ES8603477A1 - Procedimiento para preparar una 1h-imidazo (4, 5-c) quinolin-4-amina - Google Patents

Procedimiento para preparar una 1h-imidazo (4, 5-c) quinolin-4-amina

Info

Publication number
ES8603477A1
ES8603477A1 ES537677A ES537677A ES8603477A1 ES 8603477 A1 ES8603477 A1 ES 8603477A1 ES 537677 A ES537677 A ES 537677A ES 537677 A ES537677 A ES 537677A ES 8603477 A1 ES8603477 A1 ES 8603477A1
Authority
ES
Spain
Prior art keywords
imidazo
quinolines
quinolin
amines
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537677A
Other languages
English (en)
Spanish (es)
Other versions
ES537677A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riker Laboratories Inc
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Publication of ES537677A0 publication Critical patent/ES537677A0/es
Publication of ES8603477A1 publication Critical patent/ES8603477A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Physical Water Treatments (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Alarm Systems (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Luminescent Compositions (AREA)
  • Lubricants (AREA)
ES537677A 1983-11-18 1984-11-15 Procedimiento para preparar una 1h-imidazo (4, 5-c) quinolin-4-amina Expired ES8603477A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55315783A 1983-11-18 1983-11-18
US55315883A 1983-11-18 1983-11-18

Publications (2)

Publication Number Publication Date
ES537677A0 ES537677A0 (es) 1985-12-16
ES8603477A1 true ES8603477A1 (es) 1985-12-16

Family

ID=27070262

Family Applications (1)

Application Number Title Priority Date Filing Date
ES537677A Expired ES8603477A1 (es) 1983-11-18 1984-11-15 Procedimiento para preparar una 1h-imidazo (4, 5-c) quinolin-4-amina

Country Status (15)

Country Link
EP (2) EP0310950B1 (OSRAM)
JP (1) JPS60123488A (OSRAM)
KR (1) KR900005657B1 (OSRAM)
AT (2) ATE84525T1 (OSRAM)
AU (2) AU581190B2 (OSRAM)
CA (1) CA1271477A (OSRAM)
DE (3) DE3486043T2 (OSRAM)
DK (6) DK164280C (OSRAM)
ES (1) ES8603477A1 (OSRAM)
IE (1) IE57874B1 (OSRAM)
IL (2) IL84537A (OSRAM)
NL (2) NL980041I2 (OSRAM)
NO (7) NO163819C (OSRAM)
NZ (1) NZ210228A (OSRAM)
PH (1) PH22338A (OSRAM)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
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CA1306260C (en) * 1985-10-18 1992-08-11 Shionogi & Co., Ltd. Condensed imidazopyridine derivatives
US4942168A (en) * 1987-07-13 1990-07-17 Hoechst-Roussel Pharmaceuticals Inc. Hydroxyquinoline amines, and method of enhancing memory in mammals
CA1335996C (en) * 1988-02-16 1995-06-20 Susumu Takada 2-substituted carbonylimidazo¬4,5-c|quinolines
EP0361489A3 (en) * 1988-09-30 1991-06-12 Chugai Seiyaku Kabushiki Kaisha Novel 3,4-diaminoquinoline and pyridine compounds
EP0385630B1 (en) * 1989-02-27 1996-11-27 Riker Laboratories, Inc. 1H-imidazo(4,5-c)Quinolin-4-amines as antivirals
CA2011504C (en) * 1989-03-07 1998-06-02 Kenji Ohmori Imidazoquinolone derivatives
US4929624A (en) * 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
CA2021338C (en) * 1989-07-18 1996-07-16 Fumio Suzuki Imidazoquinolone derivatives
US4988815A (en) * 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
FR2654021B1 (fr) * 1989-11-07 1992-02-28 Simond Jacques Procede de vitrification de cendres volantes et dispositif pour sa mise en óoeuvre.
GB8928281D0 (en) * 1989-12-14 1990-02-21 Smith Kline French Lab Compounds
JP3016905B2 (ja) * 1990-06-01 2000-03-06 協和醗酵工業株式会社 イミダゾナフチリジン誘導体
SG46492A1 (en) * 1991-03-01 1998-02-20 Minnesota Mining & Mfg 1-Substituted 2-substituted 1H-imidazo [4,5-c] quinolin-4-amines
US5266575A (en) * 1991-11-06 1993-11-30 Minnesota Mining And Manufacturing Company 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines
IL105325A (en) * 1992-04-16 1996-11-14 Minnesota Mining & Mfg Immunogen/vaccine adjuvant composition
US5395937A (en) * 1993-01-29 1995-03-07 Minnesota Mining And Manufacturing Company Process for preparing quinoline amines
US5693811A (en) * 1996-06-21 1997-12-02 Minnesota Mining And Manufacturing Company Process for preparing tetrahdroimidazoquinolinamines
US6069149A (en) * 1997-01-09 2000-05-30 Terumo Kabushiki Kaisha Amide derivatives and intermediates for the synthesis thereof
JPH10298181A (ja) * 1997-04-25 1998-11-10 Sumitomo Pharmaceut Co Ltd タイプ２ヘルパーｔ細胞選択的免疫応答抑制剤
JP2000119271A (ja) 1998-08-12 2000-04-25 Hokuriku Seiyaku Co Ltd １ｈ―イミダゾピリジン誘導体
UA74852C2 (en) * 2000-12-08 2006-02-15 3M Innovative Properties Co Urea-substituted imidazoquinoline ethers
EP2332922A1 (en) * 2001-10-23 2011-06-15 Merck Serono S.A. N-substituted azoles and their use as MEK-1 and/or ERK-2 modulators
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WO2004009593A1 (en) 2002-07-23 2004-01-29 Biogal Gyogyszergyar Rt. Preparation of 1h-imidazo[4,5-c]quinolin-4-amines via1h-imidazo [4,5-c]quinolin-4-phthalimide intermediates
ES2282691T3 (es) 2002-07-26 2007-10-16 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Preparacion de ih-imidazo(4,5-c)quinolin-4-amina mediante nuevos int ermedios 1h-imidazo (4,5-c)quinolin-4-ciano y 1h-imidazo (4,5-c).
BRPI0412902A (pt) 2003-08-12 2006-09-26 3M Innovative Properties Co compostos contendo imidazo substituìdo por oxima
CA2536136C (en) 2003-08-27 2012-10-30 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted imidazoquinolines
AU2004270201A1 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for CD5+ B cell lymphoma
WO2005033049A2 (en) 2003-10-01 2005-04-14 Taro Pharmaceuticals U.S.A., Inc. METHOD OF PREPARING 4-AMINO-1H-IMIDAZO(4,5-c)QUINOLINES AND ACID ADDITION SALTS THEREOF
CN1897948A (zh) 2003-10-03 2007-01-17 3M创新有限公司 烷氧基取代的咪唑并喹啉
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
ITMI20032121A1 (it) * 2003-11-04 2005-05-05 Dinamite Dipharma Spa In Forma Abbr Eviata Dipharm Procedimento per la preparazione di imiquimod e suoi intermedi
JP2007511527A (ja) 2003-11-14 2007-05-10 スリーエム イノベイティブ プロパティズ カンパニー オキシム置換イミダゾ環化合物
EP1682544A4 (en) 2003-11-14 2009-05-06 3M Innovative Properties Co HYDROXYLAMINE SUBSTITUTED IMIDAZO RING COMPOUNDS
RU2409576C2 (ru) 2003-11-25 2011-01-20 3М Инновейтив Пропертиз Компани Системы, содержащие имидазольное кольцо с заместителями, и способы их получения
US8802853B2 (en) 2003-12-29 2014-08-12 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
US8735421B2 (en) 2003-12-30 2014-05-27 3M Innovative Properties Company Imidazoquinolinyl sulfonamides
US8697873B2 (en) 2004-03-24 2014-04-15 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en) 2004-06-15 2005-12-29 3M Innovative Properties Company Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006038923A2 (en) 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
AU2005322898B2 (en) 2004-12-30 2011-11-24 3M Innovative Properties Company Chiral fused (1,2)imidazo(4,5-c) ring compounds
AU2005326708C1 (en) 2004-12-30 2012-08-30 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
WO2006084251A2 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
AU2006213746A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods
US7943636B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company 1-substituted pyrazolo (3,4-C) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
WO2006107853A2 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
CN101304748A (zh) 2005-08-22 2008-11-12 加利福尼亚大学董事会 Tlr激动剂
AU2007257423B8 (en) 2006-05-31 2012-02-16 The Regents Of The University Of California Purine analogs
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
EP2125007B9 (en) 2007-02-07 2014-04-16 The Regents of The University of California Conjugates of synthetic tlr agonists and uses therefor
EP2009002A1 (en) * 2007-06-21 2008-12-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) New process for the manufacture of 1H-imidazo [4,5-c]-quinoline ring systems
WO2010088924A1 (en) 2009-02-06 2010-08-12 Telormedix Sa Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration
KR20110117705A (ko) 2009-02-11 2011-10-27 더 리전트 오브 더 유니버시티 오브 캘리포니아 톨-유사 수용체 조정제 및 질병의 치료
PT2606047T (pt) * 2010-08-17 2017-04-07 3M Innovative Properties Co Composições, formulações e métodos de um composto lipidado modificador da resposta imunitária
US8728486B2 (en) 2011-05-18 2014-05-20 University Of Kansas Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds
EP2763677B1 (en) * 2011-10-04 2020-02-26 Janus Biotherapeutics, Inc. Novel imidazole quinoline-based immune system modulators
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BR112015022923A2 (pt) * 2013-03-15 2017-07-18 Syngenta Participations Ag derivados de imidazopiridina microbicidamente ativos
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KR20180134395A (ko) 2016-04-19 2018-12-18 인네이트 튜머 이뮤니티, 인코포레이티드 Nlrp3 조정제
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US11697851B2 (en) 2016-05-24 2023-07-11 The Regents Of The University Of California Early ovarian cancer detection diagnostic test based on mRNA isoforms
TWI674261B (zh) 2017-02-17 2019-10-11 美商英能腫瘤免疫股份有限公司 Nlrp3 調節劑
CN118515666A (zh) 2017-04-27 2024-08-20 博笛生物科技有限公司 2-氨基-喹啉衍生物
MX2019015744A (es) 2017-06-23 2020-02-20 Birdie Biopharmaceuticals Inc Composiciones farmaceuticas.
FR3113287B1 (fr) 2020-08-07 2023-06-23 Phv Pharma Procédé industriel de synthèse de l’imiquimod à partir de la quinolèine-2,4-diol applicable à son utilisation pharmaceutique
EP4259135A4 (en) * 2020-12-09 2025-01-08 Pharma Cinq, LLC IMIDAZOQUINOLINE COMPOUND WITH ANTI-INFLAMMATORY, FUNGICIDAL, ANTIPARASITIC AND ANTICANCER EFFECTS

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* Cited by examiner, † Cited by third party
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US3700674A (en) * 1969-04-30 1972-10-24 American Cyanamid Co 4-alkylamino-3-nitroquinolines
RO86850B (ro) * 1982-05-03 1985-05-31 Eli Lilly And Company Procedeu pentru prepararea unor 2-fenilimidazo [4,5 c] piridine

Also Published As

Publication number Publication date
DK169179B1 (da) 1994-09-05
DE19975027I2 (de) 2000-09-21
EP0310950B1 (en) 1993-01-13
JPH0586391B2 (OSRAM) 1993-12-10
IE842952L (en) 1985-05-18
KR900005657B1 (ko) 1990-08-03
NO169437C (no) 1992-06-24
DK135991A (da) 1991-07-16
AU611997B2 (en) 1991-06-27
NO890826L (no) 1985-05-20
DK164451B (da) 1992-06-29
PH22338A (en) 1988-08-12
NO890825L (no) 1985-05-20
NO844565L (no) 1985-05-20
NO168705C (no) 1992-03-25
DK164451C (da) 1992-11-09
DK165921C (da) 1993-06-28
NO890826D0 (no) 1989-02-27
EP0145340B1 (en) 1990-01-24
NO890823D0 (no) 1989-02-27
NO165146C (no) 1991-01-02
ATE84525T1 (de) 1993-01-15
NO890824D0 (no) 1989-02-27
JPS60123488A (ja) 1985-07-02
DK136191D0 (da) 1991-07-16
NO890825D0 (no) 1989-02-27
AU581190B2 (en) 1989-02-16
NO169437B (no) 1992-03-16
NO165145B (no) 1990-09-24
DK164280B (da) 1992-06-01
DK165921B (da) 1993-02-08
DK135991D0 (da) 1991-07-16
DK542684A (da) 1985-05-19
DK135891D0 (da) 1991-07-16
DK164455C (da) 1992-11-16
IL84537A0 (en) 1988-04-29
EP0145340A3 (en) 1986-06-11
NO890822L (no) 1985-05-20
DK136191A (da) 1991-07-16
DK136091A (da) 1991-07-16
NO890824L (no) 1985-05-20
NO165147B (no) 1990-09-24
IL84537A (en) 1990-12-23
ATE49763T1 (de) 1990-02-15
ES537677A0 (es) 1985-12-16
EP0145340A2 (en) 1985-06-19
DK135891A (da) 1991-07-16
NO165147C (no) 1991-01-02
NO163819B (no) 1990-04-17
NO165145C (no) 1991-01-02
DK542684D0 (da) 1984-11-15
NL980041I2 (nl) 1999-07-01
DE3486043T2 (de) 1993-06-03
NO1999015I1 (no) 1999-07-08
NO168705B (no) 1991-12-16
DK164452C (da) 1992-11-09
NO890823L (no) 1985-05-20
NZ210228A (en) 1989-01-27
DK136091D0 (da) 1991-07-16
NO165146B (no) 1990-09-24
AU3540284A (en) 1985-05-23
NO890822D0 (no) 1989-02-27
IE57874B1 (en) 1993-05-05
DK164455B (da) 1992-06-29
DE3481124D1 (de) 1990-03-01
DK135791D0 (da) 1991-07-16
CA1271477A (en) 1990-07-10
DK164280C (da) 1992-11-30
NL980041I1 (nl) 1999-02-01
NL980043I1 (nl) 1999-02-01
AU2991189A (en) 1989-06-15
NO163819C (no) 1990-08-01
DK164452B (da) 1992-06-29
KR850003890A (ko) 1985-06-29
EP0310950A1 (en) 1989-04-12
DE3486043D1 (de) 1993-02-25
DK135791A (da) 1991-07-16

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SPCD Supplementary protection certificate rejected

Free format text: IMIQUIMOD (ZARTRA, ALDARA) MOTIVO: SUBSISTEN DEFECTOS QUE NO HAN SIDO SUBSANADOS EN EL PLAZO ESTABLECIDO.

Spc suppl protection certif: C9900011

Filing date: 19990318

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