ES8504202A1 - Procedimiento para la obtencion de nuevos derivados de sinergistinas - Google Patents

Procedimiento para la obtencion de nuevos derivados de sinergistinas

Info

Publication number
ES8504202A1
ES8504202A1 ES534314A ES534314A ES8504202A1 ES 8504202 A1 ES8504202 A1 ES 8504202A1 ES 534314 A ES534314 A ES 534314A ES 534314 A ES534314 A ES 534314A ES 8504202 A1 ES8504202 A1 ES 8504202A1
Authority
ES
Spain
Prior art keywords
azepin
azetidin
pyrrolidin
piperidin
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES534314A
Other languages
English (en)
Other versions
ES534314A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Publication of ES8504202A1 publication Critical patent/ES8504202A1/es
Publication of ES534314A0 publication Critical patent/ES534314A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06182—Dipeptides with the first amino acid being heterocyclic and Pristinamycin II; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Lubricants (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Fixed Capacitors And Capacitor Manufacturing Machines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE NUEVOS DERIVADOS DE SINERGISTINAS.CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE FORMULA (RH) CON LA PRISTINAMICINA IIA DE FORMULA (II) EN UN DISOLVENTE ORGANICO CON ALCOLEOS, METANES, EN PRESENCIA DE UNA AMINA TERCIARIA Y A UNA TEMPERATURA ENTRE 0J Y 15JC, PARA OBTENER NUEVOS DERIVADOS DE PRISTINAMICINA IIB DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES; SIENDO R UN RADICAL ALQUILTIO SUSTITUIDO POR UN RADICAL PIRROLIDINILO- O 3, PIPERIDILO-2 Y OTROS; UN RADICAL DE FORMULA HET-5 Y OTROS.SE UTILIZA PARA EL TRATAMIENTO DE AFECCIONES POR BACTERIAS GRAM-POSITIVAS.
ES534314A 1983-07-13 1984-07-13 Procedimiento para la obtencion de nuevos derivados de sinergistinas Granted ES534314A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8311707A FR2549065B1 (fr) 1983-07-13 1983-07-13 Nouveaux derives de synergistines, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
ES8504202A1 true ES8504202A1 (es) 1985-04-01
ES534314A0 ES534314A0 (es) 1985-04-01

Family

ID=9290814

Family Applications (1)

Application Number Title Priority Date Filing Date
ES534314A Granted ES534314A0 (es) 1983-07-13 1984-07-13 Procedimiento para la obtencion de nuevos derivados de sinergistinas

Country Status (18)

Country Link
US (1) US4590004A (es)
EP (1) EP0135410B1 (es)
JP (1) JPH0631252B2 (es)
KR (1) KR910002842B1 (es)
AT (1) ATE37373T1 (es)
AU (1) AU567951B2 (es)
CA (1) CA1222513A (es)
DE (1) DE3474146D1 (es)
DK (1) DK170421B1 (es)
ES (1) ES534314A0 (es)
FI (1) FI78106C (es)
FR (1) FR2549065B1 (es)
GR (1) GR82382B (es)
IE (1) IE57550B1 (es)
IL (1) IL72398A (es)
PT (1) PT78895B (es)
SU (1) SU1396968A3 (es)
ZA (1) ZA845315B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2081763A1 (es) * 1993-02-17 1996-03-01 Rhone Poulenc Rorer Sa Forma puridicada de estreptograminas, su preparacion y las composiciones farmaceuticas que la contienen.

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2576022B1 (fr) * 1985-01-11 1987-09-11 Rhone Poulenc Sante Nouveaux derives de la pristinamycine ii b, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2599036B1 (fr) * 1986-05-22 1988-09-09 Rhone Poulenc Sante Nouveaux derives de synergistines, leur preparation et les compositions pharmaceutiques qui les contiennent
GB8616768D0 (en) * 1986-07-09 1986-08-13 May & Baker Ltd Process
US4859690A (en) * 1986-11-21 1989-08-22 Merck & Co., Inc. Therapeutic virginiamycin M1 analogs
US4772595A (en) * 1986-11-21 1988-09-20 Merck & Co., Inc. Synthetic virginiamycin M1 analogs
US4762923A (en) * 1986-11-21 1988-08-09 Merck & Co. Inc. Fermentation analogs of virginiamycin M1
ES2033335T3 (es) * 1987-07-07 1993-03-16 Rhone-Poulenc Sante Nuevo procedimiento para la preparacion de derivados de la pristinamicina ii b.
FR2655343B1 (fr) * 1989-12-05 1992-05-07 Rhone Poulenc Sante Procede de preparation de synergistine.
FR2664599B1 (fr) * 1990-07-16 1993-06-18 Rhone Poulenc Sante Vinylsulfonyl pristinamycine et sa preparation.
US5242938A (en) * 1992-08-27 1993-09-07 Merck & Co., Inc. Derivatives of virginiamycin M1
FR2755857B1 (fr) * 1996-11-19 1998-12-24 Rhone Poulenc Rorer Sa Compositions pharmaceutiques stabilisees, a base de quinupristine et de dalfopristine et leur preparation
FR2766489B1 (fr) * 1997-07-28 1999-08-27 Rhone Poulenc Rorer Sa Derives de streptogramines, leur preparation et les compositions qui les contiennent
FR2795733B1 (fr) * 1999-06-30 2001-09-07 Aventis Pharma Sa Derives de streptogramines, leur preparation et les compositions qui les contiennent
FR2818644B1 (fr) * 2000-12-21 2004-10-22 Aventis Pharma Sa Derives de streptogramines, leur preparation et les compositions qui les contiennent
CN103360463B (zh) * 2012-04-08 2016-06-08 浙江海正药业股份有限公司 一种达福普汀及其中间体的分离纯化方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2549063B1 (fr) * 1983-07-13 1985-10-25 Rhone Poulenc Sante Nouveaux derives de synergistines, leur preparation et les compositions pharmaceutiques qui les contiennent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2081763A1 (es) * 1993-02-17 1996-03-01 Rhone Poulenc Rorer Sa Forma puridicada de estreptograminas, su preparacion y las composiciones farmaceuticas que la contienen.

Also Published As

Publication number Publication date
FI842813A0 (fi) 1984-07-12
FI78106C (fi) 1989-06-12
ZA845315B (en) 1985-02-27
US4590004A (en) 1986-05-20
KR910002842B1 (ko) 1991-05-06
AU567951B2 (en) 1987-12-10
IL72398A (en) 1987-10-30
FR2549065A1 (fr) 1985-01-18
DK342484A (da) 1985-01-14
AU3047184A (en) 1986-01-16
PT78895A (fr) 1984-08-01
DK170421B1 (da) 1995-08-28
JPS6075483A (ja) 1985-04-27
FR2549065B1 (fr) 1985-10-25
DK342484D0 (da) 1984-07-12
IE57550B1 (en) 1992-11-18
IL72398A0 (en) 1984-11-30
ES534314A0 (es) 1985-04-01
SU1396968A3 (ru) 1988-05-15
DE3474146D1 (en) 1988-10-27
KR850001216A (ko) 1985-03-16
FI78106B (fi) 1989-02-28
EP0135410A1 (fr) 1985-03-27
FI842813A (fi) 1985-01-14
IE841788L (en) 1985-01-13
PT78895B (fr) 1986-08-14
CA1222513A (fr) 1987-06-02
EP0135410B1 (fr) 1988-09-21
JPH0631252B2 (ja) 1994-04-27
ATE37373T1 (de) 1988-10-15
GR82382B (es) 1984-12-13

Similar Documents

Publication Publication Date Title
ES8504202A1 (es) Procedimiento para la obtencion de nuevos derivados de sinergistinas
TW289757B (es)
HU9302439D0 (en) Imidazole derivatives
MY107756A (en) Piperazine derivatives.
IL105511A0 (en) 2,4-dioxoimidazolidine derivatives,their preparation and pharmaceutical compositions containing them
HUT66660A (en) Intermediates for producing 9-[(substituted glicyl)-amido]-6-demetyl-6-deoxy-tetracyclines and pharmaceutical compositions containing them
PH30007A (en) 7-(Substituted)-9-¬(sub-stituted glycyl)amido¾-6-dimethyl-6-deoxytetra-cyclines
MX9709416A (es) Compuesto tipo quinolizinona.
HU896769D0 (en) Fungicide compositions comprising azolylmethylcyclopentane-benzylidene-derivatives as active ingredient and process for preparation of the active ingredients
MX9709451A (es) Derivados de benzisoxazol e indazol como agentes antipsicoticos.
NZ333000A (en) Isoindole and condensed ring pyrrole compounds and pharmaceutical compositions containing them
IL72397A (en) Syntergistine derivatives,process for the preparation thereof and pharmaceutical compositions containing them
IL97913A0 (en) Heterocyclic compounds,their preparation and pharmaceutical compositions containing them
TR200003142T2 (tr) Yeni oktahidro-6,10-diokso-6H-piridazino [1,2-A] [1,2] diazepin-1-karboksilik asit türevleri.
DE69115135D1 (de) 1-Alkyl-3-(Acylamino)-Epsilon-Caprolactame zur Verbesserung der Lernfähigkeit und des Gedächtnisses und diese enthaltende pharmazeutische Zubereitungen.
DK0412058T3 (da) 1-Acyl-2-pyrrolidinoner som indlærings- og hukommelsesforstærkende midler og farmaceutiske præparater indeholdende disse forbindelser
IL112099A0 (en) N-oxides of 4-arylpiperazines and 4-arylpiperidines and pharmaceutical compositions containing them
IL84093A (en) Aralkyl-4h-1,2,4-triazole derivatives,their preparation and pharmaceutical compositions containing them
DE3062375D1 (en) 1-(2-propynyloxy)-2-amino-3-propanol ethers, their preparation and pharmaceutical composition containing them
IL103854A0 (en) 6-thiono-5,6-dihydro-dibenz(b,e)azepin-11-one-11-oximes,their preparation and pharmaceutical compositions containing them
MY123217A (en) Glycopeptide derivatives and pharmaceutical compositions containing the same
MX9704262A (es) Piridazinonas como antagonistas del receptor endotelial.