ES8206457A1 - Un procedimiento para la preparacion de compuestos n-acil-n- (cicloalquil) aminoacidos. - Google Patents

Un procedimiento para la preparacion de compuestos n-acil-n- (cicloalquil) aminoacidos.

Info

Publication number
ES8206457A1
ES8206457A1 ES502153A ES502153A ES8206457A1 ES 8206457 A1 ES8206457 A1 ES 8206457A1 ES 502153 A ES502153 A ES 502153A ES 502153 A ES502153 A ES 502153A ES 8206457 A1 ES8206457 A1 ES 8206457A1
Authority
ES
Spain
Prior art keywords
cycloalkyl
amino acid
acid compounds
compositions containing
containing same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES502153A
Other languages
English (en)
Other versions
ES502153A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ATK Launch Systems LLC
Original Assignee
Morton Norwich Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morton Norwich Products Inc filed Critical Morton Norwich Products Inc
Publication of ES502153A0 publication Critical patent/ES502153A0/es
Publication of ES8206457A1 publication Critical patent/ES8206457A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS N-ACIL-N-(CICLOALQUIL) AMINOACIDOS DE FORMULA (I), EN LA QUE R1 ES HIDROGENO O ALQUILO INFERIOR; R2 ES HIDROGENO, ACETILO O BENZOILO; A ES CICLOALQUILO C5-7; M Y O VALEN 0 O 1 Y 1 O 2, RESPECTIVAMENTE, Y DCHA ES DICICLOHESILAMINA O NADA. CONSISTE EN LA REACCION DE ACILACION DE UN COMPUESTO DE FORMULA (II) CON UN AGENTE ACILANTE DE FORMILA (III), EN LAS QUE X ES BENXOILTIO, ACEILTIO O BROMO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); SEGUIDA POR EL TRATAMIENTO OPCIONAL CON DICICLOHESILAMINA, Y POSTERIOR REACCION DE HIDROLISIS DEL RADICAL ACETILO O BENZOILO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA HIPERTENSION ASOCIADA A LA ANGIOTENSINA II.
ES502153A 1980-06-09 1981-05-12 Un procedimiento para la preparacion de compuestos n-acil-n- (cicloalquil) aminoacidos. Expired ES8206457A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15742080A 1980-06-09 1980-06-09

Publications (2)

Publication Number Publication Date
ES502153A0 ES502153A0 (es) 1982-08-16
ES8206457A1 true ES8206457A1 (es) 1982-08-16

Family

ID=22563635

Family Applications (1)

Application Number Title Priority Date Filing Date
ES502153A Expired ES8206457A1 (es) 1980-06-09 1981-05-12 Un procedimiento para la preparacion de compuestos n-acil-n- (cicloalquil) aminoacidos.

Country Status (16)

Country Link
JP (1) JPS5726656A (es)
AU (1) AU6808181A (es)
BE (1) BE889152A (es)
DD (1) DD159069A5 (es)
DE (1) DE3122541A1 (es)
DK (1) DK247181A (es)
ES (1) ES8206457A1 (es)
FR (1) FR2483916A1 (es)
GB (1) GB2077719A (es)
GR (1) GR82349B (es)
IL (1) IL62293A0 (es)
IT (1) IT1148008B (es)
NL (1) NL8101163A (es)
PT (1) PT73156B (es)
SE (1) SE8102455L (es)
ZA (1) ZA811340B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
JPS57142962A (en) * 1981-02-28 1982-09-03 Santen Pharmaceut Co Ltd Cyclodextrin clathrate compound of sulfur-containing compound
US4507316A (en) * 1981-06-01 1985-03-26 Usv Pharmaceutical Corporation Antihypertensive compounds
IN163391B (es) * 1981-11-13 1988-09-17 Exxon Research Engineering Co
US4661515A (en) * 1982-07-21 1987-04-28 Usv Pharmaceutical Corporation Compounds having angiotensin converting enzyme inhibitory activity and diuretic activity
IL69228A0 (en) * 1982-07-21 1983-11-30 Usv Pharma Corp Compounds having diuretic activity and angiotensin converting inhibitory activity,methods of the preparation thereof and pharmaceutical compositions containing the same
US4442038A (en) * 1982-09-17 1984-04-10 Norwich Eaton Pharmaceuticals, Inc. Converting enzyme inhibitors
FR2562068B1 (fr) * 1984-03-29 1987-07-17 Roussel Uclaf Nouveaux derives de l'o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
EP0384636A1 (en) * 1989-02-21 1990-08-29 FISONS plc Pharmaceutically active compounds
DE4337600A1 (de) * 1993-11-01 1995-05-04 Diagnostikforschung Inst N-Alkyl-Peptidchelatbildner, deren Metallkomplexe mit Radionukliden, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Zusammesetzungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
US4108886A (en) * 1977-03-11 1978-08-22 E. R. Squibb & Sons, Inc. Thiopropanoylamino acid derivatives
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides

Also Published As

Publication number Publication date
PT73156B (en) 1982-07-16
BE889152A (fr) 1981-12-09
PT73156A (en) 1981-07-01
NL8101163A (nl) 1982-01-04
GR82349B (es) 1984-12-13
IL62293A0 (en) 1981-05-20
FR2483916A1 (fr) 1981-12-11
DK247181A (da) 1981-12-10
ES502153A0 (es) 1982-08-16
IT8148270A0 (it) 1981-04-13
AU6808181A (en) 1981-12-17
GB2077719A (en) 1981-12-23
IT1148008B (it) 1986-11-26
DD159069A5 (de) 1983-02-16
SE8102455L (sv) 1981-12-10
JPS5726656A (en) 1982-02-12
ZA811340B (en) 1982-03-31
DE3122541A1 (de) 1982-03-25

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