ES8602414A1 - Procedimiento para la preparacion de un concentrado de antitrombina iii-heparina o de antitrombina iii-heparinoide - Google Patents
Procedimiento para la preparacion de un concentrado de antitrombina iii-heparina o de antitrombina iii-heparinoideInfo
- Publication number
- ES8602414A1 ES8602414A1 ES532641A ES532641A ES8602414A1 ES 8602414 A1 ES8602414 A1 ES 8602414A1 ES 532641 A ES532641 A ES 532641A ES 532641 A ES532641 A ES 532641A ES 8602414 A1 ES8602414 A1 ES 8602414A1
- Authority
- ES
- Spain
- Prior art keywords
- heparin
- antithrombin iii
- complex
- iii
- heparinoid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8128—Antithrombin III
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE UN CONCENTRADO DE ANTITROMBINA III-HEPARINA O DE ANTITROMBINA III-HEPARINOIDE Y DE ANTITROMBINA III. CONSISTE EN MEZCLAR PLASMA HUMANO O FRACCIONES DE PLASMA QUE CONTIENEN ANTITROMBINA III CON FORMACION DE UN COMPLEJO DE ANTITROMBINA III-HEPARINOIDE CON HEPARINA O HEPARINOIDE. EL COMPLEJO FORMADO SE ADSORBE A UN INTERCAMBIADOR DE ANIONES, EL ADSORBATO SE ELUYE POR MEDIO DE UNA SOLUCION SALINA, SE ELIMINA DEL ELUATO SALES Y PROTEINAS INDESEABLES Y EL PRODUCTO OBTENIDO SE LLEVA A FORMA ESTABLE MEDIANTE LIOFILIZACION. PARA OBTENER ANTITROMBINA LIBRE SE TRATA LA SOLUCION QUE CONTIENE EL COMPLEJO CON PROTAMINA INMOVILIZADA, CON LO QUE SE DESDOBLA EL COMPLEJO Y SE FIJA LA HEPARINA A LA PROTAMINA INMOVILIZADA, LA PORCION SOBRENADANTE QUE CONTIENE LA ANTITROMBINA III SE LLEVA A FORMA ESTABLE POR LIOFILIZACION. APLICACION COMO ANTICOAGULANTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0185983A AT379310B (de) | 1983-05-20 | 1983-05-20 | Verfahren zur herstellung eines antithrombin iii-heparin- bzw. antithrombin iii-heparinoidkonzentrates |
Publications (2)
Publication Number | Publication Date |
---|---|
ES532641A0 ES532641A0 (es) | 1985-12-01 |
ES8602414A1 true ES8602414A1 (es) | 1985-12-01 |
Family
ID=3522546
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES532641A Expired ES8602414A1 (es) | 1983-05-20 | 1984-05-18 | Procedimiento para la preparacion de un concentrado de antitrombina iii-heparina o de antitrombina iii-heparinoide |
Country Status (8)
Country | Link |
---|---|
US (1) | US4510084A (es) |
EP (2) | EP0307002B1 (es) |
JP (2) | JPS59222421A (es) |
AT (3) | AT379310B (es) |
CA (1) | CA1211371A (es) |
DE (2) | DE3485288D1 (es) |
DK (2) | DK167271B1 (es) |
ES (1) | ES8602414A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58180162A (ja) * | 1982-04-19 | 1983-10-21 | 株式会社高研 | 抗血栓性医用材料 |
US4820693A (en) * | 1986-05-22 | 1989-04-11 | Angiogenics, Ltd. | Method and composition for arresting angiogenesis and capillary, cell or membrane leakage |
US4966890A (en) * | 1986-04-04 | 1990-10-30 | Angiogenics, Ltd. | Method and composition for arresting angiogenesis and capillary, cell or membrane leakage |
AT391808B (de) * | 1986-11-03 | 1990-12-10 | Immuno Ag | Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion |
CA1341379C (en) * | 1988-04-28 | 2002-07-23 | Welfide Corporation | Purified antithrombin-iii and methods of producing the same |
JP2678249B2 (ja) * | 1988-06-22 | 1997-11-17 | 株式会社ミドリ十字 | アンチトロンビン−▲iii▼製剤 |
JP3711561B2 (ja) * | 1993-04-05 | 2005-11-02 | 三菱ウェルファーマ株式会社 | アンチトロンビン−▲iii▼液状製剤およびその安定化方法 |
JPH08199580A (ja) * | 1995-01-24 | 1996-08-06 | Tetra:Kk | 斜面昇降装置 |
US6562781B1 (en) | 1995-11-30 | 2003-05-13 | Hamilton Civic Hospitals Research Development Inc. | Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
US7045585B2 (en) * | 1995-11-30 | 2006-05-16 | Hamilton Civic Hospital Research Development Inc. | Methods of coating a device using anti-thrombin heparin |
US6491965B1 (en) | 1995-11-30 | 2002-12-10 | Hamilton Civic Hospitals Research Development, Inc. | Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
AT405739B (de) | 1997-09-19 | 1999-11-25 | Immuno Ag | Verfahren zur reinigung von antithrombin iii |
US5985582A (en) * | 1997-12-09 | 1999-11-16 | Sigma-Aldrich Co. | Thrombin-based assay for antithrombin III |
US20140206844A1 (en) | 2013-01-18 | 2014-07-24 | Prothera Biologics | Methods for isolating blood products from an inter-alpha inhibitor protein-depleted blood product material |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3099600A (en) * | 1961-01-26 | 1963-07-30 | Ormonoterapia Richter Spa | Chromatographic purification of heparin |
SE392038B (sv) * | 1971-09-08 | 1977-03-14 | Kabi Ab | Forfarande for isolering av antitrombin ur blod eller blodprodukter |
US3920625A (en) * | 1973-06-19 | 1975-11-18 | Kabi Ab | Isolation of coagulation factors from biological material using cross linked sulfated, sulfonated carbohydrates |
US4119774A (en) * | 1976-03-05 | 1978-10-10 | Ab Kabi | Heparin purification method |
US4087415A (en) * | 1976-06-09 | 1978-05-02 | William L. Wilson | Antithrombin III |
US4175182A (en) * | 1978-07-03 | 1979-11-20 | Research Corporation | Separation of high-activity heparin by affinity chromatography on supported protamine |
JPS6011922B2 (ja) * | 1978-09-22 | 1985-03-29 | 天野製薬株式会社 | 高活性ヘパリンの製造法 |
AT359646B (de) * | 1979-04-19 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung von nebenwirkungs- freien plasmafraktionen |
FR2472390A1 (fr) * | 1979-05-04 | 1981-07-03 | Merieux Inst | Procede de preparation de concentres de complexe prothrombinique hautement purifies, et concentres obtenus |
GB2061687B (en) * | 1979-11-02 | 1983-04-13 | Kidd A W | Grass cutting machines and improved blade therefor |
DD148297A1 (de) * | 1979-12-21 | 1981-05-20 | Bezirks Inst Fuer Blutspende U | Verfahren zur herstellung von prothrombinkomplexkonzentraten mit verminderter thrombogenizitaet |
DE3036481A1 (de) * | 1980-09-27 | 1982-05-19 | EC Erdölchemie GmbH, 5000 Köln | Verfahren zur gemeinsamen herstellung von c 4 -oligomeren und alkyl-tert.-butylethern |
US4446126A (en) * | 1980-09-30 | 1984-05-01 | Cutter Laboratories, Inc. | Antithrombin-heparin complex and method for its production |
-
1983
- 1983-05-20 AT AT0185983A patent/AT379310B/de not_active IP Right Cessation
-
1984
- 1984-05-10 DE DE8888115353T patent/DE3485288D1/de not_active Expired - Fee Related
- 1984-05-10 DE DE8484890084T patent/DE3479503D1/de not_active Expired
- 1984-05-10 AT AT84890084T patent/ATE45747T1/de not_active IP Right Cessation
- 1984-05-10 EP EP88115353A patent/EP0307002B1/de not_active Expired - Lifetime
- 1984-05-10 EP EP84890084A patent/EP0129534B1/de not_active Expired
- 1984-05-10 AT AT88115353T patent/ATE69552T1/de not_active IP Right Cessation
- 1984-05-16 CA CA000454412A patent/CA1211371A/en not_active Expired
- 1984-05-16 DK DK241684A patent/DK167271B1/da not_active IP Right Cessation
- 1984-05-18 ES ES532641A patent/ES8602414A1/es not_active Expired
- 1984-05-18 US US06/611,639 patent/US4510084A/en not_active Expired - Lifetime
- 1984-05-19 JP JP59101637A patent/JPS59222421A/ja active Granted
-
1990
- 1990-12-07 DK DK292090A patent/DK168062B1/da not_active IP Right Cessation
-
1992
- 1992-07-28 JP JP4201213A patent/JPH07116235B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK168062B1 (da) | 1994-01-31 |
JPH05320198A (ja) | 1993-12-03 |
JPH053480B2 (es) | 1993-01-14 |
DK241684A (da) | 1984-11-21 |
DK167271B1 (da) | 1993-10-04 |
EP0129534B1 (de) | 1989-08-23 |
CA1211371A (en) | 1986-09-16 |
ATE45747T1 (de) | 1989-09-15 |
ATE69552T1 (de) | 1991-12-15 |
DE3479503D1 (en) | 1989-09-28 |
EP0129534A3 (en) | 1985-12-04 |
DK292090D0 (da) | 1990-12-07 |
ES532641A0 (es) | 1985-12-01 |
ATA185983A (de) | 1985-05-15 |
AT379310B (de) | 1985-12-27 |
DK292090A (da) | 1990-12-07 |
US4510084A (en) | 1985-04-09 |
JPH07116235B2 (ja) | 1995-12-13 |
EP0307002B1 (de) | 1991-11-21 |
DK241684D0 (da) | 1984-05-16 |
EP0307002A1 (de) | 1989-03-15 |
DE3485288D1 (de) | 1992-01-02 |
JPS59222421A (ja) | 1984-12-14 |
EP0129534A2 (de) | 1984-12-27 |
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