ES8609290A1 - Procedimiento para preparar cetonas heterociclicas nitroge- nadas con anillo de siete miembros y condensadas - Google Patents

Procedimiento para preparar cetonas heterociclicas nitroge- nadas con anillo de siete miembros y condensadas

Info

Publication number
ES8609290A1
ES8609290A1 ES544748A ES544748A ES8609290A1 ES 8609290 A1 ES8609290 A1 ES 8609290A1 ES 544748 A ES544748 A ES 544748A ES 544748 A ES544748 A ES 544748A ES 8609290 A1 ES8609290 A1 ES 8609290A1
Authority
ES
Spain
Prior art keywords
membered ring
condensed
hydrogen
ring compounds
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544748A
Other languages
English (en)
Other versions
ES544748A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1983/000127 external-priority patent/WO1984004306A1/ja
Priority claimed from PCT/JP1983/000342 external-priority patent/WO1985001730A1/ja
Priority claimed from PCT/JP1984/000119 external-priority patent/WO1985004402A1/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES8609290A1 publication Critical patent/ES8609290A1/es
Publication of ES544748A0 publication Critical patent/ES544748A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • External Artificial Organs (AREA)

Abstract

SE PREPARAN CETONAS HETEROCICLICAS NITROGENADAS CON ANILLO DE SIETE MIEMBROS CONDENSADO, REPRESENTADAS POR LA FORMULA (I), O SUS SALES FARMACEUTICAMENTE ACEPTABLES, SOMETIENDO UN COMPUESTO DE LA FORMULA (II) A UNA REACCION DE CONDENSACION, EN CONDICIONES REDUCTORAS MUY VARIADAS, CON UN COMPUESTO DE LA FORMULA (III), EN PRESENCIA DE AGUA O DE UN DISOLVENTE ORGANICO, A UNA TEMPERATURA DE C20 A B100JC Y A UNA PRESION QUE PUEDE SER IGUAL, MENOR O SUPERIOR A LA ATMOSFERICA. LOS COMPUESTOS DE FORMULA (I) Y SUS SALES SON UTILES COMO FARMACOS PARA EL DIAGNOSTICO, PREVENCION Y TRATAMIENTO DE LA HIPERTENSION Y DE LAS ENFERMEDADES CIRCULATORIAS INDUCIDAS POR ESTA, SON DE BAJA TOXICIDAD, MUY ESTABLES, DE ACCION DURADERA Y FACILMENTE ABSORBIBLES, INCLUSO POR VIA ORAL.
ES544748A 1983-04-22 1985-07-01 Procedimiento para preparar cetonas heterociclicas nitroge- nadas con anillo de siete miembros y condensadas Expired ES8609290A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/JP1983/000127 WO1984004306A1 (en) 1983-04-22 1983-04-22 Fused 7-membered ring compounds and process for their preparation
PCT/JP1983/000342 WO1985001730A1 (en) 1983-10-13 1983-10-13 Fused 7-membered ring compounds and process for their preparation
PCT/JP1984/000119 WO1985004402A1 (en) 1984-03-24 1984-03-24 Fused 7-membered ring compounds and process for their preparation

Publications (2)

Publication Number Publication Date
ES8609290A1 true ES8609290A1 (es) 1986-07-16
ES544748A0 ES544748A0 (es) 1986-07-16

Family

ID=27304084

Family Applications (2)

Application Number Title Priority Date Filing Date
ES531740A Granted ES531740A0 (es) 1983-04-22 1984-04-18 Procedimiento para preparar cetonas heterociclicas nitrogenadas con anillo de siete miembros y condensadas.
ES544748A Expired ES8609290A1 (es) 1983-04-22 1985-07-01 Procedimiento para preparar cetonas heterociclicas nitroge- nadas con anillo de siete miembros y condensadas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES531740A Granted ES531740A0 (es) 1983-04-22 1984-04-18 Procedimiento para preparar cetonas heterociclicas nitrogenadas con anillo de siete miembros y condensadas.

Country Status (17)

Country Link
US (1) US4564612A (es)
EP (1) EP0125056B1 (es)
KR (1) KR910007965B1 (es)
AT (1) ATE60061T1 (es)
AU (1) AU565188B2 (es)
CA (1) CA1209993A (es)
DE (1) DE3483920D1 (es)
ES (2) ES531740A0 (es)
FI (1) FI82455C (es)
GR (1) GR79905B (es)
HU (1) HU193008B (es)
IE (1) IE57599B1 (es)
IL (1) IL71617A (es)
NO (1) NO162235C (es)
NZ (1) NZ207915A (es)
PH (1) PH21294A (es)
PT (1) PT78454B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3423743A1 (de) * 1983-06-29 1985-01-10 Mitsui Toatsu Chemicals, Inc., Tokio/Tokyo Benzothiazepin-derivate und verfahren zu ihrer herstellung
AU570710B2 (en) * 1983-08-12 1988-03-24 Takeda Chemical Industries Ltd. 4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine derivatives
US4512988A (en) * 1984-03-01 1985-04-23 E. R. Squibb & Sons, Inc. Acylamino oxo or hydroxy substituted alkylamino thiazines and thiazepines
IL74004A (en) * 1984-03-24 1991-12-15 Takeda Chemical Industries Ltd 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine derivatives,their production and pharmaceutical compositions containing them
EP0187037A3 (en) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Piperidine derivatives, their production and use
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
JPH0657707B2 (ja) * 1987-05-25 1994-08-03 吉富製薬株式会社 ピペリジン化合物
JPS6450872A (en) * 1987-08-21 1989-02-27 Tanabe Seiyaku Co Production of 1,5-benzothiazepine derivative
EP0322779A3 (en) * 1987-12-29 1991-05-08 Yoshitomi Pharmaceutical Industries, Ltd. Benzolactam compounds and pharmaceutical uses thereof
US5290927A (en) * 1988-03-01 1994-03-01 Ajinomoto Co., Inc. Process for preparing 2',3'-dideoxyadenosine
AT393998B (de) * 1990-02-16 1992-01-10 Troendle Peter Paul Buch
US5618808A (en) * 1992-07-01 1997-04-08 Pfizer, Inc. Benzothiazepine and benzoxazepine derivatives as cholecystokinin receptor antagonists
ZA941003B (en) * 1993-02-15 1995-08-14 Wellcome Found Hypolipidaemic compounds
ZA956647B (en) * 1994-08-10 1997-02-10 Wellcome Found Hypolipidaemic compounds.
FR2781483A1 (fr) * 1998-07-21 2000-01-28 Hoechst Marion Roussel Inc Derives de thioazepinone, procede de preparation et intermediaires de ce procede, application a titre de medicament et compositions pharmaceutiques les renfermant
FR2807039A1 (fr) * 2000-03-31 2001-10-05 Adir NOUVEAU PROCEDE DE PREPARATION DE LA 11-AMINO-3-CHLORO-6,11- DIHYDRO-5,5-DIOXO-6-METHYL-DIBENZO[c,f][1,2]-THIAZEPINE ET APPLICATION A LA SYNTHESE DE LA TIANEPTINE

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3341519A (en) * 1965-04-28 1967-09-12 Squibb & Sons Inc Novel benzoxazines, benzothiazines, benzoxazepins and benzothiazepins
AU543804B2 (en) * 1980-10-31 1985-05-02 Takeda Chemical Industries Ltd. Amides having bicyclic substituents on nitrogen
EP0057998B1 (en) * 1981-01-23 1984-08-08 Takeda Chemical Industries, Ltd. Alicyclic compounds, their production and use
DE3260831D1 (en) * 1981-06-05 1984-10-31 Merck & Co Inc Perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives, process for preparing and pharmceutical composition containing the same
EP0072352B1 (de) * 1981-08-11 1986-03-05 Ciba-Geigy Ag Benzazepin-2-one, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese Verbindungen enthalten, sowie die Verbindungen zur therapeutischen Verwendung
JPS5829779A (ja) * 1981-08-17 1983-02-22 Nippon Iyakuhin Kogyo Kk Ｎ−アミノアルキル−１，５−ベンゾチアゼピン誘導体の製造法
US4477464A (en) * 1983-02-10 1984-10-16 Ciba-Geigy Corporation Hetero-benzazepine derivatives and their pharmaceutical use
US4460579A (en) * 1983-02-28 1984-07-17 E. R. Squibb & Sons, Inc. Thiazine and thiazepine containing compounds
DE3423743A1 (de) * 1983-06-29 1985-01-10 Mitsui Toatsu Chemicals, Inc., Tokio/Tokyo Benzothiazepin-derivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
FI82455C (fi) 1991-03-11
ES8602699A1 (es) 1985-12-01
EP0125056B1 (en) 1991-01-16
FI841590A (fi) 1984-10-23
NZ207915A (en) 1986-10-08
AU565188B2 (en) 1987-09-10
IL71617A (en) 1988-05-31
ES531740A0 (es) 1985-12-01
NO162235C (no) 1989-11-29
KR840008346A (ko) 1984-12-14
AU2709284A (en) 1984-10-25
ATE60061T1 (de) 1991-02-15
HU193008B (en) 1987-08-28
PT78454A (en) 1984-05-01
FI82455B (fi) 1990-11-30
FI841590A0 (fi) 1984-04-19
US4564612A (en) 1986-01-14
ES544748A0 (es) 1986-07-16
DE3483920D1 (de) 1991-02-21
KR910007965B1 (ko) 1991-10-04
NO841555L (no) 1984-10-23
EP0125056A3 (en) 1986-04-16
EP0125056A2 (en) 1984-11-14
IE840927L (en) 1984-10-22
HUT34176A (en) 1985-02-28
NO162235B (no) 1989-08-21
IL71617A0 (es) 1984-07-31
PH21294A (en) 1987-09-28
IE57599B1 (en) 1993-01-27
CA1209993A (en) 1986-08-19
GR79905B (es) 1984-10-31
PT78454B (en) 1986-08-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519