GB2007218A - Prostaglandin I2 analogues - Google Patents
Prostaglandin I2 analoguesInfo
- Publication number
- GB2007218A GB2007218A GB7838358A GB7838358A GB2007218A GB 2007218 A GB2007218 A GB 2007218A GB 7838358 A GB7838358 A GB 7838358A GB 7838358 A GB7838358 A GB 7838358A GB 2007218 A GB2007218 A GB 2007218A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- prostaglandin
- hydrogen
- optionally substituted
- represents hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003174 prostaglandin I2 derivatives Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000007717 exclusion Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002997 prostaglandinlike Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Prostaglandin analogues of the general formula:- <IMAGE> [wherein Y represents ethylene or trans-vinylene, R<1> represents hydrogen or alkyl, R<2> represents hydrogen, methyl or ethyl, R<3> represents a single bond or C1-4 alkylene, R<4> represents hydrogen, alkyl, cycloalkyl optionally substituted by at least one alkyl, or represents a phenyl or phenoxy group optionally substituted by at least one chlorine atom, trifluoromethyl or alkyl, and the double bond between C5-C6 is Z] and cyclodextrin clathrates of such acids and esters and, when R<1> represents a hydrogen atom, non-toxic salts thereof, with the exclusion of thiaprostacyclin and its methyl ester, are new compounds possessing characteristic prostaglandin-like activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11613877A JPS5452069A (en) | 1977-09-29 | 1977-09-29 | Prostaglandin i2 analog compound and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2007218A true GB2007218A (en) | 1979-05-16 |
| GB2007218B GB2007218B (en) | 1982-08-04 |
Family
ID=14679665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7838358A Expired GB2007218B (en) | 1977-09-29 | 1978-09-27 | Prostaglandin 1 anologues |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS5452069A (en) |
| DE (1) | DE2841360A1 (en) |
| FR (1) | FR2404637A1 (en) |
| GB (1) | GB2007218B (en) |
| IT (1) | IT1099217B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3310556A1 (en) * | 1982-03-25 | 1983-11-24 | Ono Pharmaceutical Co. Ltd., Osaka | USE OF PROSTAGLANDINE ANALOGS |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4291166A (en) * | 1978-03-13 | 1981-09-22 | Research Corporation | Pharmaceutically active 6,9-thiaprostacyclin analogs and derivatives thereof |
-
1977
- 1977-09-29 JP JP11613877A patent/JPS5452069A/en active Pending
-
1978
- 1978-09-22 DE DE19782841360 patent/DE2841360A1/en not_active Withdrawn
- 1978-09-27 IT IT28156/78A patent/IT1099217B/en active
- 1978-09-27 GB GB7838358A patent/GB2007218B/en not_active Expired
- 1978-09-28 FR FR7827768A patent/FR2404637A1/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3310556A1 (en) * | 1982-03-25 | 1983-11-24 | Ono Pharmaceutical Co. Ltd., Osaka | USE OF PROSTAGLANDINE ANALOGS |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2007218B (en) | 1982-08-04 |
| IT1099217B (en) | 1985-09-18 |
| FR2404637A1 (en) | 1979-04-27 |
| DE2841360A1 (en) | 1979-04-05 |
| FR2404637B1 (en) | 1982-02-05 |
| IT7828156A0 (en) | 1978-09-27 |
| JPS5452069A (en) | 1979-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |