ES8608490A1 - Procedimiento de obtencion de una preparacion farmaceutica en forma de liberacion lenta y que comprende pinacidil (n'-ciano-n-4-piridil-n'-1, 2, 2-trimetil-propilguanidina), opcionalmente junto con otros componentes - Google Patents

Procedimiento de obtencion de una preparacion farmaceutica en forma de liberacion lenta y que comprende pinacidil (n'-ciano-n-4-piridil-n'-1, 2, 2-trimetil-propilguanidina), opcionalmente junto con otros componentes

Info

Publication number
ES8608490A1
ES8608490A1 ES529660A ES529660A ES8608490A1 ES 8608490 A1 ES8608490 A1 ES 8608490A1 ES 529660 A ES529660 A ES 529660A ES 529660 A ES529660 A ES 529660A ES 8608490 A1 ES8608490 A1 ES 8608490A1
Authority
ES
Spain
Prior art keywords
pinacidil
balls
slow release
coating
piridil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529660A
Other languages
English (en)
Spanish (es)
Other versions
ES529660A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Publication of ES529660A0 publication Critical patent/ES529660A0/es
Publication of ES8608490A1 publication Critical patent/ES8608490A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
ES529660A 1983-02-11 1984-02-10 Procedimiento de obtencion de una preparacion farmaceutica en forma de liberacion lenta y que comprende pinacidil (n'-ciano-n-4-piridil-n'-1, 2, 2-trimetil-propilguanidina), opcionalmente junto con otros componentes Expired ES8608490A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK0589/83A DK58983D0 (da) 1983-02-11 1983-02-11 Farmaceutisk praeparat

Publications (2)

Publication Number Publication Date
ES529660A0 ES529660A0 (es) 1986-06-16
ES8608490A1 true ES8608490A1 (es) 1986-06-16

Family

ID=8095276

Family Applications (1)

Application Number Title Priority Date Filing Date
ES529660A Expired ES8608490A1 (es) 1983-02-11 1984-02-10 Procedimiento de obtencion de una preparacion farmaceutica en forma de liberacion lenta y que comprende pinacidil (n'-ciano-n-4-piridil-n'-1, 2, 2-trimetil-propilguanidina), opcionalmente junto con otros componentes

Country Status (15)

Country Link
US (1) US4600577A (en:Method)
JP (1) JPS59155312A (en:Method)
BE (1) BE898882A (en:Method)
DE (1) DE3404595A1 (en:Method)
DK (1) DK58983D0 (en:Method)
ES (1) ES8608490A1 (en:Method)
FR (1) FR2540727B1 (en:Method)
GB (1) GB2134785B (en:Method)
IE (1) IE56604B1 (en:Method)
IT (1) IT1196682B (en:Method)
NL (1) NL8400430A (en:Method)
NZ (1) NZ207010A (en:Method)
PH (1) PH21734A (en:Method)
SE (1) SE447871B (en:Method)
ZA (1) ZA84856B (en:Method)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS604120A (ja) * 1983-06-22 1985-01-10 Shionogi & Co Ltd 作用持続型ピナシジル製剤
US5286494A (en) * 1986-07-02 1994-02-15 Schering Aktiengesellschaft Medicinal agents with sustained action
US4861598A (en) * 1986-07-18 1989-08-29 Euroceltique, S.A. Controlled release bases for pharmaceuticals
EP0302595B1 (en) * 1987-07-07 1994-02-02 Beecham Group Plc Pinacidil for treatment of pulmonary hypertension or right heart failure
US5009894A (en) * 1988-03-07 1991-04-23 Baker Cummins Pharmaceuticals, Inc. Arrangement for and method of administering a pharmaceutical preparation
DE3822095A1 (de) * 1988-06-30 1990-01-04 Klinge Co Chem Pharm Fab Neue arzneimittelformulierung sowie verfahren zu deren herstellung
IT1246382B (it) * 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
US5328697A (en) * 1992-02-10 1994-07-12 Mallinckrodt Veterinary, Inc. Compositions and processes for the sustained release of drugs
MXPA01007463A (es) 1999-01-29 2002-06-04 Losan Pharma Gmbh Composiciones farmaceuticas.
US6210716B1 (en) * 1999-02-26 2001-04-03 Andrx Pharmaceuticals, Inc. Controlled release bupropion formulation
WO2000067754A1 (en) 1999-05-12 2000-11-16 Nitromed, Inc. Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
EP1248599B1 (de) * 2001-01-31 2007-12-05 Evonik Röhm GmbH Multipartikuläre arzneiform, enthaltend mindestens zwei unterschiedlich überzogene pelletformen
EP1768668A2 (en) 2004-06-16 2007-04-04 Tap Pharmaceutical Products, Inc. Multiple ppi dosage form
CN104069088A (zh) 2007-10-12 2014-10-01 武田制药北美公司 与食物摄入无关的治疗胃肠病症的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1489879A (en) * 1974-12-20 1977-10-26 Leo Pharm Prod Ltd N'-cyano-n'-3-pyridylguanidines
JPS54129115A (en) * 1978-03-31 1979-10-06 Yasuyo Miyauchi Long acting amoxycilin preparation
FR2453639A1 (fr) * 1979-04-09 1980-11-07 Sanofi Sa Composition medicamenteuse a liberation programmee immediate-retard a base de naftidrofuryl
DE3000979A1 (de) * 1980-01-12 1981-07-23 Dr. Karl Thomae Gmbh, 7950 Biberach Neue dipyridamol-retardformen und verfahren zu ihrer herstellung
FR2477015A1 (fr) * 1980-03-03 1981-09-04 Fabre Sa Pierre Composition pharmaceutique a base d'un alcaloide de l'ergot de seigle, a activite regulatrice sur le tonus vasculaire
JPS6056122B2 (ja) * 1980-05-21 1985-12-09 塩野義製薬株式会社 徐放性製剤
EP0052075A1 (de) * 1980-11-12 1982-05-19 Ciba-Geigy Ag Körnige Arzneimittel-Retardform
DE3127984A1 (de) * 1981-07-15 1983-02-03 Klinge Pharma GmbH, 8000 München Orale arzneimittel fuer die kariesprophylaxe

Also Published As

Publication number Publication date
GB2134785B (en) 1986-07-02
SE447871B (sv) 1986-12-22
SE8400723L (sv) 1984-08-12
ZA84856B (en) 1984-09-26
IE840146L (en) 1984-08-11
IT1196682B (it) 1988-11-25
JPS59155312A (ja) 1984-09-04
PH21734A (en) 1988-02-10
DE3404595C2 (en:Method) 1993-04-29
NZ207010A (en) 1987-06-30
DE3404595A1 (de) 1984-08-16
JPH0451528B2 (en:Method) 1992-08-19
ES529660A0 (es) 1986-06-16
SE8400723D0 (sv) 1984-02-10
IT8467131A1 (it) 1985-08-13
US4600577A (en) 1986-07-15
BE898882A (fr) 1984-08-10
IE56604B1 (en) 1991-10-09
GB8403572D0 (en) 1984-03-14
FR2540727A1 (fr) 1984-08-17
NL8400430A (nl) 1984-09-03
FR2540727B1 (fr) 1987-01-23
IT8467131A0 (it) 1984-02-13
GB2134785A (en) 1984-08-22
DK58983D0 (da) 1983-02-11

Similar Documents

Publication Publication Date Title
ES8608490A1 (es) Procedimiento de obtencion de una preparacion farmaceutica en forma de liberacion lenta y que comprende pinacidil (n'-ciano-n-4-piridil-n'-1, 2, 2-trimetil-propilguanidina), opcionalmente junto con otros componentes
IT1221012B (it) Polimeri caricati con farmaci con migliorate solubilita' e biodisponibilita',procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
NO863997D0 (no) Fremgangsmaate for fremstilling av et farmasoeytisk preparat
JPH0220606B2 (en:Method)
FR2530953B1 (fr) Emulsion perfluoro-chimique utilisable comme sang artificiel et procede pour sa preparation
DK337383D0 (da) Fremgangsmade til fremstilling af 4-amino-6,7-dimethoxyquinolin-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
NO158627C (no) Polymerisasjonsdyktig eller "levende" acryl-, maleimid- eller acryl-maleimidpolymer, fremgangsmaate for fremstillingav polymeren og anvendelse av samme i form av opploesninger, filmer eller fibere.
DE3880762D1 (de) Orale, acetaminophen enthaltende zusammensetzung mit gesteuerter arzneistoff-freisetzung und verfahren zu ihrer herstellung.
MX159928A (es) Procedimiento para revestir medicamentos
ATE69725T1 (de) Pharmazeutische zubereitungen von acrivastine.
ES521763A0 (es) Procedimiento para la preparacion de derivados de acido (2-nitro-5-ariloxi-fenilamino)-alquil-fosfonico,fosfinico y fosfonoso.
DK266486D0 (da) Quinoloncarboxylsyreestere eller farmaceutisk anvendelige hydratereller syreadditionssalte deraf, deres fremstilling og anvendelse
ES462418A1 (es) Un procedimiento para la preparacion de composiciones biolo-gicamente activas.
ES544649A0 (es) Procedimiento para la preparacion de etofibrato o compuestossimilares que contienen microgranulos de liberacion constan-te
FI832884A7 (fi) Desoksiuridiini-johdannaiset, niiden valmistusmenetelmät ja käyttö farmaseuttisina aineina.
IT1222412B (it) Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
DE68900485D1 (de) Derivate von phenoxyalkylcarbonsauere und verfahren zu ihrer herstellung.
IT8719065A0 (it) Polimeri acrilici immidizzati eprocedimento per la loro preparazione.
IT8720389A0 (it) Esteri retinoici di antibiotici, loro procedimento di preparazione e composizioni farmaceutiche e cosmetiche che li contengono.
FI854178A7 (fi) 1,2,4-triatsolo-karbamaatti ja sen happoadditiosuolat, näiden valmistusmenetelmät ja lääkeaineet.
DK573788A (da) Quinolinderivater eller farmaceutiske acceptable estere eller salte deraf, deres fremstilling og anvendelse
ATE33639T1 (de) Diniflumatsalze von vifluminsaeuremorpholinoethylestern, verfahren zu ihrer herstellung und ihre verwendung in analgetischen und antiinflammatorischen heilmitteln.
FI880210L (fi) Menetelmä valmistaa peroraalista stabiloitua, tehoainetta hidastetusti ja kontrolloidusti vapauttavaa, lääkevalmistetta
DE3577443D1 (de) Derivate von dihydroorotsaeure, deren verfahren zur herstellung und deren pharmazeutische zusammensetzungen.
DK688888A (da) Substituerede 1,4-dihydro-4-oxoquinolin-3-carboxylsyrer, farmaceutisk acceptable estre eller salte deraf, deres fremstilling og anvendelse