ES8601914A1 - Procedimiento para preparar un compuesto de 2, (monoanelado(3 4-, 4, 5- y 5, 6-) piridilalquilensulfinil)-benzimidazoles substituidos. - Google Patents
Procedimiento para preparar un compuesto de 2, (monoanelado(3 4-, 4, 5- y 5, 6-) piridilalquilensulfinil)-benzimidazoles substituidos.Info
- Publication number
- ES8601914A1 ES8601914A1 ES533853A ES533853A ES8601914A1 ES 8601914 A1 ES8601914 A1 ES 8601914A1 ES 533853 A ES533853 A ES 533853A ES 533853 A ES533853 A ES 533853A ES 8601914 A1 ES8601914 A1 ES 8601914A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- formula
- procedure
- piridilalquilensulfinil
- monoanelado
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000009835 boiling Methods 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000002731 stomach secretion inhibitor Substances 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51046883A | 1983-07-01 | 1983-07-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES533853A0 ES533853A0 (es) | 1985-12-01 |
| ES8601914A1 true ES8601914A1 (es) | 1985-12-01 |
Family
ID=24030850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES533853A Expired ES8601914A1 (es) | 1983-07-01 | 1984-06-29 | Procedimiento para preparar un compuesto de 2, (monoanelado(3 4-, 4, 5- y 5, 6-) piridilalquilensulfinil)-benzimidazoles substituidos. |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0130729A3 (OSRAM) |
| JP (1) | JPS6036483A (OSRAM) |
| KR (1) | KR890000881B1 (OSRAM) |
| AU (1) | AU573744B2 (OSRAM) |
| CA (1) | CA1259070A (OSRAM) |
| DK (1) | DK321884A (OSRAM) |
| ES (1) | ES8601914A1 (OSRAM) |
| FI (1) | FI83514C (OSRAM) |
| GR (1) | GR81445B (OSRAM) |
| IL (1) | IL72159A (OSRAM) |
| MX (1) | MX161283A (OSRAM) |
| NO (1) | NO164472C (OSRAM) |
| NZ (1) | NZ208553A (OSRAM) |
| PH (1) | PH20625A (OSRAM) |
| ZA (1) | ZA844953B (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341314C (en) | 1984-07-06 | 2001-11-06 | David Cox | Derivatives of benzimidazole, benzothiazole and benzoxazole |
| AU568441B2 (en) * | 1984-09-24 | 1987-12-24 | Upjohn Company, The | 2-(pyridylalkenesulfinyl) benzimidazole derivatives |
| EP0187977B1 (en) * | 1984-12-18 | 1990-08-29 | Otsuka Pharmaceutical Co., Ltd. | Tetrahydroquinoline derivatives, process for preparing the same and anti-peptic ulcer compositions containg the same |
| US5869513A (en) * | 1985-05-24 | 1999-02-09 | G. D. Searle & Co. | 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines |
| AU5768886A (en) | 1985-05-24 | 1986-11-27 | G.D. Searle & Co. | 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines |
| FI864138A7 (fi) * | 1985-10-16 | 1987-04-17 | Fisons Plc | Heterocykliska blandningar. |
| KR870008853A (ko) * | 1986-03-28 | 1987-10-21 | 오쯔까 아끼히꼬 | 하이드로퀴놀린 화합물의 제조방법 |
| DE3765030D1 (de) * | 1986-07-01 | 1990-10-25 | Shionogi Seiyaku Kk | Substituierte isoquinolinderivate und antiulcusmittel. |
| US4687775A (en) * | 1986-07-17 | 1987-08-18 | G. D. Searle & Co. | 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles |
| US4772619A (en) * | 1986-07-17 | 1988-09-20 | G. D. Searle & Co. | [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines |
| US4721718A (en) * | 1986-08-18 | 1988-01-26 | G. D. Searle & Co. | 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers |
| JPS6452782A (en) * | 1987-05-19 | 1989-02-28 | Shionogi & Co | Thienopyridine derivative and antiulcer agent |
| US4839365A (en) * | 1987-05-19 | 1989-06-13 | Shinogi & Co., Ltd. | Thienopyridine derivatives useful in treating gastric ulcers |
| US5945425A (en) * | 1994-04-29 | 1999-08-31 | G.D. Searle & Co. | Method of using (H+ /K+)ATPase inhibitors as antiviral agents |
| WO1997000875A1 (en) * | 1995-06-21 | 1997-01-09 | Korea Research Institute Of Chemical Technology | Benzimidazole derivatives containing fused pyridine |
| DE69634160T2 (de) * | 1995-09-21 | 2005-12-22 | Pharma Pass Ii Llc, Irvine | Ein säurelabile Omeprazol enthaltende Arzneizusammensetzung und Verfahren zu deren Herstellung |
| RU2217424C2 (ru) * | 2001-12-14 | 2003-11-27 | Федеральное государственное унитарное предприятие Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" | Способ получения 5-метокси-2-меркаптобензимидазола |
| US20060024362A1 (en) | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE416649B (sv) * | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
| SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| US4359465A (en) * | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
| IL66340A (en) * | 1981-08-13 | 1986-08-31 | Haessle Ab | Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation |
| US4472409A (en) * | 1981-11-05 | 1984-09-18 | Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung | 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects |
| SE8300736D0 (sv) * | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
-
1984
- 1984-06-14 CA CA000456621A patent/CA1259070A/en not_active Expired
- 1984-06-18 NZ NZ208553A patent/NZ208553A/en unknown
- 1984-06-18 EP EP84304112A patent/EP0130729A3/en not_active Withdrawn
- 1984-06-19 IL IL72159A patent/IL72159A/xx unknown
- 1984-06-25 MX MX201779A patent/MX161283A/es unknown
- 1984-06-27 GR GR75136A patent/GR81445B/el unknown
- 1984-06-28 ZA ZA844953A patent/ZA844953B/xx unknown
- 1984-06-28 AU AU29996/84A patent/AU573744B2/en not_active Ceased
- 1984-06-29 FI FI842631A patent/FI83514C/fi not_active IP Right Cessation
- 1984-06-29 NO NO842645A patent/NO164472C/no unknown
- 1984-06-29 PH PH30907A patent/PH20625A/en unknown
- 1984-06-29 ES ES533853A patent/ES8601914A1/es not_active Expired
- 1984-06-29 DK DK321884A patent/DK321884A/da not_active Application Discontinuation
- 1984-06-30 KR KR1019840003792A patent/KR890000881B1/ko not_active Expired
- 1984-06-30 JP JP59136436A patent/JPS6036483A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NO842645L (no) | 1985-01-02 |
| EP0130729A2 (en) | 1985-01-09 |
| FI83514B (fi) | 1991-04-15 |
| IL72159A0 (en) | 1984-10-31 |
| FI842631A0 (fi) | 1984-06-29 |
| MX161283A (es) | 1990-08-28 |
| NO164472C (no) | 1990-10-10 |
| AU2999684A (en) | 1985-01-03 |
| NO164472B (no) | 1990-07-02 |
| PH20625A (en) | 1987-03-06 |
| IL72159A (en) | 1987-12-31 |
| DK321884A (da) | 1985-01-02 |
| AU573744B2 (en) | 1988-06-23 |
| KR890000881B1 (ko) | 1989-04-12 |
| FI83514C (fi) | 1991-07-25 |
| KR850001201A (ko) | 1985-03-16 |
| NZ208553A (en) | 1987-07-31 |
| DK321884D0 (da) | 1984-06-29 |
| EP0130729A3 (en) | 1986-08-06 |
| ES533853A0 (es) | 1985-12-01 |
| GR81445B (OSRAM) | 1984-12-11 |
| CA1259070A (en) | 1989-09-05 |
| FI842631A7 (fi) | 1985-01-02 |
| ZA844953B (en) | 1985-02-27 |
| JPS6036483A (ja) | 1985-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970303 |