ATE15971T1 - Serpentin, alstonin und sempervirin, medikamente, die die tumor- und krebszellen spezifisch hemmen. - Google Patents
Serpentin, alstonin und sempervirin, medikamente, die die tumor- und krebszellen spezifisch hemmen.Info
- Publication number
- ATE15971T1 ATE15971T1 AT81400374T AT81400374T ATE15971T1 AT E15971 T1 ATE15971 T1 AT E15971T1 AT 81400374 T AT81400374 T AT 81400374T AT 81400374 T AT81400374 T AT 81400374T AT E15971 T1 ATE15971 T1 AT E15971T1
- Authority
- AT
- Austria
- Prior art keywords
- cellulose
- sempervirin
- alstonin
- serpentin
- medications
- Prior art date
Links
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 title abstract 5
- UQVUEULZDJRMJR-UHFFFAOYSA-N Sempervirine Chemical compound C1=CC2=C3C=CC=CC3=NC2=C2N1C=C1CCCCC1=C2 UQVUEULZDJRMJR-UHFFFAOYSA-N 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 2
- 201000011510 cancer Diseases 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- QEVHRUUCFGRFIF-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 QEVHRUUCFGRFIF-MDEJGZGSSA-N 0.000 title 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 2
- 239000001913 cellulose Substances 0.000 abstract 2
- 229920002678 cellulose Polymers 0.000 abstract 2
- 235000010980 cellulose Nutrition 0.000 abstract 2
- BAALMEGRQMMBJQ-UHFFFAOYSA-O 3-ethyl-12h-indolo[2,3-a]quinolizin-5-ium Chemical compound N1C2=CC=CC=C2C2=C1C1=CC=C(CC)C=[N+]1C=C2 BAALMEGRQMMBJQ-UHFFFAOYSA-O 0.000 abstract 1
- 229920002284 Cellulose triacetate Polymers 0.000 abstract 1
- 239000001856 Ethyl cellulose Substances 0.000 abstract 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract 1
- BAALMEGRQMMBJQ-UHFFFAOYSA-N Flavopereirine Natural products N1=C2C=CC=CC2=C2C1=C1C=CC(CC)=CN1C=C2 BAALMEGRQMMBJQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000001828 Gelatine Substances 0.000 abstract 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- 229920001800 Shellac Polymers 0.000 abstract 1
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 abstract 1
- 235000010489 acacia gum Nutrition 0.000 abstract 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 150000003797 alkaloid derivatives Chemical class 0.000 abstract 1
- QVBOOBQEGOUUGN-RCBQFDQVSA-N alstonine Chemical compound C1=C[CH]C2=NC3=C(C[C@@H]4C(C(=O)OC)=CO[C@@H](C)[C@@H]4C4)[N+]4=CC=C3C2=C1 QVBOOBQEGOUUGN-RCBQFDQVSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000019325 ethyl cellulose Nutrition 0.000 abstract 1
- 229920001249 ethyl cellulose Polymers 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 abstract 1
- 229920005615 natural polymer Polymers 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920002285 poly(styrene-co-acrylonitrile) Polymers 0.000 abstract 1
- -1 polyoxyethylene Polymers 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- QGSZPWIANAPIKL-UHFFFAOYSA-N sempervirine Natural products C1CC=C2C=C3N(CC=C4C3=Nc5ccccc45)C=C2C1 QGSZPWIANAPIKL-UHFFFAOYSA-N 0.000 abstract 1
- 239000004208 shellac Substances 0.000 abstract 1
- 235000013874 shellac Nutrition 0.000 abstract 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 abstract 1
- 229940113147 shellac Drugs 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229920001059 synthetic polymer Polymers 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
- AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical class N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP81400374A EP0059817B1 (de) | 1981-03-11 | 1981-03-11 | Serpentin, Alstonin und Sempervirin, Medikamente, die die Tumor- und Krebszellen spezifisch hemmen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE15971T1 true ATE15971T1 (de) | 1985-10-15 |
Family
ID=8188503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT81400374T ATE15971T1 (de) | 1981-03-11 | 1981-03-11 | Serpentin, alstonin und sempervirin, medikamente, die die tumor- und krebszellen spezifisch hemmen. |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0059817B1 (de) |
| AT (1) | ATE15971T1 (de) |
| DE (1) | DE3172570D1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2534139B1 (fr) * | 1982-10-07 | 1986-08-29 | Laruelle Claude | Nouvelle forme galenique du sulpiride, son procede de preparation et medicament comprenant cette nouvelle forme |
| FR2639830B1 (fr) * | 1988-12-02 | 1991-03-22 | Beljanski Mirko | Composition antivirale et ses applications |
| FR2694693B1 (fr) * | 1992-07-28 | 1994-10-28 | Abrax Bio Labs Sa | Composition pharmaceutique à base de flavopéréirine et son utilisation dans un traitement contre le virus VIH. |
| FR2694193B1 (fr) * | 1992-07-28 | 1994-10-28 | Abraxas Bio Labs Sa | Méthode de cytodiagnostic utilisant l'alstonine comme marqueur sélectif et kit de diagnostic contenant ce marqueur. |
| FR2759293B1 (fr) * | 1997-02-11 | 1999-04-30 | Ethypharm Lab Prod Ethiques | Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie |
| CA2578549C (en) * | 2004-05-19 | 2014-09-02 | Natural Source International | Flavopereirine and alstonine combinations in the treatment and prevention of prostate cancer |
| ATE432933T1 (de) * | 2004-06-11 | 2009-06-15 | Dabur Pharma Ltd | Flavopereirinderivate zur krebstherapie |
| WO2016179184A2 (en) | 2015-05-04 | 2016-11-10 | Northwestern University | Enantioselective syntheses of heteroyohimbine natural product intermediates |
| JP7491514B2 (ja) * | 2018-03-31 | 2024-05-28 | モレキュラー インターナショナル リサーチ， インコーポレーテッド | 予防及び治療に有効な選択的抗がん剤 |
| CN113952462B (zh) * | 2021-11-18 | 2023-07-21 | 中南大学湘雅三医院 | 合成类纤维蛇纹石纳米材料的用途 |
| CN118634224B (zh) * | 2024-06-28 | 2025-10-17 | 大连医科大学附属第二医院 | 常绿钩吻碱在制备用于治疗前列腺癌的药物中的新用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB737310A (en) * | 1952-07-24 | 1955-09-21 | Ciba Ltd | Pharmaceutical preparations of reserpine |
| GB793808A (en) * | 1954-07-22 | 1958-04-23 | Frank Mario Bardani | Sustained action pill |
| FR1347413A (fr) * | 1963-01-29 | 1963-12-27 | Italnysco S P A | Sphérules ou globules à action étalée et procédé pour leur préparation |
| FR2450607A2 (fr) * | 1978-03-13 | 1980-10-03 | Beljanski Mirko | Composition pharmaceutique contenant comme principe actif la flavopereine |
| IT1115596B (it) * | 1978-03-13 | 1986-02-03 | Bayer Italia Spa | Metodo per la preparazione di microgranuli gastoresistenti ed enterosolubili di sostanze farmaceutiche,in particolare di sostanze proteiche e microgranuli preparati con detto metodo |
| FR2419725A1 (fr) * | 1978-03-13 | 1979-10-12 | Beljanski Mirko | Serpentine, alstonine et sempervirine, medicaments inhibant specifiquement les cellules cancereuses et tumorales |
-
1981
- 1981-03-11 EP EP81400374A patent/EP0059817B1/de not_active Expired
- 1981-03-11 AT AT81400374T patent/ATE15971T1/de not_active IP Right Cessation
- 1981-03-11 DE DE8181400374T patent/DE3172570D1/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3172570D1 (en) | 1985-11-14 |
| EP0059817A1 (de) | 1982-09-15 |
| EP0059817B1 (de) | 1985-10-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |