ES8502983A1 - Procedimiento para preparar derivados de acido 5-(4-cloro-3-sulfamoilbenzoil)-2, 3-dihidro-3-benzofurancarboxilico - Google Patents

Procedimiento para preparar derivados de acido 5-(4-cloro-3-sulfamoilbenzoil)-2, 3-dihidro-3-benzofurancarboxilico

Info

Publication number
ES8502983A1
ES8502983A1 ES532481A ES532481A ES8502983A1 ES 8502983 A1 ES8502983 A1 ES 8502983A1 ES 532481 A ES532481 A ES 532481A ES 532481 A ES532481 A ES 532481A ES 8502983 A1 ES8502983 A1 ES 8502983A1
Authority
ES
Spain
Prior art keywords
sulfamoylbenzoyl
dihydro
chloro
preparation
benzofuran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532481A
Other languages
English (en)
Other versions
ES532481A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES532481A0 publication Critical patent/ES532481A0/es
Publication of ES8502983A1 publication Critical patent/ES8502983A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ACIDO 5-(4-CLORO-3-SULFAMOILBENZOIL)-2,3-DIHIDRO-2-BENZOFURANCARBOXILICO.SE OBTIENEN DERIVADOS DE ACIDO 5-(4-CLORO-3-SULFAMOILBENZOIL)-2,3-DIHIDRO-2-BENZOFURANCARBOXILICO DE LA FORMULA (I), REACCIONANDO UN DERIVADO DE ACIDO CARBOXILICO DE FORMULA (II) CON UN DERIVADO DE 2,3-DIHIDROBENZOFURANO DE FORMULA (III), DE FORMA CONOCIDA POR ACILACION DE FRIEDEL-CRAFTS PARA FORMAR COMPUESTOS DE FORMULA (IV) QUE PRODUCEN POR HIDROLISIS LOS COMPUESTOS DE FORMULA (I) Y QUE EVENTUALMENTE SE TRANSFORMAN, CON BASES ORGANICAS O INORGANICAS EN SUS SALES DE ACIDOS CARBOXILICOS, O EN SALES CON ACIDOS MINERALES DE LOS ACIDOS CARBOXILICOS LIBRES DE FORMULA (I). R1 Y R2 IGUALES O DIFERENTES, SON H, HALOGENOS O METILO O SUS SALES, Z ES H O GRUPO PROTECTOR DIMETILAMINOMETILENO Y X ES UN GRUPO ACTIVO COMO CL, Y ES -COOR3, CON R3 HIDROGENO.
ES532481A 1983-05-17 1984-05-14 Procedimiento para preparar derivados de acido 5-(4-cloro-3-sulfamoilbenzoil)-2, 3-dihidro-3-benzofurancarboxilico Expired ES8502983A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3317884A DE3317884A1 (de) 1983-05-17 1983-05-17 5-(4-chlor-3-sulfamoylbenzoyl)-2,3-dihydro-2-benzofurancarbonsaeuren und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES532481A0 ES532481A0 (es) 1985-02-01
ES8502983A1 true ES8502983A1 (es) 1985-02-01

Family

ID=6199168

Family Applications (2)

Application Number Title Priority Date Filing Date
ES532481A Expired ES8502983A1 (es) 1983-05-17 1984-05-14 Procedimiento para preparar derivados de acido 5-(4-cloro-3-sulfamoilbenzoil)-2, 3-dihidro-3-benzofurancarboxilico
ES535140A Expired ES8601952A1 (es) 1983-05-17 1984-08-14 Procedimiento para preparar derivados de acido 5-(4-cloro-3-sulfamoilbenzoil)-2,3-dihidro-2-benzofurancarboxilico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES535140A Expired ES8601952A1 (es) 1983-05-17 1984-08-14 Procedimiento para preparar derivados de acido 5-(4-cloro-3-sulfamoilbenzoil)-2,3-dihidro-2-benzofurancarboxilico

Country Status (8)

Country Link
US (1) US4574128A (es)
EP (1) EP0125678A1 (es)
JP (1) JPS59219274A (es)
DE (1) DE3317884A1 (es)
DK (1) DK240984A (es)
ES (2) ES8502983A1 (es)
GR (1) GR82065B (es)
PT (1) PT78585B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5973579A (ja) * 1982-10-19 1984-04-25 Kotobuki Seiyaku Kk ベンゾフラン又はベンゾチオフェン誘導体，この化合物を有効成分とする尿酸排泄剤及びその製造方法
JPS6163671A (ja) * 1984-09-05 1986-04-01 Shionogi & Co Ltd ２，３−ジヒドロベンゾフラン−５−スルホンアミド誘導体および降圧利尿剤
IT1239946B (it) * 1990-03-12 1993-11-27 Biomedica Foscama Industria Chimicofarmaceutica Procedimento per la sintesi degli acidi 5-acilossi e 5-alcossi-2,3-diidro-4,6,7-trimetil-2-(rs)-benzofuranacetici
ES2559061T3 (es) * 2008-06-05 2016-02-10 Agfa Graphics Nv Fotoiniciadores polimerizables del tipo II y composiciones curables
WO2020181232A1 (en) 2019-03-06 2020-09-10 C4 Therapeutics, Inc. Heterocyclic compounds for medical treatment

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1129478B (de) * 1957-11-04 1962-05-17 Geigy Ag J R Verfahren zur Herstellung von Benzophenonsulfonamiden
US3055930A (en) * 1959-02-26 1962-09-25 Geigy Chem Corp New benzophenone sulphonic acid amides
US4087542A (en) * 1975-07-09 1978-05-02 Merck & Co., Inc. 2,3-Dihydro-6,7-disubstituted-5-acyl benzofuran-2-carboxylic acids
DE2727802A1 (de) * 1977-06-21 1979-04-19 Hoechst Ag Sulfamoyl-arylketone und verfahren zu ihrer herstellung
DE3232922A1 (de) * 1982-09-04 1984-03-08 Hoechst Ag, 6230 Frankfurt Sulfamoylbenzophenon-derivate, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen

Also Published As

Publication number Publication date
DE3317884A1 (de) 1984-11-22
PT78585B (de) 1986-07-17
JPS59219274A (ja) 1984-12-10
EP0125678A1 (de) 1984-11-21
ES532481A0 (es) 1985-02-01
PT78585A (de) 1984-06-01
ES535140A0 (es) 1985-11-01
ES8601952A1 (es) 1985-11-01
DK240984A (da) 1984-11-18
DK240984D0 (da) 1984-05-16
GR82065B (es) 1984-12-13
US4574128A (en) 1986-03-04

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