ES8405399A1 - Un procedimiento para la preparacion de nuevos derivados de carbapenem. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de carbapenem.

Info

Publication number
ES8405399A1
ES8405399A1 ES521224A ES521224A ES8405399A1 ES 8405399 A1 ES8405399 A1 ES 8405399A1 ES 521224 A ES521224 A ES 521224A ES 521224 A ES521224 A ES 521224A ES 8405399 A1 ES8405399 A1 ES 8405399A1
Authority
ES
Spain
Prior art keywords
aliphatic
derivatives
heterocyclyl
cycloaliphatic
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521224A
Other languages
English (en)
Other versions
ES521224A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES521224A0 publication Critical patent/ES521224A0/es
Publication of ES8405399A1 publication Critical patent/ES8405399A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE CARBAPENEM.CONSISTE EN SOMETER UN INTERMEDIO DE FORMULA (II) A UNA REACCION DE DESPLAZAMIENTO NUCLEOFILICO EN UN DISOLVENTE ORGANICO INERTE Y EN PRESENCIA DE ION PLATA, CON UN SULFURO DE FORMULA (III) PARA DESPLAZAR EL GRUPO YODO DEL INTERMEDIO (II) CON EL GRUPO DE FORMULA (IV), Y POSTERIOR SEPARACION DEL GRUPO PROTECTOR R DEL CARBOXILO, PARA FORMAR NUEVOS DERIVADOS DE CARBAPENEM DE FORMULA (I), DONDE R ES HIDROGENO; R ES HIDROGENO, ALQUILO, ALQUENILO, ALQUINILO CON C 1 A 10; R Y R SIGNIFICAN CADA UNODE ELLOS INDEPENDIENTEMENTE ALQUILO C 1 A 6, ALQUENILO C 2 A 6, ALQUINILO C 2 A 6 Y OTROS; A ES ALQUILENO CON C 2 A 6 ATOMOS DE CADENA LINEAL O RAMIFICADA Y R ES HIDROGENO, UNA CARGA ANIONICA O UN GRUPO PROTECTOR DEL CARBOXILO.TIENE APLICACION COMO POTENTES AGENTES ACTIBACTERIANOS Y/O COMO INHIBIDORES DE BBB-LACTAMASA.
ES521224A 1982-04-08 1983-04-05 Un procedimiento para la preparacion de nuevos derivados de carbapenem. Expired ES8405399A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36662782A 1982-04-08 1982-04-08

Publications (2)

Publication Number Publication Date
ES521224A0 ES521224A0 (es) 1984-06-01
ES8405399A1 true ES8405399A1 (es) 1984-06-01

Family

ID=23443823

Family Applications (1)

Application Number Title Priority Date Filing Date
ES521224A Expired ES8405399A1 (es) 1982-04-08 1983-04-05 Un procedimiento para la preparacion de nuevos derivados de carbapenem.

Country Status (25)

Country Link
JP (1) JPS58188887A (es)
KR (1) KR880001055B1 (es)
AT (1) AT383126B (es)
AU (1) AU567092B2 (es)
BE (1) BE896407A (es)
CA (1) CA1198440A (es)
CH (1) CH661927A5 (es)
DE (1) DE3312517A1 (es)
DK (1) DK155983A (es)
ES (1) ES8405399A1 (es)
FI (1) FI74009C (es)
FR (1) FR2524888B1 (es)
GB (1) GB2118183B (es)
GR (1) GR78822B (es)
HU (1) HU190716B (es)
IE (1) IE55225B1 (es)
IL (1) IL68295A0 (es)
IT (1) IT1168854B (es)
LU (1) LU84739A1 (es)
MY (1) MY8700945A (es)
NL (1) NL8301193A (es)
OA (1) OA07395A (es)
PT (1) PT76518B (es)
SE (1) SE460197B (es)
ZA (1) ZA832411B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683301A (en) * 1982-04-08 1987-07-28 Bristol-Myers Company Carbapenem antibiotics
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
AT396473B (de) * 1984-10-02 1993-09-27 Bristol Myers Squibb Co Verfahren zur herstellung von neuen carbapenemderivaten
US4665169A (en) * 1985-09-11 1987-05-12 Bristol-Myers Company Carbapenem antibiotics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU531084B2 (en) * 1977-10-19 1983-08-11 Merck & Co., Inc. Azetidine derivatives
EP0017992A1 (en) * 1979-04-19 1980-10-29 Merck & Co. Inc. 2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates
EP0038869A1 (en) * 1980-04-30 1981-11-04 Merck & Co. Inc. Process for the preparation of 1-carbapenems, and intermediates for their preparation
HU185493B (en) * 1981-12-30 1985-02-28 Richter Gedeon Vegyeszet Process for producing new azabicyclo-bracket-3.2.0-bracket closedheptene derivatives
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics

Also Published As

Publication number Publication date
SE8301928L (sv) 1983-12-02
SE460197B (sv) 1989-09-18
JPH0524156B2 (es) 1993-04-06
CH661927A5 (de) 1987-08-31
KR880001055B1 (ko) 1988-06-18
AU567092B2 (en) 1987-11-12
OA07395A (fr) 1984-06-30
IL68295A0 (en) 1983-07-31
DE3312517A1 (de) 1983-10-20
MY8700945A (en) 1987-12-31
ATA125583A (de) 1986-10-15
IT1168854B (it) 1987-05-20
PT76518A (en) 1983-05-01
GR78822B (es) 1984-10-02
GB2118183A (en) 1983-10-26
LU84739A1 (fr) 1983-12-05
GB2118183B (en) 1985-11-27
BE896407A (fr) 1983-10-07
DK155983A (da) 1983-10-09
AU1319883A (en) 1983-10-13
NL8301193A (nl) 1983-11-01
ZA832411B (en) 1983-12-28
FI74009C (fi) 1987-12-10
HU190716B (en) 1986-10-28
FI74009B (fi) 1987-08-31
CA1198440A (en) 1985-12-24
FI831135L (fi) 1983-10-09
GB8309505D0 (en) 1983-05-11
IT8348061A0 (it) 1983-04-07
JPS58188887A (ja) 1983-11-04
AT383126B (de) 1987-05-25
DE3312517C2 (es) 1991-10-31
ES521224A0 (es) 1984-06-01
DK155983D0 (da) 1983-04-07
IE830800L (en) 1983-10-08
PT76518B (en) 1986-02-06
IE55225B1 (en) 1990-07-04
FI831135A0 (fi) 1983-04-05
SE8301928D0 (sv) 1983-04-07
KR840004429A (ko) 1984-10-15
FR2524888B1 (fr) 1985-12-13
FR2524888A1 (fr) 1983-10-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519