ES8602831A1 - Procedimiento para preparar sales de derivados de oxazafos- forina - Google Patents
Procedimiento para preparar sales de derivados de oxazafos- forinaInfo
- Publication number
- ES8602831A1 ES8602831A1 ES540778A ES540778A ES8602831A1 ES 8602831 A1 ES8602831 A1 ES 8602831A1 ES 540778 A ES540778 A ES 540778A ES 540778 A ES540778 A ES 540778A ES 8602831 A1 ES8602831 A1 ES 8602831A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- amino
- alk
- hydroxy
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZZVDXRCAGGQFAK-UHFFFAOYSA-N 2h-oxazaphosphinine Chemical class N1OC=CC=P1 ZZVDXRCAGGQFAK-UHFFFAOYSA-N 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000001340 2-chloroethyl group Chemical group [H]C([H])(Cl)C([H])([H])* 0.000 abstract 2
- -1 2-methanesulfonyloxyethyl Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- BOWUOGIPSRVRSJ-UHFFFAOYSA-N 2-aminohexano-6-lactam Chemical compound NC1CCCCNC1=O BOWUOGIPSRVRSJ-UHFFFAOYSA-N 0.000 abstract 1
- KATOCNXVWLJLIU-UHFFFAOYSA-N 3-amino-3-(difluoromethyl)piperidin-2-one Chemical compound FC(F)C1(N)CCCNC1=O KATOCNXVWLJLIU-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical group O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000007514 bases Chemical class 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
- KIWQWJKWBHZMDT-UHFFFAOYSA-N homocysteine thiolactone Chemical compound NC1CCSC1=O KIWQWJKWBHZMDT-UHFFFAOYSA-N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR SALES DE DERIVADOS DE OXAZAFOSFORINA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (I), DONDE R1, R2 Y R3 SON IGUALES O DIFERENTES Y REPRESENTAN HIDROGENO, METILO, ETILO, 2-CLOROETILO O 2-METANSULFONILOXIETILO, SIENDO POR LO MENOS DOS DE ESTOS RADICALES 2-CFLOROETILO Y/O 2-METANSULFONILOXIETILO, SIENDO A S-ALK-SO3H O N(OH) CONH-ALK-CO2H, DONDE ALK ES UN ALQUILENO C2-C6 O CH2, CON HOMOCISTEINTIOLACTONA, A-AMINO-E-CAPROLACTAMA O UN COMPLUESTO BASICO DE FORMULA (II) DONDE R4 A R8 PUEDEN SER DIVERSOS RADICALES, A TEMPERATURA ENTRE 0 5C, ENTRE VALORES DE PH 3-8, UTILIZANDO UN DISOLVENTE COMO AGUA, ALCOHOLES, ALIFATICOS INFERIORES, CETONAS ALIFATICAS O MEZCLAS DE ELLOS PARA DAR LUGAR A LA SAL CORRESPONDIENTE. DE APLICACION TERAPEUTICA EN EL TRATAMIENTO DEL CANCER.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3407585 | 1984-03-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES540778A0 ES540778A0 (es) | 1985-12-01 |
| ES8602831A1 true ES8602831A1 (es) | 1985-12-01 |
Family
ID=6229317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES540778A Expired ES8602831A1 (es) | 1984-03-01 | 1985-02-28 | Procedimiento para preparar sales de derivados de oxazafos- forina |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4716242A (es) |
| JP (1) | JPH072757B2 (es) |
| DD (1) | DD234017A5 (es) |
| DK (1) | DK93985A (es) |
| ES (1) | ES8602831A1 (es) |
| PL (2) | PL146149B1 (es) |
| PT (1) | PT80024B (es) |
| YU (2) | YU31285A (es) |
| ZA (1) | ZA851062B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE65402T1 (de) * | 1988-03-19 | 1991-08-15 | Asta Pharma Ag | Ifosfamid-mesna-lyophilisat und verfahren zu dessen herstellung. |
| DE3835772A1 (de) * | 1988-10-20 | 1990-04-26 | Deutsches Krebsforsch | Tumorhemmende saccharid-konjugate |
| US5227373A (en) * | 1991-10-23 | 1993-07-13 | Bristol-Myers Squibb Co. | Lyophilized ifosfamide compositions |
| US6828415B2 (en) | 1993-02-19 | 2004-12-07 | Zentaris Gmbh | Oligopeptide lyophilisate, their preparation and use |
| US5873584A (en) * | 1995-01-17 | 1999-02-23 | Rike Inline, Inc. | In-line roller skate frame |
| DE102004031569A1 (de) * | 2004-06-29 | 2006-02-02 | Baxter International Inc., Deerfield | Verfahren zur Herstellung von lagerstabiler Mafosfamid-Lysin-Salz Lyophilisat Bulkware und zu dessen Weiterverarbeitung zu Mafosfamid-Lysin-Salz Lyophilisat in dosierter Form |
| NZ589418A (en) * | 2004-10-25 | 2012-03-30 | Dekk Tec Inc | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
| CA2753041A1 (en) * | 2009-02-24 | 2010-09-02 | Dekk-Tec, Inc. | Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5159886A (es) * | 1974-11-20 | 1976-05-25 | Shionogi Seiyaku Kk | |
| EP0002495B1 (de) * | 1977-12-14 | 1984-02-15 | Asta-Werke Aktiengesellschaft Chemische Fabrik | Erzeugnisse zur Anwendung in der cytostatischen Therapie |
| JPS54157580A (en) * | 1978-05-29 | 1979-12-12 | Otsuka Pharmaceut Co Ltd | Optically active oxazaphosphorine derivative |
| JPS5651184A (en) * | 1979-10-03 | 1981-05-08 | Hitachi Ltd | Color solid image pickup device |
| DE3133309A1 (de) * | 1980-09-10 | 1982-04-15 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | 4-carbamoyloxy-oxazaphosphorine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
| DE3220432A1 (de) * | 1981-03-24 | 1983-12-01 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Oxazaphosphorin-4-thio-alkansulfonsaeure, ihre neutralen salze, verfahren zur herstellung derselben und diese enthaltenden pharmazeutischen praeparate |
| DE3220672A1 (de) * | 1981-03-24 | 1983-12-08 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Cis-oxazaphosphorin-4-thio-alkansulfonsaeuren, ihre neutralen salze, verfahren zur herstellung derselben und diese enthaltenden pharmazeutischen praeparate |
| DE3111428A1 (de) * | 1981-03-24 | 1982-10-07 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
| DE3132221A1 (de) * | 1981-08-14 | 1983-05-19 | Behringwerke Ag, 3550 Marburg | Neue cyclophosphamid-derivate, verfahren zu ihrer herstellung und ihre verwendung |
| DE3133077A1 (de) * | 1981-08-21 | 1983-03-10 | Henkel KGaA, 4000 Düsseldorf | Neue cytostatisch wirksame epoxidgruppen tragende 1,3,2-oxazaphosphorin-verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung in pharmazeutischen zubereitungen |
| US4618692A (en) * | 1981-09-03 | 1986-10-21 | Asta-Werke Aktiengesellschaft | 4-carbamoyloxy-oxazaphosphorins |
| DE3279834D1 (en) * | 1981-12-31 | 1989-08-31 | Asta Pharma Ag | 4-sulfido-oxaza phosphorines and their use in the treatment of cancer, and in immunosuppression |
| DE3247436A1 (de) * | 1981-12-31 | 1983-07-14 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | 4-sulfido-oxazaphosphorine und deren verwendung bei der krebsbekaempfung und zur immunsuppression |
| DE3505482A1 (de) * | 1984-03-01 | 1985-09-05 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Neue salze von oxazaphosphorin-derivaten |
-
1985
- 1985-02-12 ZA ZA851062A patent/ZA851062B/xx unknown
- 1985-02-22 US US06/704,465 patent/US4716242A/en not_active Expired - Lifetime
- 1985-02-28 PL PL1985266394A patent/PL146149B1/pl unknown
- 1985-02-28 ES ES540778A patent/ES8602831A1/es not_active Expired
- 1985-02-28 DK DK93985A patent/DK93985A/da not_active Application Discontinuation
- 1985-02-28 DD DD85273643A patent/DD234017A5/de unknown
- 1985-02-28 PT PT80024A patent/PT80024B/pt unknown
- 1985-02-28 YU YU00312/85A patent/YU31285A/xx unknown
- 1985-02-28 PL PL1985252161A patent/PL143712B1/pl unknown
- 1985-03-01 JP JP60038978A patent/JPH072757B2/ja not_active Expired - Fee Related
-
1987
- 1987-06-26 YU YU01202/87A patent/YU120287A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT80024B (pt) | 1987-09-18 |
| PL146149B1 (en) | 1988-12-31 |
| DK93985A (da) | 1985-09-02 |
| JPH072757B2 (ja) | 1995-01-18 |
| US4716242A (en) | 1987-12-29 |
| DK93985D0 (da) | 1985-02-28 |
| ZA851062B (en) | 1985-11-27 |
| PT80024A (de) | 1985-03-01 |
| DD234017A5 (de) | 1986-03-19 |
| YU120287A (en) | 1988-04-30 |
| PL143712B1 (en) | 1988-03-31 |
| PL252161A1 (en) | 1986-08-26 |
| ES540778A0 (es) | 1985-12-01 |
| YU31285A (en) | 1988-02-29 |
| JPS60222494A (ja) | 1985-11-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20050917 |