |
IE (1) | IE57913B1 (es) |
IL (1) | IL73682A (es) |
IS (1) | IS1507B (es) |
MY (1) | MY102565A (es) |
PH (1) | PH21410A (es) |
PT (1) | PT79714B (es) |
WO (1) | WO1985002845A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3485225D1 (de) * | 1983-08-18 | 1991-12-05 | Beecham Group Plc | Antivirale guanin-derivate. |
US5684153A (en) * | 1984-08-16 | 1997-11-04 | Beecham Group Plc | Process for the preparation of purine derivatives |
CA1288098C (en) * | 1984-08-24 | 1991-08-27 | Richard L. Tolman | 4-(guanin-9-yl)butanals and their 3-oxa, 3-thia and 2-ene derivatives having antiviral and antitumor activity |
SE8406538D0 (sv) * | 1984-12-21 | 1984-12-21 | Astra Laekemedel Ab | Novel derivatives of purine |
EP0216459B1 (en) * | 1985-07-27 | 1990-05-16 | Beecham Group Plc | 9-substituted guanine monohydrates |
EP0219838A3 (en) * | 1985-10-22 | 1988-04-06 | Takeda Chemical Industries, Ltd. | Carbocyclic purine nucleosides, their production and use |
US5066655A (en) * | 1987-04-24 | 1991-11-19 | Whitby Research, Inc. | N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists |
US5565566A (en) * | 1987-04-24 | 1996-10-15 | Discovery Therapeutics, Inc. | N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists |
US5175288A (en) * | 1987-08-01 | 1992-12-29 | Beecham Group P.L.C. | Process for preparing purine derivatives and intermediates thereof |
US4935427A (en) * | 1987-12-31 | 1990-06-19 | The United States Of America As Represented By The Department Of Health And Human Services | Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents |
US5284837A (en) * | 1988-05-06 | 1994-02-08 | Medivir Ab | Derivatives of purine, process for their preparation and a pharmaceutical preparation |
SE8801729D0 (sv) * | 1988-05-06 | 1988-05-06 | Astra Ab | Purine derivatives for use in therapy |
GB8817607D0 (en) * | 1988-07-23 | 1988-09-01 | Beecham Group Plc | Novel process |
GB8822236D0 (en) * | 1988-09-21 | 1988-10-26 | Beecham Group Plc | Chemical process |
CA2009109A1 (en) * | 1989-02-02 | 1990-08-02 | John Hannah | Antiviral acyclonucleosides and acyclonucleotides |
GB8904855D0 (en) * | 1989-03-03 | 1989-04-12 | Beecham Group Plc | Pharmaceutical treatment |
GB8917959D0 (en) * | 1989-08-05 | 1989-09-20 | Beecham Group Plc | Pharmaceutical formulation |
GB8922076D0 (en) * | 1989-09-28 | 1989-11-15 | Beecham Group Plc | Novel process |
GB9001886D0 (en) * | 1990-01-26 | 1990-03-28 | Beecham Group Plc | Pharmaceutical formulation |
US5674869A (en) * | 1990-07-07 | 1997-10-07 | Beecham Group Plc | Pharmaceutical treatment |
AU679763B2 (en) * | 1993-06-23 | 1997-07-10 | Merrell Pharmaceuticals Inc. | Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents |
US5869493A (en) | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
US6703394B2 (en) | 1996-02-16 | 2004-03-09 | Medivir Ab | Acyclic nucleoside derivatives |
GB9615276D0 (en) * | 1996-07-20 | 1996-09-04 | Smithkline Beecham Plc | Pharmaceuticals |
GB9615253D0 (en) * | 1996-07-20 | 1996-09-04 | Smithkline Beecham Plc | Pharmaceuticals |
GR1002949B (el) * | 1996-07-20 | 1998-07-29 | Smithkline Beecham P.L.C. | Φαρμακα |
GB9807114D0 (en) | 1998-04-02 | 1998-06-03 | Smithkline Beecham Plc | Novel process |
WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4347360A (en) * | 1980-09-16 | 1982-08-31 | Ens Bio Logicals Inc. | Ring open nucleoside analogues |
IL64501A (en) * | 1980-12-22 | 1985-07-31 | Astra Laekemedel Ab | 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use |
US4355032B2 (en) * | 1981-05-21 | 1990-10-30 | 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent | |
AU569462B2 (en) * | 1981-08-11 | 1988-02-04 | Wellcome Foundation Limited, The | Antiviral purine derivatives |
NZ201662A (en) * | 1981-08-26 | 1986-07-11 | Merck & Co Inc | 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation |
AU564576B2 (en) * | 1981-09-24 | 1987-08-20 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Purine derivatives |
US5250535A (en) * | 1982-02-01 | 1993-10-05 | Syntex Inc. | Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent |
SE8203856D0 (sv) * | 1982-06-21 | 1982-06-21 | Astra Laekemedel Ab | Novel derivatives of guanine ii |
SE8203855D0 (sv) * | 1982-06-21 | 1982-06-21 | Astra Laekemedel Ab | Novel derivatives of guanine i |
DE3485225D1 (de) * | 1983-08-18 | 1991-12-05 | Beecham Group Plc | Antivirale guanin-derivate. |
EP0216459B1 (en) * | 1985-07-27 | 1990-05-16 | Beecham Group Plc | 9-substituted guanine monohydrates |
-
1984
- 1984-11-29 IL IL73682A patent/IL73682A/xx not_active IP Right Cessation
- 1984-12-13 AU AU37873/85A patent/AU586415B2/en not_active Expired
- 1984-12-13 EP EP84850390A patent/EP0146516A3/en active Pending
- 1984-12-13 KR KR1019850700161A patent/KR910010048B1/ko not_active IP Right Cessation
- 1984-12-13 EP EP85900247A patent/EP0165289B1/en not_active Expired
- 1984-12-13 DE DE8585900247T patent/DE3477568D1/de not_active Expired
- 1984-12-13 HU HU84807A patent/HU193595B/hu unknown
- 1984-12-13 WO PCT/SE1984/000426 patent/WO1985002845A1/en active IP Right Grant
- 1984-12-13 JP JP60500231A patent/JPH0667939B2/ja not_active Expired - Lifetime
- 1984-12-17 PH PH31589A patent/PH21410A/en unknown
- 1984-12-18 GB GB08431910A patent/GB2151622B/en not_active Expired
- 1984-12-18 GR GR82499A patent/GR82499B/el unknown
- 1984-12-18 ES ES538721A patent/ES8609325A1/es not_active Expired
- 1984-12-19 IE IE3261/845A patent/IE57913B1/en not_active IP Right Cessation
- 1984-12-19 CA CA000470490A patent/CA1285560C/en not_active Expired - Lifetime
- 1984-12-19 PT PT79714A patent/PT79714B/pt unknown
- 1984-12-19 IS IS2966A patent/IS1507B/is unknown
-
1985
- 1985-08-09 DK DK362585A patent/DK159683C/da not_active IP Right Cessation
- 1985-08-19 FI FI853171A patent/FI80885C/fi active IP Right Grant
- 1985-09-12 ES ES546916A patent/ES8704170A1/es not_active Expired
-
1986
- 1986-04-30 ES ES554546A patent/ES8800946A1/es not_active Expired
-
1987
- 1987-02-06 US US07/015,481 patent/US4798833A/en not_active Expired - Lifetime
- 1987-10-01 MY MYPI87002765A patent/MY102565A/en unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20060529 |