DK159683C - 9-(4-hydroxybutyl)-guaninderivat, farmaceutisk praeparat indeholdende en saadan forbindelse og anvendelse af den til fremstilling af et laegemiddel - Google Patents

9-(4-hydroxybutyl)-guaninderivat, farmaceutisk praeparat indeholdende en saadan forbindelse og anvendelse af den til fremstilling af et laegemiddel

Info

Publication number
DK159683C
DK159683C DK362585A DK362585A DK159683C DK 159683 C DK159683 C DK 159683C DK 362585 A DK362585 A DK 362585A DK 362585 A DK362585 A DK 362585A DK 159683 C DK159683 C DK 159683C
Authority
DK
Denmark
Prior art keywords
hydroxybutyl
medicine
compound
preparation
guanine derivative
Prior art date
Application number
DK362585A
Other languages
Danish (da)
English (en)
Other versions
DK159683B (da
DK362585A (da
DK362585D0 (da
Inventor
Karl Nils-Gunnar Johansson
Bjoern Gunnar Lindborg
Jan-Olof Noren
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE8307052A external-priority patent/SE8307052D0/xx
Priority claimed from SE8307051A external-priority patent/SE8307051D0/xx
Application filed by Medivir Ab filed Critical Medivir Ab
Publication of DK362585A publication Critical patent/DK362585A/da
Publication of DK362585D0 publication Critical patent/DK362585D0/da
Publication of DK159683B publication Critical patent/DK159683B/da
Application granted granted Critical
Publication of DK159683C publication Critical patent/DK159683C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C07C43/1745—Unsaturated ethers containing halogen containing six-membered aromatic rings having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1787—Unsaturated ethers containing hydroxy or O-metal groups containing six-membered aromatic rings and having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK362585A 1983-12-20 1985-08-09 9-(4-hydroxybutyl)-guaninderivat, farmaceutisk praeparat indeholdende en saadan forbindelse og anvendelse af den til fremstilling af et laegemiddel DK159683C (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
SE8307051 1983-12-20
SE8307052 1983-12-20
SE8307052A SE8307052D0 (sv) 1983-12-20 1983-12-20 Novel derivatives of guanine novel derivatives of guanine
SE8307051A SE8307051D0 (sv) 1983-12-20 1983-12-20 Novel derivatives of alkyl guanine novel derivatives of alkyl guanine
SE8400426 1984-12-13
PCT/SE1984/000426 WO1985002845A1 (en) 1983-12-20 1984-12-13 Novel derivatives of guanine

Publications (4)

Publication Number Publication Date
DK362585A DK362585A (da) 1985-08-09
DK362585D0 DK362585D0 (da) 1985-08-09
DK159683B DK159683B (da) 1990-11-19
DK159683C true DK159683C (da) 1991-04-15

Family

ID=26658599

Family Applications (1)

Application Number Title Priority Date Filing Date
DK362585A DK159683C (da) 1983-12-20 1985-08-09 9-(4-hydroxybutyl)-guaninderivat, farmaceutisk praeparat indeholdende en saadan forbindelse og anvendelse af den til fremstilling af et laegemiddel

Country Status (20)

Country Link
US (1) US4798833A (es)
EP (2) EP0146516A3 (es)
JP (1) JPH0667939B2 (es)
KR (1) KR910010048B1 (es)
AU (1) AU586415B2 (es)
CA (1) CA1285560C (es)
DE (1) DE3477568D1 (es)
DK (1) DK159683C (es)
ES (3) ES8609325A1 (es)
FI (1) FI80885C (es)
GB (1) GB2151622B (es)
GR (1) GR82499B (es)
HU (1) HU193595B (es)
IE (1) IE57913B1 (es)
IL (1) IL73682A (es)
IS (1) IS1507B (es)
MY (1) MY102565A (es)
PH (1) PH21410A (es)
PT (1) PT79714B (es)
WO (1) WO1985002845A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3485225D1 (de) * 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
US5684153A (en) * 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
CA1288098C (en) * 1984-08-24 1991-08-27 Richard L. Tolman 4-(guanin-9-yl)butanals and their 3-oxa, 3-thia and 2-ene derivatives having antiviral and antitumor activity
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
EP0216459B1 (en) * 1985-07-27 1990-05-16 Beecham Group Plc 9-substituted guanine monohydrates
EP0219838A3 (en) * 1985-10-22 1988-04-06 Takeda Chemical Industries, Ltd. Carbocyclic purine nucleosides, their production and use
US5066655A (en) * 1987-04-24 1991-11-19 Whitby Research, Inc. N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists
US5565566A (en) * 1987-04-24 1996-10-15 Discovery Therapeutics, Inc. N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
US5175288A (en) * 1987-08-01 1992-12-29 Beecham Group P.L.C. Process for preparing purine derivatives and intermediates thereof
US4935427A (en) * 1987-12-31 1990-06-19 The United States Of America As Represented By The Department Of Health And Human Services Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents
US5284837A (en) * 1988-05-06 1994-02-08 Medivir Ab Derivatives of purine, process for their preparation and a pharmaceutical preparation
SE8801729D0 (sv) * 1988-05-06 1988-05-06 Astra Ab Purine derivatives for use in therapy
GB8817607D0 (en) * 1988-07-23 1988-09-01 Beecham Group Plc Novel process
GB8822236D0 (en) * 1988-09-21 1988-10-26 Beecham Group Plc Chemical process
CA2009109A1 (en) * 1989-02-02 1990-08-02 John Hannah Antiviral acyclonucleosides and acyclonucleotides
GB8904855D0 (en) * 1989-03-03 1989-04-12 Beecham Group Plc Pharmaceutical treatment
GB8917959D0 (en) * 1989-08-05 1989-09-20 Beecham Group Plc Pharmaceutical formulation
GB8922076D0 (en) * 1989-09-28 1989-11-15 Beecham Group Plc Novel process
GB9001886D0 (en) * 1990-01-26 1990-03-28 Beecham Group Plc Pharmaceutical formulation
US5674869A (en) * 1990-07-07 1997-10-07 Beecham Group Plc Pharmaceutical treatment
AU679763B2 (en) * 1993-06-23 1997-07-10 Merrell Pharmaceuticals Inc. Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
GB9615276D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
GB9615253D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
GR1002949B (el) * 1996-07-20 1998-07-29 Smithkline Beecham P.L.C. Φαρμακα
GB9807114D0 (en) 1998-04-02 1998-06-03 Smithkline Beecham Plc Novel process
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
IL64501A (en) * 1980-12-22 1985-07-31 Astra Laekemedel Ab 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
AU569462B2 (en) * 1981-08-11 1988-02-04 Wellcome Foundation Limited, The Antiviral purine derivatives
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
AU564576B2 (en) * 1981-09-24 1987-08-20 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Purine derivatives
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
SE8203856D0 (sv) * 1982-06-21 1982-06-21 Astra Laekemedel Ab Novel derivatives of guanine ii
SE8203855D0 (sv) * 1982-06-21 1982-06-21 Astra Laekemedel Ab Novel derivatives of guanine i
DE3485225D1 (de) * 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
EP0216459B1 (en) * 1985-07-27 1990-05-16 Beecham Group Plc 9-substituted guanine monohydrates

Also Published As

Publication number Publication date
EP0165289B1 (en) 1989-04-05
DK159683B (da) 1990-11-19
DK362585A (da) 1985-08-09
EP0146516A2 (en) 1985-06-26
ES554546A0 (es) 1987-12-01
ES8704170A1 (es) 1987-03-16
WO1985002845A1 (en) 1985-07-04
IS1507B (is) 1992-09-29
HU193595B (en) 1987-11-30
JPS61500730A (ja) 1986-04-17
GB2151622B (en) 1988-05-11
IL73682A (en) 1991-08-16
FI80885B (fi) 1990-04-30
MY102565A (en) 1992-07-31
KR850700136A (ko) 1985-10-25
ES546916A0 (es) 1987-03-16
US4798833A (en) 1989-01-17
PT79714B (en) 1986-12-30
FI853171A0 (fi) 1985-08-19
GR82499B (en) 1985-04-19
KR910010048B1 (ko) 1991-12-12
IE843261L (en) 1985-06-20
CA1285560C (en) 1991-07-02
DK362585D0 (da) 1985-08-09
PH21410A (en) 1987-10-15
AU586415B2 (en) 1989-07-13
FI853171L (fi) 1985-08-19
EP0146516A3 (en) 1985-08-14
IL73682A0 (en) 1985-02-28
DE3477568D1 (en) 1989-05-11
IE57913B1 (en) 1993-05-19
PT79714A (en) 1985-01-01
GB8431910D0 (en) 1985-01-30
ES538721A0 (es) 1986-09-01
IS2966A7 (is) 1985-06-21
ES8800946A1 (es) 1987-12-01
JPH0667939B2 (ja) 1994-08-31
AU3787385A (en) 1985-07-12
GB2151622A (en) 1985-07-24
HUT37619A (en) 1986-01-23
ES8609325A1 (es) 1986-09-01
FI80885C (fi) 1990-08-10
EP0165289A1 (en) 1985-12-27

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