ES8606415A1 - Exteres mixtos de b -ciclodextrina solubles en agua - Google Patents
Exteres mixtos de b -ciclodextrina solubles en aguaInfo
- Publication number
- ES8606415A1 ES8606415A1 ES538639A ES538639A ES8606415A1 ES 8606415 A1 ES8606415 A1 ES 8606415A1 ES 538639 A ES538639 A ES 538639A ES 538639 A ES538639 A ES 538639A ES 8606415 A1 ES8606415 A1 ES 8606415A1
- Authority
- ES
- Spain
- Prior art keywords
- beta
- cyclodextrin
- alkyl
- soluble mixed
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920000858 Cyclodextrin Polymers 0.000 title abstract 3
- 239000001116 FEMA 4028 Substances 0.000 title abstract 3
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 title abstract 3
- 235000011175 beta-cyclodextrine Nutrition 0.000 title abstract 3
- 229960004853 betadex Drugs 0.000 title abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- CHIRNDVNGYBLFR-UHFFFAOYSA-N 2-propylperoxyethanol Chemical class CCCOOCCO CHIRNDVNGYBLFR-UHFFFAOYSA-N 0.000 abstract 1
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 abstract 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- NEHMKBQYUWJMIP-NJFSPNSNSA-N chloro(114C)methane Chemical compound [14CH3]Cl NEHMKBQYUWJMIP-NJFSPNSNSA-N 0.000 abstract 1
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 abstract 1
- 229940106681 chloroacetic acid Drugs 0.000 abstract 1
- 125000001033 ether group Chemical group 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE ETERES MIXTOS DE BCICLODEXTRINA, SOLUBLES EN AGUA, CON SUSTITUYENTES ETEREOS SELECCIONADOS DEL GRUPO FORMADO POR ALQUILO C1,2, HIDROXIALQUILO C2-4 Y CARBOXIALQUILO C1,2. CONSISTE EN HACER REACCIONAR B-CICLODEXTRINA POR LO MENOS CON DOS AGENTES ETERIFICANTES ALQUILANTES, HIDROXIALQUILANTES O CARBOXIALQUILANTES DIFERENTES, EN UN MEDIO DE REACCION LIQUIDO, ALCALINO, QUE CONTIENE UN HIDROXIDO DE METAL ALCALINO, AGUA Y, OPCIONALMENTE, POR LO MENOS UN DISOLVENTE ORGANICO. DE APLICACION EN LA PRODUCCION DE COMPUESTOS DE INCLUSION O ELEMENTOS CRISTALINOS LIQUIDOS, Y TAMBIEN COMO COMPUESTO INTERMEDIO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3345780 | 1983-12-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8606415A1 true ES8606415A1 (es) | 1986-04-01 |
ES538639A0 ES538639A0 (es) | 1986-04-01 |
Family
ID=6217295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES538639A Expired ES8606415A1 (es) | 1983-12-17 | 1984-12-14 | Exteres mixtos de b -ciclodextrina solubles en agua |
Country Status (6)
Country | Link |
---|---|
US (1) | US4582900A (es) |
EP (1) | EP0146841A3 (es) |
JP (1) | JPS60152503A (es) |
BR (1) | BR8406416A (es) |
CA (1) | CA1235691A (es) |
ES (1) | ES8606415A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62112602A (ja) * | 1985-11-12 | 1987-05-23 | Kao Corp | エ−テル化シクロデキストリンの精製法 |
US4920214A (en) * | 1986-04-16 | 1990-04-24 | American Maize-Products Company | Process for producing modified cyclodextrins |
HU201783B (en) * | 1987-10-13 | 1990-12-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing partially methylized carboxy-acyl-beta-cyclodextrines and salts |
US5760015A (en) * | 1988-01-19 | 1998-06-02 | The Trustees Of The University Of Pennsylvania | Cyclodextrin compounds and methods of making and use thereof |
US5637575A (en) * | 1988-01-19 | 1997-06-10 | The Trustees Of The University Of Pennsylvania | Methods of inhibiting restenosis |
US5658894A (en) * | 1989-04-23 | 1997-08-19 | The Trustees Of The University Of Pennsylvania | Compositions for inhibiting restenosis |
US5183809A (en) * | 1990-02-15 | 1993-02-02 | The Trustees Of The University Of Pennsylvania/Childrens Hospital Corporation | Cyclodextrin polymers and cyclodextrins immobilized on a solid surface |
DE3810737A1 (de) * | 1988-03-30 | 1989-10-12 | Macherey Nagel Gmbh & Co Kg | Substituierte cyclodextrine |
US5096893A (en) * | 1989-04-03 | 1992-03-17 | The United States Of America As Represented By The Department Of Health And Human Services | Regioselective substitutions in cyclodextrins |
DE69032370T2 (de) * | 1989-04-03 | 1998-10-29 | Janssen Pharmaceutica N.V., Beerse | Regioselektive substitutionen von cyclodextrinen |
US5173481A (en) * | 1989-04-03 | 1992-12-22 | The United States Of America As Represented By The Department Of Health And Human Services | Preparation of specifically substituted cyclodextrins |
US5441944A (en) * | 1989-04-23 | 1995-08-15 | The Trustees Of The University Of Pennsylvania | Substituted cyclodextrin sulfates and their uses as growth modulating agents |
KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
DE4009840A1 (de) * | 1990-03-27 | 1991-10-02 | Consortium Elektrochem Ind | Cyclodextrin-polymerisate und verfahren zu deren herstellung |
EP0485614B1 (en) * | 1990-05-21 | 1997-08-13 | Toppan Printing Co., Ltd. | Cyclodextrin derivative |
IL100856A (en) * | 1991-02-15 | 1998-03-10 | Janssen Pharmaceutica Nv | History of carboxyl (alkyloxyalkyl of cyclodextrins, their preparation and pharmaceutical preparations containing them |
US5446030A (en) * | 1991-09-19 | 1995-08-29 | Weisz; Paul B. | Prevention of hemolysis |
US5684169A (en) * | 1992-11-27 | 1997-11-04 | Ensuiko Sugar Refining Co., Ltd. | Cyclodextrin inclusion complex of taxol, and method for its production and its use |
AU6553994A (en) * | 1993-03-31 | 1994-10-24 | Trustees Of The University Of Pennsylvania, The | Methods of affecting the growth of living tissue in mammals and compounds and compositions therefor |
DE4428654A1 (de) * | 1994-08-12 | 1996-02-15 | Consortium Elektrochem Ind | Wasserlösliche Cyclodextrinderivate mit lipophilen Substituenten und Verfahren zu ihrer Herstellung |
DE4440236A1 (de) * | 1994-11-10 | 1996-05-15 | Wacker Chemie Gmbh | Redispergierbare Polymerpulver-Zusammensetzung enthaltend Cyclodextrine oder Cyclodextrin-Derivate |
KR100435426B1 (ko) * | 1996-11-29 | 2004-08-16 | 주식회사 포스코 | 구조 이성질체의 분리에 유용한 6-디메틸옥틸실릴-2,3-디에틸-베타-시클로덱스트린 및 그 제조방법 |
KR100411289B1 (ko) * | 1996-11-29 | 2004-02-14 | 주식회사 포스코 | 회전장애 이성질체의 분리에 유용한 6-알릴디메틸실릴-2,3-디에 틸-베타-시클로덱스트린 및 그 제조방법 |
US5874418A (en) * | 1997-05-05 | 1999-02-23 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use |
KR20040019299A (ko) * | 2001-06-29 | 2004-03-05 | 바이오비트럼 에이비 | 대량 오토클레이빙 방법 |
DE10132506A1 (de) | 2001-07-05 | 2003-01-23 | Wacker Polymer Systems Gmbh | Lösungsmittelfrei herstellbare Beschichtungsmittel für verschmutzungsresistente Beschichtungen |
US6962944B2 (en) | 2001-07-31 | 2005-11-08 | Arqule, Inc. | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
US7074824B2 (en) * | 2001-07-31 | 2006-07-11 | Arqule, Inc. | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
AU2004285032A1 (en) * | 2003-10-31 | 2005-05-12 | The University Of Kansas | Sulfoalkyl ether-alkyl ether cyclodextrin derivatives |
US8492538B1 (en) | 2009-06-04 | 2013-07-23 | Jose R. Matos | Cyclodextrin derivative salts |
CN103554307B (zh) * | 2013-09-25 | 2017-01-11 | 南京师范大学 | 羧甲基‑羟丙基‑β‑环糊精及其制备方法 |
JP2019163344A (ja) * | 2016-07-25 | 2019-09-26 | 国立大学法人 東京大学 | 擬ポリロタキサン、ポリロタキサン、及びそれらの製造方法 |
CN111690079B (zh) * | 2020-07-21 | 2021-12-24 | 山东滨州智源生物科技有限公司 | 甲基倍他环糊精的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE676197C (de) * | 1937-01-05 | 1939-05-27 | I G Farbenindustrie Akt Ges | Verfahren zur Herstellung von stickstoff- und schwefelhaltigen Erzeugnissen aus Alkyleniminen und Schwefelkohlenstoff |
NL237283A (es) * | 1958-03-24 | |||
US3459731A (en) * | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
US3453257A (en) * | 1967-02-13 | 1969-07-01 | Corn Products Co | Cyclodextrin with cationic properties |
US3426011A (en) * | 1967-02-13 | 1969-02-04 | Corn Products Co | Cyclodextrins with anionic properties |
US3453258A (en) * | 1967-02-20 | 1969-07-01 | Corn Products Co | Reaction products of cyclodextrin and unsaturated compounds |
JPS602343B2 (ja) * | 1976-02-06 | 1985-01-21 | 石井 英機 | ライオトロピック型コレステリック液晶相組成物およびそれを含む素子 |
HU181703B (en) * | 1980-05-09 | 1983-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing aqueus solutuins of water insoluble or hardly soluble vitamines, steroides, localanesthetics, prostanoides and non-steroid and antiphlogistic agents |
HU181733B (en) * | 1980-08-07 | 1983-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing sorbents containing cyclodextrin on cellulose base |
JPS5941645B2 (ja) * | 1980-09-04 | 1984-10-08 | 敷島紡績株式会社 | ヒドロキシアルキル化澱粉又はデキストリンの製造方法 |
JPS58210901A (ja) * | 1982-06-01 | 1983-12-08 | Kao Corp | シクロデキストリン誘導体およびその製造方法 |
JPS6057898B2 (ja) * | 1982-08-05 | 1985-12-17 | 工業技術院長 | 包接作用を有する陽イオン交換体及びその製造方法 |
-
1984
- 1984-12-04 EP EP84114767A patent/EP0146841A3/de not_active Ceased
- 1984-12-14 BR BR8406416A patent/BR8406416A/pt unknown
- 1984-12-14 US US06/682,414 patent/US4582900A/en not_active Expired - Fee Related
- 1984-12-14 ES ES538639A patent/ES8606415A1/es not_active Expired
- 1984-12-14 CA CA000470113A patent/CA1235691A/en not_active Expired
- 1984-12-17 JP JP59264677A patent/JPS60152503A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JPS60152503A (ja) | 1985-08-10 |
EP0146841A3 (de) | 1986-11-20 |
US4582900A (en) | 1986-04-15 |
BR8406416A (pt) | 1985-10-08 |
ES538639A0 (es) | 1986-04-01 |
CA1235691A (en) | 1988-04-26 |
EP0146841A2 (de) | 1985-07-03 |
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