ES8403433A1 - Procedimiento para la preparacion de derivados de carbaciclina - Google Patents

Procedimiento para la preparacion de derivados de carbaciclina

Info

Publication number
ES8403433A1
ES8403433A1 ES523782A ES523782A ES8403433A1 ES 8403433 A1 ES8403433 A1 ES 8403433A1 ES 523782 A ES523782 A ES 523782A ES 523782 A ES523782 A ES 523782A ES 8403433 A1 ES8403433 A1 ES 8403433A1
Authority
ES
Spain
Prior art keywords
group
atoms
phenyl
hydrogen
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523782A
Other languages
English (en)
Other versions
ES523782A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES523782A0 publication Critical patent/ES523782A0/es
Publication of ES8403433A1 publication Critical patent/ES8403433A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
  • Ink Jet Recording Methods And Recording Media Thereof (AREA)
  • Drawers Of Furniture (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

CONSISTE EN LA REACCION DE ESTERIFICACION DE UN COMPUESTO DE FORMULA (II), EVENTUALMENTE PROTEGIDOS SUS GRUPOS HIDROXILO, CON UN DERIVADO DE ACIDO HALOGENOACETICO DE FORMULA (III), EN LAS QUE HAL ES CLORO, BROMO Y YODO, R5 PUEDE SER VARIOS TIPOS DE RADICALES Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA. LA REACCION SE EFECTUA EN PRESENCIA DE UNA BASE, EN UN DISOLVENTE APROTICO A TEMPERATURAS ENTRE 0JC Y 100JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS HIPOTENSORES Y BRONCODILATADORES.
ES523782A 1982-07-02 1983-07-01 Procedimiento para la preparacion de derivados de carbaciclina Expired ES8403433A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823225288 DE3225288A1 (de) 1982-07-02 1982-07-02 Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES523782A0 ES523782A0 (es) 1984-04-01
ES8403433A1 true ES8403433A1 (es) 1984-04-01

Family

ID=6167779

Family Applications (1)

Application Number Title Priority Date Filing Date
ES523782A Expired ES8403433A1 (es) 1982-07-02 1983-07-01 Procedimiento para la preparacion de derivados de carbaciclina

Country Status (21)

Country Link
US (1) US5157042A (es)
EP (1) EP0098794B1 (es)
JP (1) JPS5921642A (es)
AT (1) ATE33829T1 (es)
AU (1) AU573530B2 (es)
CA (1) CA1245646A (es)
CS (1) CS236890B2 (es)
DD (1) DD210028B3 (es)
DE (2) DE3225288A1 (es)
DK (1) DK160759C (es)
ES (1) ES8403433A1 (es)
FI (1) FI77644C (es)
GR (1) GR78625B (es)
HU (1) HU190904B (es)
IE (1) IE55191B1 (es)
IL (1) IL69135A0 (es)
NO (1) NO163225C (es)
NZ (1) NZ204777A (es)
PH (1) PH24699A (es)
SU (1) SU1380608A3 (es)
ZA (1) ZA834836B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59141536A (ja) * 1983-02-01 1984-08-14 Sumitomo Chem Co Ltd 新規ビシクロオクタン誘導体
DE3638761A1 (de) * 1986-11-13 1988-05-26 Schering Ag Verbesserte ketoreduktion von carbacyclinzwischenprodukten

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1201712A (en) * 1980-02-28 1986-03-11 Paul A. Aristoff Carbacyclin analogs
US4306075A (en) * 1980-03-28 1981-12-15 The Upjohn Company Composition and process
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FR2498035B1 (fr) * 1981-01-09 1986-01-17 Thomson Csf Procede et dispositif de synchronisation de messages
DE3221193A1 (de) * 1982-05-28 1983-12-01 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3226550A1 (de) * 1982-07-13 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
AU568662B2 (en) * 1983-07-25 1988-01-07 Schryen, J.L. Earthenware composition

Also Published As

Publication number Publication date
EP0098794A1 (de) 1984-01-18
DK303683A (da) 1984-01-03
AU573530B2 (en) 1988-06-16
DK303683D0 (da) 1983-07-01
ATE33829T1 (de) 1988-05-15
JPS5921642A (ja) 1984-02-03
NZ204777A (en) 1986-11-12
FI77644B (fi) 1988-12-30
NO163225C (no) 1990-04-25
DK160759C (da) 1991-09-23
HU190904B (en) 1986-12-28
SU1380608A3 (ru) 1988-03-07
CS236890B2 (en) 1985-05-15
DD210028B3 (de) 1990-06-13
IL69135A0 (en) 1983-10-31
NO832415L (no) 1984-01-03
EP0098794B1 (de) 1988-04-27
FI77644C (fi) 1989-04-10
DD210028A5 (de) 1984-05-30
PH24699A (en) 1990-10-01
AU1620383A (en) 1984-01-19
FI832431A0 (fi) 1983-07-01
IE831544L (en) 1984-01-02
DK160759B (da) 1991-04-15
CA1245646A (en) 1988-11-29
DE3376420D1 (en) 1988-06-01
FI832431L (fi) 1984-01-03
ES523782A0 (es) 1984-04-01
DE3225288A1 (de) 1984-01-19
GR78625B (es) 1984-09-27
NO163225B (no) 1990-01-15
JPH0437817B2 (es) 1992-06-22
IE55191B1 (en) 1990-06-20
US5157042A (en) 1992-10-20
ZA834836B (en) 1984-03-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980924