ES8403433A1 - Procedimiento para la preparacion de derivados de carbaciclina - Google Patents
Procedimiento para la preparacion de derivados de carbaciclinaInfo
- Publication number
- ES8403433A1 ES8403433A1 ES523782A ES523782A ES8403433A1 ES 8403433 A1 ES8403433 A1 ES 8403433A1 ES 523782 A ES523782 A ES 523782A ES 523782 A ES523782 A ES 523782A ES 8403433 A1 ES8403433 A1 ES 8403433A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- atoms
- phenyl
- hydrogen
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- -1 C1 -C2 -alkoxy Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 abstract 1
- XZFRIPGNUQRGPI-WLPVIMDJSA-N Carbacyclin Chemical class C1\C(=C\CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 XZFRIPGNUQRGPI-WLPVIMDJSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 150000001735 carboxylic acids Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 150000007524 organic acids Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyrane Compounds (AREA)
- Ink Jet Recording Methods And Recording Media Thereof (AREA)
- Drawers Of Furniture (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
CONSISTE EN LA REACCION DE ESTERIFICACION DE UN COMPUESTO DE FORMULA (II), EVENTUALMENTE PROTEGIDOS SUS GRUPOS HIDROXILO, CON UN DERIVADO DE ACIDO HALOGENOACETICO DE FORMULA (III), EN LAS QUE HAL ES CLORO, BROMO Y YODO, R5 PUEDE SER VARIOS TIPOS DE RADICALES Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA. LA REACCION SE EFECTUA EN PRESENCIA DE UNA BASE, EN UN DISOLVENTE APROTICO A TEMPERATURAS ENTRE 0JC Y 100JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS HIPOTENSORES Y BRONCODILATADORES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823225288 DE3225288A1 (de) | 1982-07-02 | 1982-07-02 | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (2)
Publication Number | Publication Date |
---|---|
ES523782A0 ES523782A0 (es) | 1984-04-01 |
ES8403433A1 true ES8403433A1 (es) | 1984-04-01 |
Family
ID=6167779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES523782A Expired ES8403433A1 (es) | 1982-07-02 | 1983-07-01 | Procedimiento para la preparacion de derivados de carbaciclina |
Country Status (21)
Country | Link |
---|---|
US (1) | US5157042A (es) |
EP (1) | EP0098794B1 (es) |
JP (1) | JPS5921642A (es) |
AT (1) | ATE33829T1 (es) |
AU (1) | AU573530B2 (es) |
CA (1) | CA1245646A (es) |
CS (1) | CS236890B2 (es) |
DD (1) | DD210028B3 (es) |
DE (2) | DE3225288A1 (es) |
DK (1) | DK160759C (es) |
ES (1) | ES8403433A1 (es) |
FI (1) | FI77644C (es) |
GR (1) | GR78625B (es) |
HU (1) | HU190904B (es) |
IE (1) | IE55191B1 (es) |
IL (1) | IL69135A0 (es) |
NO (1) | NO163225C (es) |
NZ (1) | NZ204777A (es) |
PH (1) | PH24699A (es) |
SU (1) | SU1380608A3 (es) |
ZA (1) | ZA834836B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59141536A (ja) * | 1983-02-01 | 1984-08-14 | Sumitomo Chem Co Ltd | 新規ビシクロオクタン誘導体 |
DE3638761A1 (de) * | 1986-11-13 | 1988-05-26 | Schering Ag | Verbesserte ketoreduktion von carbacyclinzwischenprodukten |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1201712A (en) * | 1980-02-28 | 1986-03-11 | Paul A. Aristoff | Carbacyclin analogs |
US4306075A (en) * | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
DE3048906A1 (de) * | 1980-12-19 | 1982-07-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
FR2498035B1 (fr) * | 1981-01-09 | 1986-01-17 | Thomson Csf | Procede et dispositif de synchronisation de messages |
DE3221193A1 (de) * | 1982-05-28 | 1983-12-01 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacyclinester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3225287A1 (de) * | 1982-07-02 | 1984-01-05 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3226550A1 (de) * | 1982-07-13 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
AU568662B2 (en) * | 1983-07-25 | 1988-01-07 | Schryen, J.L. | Earthenware composition |
-
1982
- 1982-07-02 DE DE19823225288 patent/DE3225288A1/de not_active Withdrawn
-
1983
- 1983-06-24 AU AU16203/83A patent/AU573530B2/en not_active Ceased
- 1983-06-30 CA CA000431622A patent/CA1245646A/en not_active Expired
- 1983-06-30 GR GR71819A patent/GR78625B/el unknown
- 1983-06-30 SU SU833611270A patent/SU1380608A3/ru active
- 1983-06-30 IL IL69135A patent/IL69135A0/xx not_active IP Right Cessation
- 1983-07-01 IE IE1544/83A patent/IE55191B1/en not_active IP Right Cessation
- 1983-07-01 DK DK303683A patent/DK160759C/da not_active IP Right Cessation
- 1983-07-01 NZ NZ204777A patent/NZ204777A/en unknown
- 1983-07-01 EP EP83730066A patent/EP0098794B1/de not_active Expired
- 1983-07-01 ZA ZA834836A patent/ZA834836B/xx unknown
- 1983-07-01 ES ES523782A patent/ES8403433A1/es not_active Expired
- 1983-07-01 DD DD83252668A patent/DD210028B3/de not_active IP Right Cessation
- 1983-07-01 FI FI832431A patent/FI77644C/fi not_active IP Right Cessation
- 1983-07-01 JP JP58118397A patent/JPS5921642A/ja active Granted
- 1983-07-01 AT AT83730066T patent/ATE33829T1/de not_active IP Right Cessation
- 1983-07-01 HU HU832395A patent/HU190904B/hu not_active IP Right Cessation
- 1983-07-01 PH PH29167A patent/PH24699A/en unknown
- 1983-07-01 DE DE8383730066T patent/DE3376420D1/de not_active Expired
- 1983-07-01 NO NO832415A patent/NO163225C/no unknown
- 1983-07-04 CS CS835037A patent/CS236890B2/cs unknown
-
1991
- 1991-06-10 US US07/713,002 patent/US5157042A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0098794A1 (de) | 1984-01-18 |
DK303683A (da) | 1984-01-03 |
AU573530B2 (en) | 1988-06-16 |
DK303683D0 (da) | 1983-07-01 |
ATE33829T1 (de) | 1988-05-15 |
JPS5921642A (ja) | 1984-02-03 |
NZ204777A (en) | 1986-11-12 |
FI77644B (fi) | 1988-12-30 |
NO163225C (no) | 1990-04-25 |
DK160759C (da) | 1991-09-23 |
HU190904B (en) | 1986-12-28 |
SU1380608A3 (ru) | 1988-03-07 |
CS236890B2 (en) | 1985-05-15 |
DD210028B3 (de) | 1990-06-13 |
IL69135A0 (en) | 1983-10-31 |
NO832415L (no) | 1984-01-03 |
EP0098794B1 (de) | 1988-04-27 |
FI77644C (fi) | 1989-04-10 |
DD210028A5 (de) | 1984-05-30 |
PH24699A (en) | 1990-10-01 |
AU1620383A (en) | 1984-01-19 |
FI832431A0 (fi) | 1983-07-01 |
IE831544L (en) | 1984-01-02 |
DK160759B (da) | 1991-04-15 |
CA1245646A (en) | 1988-11-29 |
DE3376420D1 (en) | 1988-06-01 |
FI832431L (fi) | 1984-01-03 |
ES523782A0 (es) | 1984-04-01 |
DE3225288A1 (de) | 1984-01-19 |
GR78625B (es) | 1984-09-27 |
NO163225B (no) | 1990-01-15 |
JPH0437817B2 (es) | 1992-06-22 |
IE55191B1 (en) | 1990-06-20 |
US5157042A (en) | 1992-10-20 |
ZA834836B (en) | 1984-03-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19980924 |