ES8603832A1 - Procedimiento para la obtencion de 1-fenil-3-azabiciclo (3,1,0)hexan-2,4-dionas - Google Patents

Procedimiento para la obtencion de 1-fenil-3-azabiciclo (3,1,0)hexan-2,4-dionas

Info

Publication number
ES8603832A1
ES8603832A1 ES543430A ES543430A ES8603832A1 ES 8603832 A1 ES8603832 A1 ES 8603832A1 ES 543430 A ES543430 A ES 543430A ES 543430 A ES543430 A ES 543430A ES 8603832 A1 ES8603832 A1 ES 8603832A1
Authority
ES
Spain
Prior art keywords
compounds
hydrogen
preparing
pharmaceutical preparations
preparations containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543430A
Other languages
English (en)
Other versions
ES543430A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES543430A0 publication Critical patent/ES543430A0/es
Publication of ES8603832A1 publication Critical patent/ES8603832A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/55—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 1-FENIL-3-AZABICICLO3.1.0HEXAN-2,4-DIONAS SUSTITUIDAS. CONSISTE EN CICLIZAR UN COMPUESTO DE FORMULA (II) MEDIANTE REACCION CON UN COMPUESTO SUMINISTRADOR DEL GRUPO IN-R1, PARA OBTENER 1-FENIL-3-AZABICICLO3.1.0HEXAN-2,4-DIONAS SUSTITUIDAS DE FORMULA (I) DONDE R1 ES H; R2 ES H, SULFO O ACILO; Y R3 ES H O R1 ES UN RESTO HIDROCARBURO SATURADO O INSATURADO, ALIFATICO O CICLOALIFATICO O CICLOALIFATICO-ALIFATICO HASTA 18, R2 ES H, ALQUILO INFERIOR, SULFO O ACILO Y R3 ES H O ALQUILO INFERIOR. LA REACCION SE EFECTUA EN UN DISOLVENTE POLAR INERTE, COMO BENCENO, TOLUENO Y OTROS Y A UNA TEMPERATURA DE C20 A 80JC. TIENEN APLICACIONES FARMACOLOGICAS COMO INHIBIDORES DE LA AROMATASA.
ES543430A 1982-12-21 1985-05-23 Procedimiento para la obtencion de 1-fenil-3-azabiciclo (3,1,0)hexan-2,4-dionas Expired ES8603832A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH745082 1982-12-21

Publications (2)

Publication Number Publication Date
ES543430A0 ES543430A0 (es) 1986-01-01
ES8603832A1 true ES8603832A1 (es) 1986-01-01

Family

ID=4325317

Family Applications (3)

Application Number Title Priority Date Filing Date
ES528179A Granted ES528179A0 (es) 1982-12-21 1983-12-19 Procedimiento para la obtencion de 1-fenil-3-azabiciclo(3,1,0)-hexan-2,4-dionas sustituidas
ES543430A Expired ES8603832A1 (es) 1982-12-21 1985-05-23 Procedimiento para la obtencion de 1-fenil-3-azabiciclo (3,1,0)hexan-2,4-dionas
ES543431A Expired ES8607941A1 (es) 1982-12-21 1985-05-23 Procedimiento para la obtencion de 1-fenil-3-azabiciclo (3,1,0)hexan-2,4-dionas sustituidas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES528179A Granted ES528179A0 (es) 1982-12-21 1983-12-19 Procedimiento para la obtencion de 1-fenil-3-azabiciclo(3,1,0)-hexan-2,4-dionas sustituidas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES543431A Expired ES8607941A1 (es) 1982-12-21 1985-05-23 Procedimiento para la obtencion de 1-fenil-3-azabiciclo (3,1,0)hexan-2,4-dionas sustituidas

Country Status (23)

Country Link
US (1) US4839379A (es)
EP (1) EP0114033B1 (es)
JP (1) JPS59118748A (es)
KR (1) KR900009007B1 (es)
AR (2) AR241590A1 (es)
AT (1) ATE37871T1 (es)
AU (1) AU565914B2 (es)
CA (1) CA1208649A (es)
DD (1) DD222306A5 (es)
DE (1) DE3378208D1 (es)
DK (1) DK165977C (es)
ES (3) ES528179A0 (es)
FI (1) FI79838C (es)
GR (1) GR81359B (es)
HK (1) HK24291A (es)
HU (1) HU192836B (es)
IE (1) IE56421B1 (es)
IL (1) IL70478A (es)
NO (1) NO163529C (es)
NZ (1) NZ206654A (es)
PH (1) PH22052A (es)
PT (1) PT77857B (es)
ZA (1) ZA839437B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3578608D1 (de) * 1984-06-20 1990-08-16 Ciba Geigy Ag Substituierte azabicycloheptane, ihre verwendung, pharmazeutische praeparate, welche diese verbindungen enthalten, und verfahren zur herstellung dieser verbindungen.
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
AU2869092A (en) * 1991-10-11 1993-05-03 Smithkline Beecham Corporation Heterocyclic 3-phenylpyrrolidin-2-ones, their preparation and use for the manufacture of a medicament for inhibiting tumor necrosis factor production
US5511916A (en) * 1991-12-06 1996-04-30 Aldon Pattern, Inc. Shipping container for dunnage
EP1773320A1 (en) * 2004-07-22 2007-04-18 Wyeth Method for treating nervous system disorders and conditions
WO2006012477A1 (en) * 2004-07-22 2006-02-02 Wyeth Method for treating nervous system disorders and conditions
CA2574315A1 (en) * 2004-07-22 2006-02-02 Wyeth Method for treating nervous system disorders and conditions
JP2009502798A (ja) * 2005-07-21 2009-01-29 ワイス 神経系障害および状態の処置方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE548074A (es) *
US2673205A (en) * 1951-02-13 1954-03-23 Ciba Pharm Prod Inc 3-disubstituted dioxopiperidines and the manufacture thereof
US2848455A (en) * 1955-07-18 1958-08-19 Ciba Pharm Prod Inc Alpha-(p-amino-phenyl)-alpha-lower alkyl glutarimides
GB1015618A (en) * 1962-04-10 1966-01-05 Aspro Nicholas Ltd Glutarimide therapeutic compositions
US3166571A (en) * 1962-06-06 1965-01-19 American Cyanamid Co 1-phenyl-1, 2-cyclopropane dicarboximides
US3621012A (en) * 1969-08-18 1971-11-16 Union Carbide Corp Oxidation of lactams to cyclic imides
US4164404A (en) * 1973-06-25 1979-08-14 American Cyanamid Company Dithiindicarboximide, dithiolanedicarboximide, thiapyrandicarboximide and pyrandicarboximide derivatives as plant growth regulants
US4231935A (en) * 1975-07-31 1980-11-04 American Cyanamid Company 1-Phenyl-3-azabicyclo[3.1.0]hexanes
US4131611A (en) * 1975-07-31 1978-12-26 American Cyanamid Company Azabicyclohexanes
IL65843A (en) * 1977-08-11 1986-12-31 American Cyanamid Co Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type
US4322416A (en) * 1980-06-27 1982-03-30 Merrell Dow Pharmaceuticals Inc. 10-Alkynyl steroids
US4289762A (en) * 1980-06-27 1981-09-15 Merrell Dow Pharmaceuticals Inc. 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors
DE3121153A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen "verwendung von aromatase-hemmern zur prophylaxe und therapie der prostatahyperplasie"
US4435419A (en) * 1981-07-01 1984-03-06 American Cyanamid Company Method of treating depression using azabicyclohexanes
DE3578608D1 (de) * 1984-06-20 1990-08-16 Ciba Geigy Ag Substituierte azabicycloheptane, ihre verwendung, pharmazeutische praeparate, welche diese verbindungen enthalten, und verfahren zur herstellung dieser verbindungen.

Also Published As

Publication number Publication date
ES543430A0 (es) 1986-01-01
PH22052A (en) 1988-05-13
FI834663A (fi) 1984-06-22
ATE37871T1 (de) 1988-10-15
ZA839437B (en) 1984-07-25
IL70478A0 (en) 1984-03-30
HUT34444A (en) 1985-03-28
AU2270483A (en) 1984-06-28
ES543431A0 (es) 1986-06-01
NO834710L (no) 1984-06-22
PT77857A (de) 1984-01-01
IE833006L (en) 1984-06-21
DE3378208D1 (en) 1988-11-17
FI834663A0 (fi) 1983-12-19
DK586283D0 (da) 1983-12-20
JPS59118748A (ja) 1984-07-09
IL70478A (en) 1987-09-16
AR241590A1 (es) 1992-09-30
DD222306A5 (de) 1985-05-15
DK165977C (da) 1993-07-26
CA1208649A (en) 1986-07-29
DK165977B (da) 1993-02-22
EP0114033B1 (de) 1988-10-12
PT77857B (de) 1986-04-21
NO163529B (no) 1990-03-05
IE56421B1 (en) 1991-07-31
FI79838C (fi) 1990-03-12
EP0114033A1 (de) 1984-07-25
AR241421A1 (es) 1992-07-31
US4839379A (en) 1989-06-13
ES8601130A1 (es) 1985-11-01
ES528179A0 (es) 1985-11-01
KR900009007B1 (ko) 1990-12-17
HU192836B (en) 1987-07-28
AU565914B2 (en) 1987-10-01
ES8607941A1 (es) 1986-06-01
NO163529C (no) 1990-06-13
GR81359B (es) 1984-12-11
FI79838B (fi) 1989-11-30
HK24291A (en) 1991-04-04
DK586283A (da) 1984-06-22
KR840006966A (ko) 1984-12-04
NZ206654A (en) 1987-01-23

Similar Documents

Publication Publication Date Title
DE3662038D1 (en) Benzonaphthalenic derivatives, process for their preparation and their use in pharmacy and cosmetics
ZA796651B (en) New amino-pyrimidine-carbanilides, processes for their preparation, medicaments containing these compounds and their use and also diamino-pyrimidinecarbanilides and processes for their preparation
ES8304969A1 (es) Procedimiento para la obtencion de 2-aril-3,4-diazabiciclo 4.n.0-alq-2-en-5-onas.
ES8607941A1 (es) Procedimiento para la obtencion de 1-fenil-3-azabiciclo (3,1,0)hexan-2,4-dionas sustituidas
ES8103071A1 (es) Procedimiento de preparacion de nuevos derivados aminicos del benzotiazol
DE3571130D1 (en) Isoxazole derivatives, process for their preparation, and pharmaceuticals containing these compounds
DE3261515D1 (en) Benzopyranyl ethers, process for their preparation and medicine containing those compounds and intermediates
AU584098B2 (en) Substituted azabicycloheptanes, the use thereof, pharmaceutical preparations that contain these compounds, and processes for the manufacture of these compounds
DE2962856D1 (en) Hexahydro-1,4-oxazepines, process for their preparation and pharmaceutical compositions containing them
DE3362876D1 (en) Dibenzocycloheptenylidene compounds for use in modulating the immune response
ES8303405A1 (es) Procedimiento de preparacion de derivados de quinidina.
DE3262706D1 (en) Oximes of 3"'-dehydro-cardenolide-tridigitoxosides, process for their preparation and their use as medicaments
IL58502A0 (en) 1,4-cycloalkano-oxazepines their production and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303