ES8601952A1 - Procedimiento para preparar derivados de acido 5-(4-cloro-3-sulfamoilbenzoil)-2,3-dihidro-2-benzofurancarboxilico - Google Patents

Procedimiento para preparar derivados de acido 5-(4-cloro-3-sulfamoilbenzoil)-2,3-dihidro-2-benzofurancarboxilico

Info

Publication number
ES8601952A1
ES8601952A1 ES535140A ES535140A ES8601952A1 ES 8601952 A1 ES8601952 A1 ES 8601952A1 ES 535140 A ES535140 A ES 535140A ES 535140 A ES535140 A ES 535140A ES 8601952 A1 ES8601952 A1 ES 8601952A1
Authority
ES
Spain
Prior art keywords
chloro
dihydro
carboxylic acids
sulfamoylbenzoyl
benzofuran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535140A
Other languages
English (en)
Other versions
ES535140A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8601952A1 publication Critical patent/ES8601952A1/es
Publication of ES535140A0 publication Critical patent/ES535140A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDO 5-(4-CLORO-3-SULFAMOILBRENZOIL)-2,3-DIHIDRO-2-BENZOFURANCARBOXILICO, EN FORMA DE SUS MEZCLAS RACEMICAS Y DE SUS ISOMEROS OPTICOS, ASI COMO DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 Y R2 REPRESENTAN HIDROGENO, METILO O HALOGENO. CONSISTE EN LA REACCION DE OXIDACION DE UN DERIVADO DE 2,3-DIHIDROBENZOFURANO, DE FORMULA (II), EN LA QUE Z REPRESENTA 2 HIDROGENOS O UN GRUPO PROTECTOR DIMETILAMINOMETILENO, R4 ES CH2OH O CHO, Y R1 Y R2 TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION SE EFECTUA MEDIANTE UN AGENTE OXIDANTE ADECUADO A UNA TEMPERATURA ENTRE 0 C Y 40C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES DIURETICOS Y URICOSURICOS.
ES535140A 1983-05-17 1984-08-14 Procedimiento para preparar derivados de acido 5-(4-cloro-3-sulfamoilbenzoil)-2,3-dihidro-2-benzofurancarboxilico Granted ES535140A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3317884A DE3317884A1 (de) 1983-05-17 1983-05-17 5-(4-chlor-3-sulfamoylbenzoyl)-2,3-dihydro-2-benzofurancarbonsaeuren und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES8601952A1 true ES8601952A1 (es) 1985-11-01
ES535140A0 ES535140A0 (es) 1985-11-01

Family

ID=6199168

Family Applications (2)

Application Number Title Priority Date Filing Date
ES532481A Granted ES532481A0 (es) 1983-05-17 1984-05-14 Procedimiento para preparar derivados de acido 5-(4-cloro-3-sulfamoilbenzoil)-2, 3-dihidro-3-benzofurancarboxilico
ES535140A Granted ES535140A0 (es) 1983-05-17 1984-08-14 Procedimiento para preparar derivados de acido 5-(4-cloro-3-sulfamoilbenzoil)-2,3-dihidro-2-benzofurancarboxilico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES532481A Granted ES532481A0 (es) 1983-05-17 1984-05-14 Procedimiento para preparar derivados de acido 5-(4-cloro-3-sulfamoilbenzoil)-2, 3-dihidro-3-benzofurancarboxilico

Country Status (8)

Country Link
US (1) US4574128A (es)
EP (1) EP0125678A1 (es)
JP (1) JPS59219274A (es)
DE (1) DE3317884A1 (es)
DK (1) DK240984A (es)
ES (2) ES532481A0 (es)
GR (1) GR82065B (es)
PT (1) PT78585B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5973579A (ja) * 1982-10-19 1984-04-25 Kotobuki Seiyaku Kk ベンゾフラン又はベンゾチオフェン誘導体，この化合物を有効成分とする尿酸排泄剤及びその製造方法
JPS6163671A (ja) * 1984-09-05 1986-04-01 Shionogi & Co Ltd ２，３−ジヒドロベンゾフラン−５−スルホンアミド誘導体および降圧利尿剤
IT1239946B (it) * 1990-03-12 1993-11-27 Biomedica Foscama Industria Chimicofarmaceutica Procedimento per la sintesi degli acidi 5-acilossi e 5-alcossi-2,3-diidro-4,6,7-trimetil-2-(rs)-benzofuranacetici
EP2130817B1 (en) * 2008-06-05 2016-01-06 AGFA Graphics NV Polymerizable Type II photoinitiators and curable compositions
EP3935050A4 (en) 2019-03-06 2023-01-04 C4 Therapeutics, Inc. HETEROCYCLIC COMPOUNDS FOR MEDICAL TREATMENT

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1129478B (de) * 1957-11-04 1962-05-17 Geigy Ag J R Verfahren zur Herstellung von Benzophenonsulfonamiden
US3055930A (en) * 1959-02-26 1962-09-25 Geigy Chem Corp New benzophenone sulphonic acid amides
US4087542A (en) * 1975-07-09 1978-05-02 Merck & Co., Inc. 2,3-Dihydro-6,7-disubstituted-5-acyl benzofuran-2-carboxylic acids
DE2727802A1 (de) * 1977-06-21 1979-04-19 Hoechst Ag Sulfamoyl-arylketone und verfahren zu ihrer herstellung
DE3232922A1 (de) * 1982-09-04 1984-03-08 Hoechst Ag, 6230 Frankfurt Sulfamoylbenzophenon-derivate, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen

Also Published As

Publication number Publication date
JPS59219274A (ja) 1984-12-10
US4574128A (en) 1986-03-04
PT78585B (de) 1986-07-17
ES8502983A1 (es) 1985-02-01
EP0125678A1 (de) 1984-11-21
ES532481A0 (es) 1985-02-01
DK240984A (da) 1984-11-18
PT78585A (de) 1984-06-01
DE3317884A1 (de) 1984-11-22
GR82065B (es) 1984-12-13
ES535140A0 (es) 1985-11-01
DK240984D0 (da) 1984-05-16

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